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Current Issue of Nature


Volume 562 Issue 7726, 11 October 2018

Volume 562 Issue 7726, 11 October 2018

Volume 562 Issue 7726

National health analysis

The UK Biobank is a prospective cohort study that has collected genetic and phenotypic data from some 500,000 people aged 40–69 from across the United Kingdom. The participants have undergone health measurements, provided blood, urine and saliva samples, given detailed information about themselves and agreed to have their health followed. In this week’s issue, Jonathan Marchini, Peter Donnelly and their colleagues report on the data set for the full cohort, including high-resolution genetic data and demonstration of their use in genetic association studies. In an accompanying paper, Stephen Smith, Jonathan Marchini and colleagues report brain imaging of the first 8,428 UK Biobank participants and the results of genome-wide association studies of 3,144 functional and structural brain-imaging phenotypes. They find that many of the traits are heritable and uncover many regions of the genome linked to these structural and functional measures. All of the data sets and research results from the UK Biobank are available to researchers as an open-access resource.

Cover image: Kelly Krause/Nature

This Week

News in Focus

Comment

Technology

    Technology Feature

  • Technology Feature |

    DNA sequencing is helping clinicians to unravel the underpinnings of disease in individual patients.

    • Michael Eisenstein

Careers

Futures

  • Futures |

    It pays to be well informed.

    • Zack Lux

Research

    News & Views

  • News & Views |

    UK Biobank contains a wealth of data on genetics, health and more from 500,000 participants. A detailed overview of the biobank and an analysis of its brain-imaging data show the value of this resource.

    • Nancy Cox

    Collection:

  • News & Views |

    Contrary to previous assumptions, it seems the cells that line blood vessels are derived from more than one source. In addition to their known developmental path, they can arise from progenitors of embryonic blood cells.

    • M. Luisa Iruela-Arispe
  • News & Views |

    What Nature was saying 50 and 100 years ago.

  • News & Views |

    Light-emitting diodes made from perovskite semiconductors have reached a milestone in the efficiency with which they emit light — potentially ushering in a new platform for lighting and display technology.

    • Paul Meredith
    •  & Ardalan Armin
  • News & Views |

    The movements of relocated wild animals reveal that a lost migratory skill was regained over successive generations. This suggests that skill improvements can occur over time as animals learn expertise from each other.

    • Andrew Whiten
  • News & Views |

    Experiments reveal a previously unreported type of electronic noise that is caused by temperature gradients. The finding has practical implications, and could help in detecting unwanted hotspots in electrical circuits.

    • Elke Scheer
    •  & Wolfgang Belzig
  • Articles

  • Article |

    Deep phenotype and genome-wide genetic data from 500,000 individuals from the UK Biobank, describing population structure and relatedness in the cohort, and imputation to increase the number of testable variants to 96 million.

    • Clare Bycroft
    • , Colin Freeman
    • , Desislava Petkova
    • , Gavin Band
    • , Lloyd T. Elliott
    • , Kevin Sharp
    • , Allan Motyer
    • , Damjan Vukcevic
    • , Olivier Delaneau
    • , Jared O’Connell
    • , Adrian Cortes
    • , Samantha Welsh
    • , Alan Young
    • , Mark Effingham
    • , Gil McVean
    • , Stephen Leslie
    • , Naomi Allen
    • , Peter Donnelly
    •  & Jonathan Marchini

    Collection:

  • Article |

    Genome-wide association studies of brain imaging data from 8,428 individuals in UK Biobank show that many of the 3,144 traits studied are heritable, and genes associated with individual phenotypes are identified.

    • Lloyd T. Elliott
    • , Kevin Sharp
    • , Fidel Alfaro-Almagro
    • , Sinan Shi
    • , Karla L. Miller
    • , Gwenaëlle Douaud
    • , Jonathan Marchini
    •  & Stephen M. Smith

    Collection:

  • Article |

    Germline BRCA1 loss-of-function variants are associated with predisposition to early-onset breast and ovarian cancer; here the authors use CRISPR/Cas9 genome editing to functionally assess thousands of BRCA1 variants in order to facilitate the clinical interpretation of these variants.

    • Gregory M. Findlay
    • , Riza M. Daza
    • , Beth Martin
    • , Melissa D. Zhang
    • , Anh P. Leith
    • , Molly Gasperini
    • , Joseph D. Janizek
    • , Xingfan Huang
    • , Lea M. Starita
    •  & Jay Shendure
  • Letters

  • Letter |

    Lyman-α emission from atomic hydrogen shows the location of warm gas and is ubiquitous around galaxies between redshifts of 3 and 6, thereby covering nearly all the sky.

    • L. Wisotzki
    • , R. Bacon
    • , J. Brinchmann
    • , S. Cantalupo
    • , P. Richter
    • , J. Schaye
    • , K. B. Schmidt
    • , T. Urrutia
    • , P. M. Weilbacher
    • , M. Akhlaghi
    • , N. Bouché
    • , T. Contini
    • , B. Guiderdoni
    • , E. C. Herenz
    • , H. Inami
    • , J. Kerutt
    • , F. Leclercq
    • , R. A. Marino
    • , M. Maseda
    • , A. Monreal-Ibero
    • , T. Nanayakkara
    • , J. Richard
    • , R. Saust
    • , M. Steinmetz
    •  & M. Wendt
  • Letter |

    Observations of a jet from a strongly magnetized neutron star reveal that strong magnetic fields do not prevent jet formation and suggest that stellar properties influence jet power.

    • J. van den Eijnden
    • , N. Degenaar
    • , T. D. Russell
    • , R. Wijnands
    • , J. C. A. Miller-Jones
    • , G. R. Sivakoff
    •  & J. V. Hernández Santisteban
  • Letter |

    A reinforcement learning approach allows a suitably equipped glider to navigate thermal plumes autonomously in an open field.

    • Gautam Reddy
    • , Jerome Wong-Ng
    • , Antonio Celani
    • , Terrence J. Sejnowski
    •  & Massimo Vergassola
  • Letter |

    A fundamental electronic noise—beyond electronic thermal noise and voltage-activated shot noise—that is generated by temperature differences across nanoscale conductors is demonstrated, with possible implications for thermometry and electronics.

    • Ofir Shein Lumbroso
    • , Lena Simine
    • , Abraham Nitzan
    • , Dvira Segal
    •  & Oren Tal
  • Letter |

    A strategy for managing the compositional distribution in metal halide perovskite light-emitting diodes enables them to surpass 20% external quantum efficiency—a step towards their practical application in lighting and displays.

    • Kebin Lin
    • , Jun Xing
    • , Li Na Quan
    • , F. Pelayo García de Arquer
    • , Xiwen Gong
    • , Jianxun Lu
    • , Liqiang Xie
    • , Weijie Zhao
    • , Di Zhang
    • , Chuanzhong Yan
    • , Wenqiang Li
    • , Xinyi Liu
    • , Yan Lu
    • , Jeffrey Kirman
    • , Edward H. Sargent
    • , Qihua Xiong
    •  & Zhanhua Wei
  • Letter |

    The formation of submicrometre-scale structure in perovskite light-emitting diodes can raise their external quantum efficiency beyond 20%, suggesting the possibility of both high efficiency and high brightness.

    • Yu Cao
    • , Nana Wang
    • , He Tian
    • , Jingshu Guo
    • , Yingqiang Wei
    • , Hong Chen
    • , Yanfeng Miao
    • , Wei Zou
    • , Kang Pan
    • , Yarong He
    • , Hui Cao
    • , You Ke
    • , Mengmeng Xu
    • , Ying Wang
    • , Ming Yang
    • , Kai Du
    • , Zewu Fu
    • , Decheng Kong
    • , Daoxin Dai
    • , Yizheng Jin
    • , Gongqiang Li
    • , Hai Li
    • , Qiming Peng
    • , Jianpu Wang
    •  & Wei Huang
  • Letter |

    By intercalating large ammonium molecules to exfoliate MoS2 with preservation of the 2H-phase, highly uniform solutionprocessable 2D semiconductor nanosheets are obtained for the scalable fabrication of large-area thin-film electronics.

    • Zhaoyang Lin
    • , Yuan Liu
    • , Udayabagya Halim
    • , Mengning Ding
    • , Yuanyue Liu
    • , Yiliu Wang
    • , Chuancheng Jia
    • , Peng Chen
    • , Xidong Duan
    • , Chen Wang
    • , Frank Song
    • , Mufan Li
    • , Chengzhang Wan
    • , Yu Huang
    •  & Xiangfeng Duan
  • Letter |

    Simulations of commonly proposed forest-management portfolios for Europe show that no single portfolio would meet all the requirements of the Paris Agreement, and climate benefits from forest management would be modest and local.

    • Sebastiaan Luyssaert
    • , Guillaume Marie
    • , Aude Valade
    • , Yi-Ying Chen
    • , Sylvestre Njakou Djomo
    • , James Ryder
    • , Juliane Otto
    • , Kim Naudts
    • , Anne Sofie Lansø
    • , Josefine Ghattas
    •  & Matthew J. McGrath
  • Letter |

    Low soil moisture may reduce, or even reverse, the potential benefits of climate warming on photosynthesis in mesic, seasonally cold environments, both during drought and in regularly occurring, modestly dry periods during the growing season.

    • Peter B. Reich
    • , Kerrie M. Sendall
    • , Artur Stefanski
    • , Roy L. Rich
    • , Sarah E. Hobbie
    •  & Rebecca A. Montgomery
  • Letter |

    A genome-wide association study of approximately 7,000 patients with neurodevelopmental disorders demonstrates that overall risk and clinical presentation in putative monogenic disorders is also influenced by common genetic variants present in the general population.

    • Mari E. K. Niemi
    • , Hilary C. Martin
    • , Daniel L. Rice
    • , Giuseppe Gallone
    • , Scott Gordon
    • , Martin Kelemen
    • , Kerrie McAloney
    • , Jeremy McRae
    • , Elizabeth J. Radford
    • , Sui Yu
    • , Jozef Gecz
    • , Nicholas G. Martin
    • , Caroline F. Wright
    • , David R. Fitzpatrick
    • , Helen V. Firth
    • , Matthew E. Hurles
    •  & Jeffrey C. Barrett
  • Letter |

    Cultures grown from small aggregates of mouse embryonic stem cells can be induced to organize spatial and temporal patterns of gene expression that parallel those of the early embryo, offering a potentially useful system for studying early development.

    • Leonardo Beccari
    • , Naomi Moris
    • , Mehmet Girgin
    • , David A. Turner
    • , Peter Baillie-Johnson
    • , Anne-Catherine Cossy
    • , Matthias P. Lutolf
    • , Denis Duboule
    •  & Alfonso Martinez Arias
  • Letter |

    Crystal structures of DltB, a bacterial membrane-bound O-acyltransferase, are reported both alone and in complex with the d-alanyl donor protein DltC.

    • Dan Ma
    • , Zhizhi Wang
    • , Christopher N. Merrikh
    • , Kevin S. Lang
    • , Peilong Lu
    • , Xin Li
    • , Houra Merrikh
    • , Zihe Rao
    •  & Wenqing Xu

Amendments & Corrections

Spotlight

  • Spotlight |

    Kanazawa

    An alternative Japan experience Meet the sides of Japanese cities that most international researchers never see
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