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Current Issue of Nature


Volume 572 Issue 7771, 29 August 2019

Volume 572 Issue 7771, 29 August 2019

Cancer deconstructed

When cancer cells migrate from their primary site to a secondary location in the body, they can induce the healthy cells immediately around them to create an environment — a metastatic niche — that promotes tumour formation. So far, it has proved challenging to identify the cellular processes that take place in the niche in the early stages of cancer spread. In this week’s issue, Ilaria Malanchi and her colleagues present a technique that can probe the niche’s composition. The researchers have developed a cell-penetrating fluorescent protein that is taken up by neighbouring cells. By engineering cancer cells to express this protein, the team was able to study the properties of healthy cells in a metastatic niche at early-stage metastasis. Metastatic niche analysis over time can provide a view of the changing cell composition surrounding the cancerous cells. This is illustrated on the cover by a view of metastatic breast cancer cells (yellow) that have passed the fluorescent protein to surrounding healthy cells of the niche (red), to distinguish them from non-neighbouring tissue cells (white).

Cover image: Luigi Ombrato/Ilaria Malanchi

This Week

News in Focus

Comment

Careers

Futures

  • Futures |

    Plotting a route.

    • Beth Goder

Research

    News & Views

  • News & Views |

    Electronic devices that are based on carbon nanotubes have the potential to be more energy efficient than their silicon counterparts, but have been restricted in functionality. This limitation has now been overcome.

    • Franz Kreupl
  • News & Views |

    Cancer cells that travel to a distant site can prompt the normal neighbouring cells at that location to create a tumour-promoting microenvironment. A tool that identifies these normal cells offers a way to study this process.

    • Marie-Liesse Asselin-Labat
  • News & Views |

    Inflammation and the repair of damaged tissues are regulated by immune cells called macrophages. The finding that they form a layer that shields mouse joints from damage has implications for the treatment of arthritis.

    • Christopher D. Buckley
  • News & Views |

    How Nature reported a toxicological study of alcohol in 1919, and the potential benefits of computer graphics for medical geography in 1969.

  • News & Views |

    Magnetism alone was thought to be responsible for superconductivity in copper oxides. The finding of superconductivity in a non-magnetic compound that is structurally similar to these copper oxides challenges this view.

    • George A. Sawatzky
  • News & Views |

    Flatworms called planarians can break off fragments of themselves that regenerate to form new, complete worms. The molecular cues that regulate the frequency of such fission events have been revealed.

    • Thomas W. Holstein
  • Articles

  • Article |

    A 16-bit microprocessor built from over 14,000 carbon nanotube transistors may enable energy efficiency advances in electronics technologies beyond silicon.

    • Gage Hills
    • , Christian Lau
    • , Andrew Wright
    • , Samuel Fuller
    • , Mindy D. Bishop
    • , Tathagata Srimani
    • , Pritpal Kanhaiya
    • , Rebecca Ho
    • , Aya Amer
    • , Yosi Stein
    • , Denis Murphy
    • , Arvind
    • , Anantha Chandrakasan
    •  & Max M. Shulaker
  • Article |

    A cell-penetrating fluorescent marker is used to label cells in the metastatic tumour microenvironment, revealing a variety of cell types including parenchymal cells with lung stem-cell characteristics.

    • Luigi Ombrato
    • , Emma Nolan
    • , Ivana Kurelac
    • , Antranik Mavousian
    • , Victoria Louise Bridgeman
    • , Ivonne Heinze
    • , Probir Chakravarty
    • , Stuart Horswell
    • , Estela Gonzalez-Gualda
    • , Giulia Matacchione
    • , Anne Weston
    • , Joanna Kirkpatrick
    • , Ehab Husain
    • , Valerie Speirs
    • , Lucy Collinson
    • , Alessandro Ori
    • , Joo-Hyeon Lee
    •  & Ilaria Malanchi
  • Article |

    The pore-forming and ATP-binding subunits of a mitochondrial protein complex that mediates ATP-dependent potassium currents are identified and characterized, revealing the role of this channel in mitochondrial physiology and pathologies.

    • Angela Paggio
    • , Vanessa Checchetto
    • , Antonio Campo
    • , Roberta Menabò
    • , Giulia Di Marco
    • , Fabio Di Lisa
    • , Ildiko Szabo
    • , Rosario Rizzuto
    •  & Diego De Stefani
  • Article |

    The solute carrier transporter protein SLC25A44 regulates uptake of branched-chain amino acids in mitochondria of brown adipose tissue in which they are utilized for thermogenesis.

    • Takeshi Yoneshiro
    • , Qiang Wang
    • , Kazuki Tajima
    • , Mami Matsushita
    • , Hiroko Maki
    • , Kaori Igarashi
    • , Zhipeng Dai
    • , Phillip J. White
    • , Robert W. McGarrah
    • , Olga R. Ilkayeva
    • , Yann Deleye
    • , Yasuo Oguri
    • , Mito Kuroda
    • , Kenji Ikeda
    • , Huixia Li
    • , Ayano Ueno
    • , Maki Ohishi
    • , Takamasa Ishikawa
    • , Kyeongkyu Kim
    • , Yong Chen
    • , Carlos Henrique Sponton
    • , Rachana N. Pradhan
    • , Homa Majd
    • , Vanille Juliette Greiner
    • , Momoko Yoneshiro
    • , Zachary Brown
    • , Maria Chondronikola
    • , Haruya Takahashi
    • , Tsuyoshi Goto
    • , Teruo Kawada
    • , Labros Sidossis
    • , Francis C. Szoka
    • , Michael T. McManus
    • , Masayuki Saito
    • , Tomoyoshi Soga
    •  & Shingo Kajimura
  • Letters

  • Letter |

    Algorithms based on diffractive wave propagation of light offer effective imaging of complex scenes hidden from direct view.

    • Xiaochun Liu
    • , Ibón Guillén
    • , Marco La Manna
    • , Ji Hyun Nam
    • , Syed Azer Reza
    • , Toan Huu Le
    • , Adrian Jarabo
    • , Diego Gutierrez
    •  & Andreas Velten
  • Letter |

    Superconductivity is demonstrated in an infinite-layer nickelate similar to infinite-layer copper oxides, which is synthesized using soft- chemistry topotactic reduction of the perovskite precursor phase.

    • Danfeng Li
    • , Kyuho Lee
    • , Bai Yang Wang
    • , Motoki Osada
    • , Samuel Crossley
    • , Hye Ryoung Lee
    • , Yi Cui
    • , Yasuyuki Hikita
    •  & Harold Y. Hwang
  • Letter |

    The thermal conductance of single-molecule junctions is measured using picowatt-resolution calorimetric scanning probes and is found to be nearly independent of the length of the alkanedithiol molecules studied.

    • Longji Cui
    • , Sunghoon Hur
    • , Zico Alaia Akbar
    • , Jan C. Klöckner
    • , Wonho Jeong
    • , Fabian Pauly
    • , Sung-Yeon Jang
    • , Pramod Reddy
    •  & Edgar Meyhofer
  • Letter |

    The limitations of conventional chemical doping of polymeric semiconductors can be overcome by adding a second ionic species into the system, leading to enhanced doping, electrical conductivity and stability.

    • Yu Yamashita
    • , Junto Tsurumi
    • , Masahiro Ohno
    • , Ryo Fujimoto
    • , Shohei Kumagai
    • , Tadanori Kurosawa
    • , Toshihiro Okamoto
    • , Jun Takeya
    •  & Shun Watanabe
  • Letter |

    Overfishing and warming ocean temperature have caused an increase in methylmercury concentrations in some Atlantic predatory fish, and this trend is predicted to continue unless stronger mercury and carbon emissions standards are imposed.

    • Amina T. Schartup
    • , Colin P. Thackray
    • , Asif Qureshi
    • , Clifton Dassuncao
    • , Kyle Gillespie
    • , Alex Hanke
    •  & Elsie M. Sunderland
  • Letter |

    A planarian fission protocol shows that the number of progeny and the frequency of fission initiation correlate with parent size, and TGFβ and Wnt signalling components are identified as regulators of fission behaviour.

    • Christopher P. Arnold
    • , Blair W. Benham-Pyle
    • , Jeffrey J. Lange
    • , Christopher J. Wood
    •  & Alejandro Sánchez Alvarado
  • Letter |

    The gut commensal Blautia producta secretes a lantibiotic that reduces colonization of the gut by the major pathogen vancomycin-resistant Enterococcus faecium, and transplantation of microbiota with high abundance of the lantibiotic gene enhances resistance to colonization in mice.

    • Sohn G. Kim
    • , Simone Becattini
    • , Thomas U. Moody
    • , Pavel V. Shliaha
    • , Eric R. Littmann
    • , Ruth Seok
    • , Mergim Gjonbalaj
    • , Vincent Eaton
    • , Emily Fontana
    • , Luigi Amoretti
    • , Roberta Wright
    • , Silvia Caballero
    • , Zhong-Min X. Wang
    • , Hea-Jin Jung
    • , Sejal M. Morjaria
    • , Ingrid M. Leiner
    • , Weige Qin
    • , Ruben J. J. F. Ramos
    • , Justin R. Cross
    • , Seiko Narushima
    • , Kenya Honda
    • , Jonathan U. Peled
    • , Ronald C. Hendrickson
    • , Ying Taur
    • , Marcel R. M. van den Brink
    •  & Eric G. Pamer
  • Letter |

    Analysis of macrophage subsets within joints reveals a population of CX3CR1+ tissue-resident macrophages that form a tight-junction-mediated barrier at the synovial lining, protecting the joint from the invasion of inflammatory cells.

    • Stephan Culemann
    • , Anika Grüneboom
    • , José Ángel Nicolás-Ávila
    • , Daniela Weidner
    • , Katrin Franziska Lämmle
    • , Tobias Rothe
    • , Juan A. Quintana
    • , Philipp Kirchner
    • , Branislav Krljanac
    • , Martin Eberhardt
    • , Fulvia Ferrazzi
    • , Elke Kretzschmar
    • , Martin Schicht
    • , Kim Fischer
    • , Kolja Gelse
    • , Maria Faas
    • , René Pfeifle
    • , Jochen A. Ackermann
    • , Milena Pachowsky
    • , Nina Renner
    • , David Simon
    • , Reiner F. Haseloff
    • , Arif B. Ekici
    • , Tobias Bäuerle
    • , Ingolf E. Blasig
    • , Julio Vera
    • , David Voehringer
    • , Arnd Kleyer
    • , Friedrich Paulsen
    • , Georg Schett
    • , Andrés Hidalgo
    •  & Gerhard Krönke
  • Letter |

    The CTCF paralogue BORIS is upregulated in transcriptionally reprogrammed neuroblastoma cells rendered resistant to targeted therapy, in which it promotes regulatory chromatin interactions that maintain the resistance phenotype.

    • David N. Debruyne
    • , Ruben Dries
    • , Satyaki Sengupta
    • , Davide Seruggia
    • , Yang Gao
    • , Bandana Sharma
    • , Hao Huang
    • , Lisa Moreau
    • , Michael McLane
    • , Daniel S. Day
    • , Eugenio Marco
    • , Ting Chen
    • , Nathanael S. Gray
    • , Kwok-Kin Wong
    • , Stuart H. Orkin
    • , Guo-Cheng Yuan
    • , Richard A. Young
    •  & Rani E. George

Amendments & Corrections

Nature Outlook

  • Nature Outlook |

    Cannabis

    Cannabis, the drug that defined counterculture 50 years ago, is in the spotlight again as evidence mounts of potential medical benefits, and as legal barriers fall — especially in the United States.

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