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Current Issue of Nature


Volume 559 Issue 7715, 26 July 2018

Volume 559 Issue 7715, 26 July 2018

Volume 559 Issue 7715

Malaria bites back

A member of medical staff at the malaria research project’s facility in Siem Pang, Cambodia, checks the health of a young man. Cambodia is among several countries in southeast Asia that have showed a worrying rise in resistance to artemisinin-based combination therapies, the gold-standard treatment for malaria. Although the region accounts for just 7% of malaria cases worldwide, it has repeatedly given rise to strains of drug-resistant malaria parasites that have subsequently invaded other parts of the globe. Cambodia, Thailand, Vietnam, Laos and Myanmar are now trying to eradicate the malaria parasite before resistant forms spread more widely. Researchers are aiding that effort by developing tools to improve detection of the parasite and ways to forestall drug resistance.

Cover image: Adam Dean for Nature

This Week

News in Focus

Comment

Technology

Careers

    Features

  • Career Feature |

    Scientists in areas that lack basic provisions — including dependable electricity, water supplies and funding — do research that has a high societal impact. Five people describe the challenges they face.

    • Josie Glausiusz

Futures

  • Futures |

    Total recall.

    • Griffin Ayaz Tyree

Research

    News & Views

  • News & Views |

    An excavation has uncovered stone tools in China that are about 2.1 million years old. This evidence pushes back the date of the earliest established signs of a hominin species outside Africa.

    • John Kappelman
  • News & Views |

    Atoms can exhibit wave-like behaviour to form matter waves. Such waves have been used to model the basic processes that underpin how light interacts with matter, providing an experimental platform for future research.

    • Alejandro González Tudela
    •  & J. Ignacio Cirac
  • News & Views |

    It emerges that viruses called phages, which infect bacteria, can suppress the bacterial immune system during an initial wave of unsuccessful infection, enabling subsequent viral infection to succeed.

    • Aude Bernheim
    •  & Rotem Sorek
  • News & Views |

    Clinical use of the anticancer drug methotrexate can be limited by its high toxicity. It emerges that a diet rich in the amino acid histidine increases the effectiveness of methotrexate treatment and lowers toxicity in mice.

    • Christian Frezza
  • News & Views |

    An analysis of ancient coral from the Great Barrier Reef reveals that global sea level fell rapidly at the end of the last glacial period. The findings suggest that ice sheets are more dynamic than was previously thought.

    • Pippa Whitehouse
  • Insight

  • Introduction |

    • Anna Armstrong
    • , I-han Chou
    • , Juliane Mossinger
    • , Clare Thomas
    • , Christina Tobin Kårlström
    •  & Michael White

    Insight:

  • Reviews

  • Review Article |

    The immense biodiversity of tropical ecosystems is threatened by multiple interacting local and global stressors that can only be addressed by the concerted efforts of grassroots organizations, researchers, national governments and the international community.

    • Jos Barlow
    • , Filipe França
    • , Toby A. Gardner
    • , Christina C. Hicks
    • , Gareth D. Lennox
    • , Erika Berenguer
    • , Leandro Castello
    • , Evan P. Economo
    • , Joice Ferreira
    • , Benoit Guénard
    • , Cecília Gontijo Leal
    • , Victoria Isaac
    • , Alexander C. Lees
    • , Catherine L. Parr
    • , Shaun K. Wilson
    • , Paul J. Young
    •  & Nicholas A. J. Graham

    Insight:

  • Review Article |

    Our current understanding of the spatio-temporal complexity of the El Niño–Southern Oscillation phenomenon is reviewed and a unifying framework that identifies the key factors for this complexity is proposed.

    • Axel Timmermann
    • , Soon-Il An
    • , Jong-Seong Kug
    • , Fei-Fei Jin
    • , Wenju Cai
    • , Antonietta Capotondi
    • , Kim Cobb
    • , Matthieu Lengaigne
    • , Michael J. McPhaden
    • , Malte F. Stuecker
    • , Karl Stein
    • , Andrew T. Wittenberg
    • , Kyung-Sook Yun
    • , Tobias Bayr
    • , Han-Ching Chen
    • , Yoshimitsu Chikamoto
    • , Boris Dewitte
    • , Dietmar Dommenget
    • , Pamela Grothe
    • , Eric Guilyardi
    • , Yoo-Geun Ham
    • , Michiya Hayashi
    • , Sarah Ineson
    • , Daehyun Kang
    • , Sunyong Kim
    • , WonMoo Kim
    • , June-Yi Lee
    • , Tim Li
    • , Jing-Jia Luo
    • , Shayne McGregor
    • , Yann Planton
    • , Scott Power
    • , Harun Rashid
    • , Hong-Li Ren
    • , Agus Santoso
    • , Ken Takahashi
    • , Alexander Todd
    • , Guomin Wang
    • , Guojian Wang
    • , Ruihuang Xie
    • , Woo-Hyun Yang
    • , Sang-Wook Yeh
    • , Jinho Yoon
    • , Elke Zeller
    •  & Xuebin Zhang

    Insight:

  • Review Article |

    Recent progress in machine learning in the chemical sciences and future directions in this field are discussed.

    • Keith T. Butler
    • , Daniel W. Davies
    • , Hugh Cartwright
    • , Olexandr Isayev
    •  & Aron Walsh
  • Articles

  • Article |

    Micrometre-sized particles of two niobium tungsten oxides have high volumetric capacities and rate performances, enabled by very high lithium-ion diffusion coefficients.

    • Kent J. Griffith
    • , Kamila M. Wiaderek
    • , Giannantonio Cibin
    • , Lauren E. Marbella
    •  & Clare P. Grey
  • Article |

    A female Drosophila melanogaster pheromone is recognized by males from both the same and a closely related species through conserved peripheral sensory neurons; the signal is then differentially propagated to promote conspecific and suppress interspecies courtship.

    • Laura F. Seeholzer
    • , Max Seppo
    • , David L. Stern
    •  & Vanessa Ruta
  • Article |

    A cryo-electron microscopy structure of fungal mitochondrial calcium uniporter shows that the channel is tetrameric and sheds light on channel assembly and function.

    • Nam X. Nguyen
    • , Jean-Paul Armache
    • , Changkeun Lee
    • , Yi Yang
    • , Weizhong Zeng
    • , Vamsi K. Mootha
    • , Yifan Cheng
    • , Xiao-chen Bai
    •  & Youxing Jiang
  • Article |

    X-ray and cryo-electron microscopy structures of fungal mitochondrial calcium uniporter proteins reveal a tetrameric architecture and shed light on the function of the channel.

    • Chao Fan
    • , Minrui Fan
    • , Benjamin J. Orlando
    • , Nathan M. Fastman
    • , Jinru Zhang
    • , Yan Xu
    • , Melissa G. Chambers
    • , Xiaofang Xu
    • , Kay Perry
    • , Maofu Liao
    •  & Liang Feng
  • Letters

  • Letter |

    DNA origami is used as a template to produce complex geometric shapes of nanoscale silica hybrid materials.

    • Xiaoguo Liu
    • , Fei Zhang
    • , Xinxin Jing
    • , Muchen Pan
    • , Pi Liu
    • , Wei Li
    • , Bowen Zhu
    • , Jiang Li
    • , Hong Chen
    • , Lihua Wang
    • , Jianping Lin
    • , Yan Liu
    • , Dongyuan Zhao
    • , Hao Yan
    •  & Chunhai Fan
  • Letter |

    This study of whole-soil carbon dynamics finds that, of the atmospheric carbon that is incorporated into the topmost metre of soil over 50 years, just 19 per cent reaches the subsoil, in a manner that depends on land use and aridity.

    • Jérôme Balesdent
    • , Isabelle Basile-Doelsch
    • , Joël Chadoeuf
    • , Sophie Cornu
    • , Delphine Derrien
    • , Zuzana Fekiacova
    •  & Christine Hatté
  • Letter |

    Details of the drops in sea level associated with glaciation during the Last Glacial Maximum are revealed using a coral proxy from the Great Barrier Reef.

    • Yusuke Yokoyama
    • , Tezer M. Esat
    • , William G. Thompson
    • , Alexander L. Thomas
    • , Jody M. Webster
    • , Yosuke Miyairi
    • , Chikako Sawada
    • , Takahiro Aze
    • , Hiroyuki Matsuzaki
    • , Jun’ichi Okuno
    • , Stewart Fallon
    • , Juan-Carlos Braga
    • , Marc Humblet
    • , Yasufumi Iryu
    • , Donald C. Potts
    • , Kazuhiko Fujita
    • , Atsushi Suzuki
    •  & Hironobu Kan
  • Letter |

    An Early Pleistocene artefact assemblage from the Chinese Loess Plateau indicates that hominins had left Africa by at least 2.1 million years ago, and occupied the Loess Plateau repeatedly for a long time.

    • Zhaoyu Zhu
    • , Robin Dennell
    • , Weiwen Huang
    • , Yi Wu
    • , Shifan Qiu
    • , Shixia Yang
    • , Zhiguo Rao
    • , Yamei Hou
    • , Jiubing Xie
    • , Jiangwei Han
    •  & Tingping Ouyang
  • Letter |

    Triple oxygen isotope measurements of 1.4-billion-year-old sedimentary sulfates reveal a unique mid-Proterozoic atmosphere and demonstrate that gross primary productivity in the mid-Proterozoic was between 6% and 41% of pre-anthropogenic levels.

    • Peter W. Crockford
    • , Justin A. Hayles
    • , Huiming Bao
    • , Noah J. Planavsky
    • , Andrey Bekker
    • , Philip W. Fralick
    • , Galen P. Halverson
    • , Thi Hao Bui
    • , Yongbo Peng
    •  & Boswell A. Wing
  • Letter |

    The outer membrane of Gram-negative bacteria is shown to be at least as stiff as the cell wall, and this property enables it to protect cells from mechanical pertubations.

    • Enrique R. Rojas
    • , Gabriel Billings
    • , Pascal D. Odermatt
    • , George K. Auer
    • , Lillian Zhu
    • , Amanda Miguel
    • , Fred Chang
    • , Douglas B. Weibel
    • , Julie A. Theriot
    •  & Kerwyn Casey Huang
  • Letter |

    A comprehensive characterization of the thymic stroma identifies a tuft-cell-like thymic epithelial cell population that is critical for shaping the immune niche in the thymus.

    • Chamutal Bornstein
    • , Shir Nevo
    • , Amir Giladi
    • , Noam Kadouri
    • , Marie Pouzolles
    • , François Gerbe
    • , Eyal David
    • , Alice Machado
    • , Anna Chuprin
    • , Beáta Tóth
    • , Ori Goldberg
    • , Shalev Itzkovitz
    • , Naomi Taylor
    • , Philippe Jay
    • , Valérie S. Zimmermann
    • , Jakub Abramson
    •  & Ido Amit
  • Letter |

    A comprehensive analysis of the thymic medulla identifies a tuft-cell-like thymic epithelial cell population that is necessary for shaping thymic function.

    • Corey N. Miller
    • , Irina Proekt
    • , Jakob von Moltke
    • , Kristen L. Wells
    • , Aparna R. Rajpurkar
    • , Haiguang Wang
    • , Kristin Rattay
    • , Imran S. Khan
    • , Todd C. Metzger
    • , Joshua L. Pollack
    • , Adam C. Fries
    • , Wint W. Lwin
    • , Eric J. Wigton
    • , Audrey V. Parent
    • , Bruno Kyewski
    • , David J. Erle
    • , Kristin A. Hogquist
    • , Lars M. Steinmetz
    • , Richard M. Locksley
    •  & Mark S. Anderson
  • Letter |

    Histidine metabolism influences the sensitivity of cancer cells to methotrexate, with mice bearing leukaemia xenografts showing increased response to the drug upon histidine supplementation.

    • Naama Kanarek
    • , Heather R. Keys
    • , Jason R. Cantor
    • , Caroline A. Lewis
    • , Sze Ham Chan
    • , Tenzin Kunchok
    • , Monther Abu-Remaileh
    • , Elizaveta Freinkman
    • , Lawrence D. Schweitzer
    •  & David M. Sabatini
  • Letter |

    Modulation of DNA 5-hydroxymethylcytosine by glucose reveals an AMPK–TET2–5hmC axis that links diabetes to cancer.

    • Di Wu
    • , Di Hu
    • , Hao Chen
    • , Guoming Shi
    • , Irfete S. Fetahu
    • , Feizhen Wu
    • , Kimberlie Rabidou
    • , Rui Fang
    • , Li Tan
    • , Shuyun Xu
    • , Hang Liu
    • , Christian Argueta
    • , Lei Zhang
    • , Fei Mao
    • , Guoquan Yan
    • , Jiajia Chen
    • , Zhaoru Dong
    • , Ruitu Lv
    • , Yufei Xu
    • , Mei Wang
    • , Yong Ye
    • , Shike Zhang
    • , Danielle Duquette
    • , Songmei Geng
    • , Clark Yin
    • , Christine Guo Lian
    • , George F. Murphy
    • , Gail K. Adler
    • , Rajesh Garg
    • , Lydia Lynch
    • , Pengyuan Yang
    • , Yiming Li
    • , Fei Lan
    • , Jia Fan
    • , Yang Shi
    •  & Yujiang Geno Shi

Amendments & Corrections

Collections

  • Nature Outlook |

    Alzheimer’s disease

    Alzheimer’s disease is the most common form of dementia. For decades, researchers have sought a treatment to no avail, and our understanding of the condition is now being questioned.
  • Insight |

    Tropics

    The tropics are home to a dizzying array of species, store vast quantities of carbon, drive year-to-year climate variability, and will soon be home to half the world’s population. This Insight gathers together Reviews that explore some of the most important scientific and societal challenges posed by the tropics, and some of the solutions being devised.