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Current Issue of Nature


Volume 561 Issue 7721, 6 September 2018

Volume 561 Issue 7721, 6 September 2018

Volume 561 Issue 7721

Ancient human hybrid

In this week’s issue, a team led by Viviane Slon and Svante Pääbo reveals the genome of a first-generation offspring of mixed Neanderthal and Denisovan parentage. The genome of the ancient adolescent was obtained from a bone fragment recovered from the Denisova Cave in the Altai Mountains of Siberia. The young female was at least 13 years old when she died 50,000–90,000 years ago. Neanderthals and Denisovans coexisted in Eurasia, and some specimens of mixed heritage have previously been found. But the latest discovery is the first time a first-generation child has been identified, providing direct evidence of interbreeding between the two groups. The researchers suggest that interbreeding between the groups may have been common when they met but that limited interactions allowed the groups to remain genetically distinct.

Cover image: Annette Günzel

This Week

News in Focus

Comment

Careers

Futures

  • Futures |

    Be prepared.

    • Stewart C. Baker

Research

    News & Views

  • News & Views |

    The magnetic field of Jupiter has been found to be different from all other known planetary magnetic fields. This result could have major implications for our understanding of the interiors of giant planets.

    • Chris Jones
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    A previously unknown pathway that enables mammalian cells to recognize infection and trigger an immune response requires a kinase enzyme in the host cell to bind a sugar molecule produced by infecting bacteria.

    • John-Demian Sauer
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    • Tadashi Suzuki
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    Exposure to a sulfoximine-based pesticide has substantial adverse effects on bumblebee colonies. This finding suggests that concerns over the risks of exposing bees to insecticides should not be limited to neonicotinoids.

    • Nigel E. Raine
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    The multiprotein complex PTEX enables malaria-causing parasites to survive inside red blood cells. Studies reveal how PTEX assembles, and identify a function for one of the complex’s proteins, EXP2.

    • Tania F. de Koning-Ward
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    What Nature was saying 50 and 100 years ago.

  • News & Views |

    A key step in the development of quantum computers that use neutral atoms as quantum bits is the assembly of tailored 3D arrays of atoms. Two laser-based approaches have now been reported to do this.

    • Nathan Lundblad
  • Reviews

  • Review Article |

    Longer human lives have led to a global burden of late-life disease, and so interventions, including changes to lifestyle and medical innovations, are needed to prevent disease and increase late-life health.

    • Linda Partridge
    • , Joris Deelen
    •  & P. Eline Slagboom
  • Articles

  • Article |

    Temporal information that is useful for episodic memory is encoded across a wide range of timescales in the lateral entorhinal cortex, arising inherently from its representation of ongoing experience.

    • Albert Tsao
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    • , Cheng Wang
    • , James J. Knierim
    • , May-Britt Moser
    •  & Edvard I. Moser
  • Article |

    The enzyme glutamine synthetase is active in endothelial cell migration during angiogenesis, through autopalmitoylation and the regulation of RHOJ signalling.

    • Guy Eelen
    • , Charlotte Dubois
    • , Anna Rita Cantelmo
    • , Jermaine Goveia
    • , Ulrike Brüning
    • , Michael DeRan
    • , Gopala Jarugumilli
    • , Jos van Rijssel
    • , Giorgio Saladino
    • , Federico Comitani
    • , Annalisa Zecchin
    • , Susana Rocha
    • , Rongyuan Chen
    • , Hongling Huang
    • , Saar Vandekeere
    • , Joanna Kalucka
    • , Christian Lange
    • , Francisco Morales-Rodriguez
    • , Bert Cruys
    • , Lucas Treps
    • , Leanne Ramer
    • , Stefan Vinckier
    • , Katleen Brepoels
    • , Sabine Wyns
    • , Joris Souffreau
    • , Luc Schoonjans
    • , Wouter H. Lamers
    • , Yi Wu
    • , Jurgen Haustraete
    • , Johan Hofkens
    • , Sandra Liekens
    • , Richard Cubbon
    • , Bart Ghesquière
    • , Mieke Dewerchin
    • , Francesco L. Gervasio
    • , Xuri Li
    • , Jaap D. van Buul
    • , Xu Wu
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    • , Mason Lai
    • , Yanxiang Cui
    • , Daniel E. Goldberg
    • , Pascal F. Egea
    •  & Z. Hong Zhou
  • Letters

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    • Kimberly M. Moore
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    • , Laura Kulowski
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    • , Jeremy Bloxham
    • , John E. P. Connerney
    • , Stavros Kotsiaros
    • , John L. Jørgensen
    • , José M. G. Merayo
    • , David J. Stevenson
    • , Scott J. Bolton
    •  & Steven M. Levin
  • Letter |

    Arbitrarily shaped, defect-free three-dimensional synthetic structures with up to 72 individually controlled atoms are assembled using holographic methods and moving tweezers.

    • Daniel Barredo
    • , Vincent Lienhard
    • , Sylvain de Léséleuc
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  • Letter |

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    • Qiushui Chen
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    • , Xiangyu Ou
    • , Bolong Huang
    • , Jawaher Almutlaq
    • , Ayan A. Zhumekenov
    • , Xinwei Guan
    • , Sanyang Han
    • , Liangliang Liang
    • , Zhigao Yi
    • , Juan Li
    • , Xiaoji Xie
    • , Yu Wang
    • , Ying Li
    • , Dianyuan Fan
    • , Daniel B. L. Teh
    • , Angelo H. All
    • , Omar F. Mohammed
    • , Osman M. Bakr
    • , Tom Wu
    • , Marco Bettinelli
    • , Huanghao Yang
    • , Wei Huang
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  • Letter |

    A lithographic patterning and release method is used to create a dense, fluctuating, Brownian system of mobile colloidal kite- and dart-shaped Penrose tiles over large areas that retains quasi-crystalline order.

    • Po-Yuan Wang
    •  & Thomas G. Mason
  • Letter |

    Chronic exposure to sulfoxaflor (a sulfoximine-based insecticide) has severe sub-lethal effects on bumblebee (Bombus terrestris) colonies; exposed colonies produced fewer workers and fewer reproductive offspring than unexposed control colonies.

    • Harry Siviter
    • , Mark J. F. Brown
    •  & Ellouise Leadbeater
  • Letter |

    Genomic evidence of the offspring of a Neanderthal mother and a Denisovan father suggests that mixing among different hominin groups may have more been frequent than previously appreciated.

    • Viviane Slon
    • , Fabrizio Mafessoni
    • , Benjamin Vernot
    • , Cesare de Filippo
    • , Steffi Grote
    • , Bence Viola
    • , Mateja Hajdinjak
    • , Stéphane Peyrégne
    • , Sarah Nagel
    • , Samantha Brown
    • , Katerina Douka
    • , Tom Higham
    • , Maxim B. Kozlikin
    • , Michael V. Shunkov
    • , Anatoly P. Derevianko
    • , Janet Kelso
    • , Matthias Meyer
    • , Kay Prüfer
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  • Letter |

    The bacterial metabolite ADP-heptose activates NF-κB in host cells via alpha-kinase 1 and the TIFA–TRAF signalling pathway.

    • Ping Zhou
    • , Yang She
    • , Na Dong
    • , Peng Li
    • , Huabin He
    • , Alessio Borio
    • , Qingcui Wu
    • , Shan Lu
    • , Xiaojun Ding
    • , Yong Cao
    • , Yue Xu
    • , Wenqing Gao
    • , Mengqiu Dong
    • , Jingjin Ding
    • , Da-Cheng Wang
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  • Letter |

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    • , Klara Sirokman
    • , Christina R. Hartigan
    • , Larson Hogstrom
    • , Jesse M. Engreitz
    • , Jacob C. Ulirsch
    • , Charles P. Fulco
    • , Vidya Subramanian
    • , Jenny Chen
    • , Monica Schenone
    • , Mitchell Guttman
    • , Steven A. Carr
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    • , Alexey G. Murzin
    • , Garib Murshudov
    • , Holly J. Garringer
    • , Ruben Vidal
    • , R. Anthony Crowther
    • , Bernardino Ghetti
    • , Sjors H. W. Scheres
    •  & Michel Goedert

Amendments & Corrections

  • Author Correction |

    • Shabnam Shalapour
    • , Xue-Jia Lin
    • , Ingmar N. Bastian
    • , John Brain
    • , Alastair D. Burt
    • , Alexander A. Aksenov
    • , Alison F. Vrbanac
    • , Weihua Li
    • , Andres Perkins
    • , Takaji Matsutani
    • , Zhenyu Zhong
    • , Debanjan Dhar
    • , Jose A. Navas-Molina
    • , Jun Xu
    • , Rohit Loomba
    • , Michael Downes
    • , Ruth T. Yu
    • , Ronald M. Evans
    • , Pieter C. Dorrestein
    • , Rob Knight
    • , Christopher Benner
    • , Quentin M. Anstee
    •  & Michael Karin
  • Author Correction |

    • T. B. Miller
    • , S. C. Chapman
    • , M. Aravena
    • , M. L. N. Ashby
    • , C. C. Hayward
    • , J. D. Vieira
    • , A. Weiß
    • , A. Babul
    • , M. Béthermin
    • , C. M. Bradford
    • , M. Brodwin
    • , J. E. Carlstrom
    • , Chian-Chou Chen
    • , D. J. M. Cunningham
    • , C. De Breuck
    • , A. H. Gonzalez
    • , T. R. Greve
    • , J. Harnett
    • , Y. Hezaveh
    • , K. Lacaille
    • , K. C. Litke
    • , J. Ma
    • , M. Malkan
    • , D. P. Marrone
    • , W. Morningstar
    • , E. J. Murphy
    • , D. Narayanan
    • , E. Pass
    • , R. Perry
    • , K. A. Phadke
    • , D. Rennehan
    • , K. M. Rotermund
    • , J. Simpson
    • , J. S. Spilker
    • , J. Sreevani
    • , A. A. Stark
    • , M. L. Strandet
    •  & A. L. Strom

Nature Outline