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Current Issue of Nature

Current Issue : Nature

Current Issue

Volume 554 Number 7693 pp403-554

22 February 2018

About the cover

This special issue of Nature examines one of the most misunderstood aspects of human life: adolescence. In two News Features, we explore the neuroscience of risk-taking and rebellion, and look at how the boundaries of adolescence are widening. In a Comment article, developmental psychologist Candice Odgers tackles the relationship between young people and digital technology. And a second Comment piece sees social scientists Jo Boyden and Robert Blum stress the importance of understanding the daily lives of adolescents in low- and middle-income countries. The Feinberg hypothesis, which posits that abnormal pruning of neural connections in adolescence leads to schizophrenia, is reappraised in a News & Views. And a Careers Feature looks at scientists who give teenagers jobs in the lab. Three reviews explore some paradoxes of adolescence. Paediatrician Ronald Dahl and his colleagues review the evidence for adolescence as a physical, cognitive and socio-emotional growth spurt. Epidemiologist George Patton and his colleagues explore how factors that harm adolescent health can affect the next generation. And anthropologists Carol Worthman and Kathy Trang analyse historical changes in the timing of puberty, and shifting cultural definitions of and influences on adolescence. These pieces are part of a collection on adolescence from nine journals in the Nature family and its sister publication, Scientific American. Cover image: Eric Nyquist

This Week



World View


Research Highlights


Seven Days


News in Focus




Books and Arts





naturejobs job listings and advertising features



Technology Feature

  • Deep learning for biology

    A popular artificial-intelligence method provides a powerful tool for surveying and classifying biological data. But for the uninitiated, the technology poses significant difficulties.

    • Sarah Webb


Brief Communication Arising

  • Crowther et al. reply

    • T. W. Crowther
    • M. B. Machmuller
    • J. C. Carey
    • S. D. Allison
    • J. M. Blair
    • S. D. Bridgham
    • A. J. Burton
    • F. A. Dijkstra
    • B. Elberling
    • M. Estiarte
    • K. S. Larsen
    • H. Laudon
    • M. Lupascu
    • S. Marhan
    • J. Mohan
    • S. Niu
    • J. J. Peñuelas
    • I. K. Schmidt
    • P. H. Templer
    • G. Kröel-Dulay
    • S. Frey
    • M. A. Bradford

News & Views





  • Adolescence and the next generationOpen

    • George C. Patton
    • Craig A. Olsson
    • Vegard Skirbekk
    • Richard Saffery
    • Mary E. Wlodek
    • Peter S. Azzopardi
    • Marcin Stonawski
    • Bruce Rasmussen
    • Elizabeth Spry
    • Kate Francis
    • Zulfiqar A. Bhutta
    • Nicholas J. Kassebaum
    • Ali H. Mokdad
    • Christopher J. L. Murray
    • Andrew M. Prentice
    • Nicola Reavley
    • Peter Sheehan
    • Kim Sweeny
    • Russell M. Viner
    • Susan M. Sawyer

    Investing in adolescents as the parents of the next generation is important for the wellbeing of current and future generations.


  • A molecular atlas of cell types and zonation in the brain vasculature

    • Michael Vanlandewijck
    • Liqun He
    • Maarja Andaloussi Mäe
    • Johanna Andrae
    • Koji Ando
    • Francesca Del Gaudio
    • Khayrun Nahar
    • Thibaud Lebouvier
    • Bàrbara Laviña
    • Leonor Gouveia
    • Ying Sun
    • Elisabeth Raschperger
    • Markus Räsänen
    • Yvette Zarb
    • Naoki Mochizuki
    • Annika Keller
    • Urban Lendahl
    • Christer Betsholtz

    Single-cell transcriptomic analysis of the murine blood–brain barrier provides molecular definitions of the main vascular cell types, classifies perivascular cell types and sheds light on the organization of the arteriovenous axis.

  • Structure and mechanogating mechanism of the Piezo1 channel

    • Qiancheng Zhao
    • Heng Zhou
    • Shaopeng Chi
    • Yanfeng Wang
    • Jianhua Wang
    • Jie Geng
    • Kun Wu
    • Wenhao Liu
    • Tingxin Zhang
    • Meng-Qiu Dong
    • Jiawei Wang
    • Xueming Li
    • Bailong Xiao

    The electron cryo-microscopy structure of full-length mouse Piezo1 reveals unique topological features such as the repetitive transmembrane helical units that constitute the highly curved transmembrane region, and identifies regions and single residues that are crucial for the mechanical activation of the channel.

    See also
    See also


  • A surge of light at the birth of a supernova

    • M. C. Bersten
    • G. Folatelli
    • F. García
    • S. D. Van Dyk
    • O. G. Benvenuto
    • M. Orellana
    • V. Buso
    • J. L. Sánchez
    • M. Tanaka
    • K. Maeda
    • A. V. Filippenko
    • W. Zheng
    • T. G. Brink
    • S. B. Cenko
    • T. de Jaeger
    • S. Kumar
    • T. J. Moriya
    • K. Nomoto
    • D. A. Perley
    • I. Shivvers
    • N. Smith

    The discovery of a newly born type IIb supernova reveals a rapid brightening at optical wavelengths that corresponds to the shock-breakout phase of the explosion.

  • Sterically controlled mechanochemistry under hydrostatic pressure

    • Hao Yan
    • Fan Yang
    • Ding Pan
    • Yu Lin
    • J. Nathan Hohman
    • Diego Solis-Ibarra
    • Fei Hua Li
    • Jeremy E. P. Dahl
    • Robert M. K. Carlson
    • Boryslav A. Tkachenko
    • Andrey A. Fokin
    • Peter R. Schreiner
    • Giulia Galli
    • Wendy L. Mao
    • Zhi-Xun Shen
    • Nicholas A. Melosh

    ‘Molecular anvil’ molecules consisting of a compressible mechanophore and incompressible ligands react under hydrostatic pressure to produce elemental metal via an unexplored mechanism.

    See also
  • Palladium-catalysed electrophilic aromatic C–H fluorination

    • Kumiko Yamamoto
    • Jiakun Li
    • Jeffrey A. O. Garber
    • Julian D. Rolfes
    • Gregory B. Boursalian
    • Jannik C. Borghs
    • Christophe Genicot
    • Jérôme Jacq
    • Maurice van Gastel
    • Frank Neese
    • Tobias Ritter

    An approach for the direct electrophilic C–H fluorination of arenes is reported, using a palladium catalyst and mild fluorinating reagents.

  • Meridional overturning circulation conveys fast acidification to the deep Atlantic Ocean

    • Fiz F. Perez
    • Marcos Fontela
    • Maribel I. García-Ibáñez
    • Herlé Mercier
    • Anton Velo
    • Pascale Lherminier
    • Patricia Zunino
    • Mercedes de la Paz
    • Fernando Alonso-Pérez
    • Elisa F. Guallart
    • Xose A. Padin

    There has been a reduction of about forty per cent in the transport of carbonate ions to the deep North Atlantic Ocean since preindustrial times, severely endangering cold-water corals.

  • Global patterns of tropical forest fragmentation

    • Franziska Taubert
    • Rico Fischer
    • Jürgen Groeneveld
    • Sebastian Lehmann
    • Michael S. Müller
    • Edna Rödig
    • Thorsten Wiegand
    • Andreas Huth

    Satellite data and modelling reveal that tropical forest fragments have similar size distributions across continents, and that forest fragmentation is close to a critical point, beyond which fragment numbers will strongly increase.

  • Peptidoglycan synthesis drives an FtsZ-treadmilling-independent step of cytokinesis

    • João M. Monteiro
    • Ana R. Pereira
    • Nathalie T. Reichmann
    • Bruno M. Saraiva
    • Pedro B. Fernandes
    • Helena Veiga
    • Andreia C. Tavares
    • Margarida Santos
    • Maria T. Ferreira
    • Vânia Macário
    • Michael S. VanNieuwenhze
    • Sérgio R. Filipe
    • Mariana G. Pinho

    Single-cell fluorescence microscopy reveals that cytokinesis occurs in two stages in Staphylococcus aureus, an initial slow phase followed by a faster phase after MurJ protein recruitment to the midcell triggers peptidoglycan synthesis.

  • Transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas

    • Isidoro Cobo
    • Paola Martinelli
    • Marta Flández
    • Latifa Bakiri
    • Mingfeng Zhang
    • Enrique Carrillo-de-Santa-Pau
    • Jinping Jia
    • Víctor J. Sánchez-Arévalo Lobo
    • Diego Megías
    • Irene Felipe
    • Natalia del Pozo
    • Irene Millán
    • Liv Thommesen
    • Torunn Bruland
    • Sara H. Olson
    • Jill Smith
    • Kristina Schoonjans
    • William R. Bamlet
    • Gloria M. Petersen
    • Núria Malats
    • Laufey T. Amundadottir
    • Erwin F. Wagner
    • Francisco X. Real

    In mouse pancreas cells with only one copy of the Nr5a2 gene, the orphan nuclear receptor NR5A2 undergoes a marked transcriptional shift from differentiation-specific to inflammatory genes, which results in an epithelial-cell-autonomous basal pre-inflammatory state.

    See also
  • TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

    • Daniele V. F. Tauriello
    • Sergio Palomo-Ponce
    • Diana Stork
    • Antonio Berenguer-Llergo
    • Jordi Badia-Ramentol
    • Mar Iglesias
    • Marta Sevillano
    • Sales Ibiza
    • Adrià Cañellas
    • Xavier Hernando-Momblona
    • Daniel Byrom
    • Joan A. Matarin
    • Alexandre Calon
    • Elisa I. Rivas
    • Angel R. Nebreda
    • Antoni Riera
    • Camille Stephan-Otto Attolini
    • Eduard Batlle

    A combination of TGFβ inhibition and checkpoint-inhibition therapy provokes a potent cytotoxic response against metastatic tumours derived from colorectal cancers in mice.

    See also
  • TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

    • Sanjeev Mariathasan
    • Shannon J. Turley
    • Dorothee Nickles
    • Alessandra Castiglioni
    • Kobe Yuen
    • Yulei Wang
    • Edward E. Kadel III
    • Hartmut Koeppen
    • Jillian L. Astarita
    • Rafael Cubas
    • Suchit Jhunjhunwala
    • Romain Banchereau
    • Yagai Yang
    • Yinghui Guan
    • Cecile Chalouni
    • James Ziai
    • Yasin Şenbabaoğlu
    • Stephen Santoro
    • Daniel Sheinson
    • Jeffrey Hung
    • Jennifer M. Giltnane
    • Andrew A. Pierce
    • Kathryn Mesh
    • Steve Lianoglou
    • Johannes Riegler
    • Richard A. D. Carano
    • Pontus Eriksson
    • Mattias Höglund
    • Loan Somarriba
    • Daniel L. Halligan
    • Michiel S. van der Heijden
    • Yohann Loriot
    • Jonathan E. Rosenberg
    • Lawrence Fong
    • Ira Mellman
    • Daniel S. Chen
    • Marjorie Green
    • Christina Derleth
    • Gregg D. Fine
    • Priti S. Hegde
    • Richard Bourgon
    • Thomas Powles

    In humans, TGFβ signalling is associated with lack of response to immunotherapy in immune-excluded tumours; in mouse models of this immune phenotype, robust tumour infiltration by T cells and tumour regression are observed only when checkpoint inhibition is combined with inhibition of TGFβ signalling.

    See also
  • MEK drives BRAF activation through allosteric control of KSR proteins

    • Hugo Lavoie
    • Malha Sahmi
    • Pierre Maisonneuve
    • Sara A. Marullo
    • Neroshan Thevakumaran
    • Ting Jin
    • Igor Kurinov
    • Frank Sicheri
    • Marc Therrien

    KSR–MEK complexes allosterically activate BRAF through the action of N-terminal regulatory region and kinase domain contacts, thus challenging the accepted role of KSR as a scaffold for MEK recruitment to RAF.


  • Corrigendum: mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer

    • Amaia Zabala-Letona
    • Amaia Arruabarrena-Aristorena
    • Natalia Martín-Martín
    • Sonia Fernandez-Ruiz
    • James D. Sutherland
    • Michelle Clasquin
    • Julen Tomas-Cortazar
    • Jose Jimenez
    • Ines Torres
    • Phong Quang
    • Pilar Ximenez-Embun
    • Ruzica Bago
    • Aitziber Ugalde-Olano
    • Ana Loizaga-Iriarte
    • Isabel Lacasa-Viscasillas
    • Miguel Unda
    • Verónica Torrano
    • Diana Cabrera
    • Sebastiaan M. van Liempd
    • Ylenia Cendon
    • Elena Castro
    • Stuart Murray
    • Ajinkya Revandkar
    • Andrea Alimonti
    • Yinan Zhang
    • Amelia Barnett
    • Gina Lein
    • David Pirman
    • Ana R. Cortazar
    • Leire Arreal
    • Ludmila Prudkin
    • Ianire Astobiza
    • Lorea Valcarcel-Jimenez
    • Patricia Zuñiga-García
    • Itziar Fernandez-Dominguez
    • Marco Piva
    • Alfredo Caro-Maldonado
    • Pilar Sánchez-Mosquera
    • Mireia Castillo-Martín
    • Violeta Serra
    • Naiara Beraza
    • Antonio Gentilella
    • George Thomas
    • Mikel Azkargorta
    • Felix Elortza
    • Rosa Farràs
    • David Olmos
    • Alejo Efeyan
    • Juan Anguita
    • Javier Muñoz
    • Juan M. Falcón-Pérez
    • Rosa Barrio
    • Teresa Macarulla
    • Jose M. Mato
    • Maria L. Martinez-Chantar
    • Carlos Cordon-Cardo
    • Ana M. Aransay
    • Kevin Marks
    • José Baselga
    • Josep Tabernero
    • Paolo Nuciforo
    • Brendan D. Manning
    • Katya Marjon
    • Arkaitz Carracedo