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Current Issue of Nature


Current Issue : Nature

Current Issue

Volume 555 Number 7698 pp559-688

29 March 2018

About the cover

The dark caves that blind Mexican cavefish (Astyanax mexicanus) call home is an extreme environment in which food is scarce. As a result, the fish lead a famine-and-feast way life that has led them to adapt in a remarkable way, as Nicolas Rohner, Cliff Tabin and their colleagues reveal in this week's issue. The cavefish carry a mutation in the insulin receptor that would cause severe type 2 diabetes in humans. The resulting high blood-glucose levels seem to cause no ill effects in the fish, which are healthy and have a normal lifespan. The authors speculate that the fish have evolved compensatory mechanisms in their regulation of glucose that allow them to survive in their challenging environment. Cover image: Paulo Oliveira/Alamy

This Week

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Seven Days

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  • Cybersecurity needs women

    Safeguarding our lives online requires skills and experiences that lie beyond masculine stereotypes of the hacker and soldier, says Winifred R. Poster.

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Brief Communications Arising

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Articles

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  • De novo mutations in regulatory elements in neurodevelopmental disorders

    • Patrick J. Short
    • Jeremy F. McRae
    • Giuseppe Gallone
    • Alejandro Sifrim
    • Hyejung Won
    • Daniel H. Geschwind
    • Caroline F. Wright
    • Helen V. Firth
    • David R. FitzPatrick
    • Jeffrey C. Barrett
    • Matthew E. Hurles

    Analysis of rare de novo mutations in gene regulatory elements suggests that 1–3% of patients with neurodevelopmental disorders carry such mutations in elements that are active in the fetal brain.

  • Encoding of danger by parabrachial CGRP neurons

    • Carlos A. Campos
    • Anna J. Bowen
    • Carolyn W. Roman
    • Richard D. Palmiter

    Single-cell recordings show that CGRP-expressing neurons in the parabrachial nucleus in mice respond to both noxious stimuli and signals of feeding satiety.

  • Extensive impact of non-antibiotic drugs on human gut bacteria

    • Lisa Maier
    • Mihaela Pruteanu
    • Michael Kuhn
    • Georg Zeller
    • Anja Telzerow
    • Exene Erin Anderson
    • Ana Rita Brochado
    • Keith Conrad Fernandez
    • Hitomi Dose
    • Hirotada Mori
    • Kiran Raosaheb Patil
    • Peer Bork
    • Athanasios Typas

    A screen of more than 1,000 drugs shows that about a quarter of the non-antibiotic drugs inhibit the growth of at least one commensal bacterial strain in vitro.

Letters

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  • A galaxy lacking dark matter

    • Pieter van Dokkum
    • Shany Danieli
    • Yotam Cohen
    • Allison Merritt
    • Aaron J. Romanowsky
    • Roberto Abraham
    • Jean Brodie
    • Charlie Conroy
    • Deborah Lokhorst
    • Lamiya Mowla
    • Ewan O’Sullivan
    • Jielai Zhang

    Galaxies normally have far more dark matter than normal matter, but the dynamics of objects within the ultra-diffuse galaxy NGC1052–DF2 suggest that it has a very little dark matter component.

  • A programmable two-qubit quantum processor in silicon

    • T. F. Watson
    • S. G. J. Philips
    • E. Kawakami
    • D. R. Ward
    • P. Scarlino
    • M. Veldhorst
    • D. E. Savage
    • M. G. Lagally
    • Mark Friesen
    • S. N. Coppersmith
    • M. A. Eriksson
    • L. M. K. Vandersypen

    A two-qubit quantum processor in a silicon device is demonstrated, which can perform the Deutsch–Josza algorithm and the Grover search algorithm.

    See also
  • Massive Dirac fermions in a ferromagnetic kagome metal

    • Linda Ye
    • Mingu Kang
    • Junwei Liu
    • Felix von Cube
    • Christina R. Wicker
    • Takehito Suzuki
    • Chris Jozwiak
    • Aaron Bostwick
    • Eli Rotenberg
    • David C. Bell
    • Liang Fu
    • Riccardo Comin
    • Joseph G. Checkelsky

    Fe3Sn2 hosts massive Dirac fermions, owing to the underlying symmetry properties of the bilayer kagome lattice in the ferromagnetic state and the atomic spin–orbit coupling.

  • Timing of oceans on Mars from shoreline deformation

    • Robert I. Citron
    • Michael Manga
    • Douglas J. Hemingway

    Ancient shorelines on Mars must have formed before and during the emplacement of the Tharsis volcanic province, instead of afterwards as previously assumed, suggesting that oceans on Mars formed early.

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  • Insulin resistance in cavefish as an adaptation to a nutrient-limited environment

    • Misty R. Riddle
    • Ariel C. Aspiras
    • Karin Gaudenz
    • Robert Peuß
    • Jenny Y. Sung
    • Brian Martineau
    • Megan Peavey
    • Andrew C. Box
    • Julius A. Tabin
    • Suzanne McGaugh
    • Richard Borowsky
    • Clifford J. Tabin
    • Nicolas Rohner

    Cavefish populations of the Mexican tetra, Astyanax mexicanus, carry a mutation in the insulin receptor gene that renders them insulin- and starvation-resistant relative to surface populations of the same species.

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  • Reconstructing the genetic history of late Neanderthals

    • Mateja Hajdinjak
    • Qiaomei Fu
    • Alexander Hübner
    • Martin Petr
    • Fabrizio Mafessoni
    • Steffi Grote
    • Pontus Skoglund
    • Vagheesh Narasimham
    • Hélène Rougier
    • Isabelle Crevecoeur
    • Patrick Semal
    • Marie Soressi
    • Sahra Talamo
    • Jean-Jacques Hublin
    • Ivan Gušić
    • Željko Kućan
    • Pavao Rudan
    • Liubov V. Golovanova
    • Vladimir B. Doronichev
    • Cosimo Posth
    • Johannes Krause
    • Petra Korlević
    • Sarah Nagel
    • Birgit Nickel
    • Montgomery Slatkin
    • Nick Patterson
    • David Reich
    • Kay Prüfer
    • Matthias Meyer
    • Svante Pääbo
    • Janet Kelso

    Genetic similarity among late Neanderthals is predicted well by their geographical location, and although some of these Neanderthals were contemporaneous with early modern humans, their genomes show no evidence of recent gene flow from modern humans.

  • A TRP channel trio mediates acute noxious heat sensing

    • Ine Vandewauw
    • Katrien De Clercq
    • Marie Mulier
    • Katharina Held
    • Silvia Pinto
    • Nele Van Ranst
    • Andrei Segal
    • Thierry Voet
    • Rudi Vennekens
    • Katharina Zimmermann
    • Joris Vriens
    • Thomas Voets

    Three transient receptor potential channels (TRPA1, TRPV1 and TRPM3) mediate sensitivity to acute noxious heat in mice in a redundant system; mice lacking all three show severe deficits in heat sensing, whereas double-knockout mice do not.

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  • Electromechanical vortex filaments during cardiac fibrillation

    • J. Christoph
    • M. Chebbok
    • C. Richter
    • J. Schröder-Schetelig
    • P. Bittihn
    • S. Stein
    • I. Uzelac
    • F. H. Fenton
    • G. Hasenfuß
    • R. F. Gilmour Jr.
    • S. Luther

    Using optical mapping and 3D ultrasound, the dynamics and interactions between electrical and mechanical phase singularities were analysed by simultaneously measuring the membrane potential, intracellular calcium concentration and mechanical contractions of the heart during normal rhythm and fibrillation.

    See also
  • The protein histidine phosphatase LHPP is a tumour suppressor

    • Sravanth K. Hindupur
    • Marco Colombi
    • Stephen R. Fuhs
    • Matthias S. Matter
    • Yakir Guri
    • Kevin Adam
    • Marion Cornu
    • Salvatore Piscuoglio
    • Charlotte K. Y. Ng
    • Charles Betz
    • Dritan Liko
    • Luca Quagliata
    • Suzette Moes
    • Paul Jenoe
    • Luigi M. Terracciano
    • Markus H. Heim
    • Tony Hunter
    • Michael N. Hall

    Decreased expression of histidine phosphatase LHPP, a novel tumour suppressor, results in increased global histidine phosphorylation and hepatocellular carcinoma.

Erratum

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