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Current Issue of Nature

Current Issue : Nature

Current Issue

Volume 548 Number 7667 pp259-366

17 August 2017

About the cover

The cover image shows a conceptualized view of an individual with multiple cancers that have spread from their primary site, or metastasized. The primary cancers represented include prostate cancer (blue), breast cancer (pink), lung cancer (green) and colon cancer (orange). In this issue, Arul Chinnaiyan and colleagues report sequences of the DNA and RNA of 500 diverse human metastatic cancers as part of the Michigan Oncology Sequencing Program. The researchers characterize the landscape of genomic alterations in the cancers, including some mutations in germline DNA. They also show that clinical RNA sequencing can be used to characterize gene fusions, transcriptional signatures and the immune microenvironment of metastatic cancer. Cover image: Ella Marushchenko and Elina Karimullina (Ella Maru Studio, Inc.)

This Week



World View


Research Highlights


Seven Days


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Books and Arts

  • Seismology: Quake news from America

    Roger Bilham savours two rich accounts of seismicity across the continent.

    • Review of Quakeland: On the Road to America's Next Devastating Earthquake and The Great Quake: How the Biggest Earthquake in North America Changed Our Understanding of the Planet
      Kathryn Miles & Henry Fountain
  • Books in brief

    Barbara Kiser reviews five of the week's best science picks.






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  • New gliding mammaliaforms from the Jurassic

    • Qing-Jin Meng
    • David M. Grossnickle
    • Di Liu
    • Yu-Guang Zhang
    • April I. Neander
    • Qiang Ji
    • Zhe-Xi Luo

    Maiopatagium, a haramiyid from the Jurassic Tiaojishan Formation (around 160 million years ago) of China was specialised for gliding with a patagium (wing membrane) and a fused wishbone, reminiscent of that of birds.

  • Integrative clinical genomics of metastatic cancer

    • Dan R. Robinson
    • Yi-Mi Wu
    • Robert J. Lonigro
    • Pankaj Vats
    • Erin Cobain
    • Jessica Everett
    • Xuhong Cao
    • Erica Rabban
    • Chandan Kumar-Sinha
    • Victoria Raymond
    • Scott Schuetze
    • Ajjai Alva
    • Javed Siddiqui
    • Rashmi Chugh
    • Francis Worden
    • Mark M. Zalupski
    • Jeffrey Innis
    • Rajen J. Mody
    • Scott A. Tomlins
    • David Lucas
    • Laurence H. Baker
    • Nithya Ramnath
    • Ann F. Schott
    • Daniel F. Hayes
    • Joseph Vijai
    • Kenneth Offit
    • Elena M. Stoffel
    • J. Scott Roberts
    • David C. Smith
    • Lakshmi P. Kunju
    • Moshe Talpaz
    • Marcin Cieślik
    • Arul M. Chinnaiyan

    Clinical exome and transcriptome sequencing of 500 adult patients with metastatic solid tumours of diverse lineage and biopsy site, as part of the Michigan Oncology Sequencing (MI-ONCOSEQ) Program.

    See also


  • Ram-pressure feeding of supermassive black holes

    • Bianca M. Poggianti
    • Yara L. Jaffé
    • Alessia Moretti
    • Marco Gullieuszik
    • Mario Radovich
    • Stephanie Tonnesen
    • Jacopo Fritz
    • Daniela Bettoni
    • Benedetta Vulcani
    • Giovanni Fasano
    • Callum Bellhouse
    • George Hau
    • Alessandro Omizzolo

    The majority of ‘jellyfish’ galaxies, characterized by long ‘tentacles’ of gas, also have active nuclei, indicating that gas is being fed to the central supermassive black hole by ram pressure.

  • An early modern human presence in Sumatra 73,000–63,000 years ago

    • K. E. Westaway
    • J. Louys
    • R. Due Awe
    • M. J. Morwood
    • G. J. Price
    • J.-x. Zhao
    • M. Aubert
    • R. Joannes-Boyau
    • T. M. Smith
    • M. M. Skinner
    • T. Compton
    • R. M. Bailey
    • G. D. van den Bergh
    • J. de Vos
    • A. W. G. Pike
    • C. Stringer
    • E. W. Saptomo
    • Y. Rizal
    • J. Zaim
    • W. D. Santoso
    • A. Trihascaryo
    • L. Kinsley
    • B. Sulistyanto

    Morphological analysis of teeth found at Lida Ajer shows that these belong to Homo sapiens, indicating that modern humans were in Sumatra between 73,000 and 63,000 years ago.

  • Rewiring the taste system

    • Hojoon Lee
    • Lindsey J. Macpherson
    • Camilo A. Parada
    • Charles S. Zuker
    • Nicholas J. P. Ryba

    Taste-receptor cells use distinct semaphorins to guide wiring of the peripheral taste system; targeted ectopic expression of SEMA3A or SEMA7A leads to bitter neurons responding to sweet tastes or sweet neurons responding to bitter tastes.

    See also
  • Correction of aberrant growth preserves tissue homeostasis

    • Samara Brown
    • Cristiana M. Pineda
    • Tianchi Xin
    • Jonathan Boucher
    • Kathleen C. Suozzi
    • Sangbum Park
    • Catherine Matte-Martone
    • David G. Gonzalez
    • Julie Rytlewski
    • Slobodan Beronja
    • Valentina Greco

    Intravital imaging reveals unanticipated plasticity of adult skin epithelium in mice when faced with mutational or non-mutational insults, and elucidates the dynamic cellular behaviours used for its return to a homeostatic state.

    See also
  • m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways

    • Hua-Bing Li
    • Jiyu Tong
    • Shu Zhu
    • Pedro J. Batista
    • Erin E. Duffy
    • Jun Zhao
    • Will Bailis
    • Guangchao Cao
    • Lina Kroehling
    • Yuanyuan Chen
    • Geng Wang
    • James P. Broughton
    • Y. Grace Chen
    • Yuval Kluger
    • Matthew D. Simon
    • Howard Y. Chang
    • Zhinan Yin
    • Richard A. Flavell

    The authors assess the role of N 6-methyladenosine in T cell development and function, and show that RNA methylation controls T cell homeostasis by regulating IL-7-mediated STAT5 activation.

  • Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood

    • Julia Joung
    • Jesse M. Engreitz
    • Silvana Konermann
    • Omar O. Abudayyeh
    • Vanessa K. Verdine
    • Francois Aguet
    • Jonathan S. Gootenberg
    • Neville E. Sanjana
    • Jason B. Wright
    • Charles P. Fulco
    • Yuen-Yi Tseng
    • Charles H. Yoon
    • Jesse S. Boehm
    • Eric S. Lander
    • Feng Zhang

    Long noncoding RNAs are investigated using a CRISPR–Cas9 activation screen and shown to confer BRAF inhibitor resistance on melanoma cells through various local mechanisms.

  • mRNA 3′ uridylation and poly(A) tail length sculpt the mammalian maternal transcriptome

    • Marcos Morgan
    • Christian Much
    • Monica DiGiacomo
    • Chiara Azzi
    • Ivayla Ivanova
    • Dimitrios M. Vitsios
    • Jelena Pistolic
    • Paul Collier
    • Pedro N. Moreira
    • Vladimir Benes
    • Anton J. Enright
    • Dónal O’Carroll

    TUT4 and TUT7 mediate 3′ uridylation of mRNA transcripts, preferentially those with short poly(A) tails; in the absence of TUT4 and TUT7, oocytes cannot mature and female mice are infertile.

  • Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3

    • Stefan Schoebel
    • Wei Mi
    • Alexander Stein
    • Sergey Ovchinnikov
    • Ryan Pavlovicz
    • Frank DiMaio
    • David Baker
    • Melissa G. Chambers
    • Huayou Su
    • Dongsheng Li
    • Tom A. Rapoport
    • Maofu Liao

    The structure of yeast Hrd1 in complex with Hrd3 shows that Hrd1 forms an aqueous cavity with a lateral seal within the endoplasmic reticulum membrane, shedding light on how misfolded proteins are transported out of the endoplasmic reticulum.

  • Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA6

    • Reiya Taniguchi
    • Asuka Inoue
    • Misa Sayama
    • Akiharu Uwamizu
    • Keitaro Yamashita
    • Kunio Hirata
    • Masahito Yoshida
    • Yoshiki Tanaka
    • Hideaki E. Kato
    • Yoshiko Nakada-Nakura
    • Yuko Otani
    • Tomohiro Nishizawa
    • Takayuki Doi
    • Tomohiko Ohwada
    • Ryuichiro Ishitani
    • Junken Aoki
    • Osamu Nureki

    Determination of the crystal structure of the zebrafish LPA6 receptor shows that the lipid ligand binds to an unusual ligand-binding pocket in the receptor that is laterally accessible through the membrane.