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Current Issue of Nature


Volume 558 Issue 7711, 28 June 2018

Volume 558 Issue 7711, 28 June 2018

Volume 558 Issue 7711

Five hubs of Asian science

The cover shows the Supertree Grove in Singapore, one of five key research hubs in Asia profiled in a special issue this week. Along with Hong Kong, Malaysia, South Korea and Taiwan, Singapore is investing in science and increasing its global reach as a result. Scientists from across these five centres provide an insight into the breadth of dynamic work being done — from genome editing to green-energy development — and the way the changing research landscape is attracting skills to the region. They also reveal how a focus on science is helping to address public concerns such as health care and air pollution. These five hubs might not be heaviest hitters in the continent, but they are rapidly becoming a major force in the global scientific landscape.

Cover image: Alamy

This Week

News in Focus

Comment

Careers

Futures

  • Futures |

    Preservation strategy.

    • Jeremy Szal

Research

    News & Views

  • News & Views |

    An analysis of meteoritic material from Mars provides an accurate timeline of the planet’s early history. The results have major implications for our understanding of the processes involved in rocky-planet formation.

    • Linda T. Elkins-Tanton
  • News & Views |

    A molecule standing on a metal surface has been found to emit electrons in the presence of an applied electric field. The emitted electrons produce an interference pattern reminiscent of a classic physics experiment.

    • Thomas Greber
  • News & Views |

    Weight loss and tissue wasting often occur in pancreatic cancer. Analyses of human and mouse data reveal a mechanism behind these events, and raise the question of whether tissue wasting affects cancer survival rates.

    • J. Matthias Löhr
  • News & Views |

    The idea that everyone in the world is connected to everyone else by just six degrees of separation was explained by the ‘small-world’ network model 20 years ago. What seemed to be a niche finding turned out to have huge consequences.

    • Alessandro Vespignani
  • Reviews

  • Review Article |

    Because climate change is expected to intensify regional-scale droughts, it is important to identify the physiological thresholds that precipitate the mortality of trees and the mechanisms of recovery after drought.

    • Brendan Choat
    • , Timothy J. Brodribb
    • , Craig R. Brodersen
    • , Remko A. Duursma
    • , Rosana López
    •  & Belinda E. Medlyn
  • Articles

  • Article |

    A PI3KCA inhibitor reverses symptoms in a mouse model of PROS/CLOVES syndrome, which results from gain-of-function mutations in PI3KCA, and produces improvements in patients with PROS/CLOVES syndrome.

    • Quitterie Venot
    • , Thomas Blanc
    • , Smail Hadj Rabia
    • , Laureline Berteloot
    • , Sophia Ladraa
    • , Jean-Paul Duong
    • , Estelle Blanc
    • , Simon C. Johnson
    • , Clément Hoguin
    • , Olivia Boccara
    • , Sabine Sarnacki
    • , Nathalie Boddaert
    • , Stephanie Pannier
    • , Frank Martinez
    • , Sato Magassa
    • , Junna Yamaguchi
    • , Bertrand Knebelmann
    • , Pierre Merville
    • , Nicolas Grenier
    • , Dominique Joly
    • , Valérie Cormier-Daire
    • , Caroline Michot
    • , Christine Bole-Feysot
    • , Arnaud Picard
    • , Véronique Soupre
    • , Stanislas Lyonnet
    • , Jeremy Sadoine
    • , Lotfi Slimani
    • , Catherine Chaussain
    • , Cécile Laroche-Raynaud
    • , Laurent Guibaud
    • , Christine Broissand
    • , Jeanne Amiel
    • , Christophe Legendre
    • , Fabiola Terzi
    •  & Guillaume Canaud
  • Article |

    A cryo-electron structure of the µ-opioid receptor in complex with the peptide agonist DAMGO and the inhibitory G protein Gi reveals structural determinants of its G protein-binding specificity.

    • Antoine Koehl
    • , Hongli Hu
    • , Shoji Maeda
    • , Yan Zhang
    • , Qianhui Qu
    • , Joseph M. Paggi
    • , Naomi R. Latorraca
    • , Daniel Hilger
    • , Roger Dawson
    • , Hugues Matile
    • , Gebhard F. X. Schertler
    • , Sebastien Granier
    • , William I. Weis
    • , Ron O. Dror
    • , Aashish Manglik
    • , Georgios Skiniotis
    •  & Brian K. Kobilka
  • Article |

    The cryo-electron microscopy structure of human rhodopsin bound to the inhibitory Gi protein-coupled receptor provides insights into ligand–receptor–G-protein interactions.

    • Yanyong Kang
    • , Oleg Kuybeda
    • , Parker W. de Waal
    • , Somnath Mukherjee
    • , Ned Van Eps
    • , Przemyslaw Dutka
    • , X. Edward Zhou
    • , Alberto Bartesaghi
    • , Satchal Erramilli
    • , Takefumi Morizumi
    • , Xin Gu
    • , Yanting Yin
    • , Ping Liu
    • , Yi Jiang
    • , Xing Meng
    • , Gongpu Zhao
    • , Karsten Melcher
    • , Oliver P. Ernst
    • , Anthony A. Kossiakoff
    • , Sriram Subramaniam
    •  & H. Eric Xu
  • Article |

    The cryo-electron microscopy structure of the human adenosine A1 receptor in complex with adenosine and heterotrimeric Gi2 protein provides molecular insights into receptor and G-protein selectivity.

    • Christopher J. Draper-Joyce
    • , Maryam Khoshouei
    • , David M. Thal
    • , Yi-Lynn Liang
    • , Anh T. N. Nguyen
    • , Sebastian G. B. Furness
    • , Hariprasad Venugopal
    • , Jo-Anne Baltos
    • , Jürgen M. Plitzko
    • , Radostin Danev
    • , Wolfgang Baumeister
    • , Lauren T. May
    • , Denise Wootten
    • , Patrick M. Sexton
    • , Alisa Glukhova
    •  & Arthur Christopoulos
  • Letters

  • Letter |

    The detection of complex organic molecules with masses higher than 200 atomic mass units in ice grains emitted from Enceladus indicates the presence of a thin organic-rich layer on top of the moon’s subsurface ocean.

    • Frank Postberg
    • , Nozair Khawaja
    • , Bernd Abel
    • , Gael Choblet
    • , Christopher R. Glein
    • , Murthy S. Gudipati
    • , Bryana L. Henderson
    • , Hsiang-Wen Hsu
    • , Sascha Kempf
    • , Fabian Klenner
    • , Georg Moragas-Klostermeyer
    • , Brian Magee
    • , Lenz Nölle
    • , Mark Perry
    • , René Reviol
    • , Jürgen Schmidt
    • , Ralf Srama
    • , Ferdinand Stolz
    • , Gabriel Tobie
    • , Mario Trieloff
    •  & J. Hunter Waite
  • Letter |

    One-way propagation of light through a standard telecommunications fibre is demonstrated by coupling the fibre to a rapidly rotating silica-glass sphere.

    • Shai Maayani
    • , Raphael Dahan
    • , Yuri Kligerman
    • , Eduard Moses
    • , Absar U. Hassan
    • , Hui Jing
    • , Franco Nori
    • , Demetrios N. Christodoulides
    •  & Tal Carmon
  • Letter |

    Precision control over matter at the atomic scale enables a planar dye molecule to be lifted up and placed on its edge—a configuration that is surprisingly stable.

    • Taner Esat
    • , Niklas Friedrich
    • , F. Stefan Tautz
    •  & Ruslan Temirov
  • Letter |

    Isotopic compositions of ancient zircons from the NWA 7034 Martian meteorite suggest that Mars must have formed its primordial crust extremely swiftly, less than 20 million years after the formation of the Solar System.

    • Laura C. Bouvier
    • , Maria M. Costa
    • , James N. Connelly
    • , Ninna K. Jensen
    • , Daniel Wielandt
    • , Michael Storey
    • , Alexander A. Nemchin
    • , Martin J. Whitehouse
    • , Joshua F. Snape
    • , Jeremy J. Bellucci
    • , Frédéric Moynier
    • , Arnaud Agranier
    • , Bleuenn Gueguen
    • , Maria Schönbächler
    •  & Martin Bizzarro
  • Letter |

     In the midbrain defensive circuit, the decision to escape is computed by an unreliable synaptic connection that thresholds threat information integrated in the medial superior colliculus, and controls activation of dorsal periaqueductal grey neurons.

    • Dominic A. Evans
    • , A. Vanessa Stempel
    • , Ruben Vale
    • , Sabine Ruehle
    • , Yaara Lefler
    •  & Tiago Branco
  • Letter |

    An analysis based on functional metagenomics reveals a previously unknown group of microbial light-sensory rhodopsins that are widespread among a diverse range of microorganisms.

    • Alina Pushkarev
    • , Keiichi Inoue
    • , Shirley Larom
    • , José Flores-Uribe
    • , Manish Singh
    • , Masae Konno
    • , Sahoko Tomida
    • , Shota Ito
    • , Ryoko Nakamura
    • , Satoshi P. Tsunoda
    • , Alon Philosof
    • , Itai Sharon
    • , Natalya Yutin
    • , Eugene V. Koonin
    • , Hideki Kandori
    •  & Oded Béjà
  • Letter |

    Pancreatic ductal adenocarcinoma in mice induces loss of adipose tissue through altered function of the exocrine pancreas, and supplementing pancreatic enzymes attenuates the wasting of peripheral tissues induced by pancreatic cancer.

    • Laura V. Danai
    • , Ana Babic
    • , Michael H. Rosenthal
    • , Emily A. Dennstedt
    • , Alexander Muir
    • , Evan C. Lien
    • , Jared R. Mayers
    • , Karen Tai
    • , Allison N. Lau
    • , Paul Jones-Sali
    • , Carla M. Prado
    • , Gloria M. Petersen
    • , Naoki Takahashi
    • , Motokazu Sugimoto
    • , Jen Jen Yeh
    • , Nicole Lopez
    • , Nabeel Bardeesy
    • , Carlos Fernandez-del Castillo
    • , Andrew S. Liss
    • , Albert C. Koong
    • , Justin Bui
    • , Chen Yuan
    • , Marisa W. Welch
    • , Lauren K. Brais
    • , Matthew H. Kulke
    • , Courtney Dennis
    • , Clary B. Clish
    • , Brian M. Wolpin
    •  & Matthew G. Vander Heiden
  • Letter |

    Enzymes that catalyse modifications of wobble uridine 34 tRNA are essential for the survival of melanoma cells that rely on HIF1α-dependent metabolism through codon-dependent regulation of the translation of HIF1A mRNA.

    • Francesca Rapino
    • , Sylvain Delaunay
    • , Florian Rambow
    • , Zhaoli Zhou
    • , Lars Tharun
    • , Pascal De Tullio
    • , Olga Sin
    • , Kateryna Shostak
    • , Sebastian Schmitz
    • , Jolanda Piepers
    • , Bart Ghesquière
    • , Latifa Karim
    • , Benoit Charloteaux
    • , Diane Jamart
    • , Alexandra Florin
    • , Charles Lambert
    • , Andrée Rorive
    • , Guy Jerusalem
    • , Eleonora Leucci
    • , Michael Dewaele
    • , Marc Vooijs
    • , Sebastian A. Leidel
    • , Michel Georges
    • , Marianne Voz
    • , Bernard Peers
    • , Reinhard Büttner
    • , Jean-Christophe Marine
    • , Alain Chariot
    •  & Pierre Close
  • Letter |

    Viperin inhibits the replication of various viruses by catalysing the conversion of CTP to ddhCTP, which is a unique nucleotide that functions as replication-chain terminator of RNA-dependent RNA polymerases.

    • Anthony S. Gizzi
    • , Tyler L. Grove
    • , Jamie J. Arnold
    • , Joyce Jose
    • , Rohit K. Jangra
    • , Scott J. Garforth
    • , Quan Du
    • , Sean M. Cahill
    • , Natalya G. Dulyaninova
    • , James D. Love
    • , Kartik Chandran
    • , Anne R. Bresnick
    • , Craig E. Cameron
    •  & Steven C. Almo
  • Letter |

    The high-resolution structure of the serotonin 5-HT1B receptor in complex with the agonist donitriptan and a Go heterotrimer highlights features that may underly the specificity of receptor–G-protein coupling and kinetics of signalling.

    • Javier García-Nafría
    • , Rony Nehmé
    • , Patricia C. Edwards
    •  & Christopher G. Tate

Amendments & Corrections

Nature Index

  • Nature Index |

    Nature Index 2018 Earth and Environmental Sciences

    The US remains by far the largest producer of high quality Earth and environmental sciences research, but China’s output has grown rapidly since 2012 to take over second place from the United Kingdom