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Current Issue of Nature


Current Issue : Nature

Current Issue

Volume 552 Number 7685 pp291-430

21 December 2017

About the cover

As 2017 draws to a close, we once again select 'Nature's 10' — ten people who this year played an important part in shaping the trends, events and challenges for science. The cover design speaks to the increasingly important role of artificial intelligence in science and technology. The image was created in the style of a machine-learning algorithm designed to solve the travelling salesman problem, which asks for the optimum path between a given set of points. Thus, the '10' was created using a single line. Image by Martin Krzywinski

This Week

Editorials

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World View

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Research Highlights

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Seven Days

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News in Focus

Feature

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  • Nature’s 10

    Ten people who mattered this year.

    • Heidi Ledford
    • Davide Castelvecchi
    • Elie Dolgin
    • Sara Reardon
    • Elizabeth Gibney
    • Nicky Phillips
    • Alexandra Witze

comment

Books and Arts

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Careers

Naturejobs

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naturejobs job listings and advertising features

Futures

Specials

Outlook on Cancer immunotherapy

Outlook

spotlight on Kanagawa

Spotlight

  • A smart place to work

    Cheap housing, close proximity to Tokyo and a burgeoning research ecosystem are thrusting the ancient prefecture of Kanagawa into the modern world.

    • Brett Davis

research

Articles

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  • Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

    • Carmen Venegas
    • Sathish Kumar
    • Bernardo S. Franklin
    • Tobias Dierkes
    • Rebecca Brinkschulte
    • Dario Tejera
    • Ana Vieira-Saecker
    • Stephanie Schwartz
    • Francesco Santarelli
    • Markus P. Kummer
    • Angelika Griep
    • Ellen Gelpi
    • Michael Beilharz
    • Dietmar Riedel
    • Douglas T. Golenbock
    • Matthias Geyer
    • Jochen Walter
    • Eicke Latz
    • Michael T. Heneka

    Deposition and spreading of amyloid-β pathology in mice requires binding to microglia-released ASC specks.

    See also
  • Origin and differentiation of human memory CD8 T cells after vaccination

    • Rama S. Akondy
    • Mark Fitch
    • Srilatha Edupuganti
    • Shu Yang
    • Haydn T. Kissick
    • Kelvin W. Li
    • Ben A. Youngblood
    • Hossam A. Abdelsamed
    • Donald J. McGuire
    • Kristen W. Cohen
    • Gabriela Alexe
    • Shashi Nagar
    • Megan M. McCausland
    • Satish Gupta
    • Pramila Tata
    • W. Nicholas Haining
    • M. Juliana McElrath
    • David Zhang
    • Bin Hu
    • William J. Greenleaf
    • Jorg J. Goronzy
    • Mark J. Mulligan
    • Marc Hellerstein
    • Rafi Ahmed

    In vivo deuterium labelling reveals a quiescent population of long-lived human virus-specific memory CD8 T cells that maintain the epigenetic landscape of effector cells, which facilitates rapid responses to pathogen re-exposure.

    See also
    See also
  • Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40

    • Haijuan Yang
    • Xiaolu Jiang
    • Buren Li
    • Hyo J. Yang
    • Meredith Miller
    • Angela Yang
    • Ankita Dhar
    • Nikola P. Pavletich

    The cryo-electron microscopy and crystal structures of several mTORC1 complexes, and accompanying biochemical analyses, shed light on how mTORC1 is regulated and how cancer mutations lead to its hyperactivation.

Letters

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  • Blazar spectral variability as explained by a twisted inhomogeneous jet

    • C. M. Raiteri
    • M. Villata
    • J. A. Acosta-Pulido
    • I. Agudo
    • A. A. Arkharov
    • R. Bachev
    • G. V. Baida
    • E. Benítez
    • G. A. Borman
    • W. Boschin
    • V. Bozhilov
    • M. S. Butuzova
    • P. Calcidese
    • M. I. Carnerero
    • D. Carosati
    • C. Casadio
    • N. Castro-Segura
    • W.-P. Chen
    • G. Damljanovic
    • F. D’Ammando
    • A. Di Paola
    • J. Echevarría
    • N. V. Efimova
    • Sh. A. Ehgamberdiev
    • C. Espinosa
    • A. Fuentes
    • A. Giunta
    • J. L. Gómez
    • T. S. Grishina
    • M. A. Gurwell
    • D. Hiriart
    • H. Jermak
    • B. Jordan
    • S. G. Jorstad
    • M. Joshi
    • E. N. Kopatskaya
    • K. Kuratov
    • O. M. Kurtanidze
    • S. O. Kurtanidze
    • A. Lähteenmäki
    • V. M. Larionov
    • E. G. Larionova
    • L. V. Larionova
    • C. Lázaro
    • C. S. Lin
    • M. P. Malmrose
    • A. P. Marscher
    • K. Matsumoto
    • B. McBreen
    • R. Michel
    • B. Mihov
    • M. Minev
    • D. O. Mirzaqulov
    • A. A. Mokrushina
    • S. N. Molina
    • J. W. Moody
    • D. A. Morozova
    • S. V. Nazarov
    • M. G. Nikolashvili
    • J. M. Ohlert
    • D. N. Okhmat
    • E. Ovcharov
    • F. Pinna
    • T. A. Polakis
    • C. Protasio
    • T. Pursimo
    • F. J. Redondo-Lorenzo
    • N. Rizzi
    • G. Rodriguez-Coira
    • K. Sadakane
    • A. C. Sadun
    • M. R. Samal
    • S. S. Savchenko
    • E. Semkov
    • B. A. Skiff
    • L. Slavcheva-Mihova
    • P. S. Smith
    • I. A. Steele
    • A. Strigachev
    • J. Tammi
    • C. Thum
    • M. Tornikoski
    • Yu. V. Troitskaya
    • I. S. Troitsky
    • A. A. Vasilyev
    • O. Vince

    The spectral variability of the blazar CTA 102 during a recent extreme outburst could be explained by a twisted, inhomogeneous jet containing regions of different orientations that vary in time.

  • A brief visit from a red and extremely elongated interstellar asteroid

    • Karen J. Meech
    • Robert Weryk
    • Marco Micheli
    • Jan T. Kleyna
    • Olivier R. Hainaut
    • Robert Jedicke
    • Richard J. Wainscoat
    • Kenneth C. Chambers
    • Jacqueline V. Keane
    • Andreea Petric
    • Larry Denneau
    • Eugene Magnier
    • Travis Berger
    • Mark E. Huber
    • Heather Flewelling
    • Chris Waters
    • Eva Schunova-Lilly
    • Serge Chastel

    The first interstellar object to be detected in the Solar System is asteroidal in nature and has a shape unlike any Solar System body, with a length about ten times its width.

  • Discovery of a big void in Khufu’s Pyramid by observation of cosmic-ray muons

    • Kunihiro Morishima
    • Mitsuaki Kuno
    • Akira Nishio
    • Nobuko Kitagawa
    • Yuta Manabe
    • Masaki Moto
    • Fumihiko Takasaki
    • Hirofumi Fujii
    • Kotaro Satoh
    • Hideyo Kodama
    • Kohei Hayashi
    • Shigeru Odaka
    • Sébastien Procureur
    • David Attié
    • Simon Bouteille
    • Denis Calvet
    • Christopher Filosa
    • Patrick Magnier
    • Irakli Mandjavidze
    • Marc Riallot
    • Benoit Marini
    • Pierre Gable
    • Yoshikatsu Date
    • Makiko Sugiura
    • Yasser Elshayeb
    • Tamer Elnady
    • Mustapha Ezzy
    • Emmanuel Guerriero
    • Vincent Steiger
    • Nicolas Serikoff
    • Jean-Baptiste Mouret
    • Bernard Charlès
    • Hany Helal
    • Mehdi Tayoubi

    Cosmic-ray muon radiography has been used to non-invasively visualize the voids in the Great Pyramid (Khufu’s Pyramid), revealing a large void situated above the Grand Gallery.

  • Synchrotron scanning reveals amphibious ecomorphology in a new clade of bird-like dinosaurs

    • Andrea Cau
    • Vincent Beyrand
    • Dennis F. A. E. Voeten
    • Vincent Fernandez
    • Paul Tafforeau
    • Koen Stein
    • Rinchen Barsbold
    • Khishigjav Tsogtbaatar
    • Philip J. Currie
    • Pascal Godefroit

    The recently discovered theropod Halszkaraptor escuillei reveals a novel basal dromaeosaurid clade, and its adaptations that suggest a semi-aquatic predatory lifestyle add an additional ecomorphology to those developed by non-avian maniraptorans.

  • Atmospheric trace gases support primary production in Antarctic desert surface soilOpen

    • Mukan Ji
    • Chris Greening
    • Inka Vanwonterghem
    • Carlo R. Carere
    • Sean K. Bay
    • Jason A. Steen
    • Kate Montgomery
    • Thomas Lines
    • John Beardall
    • Josie van Dorst
    • Ian Snape
    • Matthew B. Stott
    • Philip Hugenholtz
    • Belinda C. Ferrari

    Metagenomic and biochemical analyses of soil samples from Antarctic desert regions provides evidence that bacteria in these soils derive carbon and energy from atmospheric CO, H2 and CO2.

    See also
  • Effector CD8 T cells dedifferentiate into long-lived memory cells

    • Ben Youngblood
    • J. Scott Hale
    • Haydn T. Kissick
    • Eunseon Ahn
    • Xiaojin Xu
    • Andreas Wieland
    • Koichi Araki
    • Erin E. West
    • Hazem E. Ghoneim
    • Yiping Fan
    • Pranay Dogra
    • Carl W. Davis
    • Bogumila T. Konieczny
    • Rustom Antia
    • Xiaodong Cheng
    • Rafi Ahmed

    DNA methylation profiling of virus-specific T cells during acute viral infection in mice provides evidence that a fate-permissive subset of effector CD8 T cells dedifferentiates into long-lived memory T cells.

    See also
    See also
  • Dynamics of phosphoinositide conversion in clathrin-mediated endocytic traffic

    • Kangmin He
    • Robert Marsland III
    • Srigokul Upadhyayula
    • Eli Song
    • Song Dang
    • Benjamin R. Capraro
    • Weiming Wang
    • Wesley Skillern
    • Raphael Gaudin
    • Minghe Ma
    • Tom Kirchhausen

    ‘Coincidence-detecting’ phosphoinositide sensors are used to study changes in the phosphoinositide lipid species found in membranes during the development and maturation of endocytic clathrin-coated vesicles.

  • Evolution of a designed protein assembly encapsulating its own RNA genome

    • Gabriel L. Butterfield
    • Marc J. Lajoie
    • Heather H. Gustafson
    • Drew L. Sellers
    • Una Nattermann
    • Daniel Ellis
    • Jacob B. Bale
    • Sharon Ke
    • Garreck H. Lenz
    • Angelica Yehdego
    • Rashmi Ravichandran
    • Suzie H. Pun
    • Neil P. King
    • David Baker

    Computationally designed icosahedral protein-based assemblies can protect their genetic material and evolve in biochemical environments, suggesting a route to the custom design of synthetic nanomaterials for non-viral drug delivery.

  • Cryo-EM structures of the TMEM16A calcium-activated chloride channel

    • Shangyu Dang
    • Shengjie Feng
    • Jason Tien
    • Christian J. Peters
    • David Bulkley
    • Marco Lolicato
    • Jianhua Zhao
    • Kathrin Zuberbühler
    • Wenlei Ye
    • Lijun Qi
    • Tingxu Chen
    • Charles S. Craik
    • Yuh Nung Jan
    • Daniel L. Minor Jr
    • Yifan Cheng
    • Lily Yeh Jan

    Electron cryo-microscopy density maps of mouse TMEM16A reconstituted in nanodiscs or solubilized in detergent reveal two functional states of calcium-activated chloride channels.

    See also

Corrigenda

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Erratum

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  • Erratum: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity

    • Shabnam Shalapour
    • Xue-Jia Lin
    • Ingmar N. Bastian
    • John Brain
    • Alastair D. Burt
    • Alexander A. Aksenov
    • Alison F. Vrbanac
    • Weihua Li
    • Andres Perkins
    • Takaji Matsutani
    • Zhenyu Zhong
    • Debanjan Dhar
    • Jose A. Navas-Molina
    • Jun Xu
    • Rohit Loomba
    • Michael Downes
    • Ruth T. Yu
    • Ronald M. Evans
    • Pieter C. Dorrestein
    • Rob Knight
    • Christopher Benner
    • Quentin M. Anstee
    • Michael Karin