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Current Issue of Nature

Current Issue : Nature

Current Issue

Volume 542 Number 7641 pp271-386

16 February 2017

About the cover

The cover shows women threshing quinoa in Peru’s highlands. In this issue, Mark Tester and colleagues report a reference genome for quinoa (Chenopodium quinoa), a highly nutritious crop that can grow under a wide range of environmental conditions. Long-read sequencing combined with optical, chromosome-contact and genetic maps was used to generate the allotetraploid genome. The authors also sequenced the genomes of additional diploid and tetraploid Chenopodium species, characterizing genetic diversity and the evolution of sub-genomes in the crop. In the process, Tester and colleagues identified a transcription factor that regulates the biosynthesis of bitter-tasting saponins in quinoa, as well as markers that might be used to develop sweet commercial varieties. Cover image: Lynn Johnson/National Geographic Creative.

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      • The genome of Chenopodium quinoaOpen

        • David E. Jarvis
        • Yung Shwen Ho
        • Damien J. Lightfoot
        • Sandra M. Schmöckel
        • Bo Li
        • Theo J. A. Borm
        • Hajime Ohyanagi
        • Katsuhiko Mineta
        • Craig T. Michell
        • Noha Saber
        • Najeh M. Kharbatia
        • Ryan R. Rupper
        • Aaron R. Sharp
        • Nadine Dally
        • Berin A. Boughton
        • Yong H. Woo
        • Ge Gao
        • Elio G. W. M. Schijlen
        • Xiujie Guo
        • Afaque A. Momin
        • Sónia Negrão
        • Salim Al-Babili
        • Christoph Gehring
        • Ute Roessner
        • Christian Jung
        • Kevin Murphy
        • Stefan T. Arold
        • Takashi Gojobori
        • C. Gerard van der Linden
        • Eibertus N. van Loo
        • Eric N. Jellen
        • Peter J. Maughan
        • Mark Tester

        Constructing a reference genome for quinoa (Chenopodium quinoa) allows for genetic diversity during the evolution of sub-genomes in quinoa to be characterized and markers that may be used to develop sweet commercial varieties are identified.

        See also
      • Identity and dynamics of mammary stem cells during branching morphogenesis

        • Colinda L. G. J. Scheele
        • Edouard Hannezo
        • Mauro J. Muraro
        • Anoek Zomer
        • Nathalia S. M. Langedijk
        • Alexander van Oudenaarden
        • Benjamin D. Simons
        • Jacco van Rheenen

        The formation of the branched epithelial network of the mouse mammary gland during puberty is driven by a heterogeneous population of stem cells at the terminal end buds of the epithelium.


      • Photovoltage field-effect transistors

        • Valerio Adinolfi
        • Edward H. Sargent

        A photovoltage field-effect transistor is demonstrated that is very sensitive to infrared light and has high gain.

      • Stable colloids in molten inorganic salts

        • Hao Zhang
        • Kinjal Dasbiswas
        • Nicholas B. Ludwig
        • Gang Han
        • Byeongdu Lee
        • Suri Vaikuntanathan
        • Dmitri V. Talapin

        A class of colloids is reported in which inorganic solute particles—such as metals and semiconductors—are dispersed in molten inorganic salts.

      • Primordial helium entrained by the hottest mantle plumes

        • M. G. Jackson
        • J. G. Konter
        • T.W. Becker

        Analysis of helium isotope ratios in volcanic hotspot lavas suggests that hotter, more buoyant plumes upwelling from the deep mantle entrain high-3He/4He material, unlike cooler, less buoyant plumes, implying the existence of a dense, relatively undisturbed primordial reservoir in the deep mantle.

      • Mega-evolutionary dynamics of the adaptive radiation of birds

        • Christopher R. Cooney
        • Jen A. Bright
        • Elliot J. R. Capp
        • Angela M. Chira
        • Emma C. Hughes
        • Christopher J. A. Moody
        • Lara O. Nouri
        • Zoë K. Varley
        • Gavin H. Thomas

        A study of more than 2,000 bird species shows that diversity in bill shape expands towards extreme morphologies early in avian evolution in a series of major jumps, before switching to a second phase in which bills repeatedly evolve similar shapes by subdividing increasingly tight regions of already occupied niche space.

        See also
      • Early brain development in infants at high risk for autism spectrum disorder

        • Heather Cody Hazlett
        • Hongbin Gu
        • Brent C. Munsell
        • Sun Hyung Kim
        • Martin Styner
        • Jason J. Wolff
        • Jed T. Elison
        • Meghan R. Swanson
        • Hongtu Zhu
        • Kelly N. Botteron
        • D. Louis Collins
        • John N. Constantino
        • Stephen R. Dager
        • Annette M. Estes
        • Alan C. Evans
        • Vladimir S. Fonov
        • Guido Gerig
        • Penelope Kostopoulos
        • Robert C. McKinstry
        • Juhi Pandey
        • Sarah Paterson
        • John R. Pruett
        • Robert T. Schultz
        • Dennis W. Shaw
        • Lonnie Zwaigenbaum
        • Joseph Piven
        • The IBIS Network

        Surface area expansion from 6–12 months precedes brain overgrowth in high risk infants diagnosed with autism at 24 months and cortical features in the first year predict individual diagnostic outcomes.

      • Single-cell spatial reconstruction reveals global division of labour in the mammalian liver

        • Keren Bahar Halpern
        • Rom Shenhav
        • Orit Matcovitch-Natan
        • Beáta Tóth
        • Doron Lemze
        • Matan Golan
        • Efi E. Massasa
        • Shaked Baydatch
        • Shanie Landen
        • Andreas E. Moor
        • Alexander Brandis
        • Amir Giladi
        • Avigail Stokar-Avihail
        • Eyal David
        • Ido Amit
        • Shalev Itzkovitz

        Single-molecule fluorescence in situ hybridization is performed to identify several landmark genes in the liver and their level of expression in single-cell RNA sequencing is used to spatially reconstruct the zonation of all liver genes.

      • Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer

        • Giannicola Genovese
        • Alessandro Carugo
        • James Tepper
        • Frederick Scott Robinson
        • Liren Li
        • Maria Svelto
        • Luigi Nezi
        • Denise Corti
        • Rosalba Minelli
        • Piergiorgio Pettazzoni
        • Tony Gutschner
        • Chia-Chin Wu
        • Sahil Seth
        • Kadir Caner Akdemir
        • Elisabetta Leo
        • Samirkumar Amin
        • Marco Dal Molin
        • Haoqiang Ying
        • Lawrence N. Kwong
        • Simona Colla
        • Koichi Takahashi
        • Papia Ghosh
        • Virginia Giuliani
        • Florian Muller
        • Prasenjit Dey
        • Shan Jiang
        • Jill Garvey
        • Chang-Gong Liu
        • Jianhua Zhang
        • Timothy P. Heffernan
        • Carlo Toniatti
        • Jason B. Fleming
        • Michael G. Goggins
        • Laura D. Wood
        • Alessandro Sgambato
        • Abbas Agaimy
        • Anirban Maitra
        • Charles W. M. Roberts
        • Huamin Wang
        • Andrea Viale
        • Ronald A. DePinho
        • Giulio F. Draetta
        • Lynda Chin

        Depletion of Smarcb1 activates the Myc network of signalling cascades, increasing protein metabolism and activation of survival pathways allowing highly aggressive Kras-independent pancreatic cancer cells to develop.

      • C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress

        • Ilija Melentijevic
        • Marton L. Toth
        • Meghan L. Arnold
        • Ryan J. Guasp
        • Girish Harinath
        • Ken C. Nguyen
        • Daniel Taub
        • J. Alex Parker
        • Christian Neri
        • Christopher V. Gabel
        • David H. Hall
        • Monica Driscoll

        Adult neurons from Caenorhabditis elegans can extrude large membrane-surrounded vesicles, known as exophers, containing protein aggregates and dysfunctional organelles that threaten neuronal homeostasis.