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Current Issue of Nature

Volume 566 Issue 7742, 7 February 2019

Volume 566 Issue 7742, 7 February 2019

Volume 566 Issue 7742

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Melting point

Two papers in this week’s issue focus on the melting ice sheets. In one, Nicholas Golledge and his colleagues examine the cascading effects of melt from the Greenland and Antarctic ice sheets. Using satellite measurements of recent ice-mass changes, the researchers refine current simulations to show that future ice-sheet melt will increase sea level by up to 25 centimetres by 2100, and that this will slow major aspects of ocean circulation, further enhance Antarctic melt and increase climate variability. In a second paper, Tamsin Edwards and her colleagues revisit the controversial marine ice-cliff instability hypothesis, which posits that coastal ice cliffs in Antarctica rapidly collapse when ice shelves melt. The researchers find that ice-cliff collapse is not required to explain past rises in sea level and suggest that this casts doubt on the need to include the hypothesis in projections. As a result, the team’s model predicts that there is only a 5% chance that the Antarctic contribution to sea-level rise will exceed 39 centimetres by 2100.

Cover image: Tom Hegen

This Week

News in Focus

Comment

Technology

Careers

Futures

  • Futures |

    A bid for freedom.

    • Michael Adam Robson

Research

    News & Views

  • News & Views |

    A method for making a version of a gene more likely to be inherited than normal, generating what is called a gene drive, might be used to control insect populations. It has now been reported to work in mammals, too.

    • Bruce R. Conklin

  • News & Views |

    A technique that harnesses energy loss has been used to produce a phase of matter in which particles of light are locked in place. This opens a path to realizing previously unseen exotic phases of matter.

    • Kaden R. A. Hazzard

  • News & Views |

    DNA sequences called retrotransposons can copy themselves and reintegrate at new sites in the genome, causing damage. It now seems that inhibiting this process can prevent age-related health decline in mice.

    • Bennett Childs
    •  & Jan van Deursen

  • News & Views |

    Mass loss from the Greenland and Antarctic ice sheets is accelerating as a result of rising global temperatures. Two studies explore how this mass loss will affect sea level and other aspects of the climate in the future.

    • Hélène Seroussi

  • News & Views |

    How Nature reported a strange natural phenomenon in 1969, and an anti-louse campaign in 1919.

  • News & Views |

    The gut is an active site of immune defence against disease-causing microbes. A study in mice shows that a type of immune cell in the gut’s wall also helps to regulate sugar and fat metabolism.

    • Daria Esterházy
    •  & Daniel Mucida

    • Articles

  • Article |

    Engineered dissipation is used to stabilize a Mott-insulator phase of photons trapped in a superconducting circuit, providing insights into thermalization processes in strongly correlated quantum matter.

    • Ruichao Ma
    • , Brendan Saxberg
    • , Clai Owens
    • , Nelson Leung
    • , Yao Lu
    • , Jonathan Simon
    •  & David I. Schuster

  • Article |

    By better quantifying uncertainties for marine ice-cliff instability, future Antarctic ice loss is predicted to be much lower than previously estimated.

    • Tamsin L. Edwards
    • , Mark A. Brandon
    • , Gael Durand
    • , Neil R. Edwards
    • , Nicholas R. Golledge
    • , Philip B. Holden
    • , Isabel J. Nias
    • , Antony J. Payne
    • , Catherine Ritz
    •  & Andreas Wernecke

  • Article |

    Increased meltwater from the Greenland and Antarctic ice sheets will slow the Atlantic overturning circulation and warm the subsurface ocean around Antarctica, further increasing Antarctic ice loss.

    • Nicholas R. Golledge
    • , Elizabeth D. Keller
    • , Natalya Gomez
    • , Kaitlin A. Naughten
    • , Jorge Bernales
    • , Luke D. Trusel
    •  & Tamsin L. Edwards

  • Article |

    During cellular senescence in human and mouse cells, L1 transposons become transcriptionally derepressed and trigger a type-1 interferon response, which contributes to age-associated inflammation and age-related phenotypes.

    • Marco De Cecco
    • , Takahiro Ito
    • , Anna P. Petrashen
    • , Amy E. Elias
    • , Nicholas J. Skvir
    • , Steven W. Criscione
    • , Alberto Caligiana
    • , Greta Brocculi
    • , Emily M. Adney
    • , Jef D. Boeke
    • , Oanh Le
    • , Christian Beauséjour
    • , Jayakrishna Ambati
    • , Kameshwari Ambati
    • , Matthew Simon
    • , Andrei Seluanov
    • , Vera Gorbunova
    • , P. Eline Slagboom
    • , Stephen L. Helfand
    • , Nicola Neretti
    •  & John M. Sedivy

  • Article |

    The activation mechanism of metabotropic glutamate receptor subtype 5, a member of the family C G-protein-coupled receptors, is characterized by a combination of cryo-electron microscopy, crystallography and signalling studies.

    • Antoine Koehl
    • , Hongli Hu
    • , Dan Feng
    • , Bingfa Sun
    • , Yan Zhang
    • , Michael J. Robertson
    • , Matthew Chu
    • , Tong Sun Kobilka
    • , Toon Laermans
    • , Jan Steyaert
    • , Jeffrey Tarrasch
    • , Somnath Dutta
    • , Rasmus Fonseca
    • , William I. Weis
    • , Jesper M. Mathiesen
    • , Georgios Skiniotis
    •  & Brian K. Kobilka

    • Letters

  • Letter |

    Simulations of early galaxy formation suggest that the dynamics of structure formation, rather than the Lyman–Werner flux, drives the formation of massive black holes in the early Universe.

    • John H. Wise
    • , John A. Regan
    • , Brian W. O’Shea
    • , Michael L. Norman
    • , Turlough P. Downes
    •  & Hao Xu

  • Letter |

    The thermal vibrations of a carbon nanotube are directly measured in real time with high displacement sensitivity and fine time resolution, revealing dynamics undetected by previous time-averaged measurements.

    • Arthur W. Barnard
    • , Mian Zhang
    • , Gustavo S. Wiederhecker
    • , Michal Lipson
    •  & Paul L. McEuen

  • Letter |

    Sequencing of total and ribosome-associated mRNAs enables identification of specific mRNAs that are differentially translationally regulated along the neuronal stem cell lineage, independently of their availability.

    • Avni Baser
    • , Maxim Skabkin
    • , Susanne Kleber
    • , Yonglong Dang
    • , Gülce S. Gülcüler Balta
    • , Georgios Kalamakis
    • , Manuel Göpferich
    • , Damian Carvajal Ibañez
    • , Roman Schefzik
    • , Alejandro Santos Lopez
    • , Enric Llorens Bobadilla
    • , Carsten Schultz
    • , Bernd Fischer
    •  & Ana Martin-Villalba

  • Letter |

    In the mouse intestine, pyruvate and lactate produced from bacterial metabolites enhance immune responses through inducing dendrite protrusion, mediated by GPR31, of small intestinal mononuclear cells that express CX3CR1.

    • Naoki Morita
    • , Eiji Umemoto
    • , Setsuko Fujita
    • , Akio Hayashi
    • , Junichi Kikuta
    • , Ikuo Kimura
    • , Takeshi Haneda
    • , Toshio Imai
    • , Asuka Inoue
    • , Hitomi Mimuro
    • , Yuichi Maeda
    • , Hisako Kayama
    • , Ryu Okumura
    • , Junken Aoki
    • , Nobuhiko Okada
    • , Toshiyuki Kida
    • , Masaru Ishii
    • , Ryusuke Nabeshima
    •  & Kiyoshi Takeda

  • Letter |

    Integrin β7-dependent Glp1rhigh natural gut intraepithelial T lymphocytes that reside in the small intestine modulate dietary metabolism in mice by restricting the bioavailability of GLP-1.

    • Shun He
    • , Florian Kahles
    • , Sara Rattik
    • , Manfred Nairz
    • , Cameron S. McAlpine
    • , Atsushi Anzai
    • , Daniel Selgrade
    • , Ashley M. Fenn
    • , Christopher T. Chan
    • , John E. Mindur
    • , Colin Valet
    • , Wolfram C. Poller
    • , Lennard Halle
    • , Noemi Rotllan
    • , Yoshiko Iwamoto
    • , Gregory R. Wojtkiewicz
    • , Ralph Weissleder
    • , Peter Libby
    • , Carlos Fernández-Hernando
    • , Daniel J. Drucker
    • , Matthias Nahrendorf
    •  & Filip K. Swirski

  • Letter |

    An assay to measure the latent HIV-1 reservoir that separately quantifies intact and defective proviruses will facilitate evaluation of HIV-1 cure strategies by measuring the provirues that pose a barrier to cure.

    • Katherine M. Bruner
    • , Zheng Wang
    • , Francesco R. Simonetti
    • , Alexandra M. Bender
    • , Kyungyoon J. Kwon
    • , Srona Sengupta
    • , Emily J. Fray
    • , Subul A. Beg
    • , Annukka A. R. Antar
    • , Katharine M. Jenike
    • , Lynn N. Bertagnolli
    • , Adam A. Capoferri
    • , Joshua T. Kufera
    • , Andrew Timmons
    • , Christopher Nobles
    • , John Gregg
    • , Nikolas Wada
    • , Ya-Chi Ho
    • , Hao Zhang
    • , Joseph B. Margolick
    • , Joel N. Blankson
    • , Steven G. Deeks
    • , Frederic D. Bushman
    • , Janet D. Siliciano
    • , Gregory M. Laird
    •  & Robert F. Siliciano

  • Letter |

    Three-dimensional imaging of mouse pancreatic ducts before and after oncogenic transformation reveals that epithelial tumorigenesis is determined by the relationship between tissue curvature and apical–basal mechanical tension.

    • Hendrik A. Messal
    • , Silvanus Alt
    • , Rute M. M. Ferreira
    • , Christopher Gribben
    • , Victoria Min-Yi Wang
    • , Corina G. Cotoi
    • , Guillaume Salbreux
    •  & Axel Behrens

    Collection:

Amendments & Corrections

  • Author Correction |

    • Serena Nik-Zainal
    • , Helen Davies
    • , Johan Staaf
    • , Manasa Ramakrishna
    • , Dominik Glodzik
    • , Xueqing Zou
    • , Inigo Martincorena
    • , Ludmil B. Alexandrov
    • , Sancha Martin
    • , David C. Wedge
    • , Peter Van Loo
    • , Young Seok Ju
    • , Marcel Smid
    • , Arie B. Brinkman
    • , Sandro Morganella
    • , Miriam R. Aure
    • , Ole Christian Lingjærde
    • , Anita Langerød
    • , Markus Ringnér
    • , Sung-Min Ahn
    • , Sandrine Boyault
    • , Jane E. Brock
    • , Annegien Broeks
    • , Adam Butler
    • , Christine Desmedt
    • , Luc Dirix
    • , Serge Dronov
    • , Aquila Fatima
    • , John A. Foekens
    • , Moritz Gerstung
    • , Gerrit K. J. Hooijer
    • , Se Jin Jang
    • , David R. Jones
    • , Hyung-Yong Kim
    • , Tari A. King
    • , Savitri Krishnamurthy
    • , Hee Jin Lee
    • , Jeong-Yeon Lee
    • , Yilong Li
    • , Stuart McLaren
    • , Andrew Menzies
    • , Ville Mustonen
    • , Sarah O’Meara
    • , Iris Pauporté
    • , Xavier Pivot
    • , Colin A. Purdie
    • , Keiran Raine
    • , Kamna Ramakrishnan
    • , F. Germán Rodríguez-González
    • , Gilles Romieu
    • , Anieta M. Sieuwerts
    • , Peter T. Simpson
    • , Rebecca Shepherd
    • , Lucy Stebbings
    • , Olafur A. Stefansson
    • , Jon Teague
    • , Stefania Tommasi
    • , Isabelle Treilleux
    • , Gert G. Van den Eynden
    • , Peter Vermeulen
    • , Anne Vincent-Salomon
    • , Lucy Yates
    • , Carlos Caldas
    • , Laura van’t Veer
    • , Andrew Tutt
    • , Stian Knappskog
    • , Benita Kiat Tee Tan
    • , Jos Jonkers
    • , Åke Borg
    • , Naoto T. Ueno
    • , Christos Sotiriou
    • , Alain Viari
    • , P. Andrew Futreal
    • , Peter J. Campbell
    • , Paul N. Span
    • , Steven Van Laere
    • , Sunil R. Lakhani
    • , Jorunn E. Eyfjord
    • , Alastair M. Thompson
    • , Ewan Birney
    • , Hendrik G. Stunnenberg
    • , Marc J. van de Vijver
    • , John W. M. Martens
    • , Anne-Lise Børresen-Dale
    • , Andrea L. Richardson
    • , Gu Kong
    • , Gilles Thomas
    •  & Michael R. Stratton

  • Author Correction |

    • Govinda Adhikari
    • , Pushparaj Adhikari
    • , Estella Barbosa de Souza
    • , Nelson Carlin
    • , Seonho Choi
    • , Mitra Djamal
    • , Anthony C. Ezeribe
    • , Chang Hyon Ha
    • , Insik Hahn
    • , Antonia J. F. Hubbard
    • , Eunju Jeon
    • , Jay Hyun Jo
    • , Hanwool Joo
    • , Woon Gu Kang
    • , Woosik Kang
    • , Matthew Kauer
    • , Bonghee Kim
    • , Hongjoo Kim
    • , Hyounggyu Kim
    • , Kyungwon Kim
    • , Nam Young Kim
    • , Sun Kee Kim
    • , Yeongduk Kim
    • , Yong-Hamb Kim
    • , Young Ju Ko
    • , Vitaly A. Kudryavtsev
    • , Hyun Su Lee
    • , Jaison Lee
    • , Jooyoung Lee
    • , Moo Hyun Lee
    • , Douglas S. Leonard
    • , Warren A. Lynch
    • , Reina H. Maruyama
    • , Frederic Mouton
    • , Stephen L. Olsen
    • , Byungju Park
    • , Hyang Kyu Park
    • , Hyeonseo Park
    • , Jungsic Park
    • , Kangsoon Park
    • , Walter C. Pettus
    • , Hafizh Prihtiadi
    • , Sejin Ra
    • , Carsten Rott
    • , Andrew Scarff
    • , Keon Ah Shin
    • , Neil J. C. Spooner
    • , William G. Thompson
    • , Liang Yang
    •  & Seok Hyun Yong
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