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Current Issue of Nature


Current Issue : Nature

Current Issue

Volume 554 Number 7690 pp5-132

1 February 2018

About the cover

In this issue, Elly Tanaka, Eugene Myers and their colleagues report the 32-billion-base genome of the axolotl (Ambystoma mexicanum), a model organism for developmental, regeneration and evolutionary studies. The team overcame the challenges of sequencing and assembling this large and complex genome, which features many lengthy repetitive regions, by using long-read sequencing, optical mapping and a new computer algorithm known as MARVEL. The researchers estimate that the genome contains around 23,000 protein-coding genes and note that the gene Pax3, which is essential in many animals for development, is absent. Gene editing of the related gene, Pax7, showed that it steps into the breach for some functions. The assembled genome should offer fresh opportunities for the study of evolution, development and regeneration. Cover image: Avalon/Photoshot/Alamy

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  • The axolotl genome and the evolution of key tissue formation regulatorsOpen

    • Sergej Nowoshilow
    • Siegfried Schloissnig
    • Ji-Feng Fei
    • Andreas Dahl
    • Andy W. C. Pang
    • Martin Pippel
    • Sylke Winkler
    • Alex R. Hastie
    • George Young
    • Juliana G. Roscito
    • Francisco Falcon
    • Dunja Knapp
    • Sean Powell
    • Alfredo Cruz
    • Han Cao
    • Bianca Habermann
    • Michael Hiller
    • Elly M. Tanaka
    • Eugene W. Myers

    Sequencing and assembly of the 32-Gb genome of the Mexican axolotl reveals that it lacks the developmental gene Pax3, which is essential in other vertebrates; the genome sequence could improve our understanding of the evolution of the axolotl’s remarkable regenerative capabilities.

    See also
    See also
  • The genome of Schmidtea mediterranea and the evolution of core cellular mechanismsOpen

    • Markus Alexander Grohme
    • Siegfried Schloissnig
    • Andrei Rozanski
    • Martin Pippel
    • George Robert Young
    • Sylke Winkler
    • Holger Brandl
    • Ian Henry
    • Andreas Dahl
    • Sean Powell
    • Michael Hiller
    • Eugene Myers
    • Jochen Christian Rink

    An improved genome assembly for Schmidtea mediterranea shows that the genome is highly polymorphic and repetitive, and lacks multiple genes encoding core components of cell biological mechanisms.

    See also
    See also
  • Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes

    • Sebastian Mueller
    • Thomas Engleitner
    • Roman Maresch
    • Magdalena Zukowska
    • Sebastian Lange
    • Thorsten Kaltenbacher
    • Björn Konukiewitz
    • Rupert Öllinger
    • Maximilian Zwiebel
    • Alex Strong
    • Hsi-Yu Yen
    • Ruby Banerjee
    • Sandra Louzada
    • Beiyuan Fu
    • Barbara Seidler
    • Juliana Götzfried
    • Kathleen Schuck
    • Zonera Hassan
    • Andreas Arbeiter
    • Nina Schönhuber
    • Sabine Klein
    • Christian Veltkamp
    • Mathias Friedrich
    • Lena Rad
    • Maxim Barenboim
    • Christoph Ziegenhain
    • Julia Hess
    • Oliver M. Dovey
    • Stefan Eser
    • Swati Parekh
    • Fernando Constantino-Casas
    • Jorge de la Rosa
    • Marta I. Sierra
    • Mario Fraga
    • Julia Mayerle
    • Günter Klöppel
    • Juan Cadiñanos
    • Pentao Liu
    • George Vassiliou
    • Wilko Weichert
    • Katja Steiger
    • Wolfgang Enard
    • Roland M. Schmid
    • Fengtang Yang
    • Kristian Unger
    • Günter Schneider
    • Ignacio Varela
    • Allan Bradley
    • Dieter Saur
    • Roland Rad

    Oncogenic dosage variation along distinct evolutionary routes defines fundamental aspects of pancreatic cancer biology and phenotypic diversification.

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  • Generating carbyne equivalents with photoredox catalysis

    • Zhaofeng Wang
    • Ana G. Herraiz
    • Ana M. del Hoyo
    • Marcos G. Suero

    A photocatalytic strategy is described that generates diazomethyl radicals as direct equivalents of carbynes, which are often too reactive to use, enabling the functionalization of a range of medically useful compounds.

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  • Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells

    • Joana Carrelha
    • Yiran Meng
    • Laura M. Kettyle
    • Tiago C. Luis
    • Ruggiero Norfo
    • Verónica Alcolea
    • Hanane Boukarabila
    • Francesca Grasso
    • Adriana Gambardella
    • Amit Grover
    • Kari Högstrand
    • Allegra M. Lord
    • Alejandra Sanjuan-Pla
    • Petter S. Woll
    • Claus Nerlov
    • Sten Eirik W. Jacobsen

    Analysis of transplantation of single haematopoietic stem cells in mice defines stable lineage-restricted fates in long-term self-renewing multipotent stem cells, including a class of multipotent stem cells that exclusively replenishes the megakaryocyte/platelet lineage.

  • Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders

    • Eliezer Calo
    • Bo Gu
    • Margot E. Bowen
    • Fardin Aryan
    • Antoine Zalc
    • Jialiang Liang
    • Ryan A. Flynn
    • Tomek Swigut
    • Howard Y. Chang
    • Laura D. Attardi
    • Joanna Wysocka

    Mutations associated with Treacher Collins syndrome perturb the subnuclear localization of an RNA helicase involved in ribosome biogenesis through activation of p53 protein, illustrating how disruption in general regulators that compromise nucleolar homeostasis can result in tissue-selective malformations.

  • A major lineage of non-tailed dsDNA viruses as unrecognized killers of marine bacteria

    • Kathryn M. Kauffman
    • Fatima A. Hussain
    • Joy Yang
    • Philip Arevalo
    • Julia M. Brown
    • William K. Chang
    • David VanInsberghe
    • Joseph Elsherbini
    • Radhey S. Sharma
    • Michael B. Cutler
    • Libusha Kelly
    • Martin F. Polz

    Members of a family of marine dsDNA non-tailed bacterial viruses have short, 10-kb genomes, infect a broader range of hosts than tailed viruses and belong to the double jelly roll capsid lineage of viruses, which are associated with diverse bacterial and archaeal hosts.

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  • Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation

    • Qicong Shen
    • Qian Zhang
    • Yang Shi
    • Qingzhu Shi
    • Yanyan Jiang
    • Yan Gu
    • Zhiqing Li
    • Xia Li
    • Kai Zhao
    • Chunmei Wang
    • Nan Li
    • Xuetao Cao

    A report of RNA 5-methylcytosine oxidation by mammalian Tet2, showing that Tet2 promotes infection-induced myelopoiesis in mice via a mechanism involving the repression of Socs3 mRNA, a previously unknown regulatory role of Tet2 at the epitranscriptomic level.

  • Mitochondrial translation requires folate-dependent tRNA methylation

    • Raphael J. Morscher
    • Gregory S. Ducker
    • Sophia Hsin-Jung Li
    • Johannes A. Mayer
    • Zemer Gitai
    • Wolfgang Sperl
    • Joshua D. Rabinowitz

    Mammalian mitochondria use folate-bound one-carbon units generated by the enzyme SHMT2 to methylate tRNA, and this modification is required for mitochondrial translation and thus oxidative phosphorylation.