This page is brought to you by Brian Golding (Golding@McMaster.CA) and is copied locally here to speed your access. To go to the original page (should you find something interesting or should you wish to follow links) click on

Current Issue of Nature


Volume 559 Issue 7714, 19 July 2018

Volume 559 Issue 7714, 19 July 2018

Volume 559 Issue 7714

Parsed judgement

Whether it is bacteria following chemical gradients or humans unpicking a complex odour, the ability to recognize molecular patterns is a key attribute of organisms. DNA-based neural networks can perform the same task in molecular computing but have so far been limited to a set of no more than 4 patterns of 4 bits each. In this week’s issue, Lulu Qian and Kevin Cherry increase those numbers to 9 and 100, demonstrating a set-up that can correctly identify the numbers 1–9 written to a 10 × 10 pixel grid. Their network uses the ‘winner take all’ competitive strategy to refine its output and determine which of the numbers it is viewing. The researchers show that even when 30 of the 100 bits of a given pattern are flipped — analogous to the variation in handwritten characters — their network can ‘remember’ the pattern correctly and recognize the digit. This suggests that molecular computation circuits can classify highly complex and noisy information based on something akin to a memory.

Cover image: Olivier Wyart

This Week

News in Focus

Comment

Careers

Futures

  • Futures |

    Cold comfort.

    • Kurt Pankau

Research

    News & Views

  • News & Views |

    An electron microscope has been developed that produces images at higher resolution than conventional approaches can achieve, and is suitable for studying fragile materials that can be damaged by electron beams.

    • John Rodenburg
  • News & Views |

    An analysis of gene-expression patterns in single cells provides detailed insights into the developmental processes that lead to maturation of the coronary arteries.

    • Arndt F. Siekmann
  • News & Views |

    New species of marine fishes are found to emerge at a faster rate in high-latitude oceans, which have lower densities of species, than in the species-rich tropics. Are the tropics too crowded for new species to take hold?

    • Arne O. Mooers
    •  & Dan A. Greenberg
  • Articles

  • Article |

    Combining an electron microscope pixel-array detector that collects the entire distribution of scattered electrons with full-field ptychography greatly improves image resolution and contrast compared to traditional techniques, even at low beam energies.

    • Yi Jiang
    • , Zhen Chen
    • , Yimo Han
    • , Pratiti Deb
    • , Hui Gao
    • , Saien Xie
    • , Prafull Purohit
    • , Mark W. Tate
    • , Jiwoong Park
    • , Sol M. Gruner
    • , Veit Elser
    •  & David A. Muller
  • Article |

    Analysis of genotyping data for more than 150,000 individuals from the UK Biobank using long-range phase information sheds light on mechanisms of clonal haematopoiesis.

    • Po-Ru Loh
    • , Giulio Genovese
    • , Robert E. Handsaker
    • , Hilary K. Finucane
    • , Yakir A. Reshef
    • , Pier Francesco Palamara
    • , Brenda M. Birmann
    • , Michael E. Talkowski
    • , Samuel F. Bakhoum
    • , Steven A. McCarroll
    •  & Alkes L. Price
  • Article |

    During development, new arteries can arise from pre-existing veins; the cell fate switch involved occurs gradually and before the onset of blood flow in mouse embryo hearts.

    • Tianying Su
    • , Geoff Stanley
    • , Rahul Sinha
    • , Gaetano D’Amato
    • , Soumya Das
    • , Siyeon Rhee
    • , Andrew H. Chang
    • , Aruna Poduri
    • , Brian Raftrey
    • , Thanh Theresa Dinh
    • , Walter A. Roper
    • , Guang Li
    • , Kelsey E. Quinn
    • , Kathleen M. Caron
    • , Sean Wu
    • , Lucile Miquerol
    • , Eugene C. Butcher
    • , Irving Weissman
    • , Stephen Quake
    •  & Kristy Red-Horse
  • Article |

    IL-23 produced by myeloid-derived suppressor cells regulates castration resistance in prostate cancer by sustaining androgen receptor signalling.

    • Arianna Calcinotto
    • , Clarissa Spataro
    • , Elena Zagato
    • , Diletta Di Mitri
    • , Veronica Gil
    • , Mateus Crespo
    • , Gaston De Bernardis
    • , Marco Losa
    • , Michela Mirenda
    • , Emiliano Pasquini
    • , Andrea Rinaldi
    • , Semini Sumanasuriya
    • , Maryou B. Lambros
    • , Antje Neeb
    • , Roberta Lucianò
    • , Carlo A. Bravi
    • , Daniel Nava-Rodrigues
    • , David Dolling
    • , Tommaso Prayer-Galetti
    • , Ana Ferreira
    • , Alberto Briganti
    • , Antonio Esposito
    • , Simon Barry
    • , Wei Yuan
    • , Adam Sharp
    • , Johann de Bono
    •  & Andrea Alimonti
  • Letters

  • Letter |

    A 26-million-year record of equatorial sea surface temperatures reveals synchronous changes of tropical and polar temperatures during the Eocene epoch forced by variations in concentrations of atmospheric carbon dioxide, with a constant degree of polar amplification.

    • Margot J. Cramwinckel
    • , Matthew Huber
    • , Ilja J. Kocken
    • , Claudia Agnini
    • , Peter K. Bijl
    • , Steven M. Bohaty
    • , Joost Frieling
    • , Aaron Goldner
    • , Frederik J. Hilgen
    • , Elizabeth L. Kip
    • , Francien Peterse
    • , Robin van der Ploeg
    • , Ursula Röhl
    • , Stefan Schouten
    •  & Appy Sluijs
  • Letter |

    Contrary to previous hypotheses, high-latitude fish lineages form new species at much faster rates than their tropical counterparts especially in geographical regions that are characterized by low surface temperatures and high endemism.

    • Daniel L. Rabosky
    • , Jonathan Chang
    • , Pascal O. Title
    • , Peter F. Cowman
    • , Lauren Sallan
    • , Matt Friedman
    • , Kristin Kaschner
    • , Cristina Garilao
    • , Thomas J. Near
    • , Marta Coll
    •  & Michael E. Alfaro
  • Letter |

    The career trajectories of around 30,000 artists, film directors and scientists show that individuals in each domain have ‘hot streaks’ during which their works have increased impact, despite showing no increase in productivity.

    • Lu Liu
    • , Yang Wang
    • , Roberta Sinatra
    • , C. Lee Giles
    • , Chaoming Song
    •  & Dashun Wang
  • Letter |

    Individuals who are at high risk of developing acute myeloid leukaemia can be identified years before diagnosis using genetic information from blood samples.

    • Sagi Abelson
    • , Grace Collord
    • , Stanley W. K. Ng
    • , Omer Weissbrod
    • , Netta Mendelson Cohen
    • , Elisabeth Niemeyer
    • , Noam Barda
    • , Philip C. Zuzarte
    • , Lawrence Heisler
    • , Yogi Sundaravadanam
    • , Robert Luben
    • , Shabina Hayat
    • , Ting Ting Wang
    • , Zhen Zhao
    • , Iulia Cirlan
    • , Trevor J. Pugh
    • , David Soave
    • , Karen Ng
    • , Calli Latimer
    • , Claire Hardy
    • , Keiran Raine
    • , David Jones
    • , Diana Hoult
    • , Abigail Britten
    • , John D. McPherson
    • , Mattias Johansson
    • , Faridah Mbabaali
    • , Jenna Eagles
    • , Jessica K. Miller
    • , Danielle Pasternack
    • , Lee Timms
    • , Paul Krzyzanowski
    • , Philip Awadalla
    • , Rui Costa
    • , Eran Segal
    • , Scott V. Bratman
    • , Philip Beer
    • , Sam Behjati
    • , Inigo Martincorena
    • , Jean C. Y. Wang
    • , Kristian M. Bowles
    • , J. Ramón Quirós
    • , Anna Karakatsani
    • , Carlo La Vecchia
    • , Antonia Trichopoulou
    • , Elena Salamanca-Fernández
    • , José M. Huerta
    • , Aurelio Barricarte
    • , Ruth C. Travis
    • , Rosario Tumino
    • , Giovanna Masala
    • , Heiner Boeing
    • , Salvatore Panico
    • , Rudolf Kaaks
    • , Alwin Krämer
    • , Sabina Sieri
    • , Elio Riboli
    • , Paolo Vineis
    • , Matthieu Foll
    • , James McKay
    • , Silvia Polidoro
    • , Núria Sala
    • , Kay-Tee Khaw
    • , Roel Vermeulen
    • , Peter J. Campbell
    • , Elli Papaemmanuil
    • , Mark D. Minden
    • , Amos Tanay
    • , Ran D. Balicer
    • , Nicholas J. Wareham
    • , Moritz Gerstung
    • , John E. Dick
    • , Paul Brennan
    • , George S. Vassiliou
    •  & Liran I. Shlush
  • Letter |

    A non-viral strategy to introduce large DNA sequences into T cells enables the correction of a pathogenic mutation that causes autoimmunity, and the replacement of an endogenous T-cell receptor with an engineered receptor that can recognize cancer antigens.

    • Theodore L. Roth
    • , Cristina Puig-Saus
    • , Ruby Yu
    • , Eric Shifrut
    • , Julia Carnevale
    • , P. Jonathan Li
    • , Joseph Hiatt
    • , Justin Saco
    • , Paige Krystofinski
    • , Han Li
    • , Victoria Tobin
    • , David N. Nguyen
    • , Michael R. Lee
    • , Amy L. Putnam
    • , Andrea L. Ferris
    • , Jeff W. Chen
    • , Jean-Nicolas Schickel
    • , Laurence Pellerin
    • , David Carmody
    • , Gorka Alkorta-Aranburu
    • , Daniela del Gaudio
    • , Hiroyuki Matsumoto
    • , Montse Morell
    • , Ying Mao
    • , Min Cho
    • , Rolen M. Quadros
    • , Channabasavaiah B. Gurumurthy
    • , Baz Smith
    • , Michael Haugwitz
    • , Stephen H. Hughes
    • , Jonathan S. Weissman
    • , Kathrin Schumann
    • , Jonathan H. Esensten
    • , Andrew P. May
    • , Alan Ashworth
    • , Gary M. Kupfer
    • , Siri Atma W. Greeley
    • , Rosa Bacchetta
    • , Eric Meffre
    • , Maria Grazia Roncarolo
    • , Neil Romberg
    • , Kevan C. Herold
    • , Antoni Ribas
    • , Manuel D. Leonetti
    •  & Alexander Marson
  • Letter |

    Structural mass spectrometry of full-length human parkin and a structure of the activated parkin core reveal large-scale domain rearrangements involved in activation of parkin by PINK1.

    • Christina Gladkova
    • , Sarah L. Maslen
    • , J. Mark Skehel
    •  & David Komander
  • Letter |

    Mass spectrometry-based assays are used to reveal specificity and structural determinants of lipid binding to class A G-protein-coupled receptors, and the effects of specific lipids on receptor coupling to G proteins.

    • Hsin-Yung Yen
    • , Kin Kuan Hoi
    • , Idlir Liko
    • , George Hedger
    • , Michael R. Horrell
    • , Wanling Song
    • , Di Wu
    • , Philipp Heine
    • , Tony Warne
    • , Yang Lee
    • , Byron Carpenter
    • , Andreas Plückthun
    • , Christopher G. Tate
    • , Mark S. P. Sansom
    •  & Carol V. Robinson

Amendments & Corrections

  • Author Correction |

    • Susanne N. Gröbner
    • , Barbara C. Worst
    • , Joachim Weischenfeldt
    • , Ivo Buchhalter
    • , Kortine Kleinheinz
    • , Vasilisa A. Rudneva
    • , Pascal D. Johann
    • , Gnana Prakash Balasubramanian
    • , Maia Segura-Wang
    • , Sebastian Brabetz
    • , Sebastian Bender
    • , Barbara Hutter
    • , Dominik Sturm
    • , Elke Pfaff
    • , Daniel Hübschmann
    • , Gideon Zipprich
    • , Michael Heinold
    • , Jürgen Eils
    • , Christian Lawerenz
    • , Serap Erkek
    • , Sander Lambo
    • , Sebastian Waszak
    • , Claudia Blattmann
    • , Arndt Borkhardt
    • , Michaela Kuhlen
    • , Angelika Eggert
    • , Simone Fulda
    • , Manfred Gessler
    • , Jenny Wegert
    • , Roland Kappler
    • , Daniel Baumhoer
    • , Stefan Burdach
    • , Renate Kirschner-Schwabe
    • , Udo Kontny
    • , Andreas E. Kulozik
    • , Dietmar Lohmann
    • , Simone Hettmer
    • , Cornelia Eckert
    • , Stefan Bielack
    • , Michaela Nathrath
    • , Charlotte Niemeyer
    • , Günther H. Richter
    • , Johannes Schulte
    • , Reiner Siebert
    • , Frank Westermann
    • , Jan J. Molenaar
    • , Gilles Vassal
    • , Hendrik Witt
    • , Birgit Burkhardt
    • , Christian P. Kratz
    • , Olaf Witt
    • , Cornelis M. van Tilburg
    • , Christof M. Kramm
    • , Gudrun Fleischhack
    • , Uta Dirksen
    • , Stefan Rutkowski
    • , Michael Frühwald
    • , Katja von Hoff
    • , Stephan Wolf
    • , Thomas Klingebiel
    • , Ewa Koscielniak
    • , Pablo Landgraf
    • , Jan Koster
    • , Adam C. Resnick
    • , Jinghui Zhang
    • , Yanling Liu
    • , Xin Zhou
    • , Angela J. Waanders
    • , Danny A. Zwijnenburg
    • , Pichai Raman
    • , Benedikt Brors
    • , Ursula D. Weber
    • , Paul A. Northcott
    • , Kristian W. Pajtler
    • , Marcel Kool
    • , Rosario M. Piro
    • , Jan O. Korbel
    • , Matthias Schlesner
    • , Roland Eils
    • , David T. W. Jones
    • , Peter Lichter
    • , Lukas Chavez
    • , Marc Zapatka
    • , Stefan M. Pfister
    • , Peter Lichter
    • , Ursula Weber
    • , Roland Eils
    • , Andrey Korshunov
    • , Olaf Witt
    • , Stefan Pfister
    • , Guido Reifenberger
    • , Jörg Felsberg
    • , Christof von Kalle
    • , Manfred Schmidt
    • , Cynthia Bartholomä
    • , Michael Taylor
    • , Stefan Pfister
    • , David Jones
    • , Peter Lichter
    • , Natalie Jäger
    • , Ivo Buchhalter
    • , Jan Korbel
    • , Adrian Stütz
    • , Tobias Rausch
    • , Bernhard Radlwimmer
    • , Marie-Laure Yaspo
    • , Hans Lehrach
    • , Hans-Jörg Warnatz
    • , Pablo Landgraf
    • , Arndt Borkhardt
    • , Benedikt Brors
    • , Marc Zapatka
    • , Roland Eils
    • , Roland Eils
    • , Jürgen Eils
    • , Christian Lawerenz
    • , Reiner Siebert
    • , Susanne Wagner
    • , Andrea Haake
    • , Julia Richter
    • , Gesine Richter
    • , Roland Eils
    • , Chris Lawerenz
    • , Jürgen Eils
    • , Jules Kerssemakers
    • , Christina Jaeger-Schmidt
    • , Ingrid Scholz
    • , Anke K. Bergmann
    • , Christoph Borst
    • , Birgit Burkhardt
    • , Alexander Claviez
    • , Martin Dreyling
    • , Sonja Eberth
    • , Hermann Einsele
    • , Norbert Frickhofen
    • , Siegfried Haas
    • , Martin-Leo Hansmann
    • , Dennis Karsch
    • , Michael Kneba
    • , Jasmin Lisfeld
    • , Luisa Mantovani-Löffler
    • , Marius Rohde
    • , German Ott
    • , Christina Stadler
    • , Peter Staib
    • , Stephan Stilgenbauer
    • , Lorenz Trümper
    • , Thorsten Zenz
    • , Martin-Leo Hansmann
    • , Dieter Kube
    • , Ralf Küppers
    • , Marc Weniger
    • , Michael Hummel
    • , Wolfram Klapper
    • , Ulrike Kostezka
    • , Dido Lenze
    • , Peter Möller
    • , Andreas Rosenwald
    • , German Ott
    • , Monika Szczepanowski
    • , Ole Ammerpohl
    • , Sietse M. Aukema
    • , Vera Binder
    • , Arndt Borkhardt
    • , Andrea Haake
    • , Jessica I. Hoell
    • , Ellen Leich
    • , Peter Lichter
    • , Cristina López
    • , Inga Nagel
    • , Jordan Pischimariov
    • , Bernhard Radlwimmer
    • , Julia Richter
    • , Philip Rosenstiel
    • , Andreas Rosenwald
    • , Markus Schilhabel
    • , Stefan Schreiber
    • , Inga Vater
    • , Rabea Wagener
    • , Reiner Siebert
    • , Stephan H. Bernhart
    • , Hans Binder
    • , Benedikt Brors
    • , Gero Doose
    • , Roland Eils
    • , Steve Hoffmann
    • , Lydia Hopp
    • , Daniel Hübschmann
    • , Kortine Kleinheinz
    • , Helene Kretzmer
    • , Markus Kreuz
    • , Jan Korbel
    • , David Langenberger
    • , Markus Loeffler
    • , Maciej Rosolowski
    • , Matthias Schlesner
    • , Peter F. Stadler
    •  & Stephanie Sungalee