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Current Issue of Nature


Current Issue : Nature

Current Issue

Volume 551 Number 7680 pp271-398

16 November 2017

About the cover

The cover image depicts colonies derived from human epidermal stem cells (holoclones). Transgenic holoclones from a 7-year-old boy were used to reconstruct his damaged skin. A severe case of junctional epidermolysis bullosa, a genetic disorder in which the integrity of the skin is compromised, meant that much of the boy's skin developed chronic blisters and wounds. In this week's issue, Michele De Luca and his colleagues describe how they approached the boy's treatment. A viral vector was used to transduce stem cells derived from the patient's skin with a functional version of the affected gene, in this case a mutated β3 chain of laminin-332. These stem cells were then used to grow large sheets of functional epidermis that could be used as surgical grafts to replace 80% of the boy's skin. The research also provided insight into the generation of the epidermis and revealed that it is sustained by defined, long-lived stem cells. An accompanying News & Views piece explores the limitations and wider implications of the technique, including the potential of translational research to guide combinatorial stem-cell and gene therapies to treat otherwise incurable diseases. Cover image: Sergio Bondanza & Francesca La Mantia/Centre for Regenerative Medicine ‘Stefano Ferrari’ & Holostem Terapie Avanzate

This Week

Editorials

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World View

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Research Highlights

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Seven Days

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News in Focus

Feature

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comment

Books and Arts

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  • Bioethics: Justice in genomics

    Rosario Isasi examines a study on the societal impact of grand sequencing projects.

    • Review of The Postgenomic Condition: Ethics, Justice, and Knowledge After the Genome
      Jenny Reardon
  • Economics: How science got a golden ticket

    Ehsan Masood hails an account of the mixed implications of governments valuing research as an investment.

    • Review of Capitalism Without Capital: The Rise of the Intangible Economy
      Jonathan Haskel & Stian Westlake

Correspondence

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Careers

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Q&As

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naturejobs job listings and advertising features

Futures

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  • Need a paper? Get a plug-in

    A collection of web-browser plug-ins is making the scholarly literature more discoverable. 

    • Dalmeet Singh Chawla

research

Review

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Articles

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  • Regeneration of the entire human epidermis using transgenic stem cells

    • Tobias Hirsch
    • Tobias Rothoeft
    • Norbert Teig
    • Johann W. Bauer
    • Graziella Pellegrini
    • Laura De Rosa
    • Davide Scaglione
    • Julia Reichelt
    • Alfred Klausegger
    • Daniela Kneisz
    • Oriana Romano
    • Alessia Secone Seconetti
    • Roberta Contin
    • Elena Enzo
    • Irena Jurman
    • Sonia Carulli
    • Frank Jacobsen
    • Thomas Luecke
    • Marcus Lehnhardt
    • Meike Fischer
    • Maximilian Kueckelhaus
    • Daniela Quaglino
    • Michele Morgante
    • Silvio Bicciato
    • Sergio Bondanza
    • Michele De Luca

    Autologous transgenic epidermal stem cell cultures are used to reconstitute almost the entire epidermis of a patient with severe junctional epidermolysis bullosa.

    See also
  • A single-cell survey of the small intestinal epithelium

    • Adam L. Haber
    • Moshe Biton
    • Noga Rogel
    • Rebecca H. Herbst
    • Karthik Shekhar
    • Christopher Smillie
    • Grace Burgin
    • Toni M. Delorey
    • Michael R. Howitt
    • Yarden Katz
    • Itay Tirosh
    • Semir Beyaz
    • Danielle Dionne
    • Mei Zhang
    • Raktima Raychowdhury
    • Wendy S. Garrett
    • Orit Rozenblatt-Rosen
    • Hai Ning Shi
    • Omer Yilmaz
    • Ramnik J. Xavier
    • Aviv Regev

    Profiling of 53,193 individual epithelial cells from the mouse small intestine identifies previously unknown cell subtypes and corresponding gene markers, providing insight into gut homeostasis and response to pathogens.

  • Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity

    • Shabnam Shalapour
    • Xue-Jia Lin
    • Ingmar N. Bastian
    • John Brain
    • Alastair D. Burt
    • Alexander A. Aksenov
    • Alison F. Vrbanac
    • Weihua Li
    • Andres Perkins
    • Takaji Matsutani
    • Zhenyu Zhong
    • Debanjan Dhar
    • Jose A. Navas-Molina
    • Jun Xu
    • Rohit Loomba
    • Michael Downes
    • Ruth T. Yu
    • Ronald M. Evans
    • Pieter C. Dorrestein
    • Rob Knight
    • Christopher Benner
    • Quentin M. Anstee
    • Michael Karin

    IgA+ B cells expressing programmed death ligand 1 (PD-L1) and interleukin 10 accumulate in the inflamed livers of humans and mice with non-alcoholic fatty liver disease where they promote the progression to hepatocellular carcinoma by limiting the local activation of PD-1-expressing CD8+ T cells.

  • Dynamics of P-type ATPase transport revealed by single-molecule FRET

    • Mateusz Dyla
    • Daniel S. Terry
    • Magnus Kjaergaard
    • Thomas L.-M. Sørensen
    • Jacob Lauwring Andersen
    • Jens Peter Andersen
    • Charlotte Rohde Knudsen
    • Roger B. Altman
    • Poul Nissen
    • Scott C. Blanchard

    Single-molecule fluorescence resonance energy transfer is used to identify the rate-limiting step and new intermediates in the conformational cycle of the Listeria monocytogenes calcium transporter LMCA1.

Letters

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  • Granular materials flow like complex fluids

    • Binquan Kou
    • Yixin Cao
    • Jindong Li
    • Chengjie Xia
    • Zhifeng Li
    • Haipeng Dong
    • Ang Zhang
    • Jie Zhang
    • Walter Kob
    • Yujie Wang

    The relaxation dynamics of granular materials is more like that of complex fluids than that of thermal glass-forming systems, owing to the absence of the ‘cage effect’.

  • Reductions in global biodiversity loss predicted from conservation spending

    • Anthony Waldron
    • Daniel C. Miller
    • Dave Redding
    • Arne Mooers
    • Tyler S. Kuhn
    • Nate Nibbelink
    • J. Timmons Roberts
    • Joseph A. Tobias
    • John L. Gittleman

    Empirical two-part models describe the relationship between conservation spending, human development pressures and biodiversity loss and can inform sustainable development strategies by predicting the effects of financing decisions on future biodiversity losses.

    See also
  • Parallel palaeogenomic transects reveal complex genetic history of early European farmers

    • Mark Lipson
    • Anna Szécsényi-Nagy
    • Swapan Mallick
    • Annamária Pósa
    • Balázs Stégmár
    • Victoria Keerl
    • Nadin Rohland
    • Kristin Stewardson
    • Matthew Ferry
    • Megan Michel
    • Jonas Oppenheimer
    • Nasreen Broomandkhoshbacht
    • Eadaoin Harney
    • Susanne Nordenfelt
    • Bastien Llamas
    • Balázs Gusztáv Mende
    • Kitti Köhler
    • Krisztián Oross
    • Mária Bondár
    • Tibor Marton
    • Anett Osztás
    • János Jakucs
    • Tibor Paluch
    • Ferenc Horváth
    • Piroska Csengeri
    • Judit Koós
    • Katalin Sebők
    • Alexandra Anders
    • Pál Raczky
    • Judit Regenye
    • Judit P. Barna
    • Szilvia Fábián
    • Gábor Serlegi
    • Zoltán Toldi
    • Emese Gyöngyvér Nagy
    • János Dani
    • Erika Molnár
    • György Pálfi
    • László Márk
    • Béla Melegh
    • Zsolt Bánfai
    • László Domboróczki
    • Javier Fernández-Eraso
    • José Antonio Mujika-Alustiza
    • Carmen Alonso Fernández
    • Javier Jiménez Echevarría
    • Ruth Bollongino
    • Jörg Orschiedt
    • Kerstin Schierhold
    • Harald Meller
    • Alan Cooper
    • Joachim Burger
    • Eszter Bánffy
    • Kurt W. Alt
    • Carles Lalueza-Fox
    • Wolfgang Haak
    • David Reich

    In European Neolithic populations, the arrival of farmers prompted admixture with local hunter-gatherers over many centuries, resulting in distinct signatures in each region due to a complex series of interactions.

  • Locomotor speed control circuits in the caudal brainstem

    • Paolo Capelli
    • Chiara Pivetta
    • Maria Soledad Esposito
    • Silvia Arber

    In the mouse caudal brainstem, functionally distinct neuronal subpopulations, which are distinguishable by neurotransmitter identity, connectivity and location, regulate locomotion parameters.

  • BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

    • Simon Raffel
    • Mattia Falcone
    • Niclas Kneisel
    • Jenny Hansson
    • Wei Wang
    • Christoph Lutz
    • Lars Bullinger
    • Gernot Poschet
    • Yannic Nonnenmacher
    • Andrea Barnert
    • Carsten Bahr
    • Petra Zeisberger
    • Adriana Przybylla
    • Markus Sohn
    • Martje Tönjes
    • Ayelet Erez
    • Lital Adler
    • Patrizia Jensen
    • Claudia Scholl
    • Stefan Fröhling
    • Sibylle Cocciardi
    • Patrick Wuchter
    • Christian Thiede
    • Anne Flörcken
    • Jörg Westermann
    • Gerhard Ehninger
    • Peter Lichter
    • Karsten Hiller
    • Rüdiger Hell
    • Carl Herrmann
    • Anthony D. Ho
    • Jeroen Krijgsveld
    • Bernhard Radlwimmer
    • Andreas Trumpp

    The mechanistic basis for the role of the metabolic enzyme BCAA transaminase 1 (BCAT1) in acute myeloid leukaemias.

  • A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair

    • Joshua R. Brickner
    • Jennifer M. Soll
    • Patrick M. Lombardi
    • Cathrine B. Vågbø
    • Miranda C. Mudge
    • Clement Oyeniran
    • Renana Rabe
    • Jessica Jackson
    • Meagan E. Sullender
    • Elyse Blazosky
    • Andrea K. Byrum
    • Yu Zhao
    • Mark A. Corbett
    • Jozef Gécz
    • Michael Field
    • Alessandro Vindigni
    • Geir Slupphaug
    • Cynthia Wolberger
    • Nima Mosammaparast

    A signalling mechanism in human cells for sensing DNA damage induced by alkylation involves ubiquitin-dependent recruitment of the alkylation repair complex ASCC to the vicinity of the damage and co-localization with transcription and splicing factors.

  • Structure and assembly of the Ebola virus nucleocapsid

    • William Wan
    • Larissa Kolesnikova
    • Mairi Clarke
    • Alexander Koehler
    • Takeshi Noda
    • Stephan Becker
    • John A. G. Briggs

    Application of cryo-electron tomography and subtomogram averaging to determine the structure of the Ebola virus nucleocapsid within intact viruses and recombinant nucleocapsid-like assemblies.

Corrigenda

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  • Corrigendum: High-throughput discovery of novel developmental phenotypes

    • Mary E. Dickinson
    • Ann M. Flenniken
    • Xiao Ji
    • Lydia Teboul
    • Michael D. Wong
    • Jacqueline K. White
    • Terrence F. Meehan
    • Wolfgang J. Weninger
    • Henrik Westerberg
    • Hibret Adissu
    • Candice N. Baker
    • Lynette Bower
    • James M. Brown
    • L. Brianna Caddle
    • Francesco Chiani
    • Dave Clary
    • James Cleak
    • Mark J. Daly
    • James M. Denegre
    • Brendan Doe
    • Mary E. Dolan
    • Sarah M. Edie Helmut Fuchs
    • Valerie Gailus-Durner
    • Antonella Galli
    • Alessia Gambadoro
    • Juan Gallegos
    • Shiying Guo
    • Neil R. Horner
    • Chih-Wei Hsu
    • Sara J. Johnson
    • Sowmya Kalaga
    • Lance C. Keith
    • Louise Lanoue
    • Thomas N. Lawson
    • Monkol Lek
    • Manuel Mark
    • Susan Marschall
    • Jeremy Mason
    • Melissa L. McElwee
    • Susan Newbigging Lauryl M. J. Nutter
    • Kevin A. Peterson
    • Ramiro Ramirez-Solis
    • Douglas J. Rowland
    • Edward Ryder
    • Kaitlin E. Samocha
    • John R. Seavitt
    • Mohammed Selloum
    • Zsombor Szoke-Kovacs
    • Masaru Tamura
    • Amanda G. Trainor
    • Ilinca Tudose
    • Shigeharu Wakana
    • Jonathan Warren
    • Olivia Wendling
    • David B. West
    • Leeyean Wong
    • Atsushi Yoshiki
    • The International Mouse Phenotyping Consortium
    • Wolfgang Wurst
    • Daniel G. MacArthur
    • Glauco P. Tocchini-Valentini
    • Xiang Gao
    • Paul Flicek
    • Allan Bradley
    • William C. Skarnes
    • Monica J. Justice
    • Helen E. Parkinson
    • Mark Moore
    • Sara Wells
    • Robert E. Braun
    • Karen L. Svenson
    • Martin Hrabe de Angelis
    • Yann Herault
    • Tim Mohun
    • Ann-Marie Mallon
    • R. Mark Henkelman
    • Steve D. M. Brown
    • David J. Adams
    • K. C. Kent Lloyd
    • Colin McKerlie
    • Arthur L. Beaudet
    • Maja Bućan Stephen A. Murray

Erratum

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  • Erratum: Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15

    • Jer-Yuan Hsu
    • Suzanne Crawley
    • Michael Chen
    • Dina A. Ayupova
    • Darrin A. Lindhout
    • Jared Higbee
    • Alan Kutach
    • William Joo
    • Zhengyu Gao
    • Diana Fu
    • Carmen To
    • Kalyani Mondal
    • Betty Li
    • Avantika Kekatpure
    • Marilyn Wang
    • Teresa Laird
    • Geoffrey Horner
    • Jackie Chan
    • Michele McEntee
    • Manuel Lopez
    • Damodharan Lakshminarasimhan
    • Andre White
    • Sheng-Ping Wang
    • Jun Yao
    • Junming Yie
    • Hugo Matern
    • Mark Solloway
    • Raj Haldankar
    • Thomas Parsons
    • Jie Tang
    • Wenyan D. Shen
    • Yu Alice Chen
    • Hui Tian
    • Bernard B. Allan