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Current Issue of Nature


Current Issue : Nature

Current Issue

Volume 551 Number 7678 pp5-128

2 November 2017

About the cover

The cover image depicts an artist’s impression of the merger of two neutron stars, giving rise to a low-luminosity transient object called a kilonova. Just such an event was observed on 17 August 2017 by the Advanced LIGO and Virgo detectors, initially in the form of gravitational waves. Importantly, this event, called GW170817, was accompanied by strong electromagnetic signals that were observed by a number of facilities. As a result, a significant amount of information has been gathered about the resultant γ-ray burst, and six papers and a News & Views in this issue examine the details of the kilonova. Optical and near-infrared emissions from the event are reported in three papers by Iair Arcavi and his colleagues, Elena Pian and her team, and Stephen Smartt and his colleagues, affirming that GW170817 was indeed a kilonova. Eleonora Troja and her colleagues report on X-ray emissions from the merger, which indicate that the ejecta jet from GW170817 was seen somewhat off axis. In a fifth paper, Daniel Kasen and his collaborators examine the production of heavy elements in the kilonova event, using the latest observations to help constrain their predictions; they suggest that neutron-star mergers provide most of the heavy elements in the Universe. And Daniel Holz along with teams at multiple observatories managed to use the kilonova to independently re-calibrate the Hubble constant, getting a result that is consistent with other determinations. Cover image: Aurore Simonnet

This Week

Editorials

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World View

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Research Highlights

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Seven Days

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News in Focus

Feature

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comment

Books and Arts

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  • Astrophysics: Chasing ghosts in Antarctica

    Alexandra Witze welcomes a history of IceCube, an ambitious neutrino observatory.

    • Review of The Telescope in the Ice: Inventing a New Astronomy at the South Pole
      Mark Bowen
  • Books in brief

    Barbara Kiser reviews five of the week's best science picks.

  • Zoology: The joys of spinelessness

    Lisa-ann Gershwin delights in two books on marine invertebrates.

    • Review of Spineless: The Science of Jellyfish and the Art of Growing a Backbone and Squid Empire: The Rise and Fall of the Cephalopods
      Juli Berwald & Danna Staaf

Careers

Features

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  • Competitions: Grand challenges

    Scientists lured by big-prize competitions should weigh contests' aims and non-monetary benefits before entering.

    • Virginia Gewin

Q&As

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naturejobs job listings and advertising features

Futures

research

Brief Communication Arising

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Articles

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  • Two independent modes of chromatin organization revealed by cohesin removal

    • Wibke Schwarzer
    • Nezar Abdennur
    • Anton Goloborodko
    • Aleksandra Pekowska
    • Geoffrey Fudenberg
    • Yann Loe-Mie
    • Nuno A Fonseca
    • Wolfgang Huber
    • Christian H. Haering
    • Leonid Mirny
    • Francois Spitz

    Depletion of chromosome-associated cohesin leads to loss of topologically associating domains in interphase chromosomes, without affecting segregation into compartments, and instead, it unmasks a finer compartment structure that reflects local chromatin and transcriptional activity.

    See also
  • Structure of phycobilisome from the red alga Griffithsia pacifica

    • Jun Zhang
    • Jianfei Ma
    • Desheng Liu
    • Song Qin
    • Shan Sun
    • Jindong Zhao
    • Sen-Fang Sui

    Single-particle cryo-electron microscopy is used to resolve the structure of the phycobilisome, a 16.8-megadalton light-harvesting megacomplex, from the red alga Griffithsia pacifica at a resolution of 3.5 Å.

Letters

Top
  • Optical emission from a kilonova following a gravitational-wave-detected neutron-star merger

    • Iair Arcavi
    • Griffin Hosseinzadeh
    • D. Andrew Howell
    • Curtis McCully
    • Dovi Poznanski
    • Daniel Kasen
    • Jennifer Barnes
    • Michael Zaltzman
    • Sergiy Vasylyev
    • Dan Maoz
    • Stefano Valenti

    Optical to near-infrared observations of a transient coincident with the detection of the gravitational-wave signature of a binary neutron-star merger and a low-luminosity short-duration γ-ray burst are presented and modelled.

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  • Spectroscopic identification of r-process nucleosynthesis in a double neutron-star merger

    • E. Pian
    • P. D’Avanzo
    • S. Benetti
    • M. Branchesi
    • E. Brocato
    • S. Campana
    • E. Cappellaro
    • S. Covino
    • V. D’Elia
    • J. P. U. Fynbo
    • F. Getman
    • G. Ghirlanda
    • G. Ghisellini
    • A. Grado
    • G. Greco
    • J. Hjorth
    • C. Kouveliotou
    • A. Levan
    • L. Limatola
    • D. Malesani
    • P. A. Mazzali
    • A. Melandri
    • P. Møller
    • L. Nicastro
    • E. Palazzi
    • S. Piranomonte
    • A. Rossi
    • O. S. Salafia
    • J. Selsing
    • G. Stratta
    • M. Tanaka
    • N. R. Tanvir
    • L. Tomasella
    • D. Watson
    • S. Yang
    • L. Amati
    • L. A. Antonelli
    • S. Ascenzi
    • M. G. Bernardini
    • M. Boër
    • F. Bufano
    • A. Bulgarelli
    • M. Capaccioli
    • P. Casella
    • A. J. Castro-Tirado
    • E. Chassande-Mottin
    • R. Ciolfi
    • C. M. Copperwheat
    • M. Dadina
    • G. De Cesare
    • A. Di Paola
    • Y. Z. Fan
    • B. Gendre
    • G. Giuffrida
    • A. Giunta
    • L. K. Hunt
    • G. L. Israel
    • Z.-P. Jin
    • M. M. Kasliwal
    • S. Klose
    • M. Lisi
    • F. Longo
    • E. Maiorano
    • M. Mapelli
    • N. Masetti
    • L. Nava
    • B. Patricelli
    • D. Perley
    • A. Pescalli
    • T. Piran
    • A. Possenti
    • L. Pulone
    • M. Razzano
    • R. Salvaterra
    • P. Schipani
    • M. Spera
    • A. Stamerra
    • L. Stella
    • G. Tagliaferri
    • V. Testa
    • E. Troja
    • M. Turatto
    • S. D. Vergani
    • D. Vergani

    Observations of the transient associated with the gravitational-wave event GW170817 and γ-ray burst GRB 170817A reveal a bright kilonova with fast-moving ejecta, including lanthanides synthesized by rapid neutron capture.

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  • The X-ray counterpart to the gravitational-wave event GW170817

    • E. Troja
    • L. Piro
    • H. van Eerten
    • R. T. Wollaeger
    • M. Im
    • O. D. Fox
    • N. R. Butler
    • S. B. Cenko
    • T. Sakamoto
    • C. L. Fryer
    • R. Ricci
    • A. Lien
    • R. E. Ryan Jr
    • O. Korobkin
    • S.-K. Lee
    • J. M. Burgess
    • W. H. Lee
    • A. M. Watson
    • C. Choi
    • S. Covino
    • P. D’Avanzo
    • C. J. Fontes
    • J. Becerra González
    • H. G. Khandrika
    • J. Kim
    • S.-L. Kim
    • C.-U. Lee
    • H. M. Lee
    • A. Kutyrev
    • G. Lim
    • R. Sánchez-Ramírez
    • S. Veilleux
    • M. H. Wieringa
    • Y. Yoon

    Detection of X-ray emission at a location coincident with the kilonova transient of the gravitational-wave event GW170817 provides the missing observational link between short γ-ray bursts and gravitational waves from neutron-star mergers.

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  • A kilonova as the electromagnetic counterpart to a gravitational-wave source

    • S. J. Smartt
    • T.-W. Chen
    • A. Jerkstrand
    • M. Coughlin
    • E. Kankare
    • S. A. Sim
    • M. Fraser
    • C. Inserra
    • K. Maguire
    • K. C. Chambers
    • M. E. Huber
    • T. Krühler
    • G. Leloudas
    • M. Magee
    • L. J. Shingles
    • K. W. Smith
    • D. R. Young
    • J. Tonry
    • R. Kotak
    • A. Gal-Yam
    • J. D. Lyman
    • D. S. Homan
    • C. Agliozzo
    • J. P. Anderson
    • C. R. Angus
    • C. Ashall
    • C. Barbarino
    • F. E. Bauer
    • M. Berton
    • M. T. Botticella
    • M. Bulla
    • J. Bulger
    • G. Cannizzaro
    • Z. Cano
    • R. Cartier
    • A. Cikota
    • P. Clark
    • A. De Cia
    • M. Della Valle
    • L. Denneau
    • M. Dennefeld
    • L. Dessart
    • G. Dimitriadis
    • N. Elias-Rosa
    • R. E. Firth
    • H. Flewelling
    • A. Flörs
    • A. Franckowiak
    • C. Frohmaier
    • L. Galbany
    • S. González-Gaitán
    • J. Greiner
    • M. Gromadzki
    • A. Nicuesa Guelbenzu
    • C. P. Gutiérrez
    • A. Hamanowicz
    • L. Hanlon
    • J. Harmanen
    • K. E. Heintz
    • A. Heinze
    • M.-S. Hernandez
    • S. T. Hodgkin
    • I. M. Hook
    • L. Izzo
    • P. A. James
    • P. G. Jonker
    • W. E. Kerzendorf
    • S. Klose
    • Z. Kostrzewa-Rutkowska
    • M. Kowalski
    • M. Kromer
    • H. Kuncarayakti
    • A. Lawrence
    • T. B. Lowe
    • E. A. Magnier
    • I. Manulis
    • A. Martin-Carrillo
    • S. Mattila
    • O. McBrien
    • A. Müller
    • J. Nordin
    • D. O’Neill
    • F. Onori
    • J. T. Palmerio
    • A. Pastorello
    • F. Patat
    • G. Pignata
    • Ph. Podsiadlowski
    • M. L. Pumo
    • S. J. Prentice
    • A. Rau
    • A. Razza
    • A. Rest
    • T. Reynolds
    • R. Roy
    • A. J. Ruiter
    • K. A. Rybicki
    • L. Salmon
    • P. Schady
    • A. S. B. Schultz
    • T. Schweyer
    • I. R. Seitenzahl
    • M. Smith
    • J. Sollerman
    • B. Stalder
    • C. W. Stubbs
    • M. Sullivan
    • H. Szegedi
    • F. Taddia
    • S. Taubenberger
    • G. Terreran
    • B. van Soelen
    • J. Vos
    • R. J. Wainscoat
    • N. A. Walton
    • C. Waters
    • H. Weiland
    • M. Willman
    • P. Wiseman
    • D. E. Wright
    • Ł. Wyrzykowski
    • O. Yaron

    Observations and modelling of an optical transient counterpart to a gravitational-wave event and γ-ray burst reveal that neutron-star mergers produce gravitational waves and radioactively powered kilonovae, and are a source of heavy elements.

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  • Origin of the heavy elements in binary neutron-star mergers from a gravitational-wave event

    • Daniel Kasen
    • Brian Metzger
    • Jennifer Barnes
    • Eliot Quataert
    • Enrico Ramirez-Ruiz

    Modelling the electromagnetic emission of kilonovae enables the mass, velocity and composition (with some heavy elements) of the ejecta from a neutron-star merger to be derived from the observations.

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  • A gravitational-wave standard siren measurement of the Hubble constant

    • The LIGO Scientific Collaboration and The Virgo Collaboration
    • The 1M2H Collaboration
    • The Dark Energy Camera GW-EM Collaboration and the DES Collaboration
    • The DLT40 Collaboration
    • The Las Cumbres Observatory Collaboration
    • The VINROUGE Collaboration
    • The MASTER Collaboration

    The astronomical event GW170817, detected in gravitational and electromagnetic waves, is used to determine the expansion rate of the Universe, which is consistent with and independent of existing measurements.

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  • Association analysis identifies 65 new breast cancer risk loci

    • Kyriaki Michailidou
    • Sara Lindström
    • Joe Dennis
    • Jonathan Beesley
    • Shirley Hui
    • Siddhartha Kar
    • Audrey Lemaçon
    • Penny Soucy
    • Dylan Glubb
    • Asha Rostamianfar
    • Manjeet K. Bolla
    • Qin Wang
    • Jonathan Tyrer
    • Ed Dicks
    • Andrew Lee
    • Zhaoming Wang
    • Jamie Allen
    • Renske Keeman
    • Ursula Eilber
    • Juliet D. French
    • Xiao Qing Chen
    • Laura Fachal
    • Karen McCue
    • Amy E. McCart Reed
    • Maya Ghoussaini
    • Jason S. Carroll
    • Xia Jiang
    • Hilary Finucane
    • Marcia Adams
    • Muriel A. Adank
    • Habibul Ahsan
    • Kristiina Aittomäki
    • Hoda Anton-Culver
    • Natalia N. Antonenkova
    • Volker Arndt
    • Kristan J. Aronson
    • Banu Arun
    • Paul L. Auer
    • François Bacot
    • Myrto Barrdahl
    • Caroline Baynes
    • Matthias W. Beckmann
    • Sabine Behrens
    • Javier Benitez
    • Marina Bermisheva
    • Leslie Bernstein
    • Carl Blomqvist
    • Natalia V. Bogdanova
    • Stig E. Bojesen
    • Bernardo Bonanni
    • Anne-Lise Børresen-Dale
    • Judith S. Brand
    • Hiltrud Brauch
    • Paul Brennan
    • Hermann Brenner
    • Louise Brinton
    • Per Broberg
    • Ian W. Brock
    • Annegien Broeks
    • Angela Brooks-Wilson
    • Sara Y. Brucker
    • Thomas Brüning
    • Barbara Burwinkel
    • Katja Butterbach
    • Qiuyin Cai
    • Hui Cai
    • Trinidad Caldés
    • Federico Canzian
    • Angel Carracedo
    • Brian D. Carter
    • Jose E. Castelao
    • Tsun L. Chan
    • Ting-Yuan David Cheng
    • Kee Seng Chia
    • Ji-Yeob Choi
    • Hans Christiansen
    • Christine L. Clarke
    • NBCS Collaborators
    • Margriet Collée
    • Don M. Conroy
    • Emilie Cordina-Duverger
    • Sten Cornelissen
    • David G. Cox
    • Angela Cox
    • Simon S. Cross
    • Julie M. Cunningham
    • Kamila Czene
    • Mary B. Daly
    • Peter Devilee
    • Kimberly F. Doheny
    • Thilo Dörk
    • Isabel dos-Santos-Silva
    • Martine Dumont
    • Lorraine Durcan
    • Miriam Dwek
    • Diana M. Eccles
    • Arif B. Ekici
    • A. Heather Eliassen
    • Carolina Ellberg
    • Mingajeva Elvira
    • Christoph Engel
    • Mikael Eriksson
    • Peter A. Fasching
    • Jonine Figueroa
    • Dieter Flesch-Janys
    • Olivia Fletcher
    • Henrik Flyger
    • Lin Fritschi
    • Valerie Gaborieau
    • Marike Gabrielson
    • Manuela Gago-Dominguez
    • Yu-Tang Gao
    • Susan M. Gapstur
    • José A. García-Sáenz
    • Mia M. Gaudet
    • Vassilios Georgoulias
    • Graham G. Giles
    • Gord Glendon
    • Mark S. Goldberg
    • David E. Goldgar
    • Anna González-Neira
    • Grethe I. Grenaker Alnæs
    • Mervi Grip
    • Jacek Gronwald
    • Anne Grundy
    • Pascal Guénel
    • Lothar Haeberle
    • Eric Hahnen
    • Christopher A. Haiman
    • Niclas Håkansson
    • Ute Hamann
    • Nathalie Hamel
    • Susan Hankinson
    • Patricia Harrington
    • Steven N. Hart
    • Jaana M. Hartikainen
    • Mikael Hartman
    • Alexander Hein
    • Jane Heyworth
    • Belynda Hicks
    • Peter Hillemanns
    • Dona N. Ho
    • Antoinette Hollestelle
    • Maartje J. Hooning
    • Robert N. Hoover
    • John L. Hopper
    • Ming-Feng Hou
    • Chia-Ni Hsiung
    • Guanmengqian Huang
    • Keith Humphreys
    • Junko Ishiguro
    • Hidemi Ito
    • Motoki Iwasaki
    • Hiroji Iwata
    • Anna Jakubowska
    • Wolfgang Janni
    • Esther M. John
    • Nichola Johnson
    • Kristine Jones
    • Michael Jones
    • Arja Jukkola-Vuorinen
    • Rudolf Kaaks
    • Maria Kabisch
    • Katarzyna Kaczmarek
    • Daehee Kang
    • Yoshio Kasuga
    • Michael J. Kerin
    • Sofia Khan
    • Elza Khusnutdinova
    • Johanna I. Kiiski
    • Sung-Won Kim
    • Julia A. Knight
    • Veli-Matti Kosma
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    • Ute Krüger
    • Ava Kwong
    • Diether Lambrechts
    • Loic Le Marchand
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    • Min Hyuk Lee
    • Jong Won Lee
    • Chuen Neng Lee
    • Flavio Lejbkowicz
    • Jingmei Li
    • Jenna Lilyquist
    • Annika Lindblom
    • Jolanta Lissowska
    • Wing-Yee Lo
    • Sibylle Loibl
    • Jirong Long
    • Artitaya Lophatananon
    • Jan Lubinski
    • Craig Luccarini
    • Michael P. Lux
    • Edmond S. K. Ma
    • Robert J. MacInnis
    • Tom Maishman
    • Enes Makalic
    • Kathleen E. Malone
    • Ivana Maleva Kostovska
    • Arto Mannermaa
    • Siranoush Manoukian
    • JoAnn E. Manson
    • Sara Margolin
    • Shivaani Mariapun
    • Maria Elena Martinez
    • Keitaro Matsuo
    • Dimitrios Mavroudis
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    • Usha Menon
    • Jeffery Meyer
    • Hui Miao
    • Nicola Miller
    • Nur Aishah Mohd Taib
    • Kenneth Muir
    • Anna Marie Mulligan
    • Claire Mulot
    • Susan L. Neuhausen
    • Heli Nevanlinna
    • Patrick Neven
    • Sune F. Nielsen
    • Dong-Young Noh
    • Børge G. Nordestgaard
    • Aaron Norman
    • Olufunmilayo I. Olopade
    • Janet E. Olson
    • Håkan Olsson
    • Curtis Olswold
    • Nick Orr
    • V. Shane Pankratz
    • Sue K. Park
    • Tjoung-Won Park-Simon
    • Rachel Lloyd
    • Jose I. A. Perez
    • Paolo Peterlongo
    • Julian Peto
    • Kelly-Anne Phillips
    • Mila Pinchev
    • Dijana Plaseska-Karanfilska
    • Ross Prentice
    • Nadege Presneau
    • Darya Prokofyeva
    • Elizabeth Pugh
    • Katri Pylkäs
    • Brigitte Rack
    • Paolo Radice
    • Nazneen Rahman
    • Gadi Rennert
    • Hedy S. Rennert
    • Valerie Rhenius
    • Atocha Romero
    • Jane Romm
    • Kathryn J. Ruddy
    • Thomas Rüdiger
    • Anja Rudolph
    • Matthias Ruebner
    • Emiel J. T. Rutgers
    • Emmanouil Saloustros
    • Dale P. Sandler
    • Suleeporn Sangrajrang
    • Elinor J. Sawyer
    • Daniel F. Schmidt
    • Rita K. Schmutzler
    • Andreas Schneeweiss
    • Minouk J. Schoemaker
    • Fredrick Schumacher
    • Peter Schürmann
    • Rodney J. Scott
    • Christopher Scott
    • Sheila Seal
    • Caroline Seynaeve
    • Mitul Shah
    • Priyanka Sharma
    • Chen-Yang Shen
    • Grace Sheng
    • Mark E. Sherman
    • Martha J. Shrubsole
    • Xiao-Ou Shu
    • Ann Smeets
    • Christof Sohn
    • Melissa C. Southey
    • John J. Spinelli
    • Christa Stegmaier
    • Sarah Stewart-Brown
    • Jennifer Stone
    • Daniel O. Stram
    • Harald Surowy
    • Anthony Swerdlow
    • Rulla Tamimi
    • Jack A. Taylor
    • Maria Tengström
    • Soo H. Teo
    • Mary Beth Terry
    • Daniel C. Tessier
    • Somchai Thanasitthichai
    • Kathrin Thöne
    • Rob A. E. M. Tollenaar
    • Ian Tomlinson
    • Ling Tong
    • Diana Torres
    • Thérèse Truong
    • Chiu-Chen Tseng
    • Shoichiro Tsugane
    • Hans-Ulrich Ulmer
    • Giske Ursin
    • Michael Untch
    • Celine Vachon
    • Christi J. van Asperen
    • David Van Den Berg
    • Ans M. W. van den Ouweland
    • Lizet van der Kolk
    • Rob B. van der Luijt
    • Daniel Vincent
    • Jason Vollenweider
    • Quinten Waisfisz
    • Shan Wang-Gohrke
    • Clarice R. Weinberg
    • Camilla Wendt
    • Alice S. Whittemore
    • Hans Wildiers
    • Walter Willett
    • Robert Winqvist
    • Alicja Wolk
    • Anna H. Wu
    • Lucy Xia
    • Taiki Yamaji
    • Xiaohong R. Yang
    • Cheng Har Yip
    • Keun-Young Yoo
    • Jyh-Cherng Yu
    • Wei Zheng
    • Ying Zheng
    • Bin Zhu
    • Argyrios Ziogas
    • Elad Ziv
    • ABCTB Investigators
    • ConFab/AOCS Investigators
    • Sunil R. Lakhani
    • Antonis C. Antoniou
    • Arnaud Droit
    • Irene L. Andrulis
    • Christopher I. Amos
    • Fergus J. Couch
    • Paul D. P. Pharoah
    • Jenny Chang-Claude
    • Per Hall
    • David J. Hunter
    • Roger L. Milne
    • Montserrat García-Closas
    • Marjanka K. Schmidt
    • Stephen J. Chanock
    • Alison M. Dunning
    • Stacey L. Edwards
    • Gary D. Bader
    • Georgia Chenevix-Trench
    • Jacques Simard
    • Peter Kraft
    • Douglas F. Easton

    Association analysis identifies 65 new breast cancer risk loci, predicts target genes for known risk loci and demonstrates a strong overlap with somatic driver genes in breast tumours.

    See also
  • Single-cell transcriptomics reconstructs fate conversion from fibroblast to cardiomyocyte

    • Ziqing Liu
    • Li Wang
    • Joshua D. Welch
    • Hong Ma
    • Yang Zhou
    • Haley Ruth Vaseghi
    • Shuo Yu
    • Joseph Blake Wall
    • Sahar Alimohamadi
    • Michael Zheng
    • Chaoying Yin
    • Weining Shen
    • Jan F. Prins
    • Jiandong Liu
    • Li Qian

    Single-cell transcriptomics analyses of cell intermediates during the reprogramming from fibroblast to cardiomyocyte were used to reconstruct the reprogramming trajectory and to uncover intermediate cell populations, gene pathways and regulators involved in this process.

  • Reversing SKI–SMAD4-mediated suppression is essential for TH17 cell differentiation

    • Song Zhang
    • Motoki Takaku
    • Liyun Zou
    • Ai-di Gu
    • Wei-chun Chou
    • Ge Zhang
    • Bing Wu
    • Qing Kong
    • Seddon Y. Thomas
    • Jonathan S. Serody
    • Xian Chen
    • Xiaojiang Xu
    • Paul A. Wade
    • Donald N. Cook
    • Jenny P. Y. Ting
    • Yisong Y. Wan

    TGFβ signalling regulates T helper 17 (TH17) cell differentiation by reversing SKI–SMAD4-mediated suppression of RORγt, revealing a potential therapeutic target for treating TH17-related diseases.

  • IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity

    • Martina Molgora
    • Eduardo Bonavita
    • Andrea Ponzetta
    • Federica Riva
    • Marialuisa Barbagallo
    • Sébastien Jaillon
    • Branka Popović
    • Giovanni Bernardini
    • Elena Magrini
    • Francesca Gianni
    • Santiago Zelenay
    • Stipan Jonjić
    • Angela Santoni
    • Cecilia Garlanda
    • Alberto Mantovani

    Interleukin-1 receptor 8 (IL-1R8), a negative regulator of the IL-1 family of cytokines, restrains the activity of natural killer (NK) cells, suggesting that IL-1R8 acts as a checkpoint regulator of NK cell activation and that its blockade may be of use in cancer therapy.

  • Glucose feeds the TCA cycle via circulating lactate

    • Sheng Hui
    • Jonathan M. Ghergurovich
    • Raphael J. Morscher
    • Cholsoon Jang
    • Xin Teng
    • Wenyun Lu
    • Lourdes A. Esparza
    • Tannishtha Reya
    • Le Zhan
    • Jessie Yanxiang Guo
    • Eileen White
    • Joshua D. Rabinowitz

    Metabolic flux analysis in mice reveals that lactate often acts as the primary carbon source for the tricarboxylic acid cycle both in normal tissues and in tumour microenvironments.