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Current Issue of Nature


Volume 561 Issue 7723, 20 September 2018

Volume 561 Issue 7723, 20 September 2018

Volume 561 Issue 7723

Grow with the flow

The cover is an artistic rendering of the elongation of the posterior body axis in a vertebrate embryo, highlighting the similarity between the physics of tissue morphogenesis and glass moulding. In this issue, Otger Campàs and his colleagues combine in vivo measurements of tissue mechanics, analysis of cellular dynamics and theoretical modelling to reveal the physical mechanism behind tissue morphogenesis in zebrafish embryos. The higher activity of cells at the posterior end of the body (glowing orange) ‘melts’ the tissue into a fluid-like state that enables remodelling. As body elongation proceeds, cells progressively become less active (blueish region), ‘freezing’ the tissue into a solid-like state that establishes tissue architecture. The fluid-to-solid transition is caused by cellular jamming of the foam-like (cellular) tissue architecture.

Cover image: Brian Long

This Week

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Futures

Research

    News & Views

  • News & Views Forum |

    The structures of anion-conducting channelrhodopsin proteins have been solved and used to develop a tool for optogenetics. Experts discuss what the structures tell us about ion conduction, and why the tool is needed.

    • Patrick Scheerer
    • , Elizabeth Unger
    •  & Lin Tian
  • News & Views |

    Bird migration is influenced by weather, making it hard to predict when birds will pass through a particular place on their route. A model that forecasts bird migrations has been developed using radar data and weather information.

    • Mary Abraham
  • News & Views |

    Photoemission, the ejection of an electron from a material on the absorption of a photon, is one of the fastest processes in nature. An experiment demonstrates how the dynamics of this process can be captured in real time.

    • Thomas Fennel
  • News & Views |

    Collections of cells in the tails of zebrafish embryos have now been found to transition between behaving as solids and fluids. This transition is responsible for the head-to-tail elongation of the embryo.

    • Pierre-François Lenne
    •  & Vikas Trivedi
  • News & Views |

    Spinal-cord injury can render intact neuronal circuits functionally dormant. Targeted reduction of neuronal inhibition in the injured region has now enabled reactivation of these circuits in mice, restoring basic locomotion.

    • Grégoire Courtine
  • News & Views |

    Experiments show that short bunches of protons can produce electric fields that are strong enough to accelerate energetic electrons compactly. This discovery could lead to miniaturized high-energy particle accelerators.

    • Toshiki Tajima
  • News & Views |

    What Nature was saying 50 and 100 years ago.

  • Brief Communications Arising

  • Brief Communications Arising |

    • Lynn N. Bertagnolli
    • , Jennifer A. White
    • , Francesco R. Simonetti
    • , Subul A. Beg
    • , Jun Lai
    • , Costin Tomescu
    • , Alexandra J. Murray
    • , Annukka A. R. Antar
    • , Hao Zhang
    • , Joseph B. Margolick
    • , Rebecca Hoh
    • , Stephen G. Deeks
    • , Pablo Tebas
    • , Luis J. Montaner
    • , Robert F. Siliciano
    • , Gregory M. Laird
    •  & Janet D. Siliciano
  • Brief Communications Arising |

    • Christa E. Osuna
    • , So-Yon Lim
    • , Jessica L. Kublin
    • , Richard Apps
    • , Elsa Chen
    • , Talia M. Mota
    • , Szu-Han Huang
    • , Yanqin Ren
    • , Nathaniel D. Bachtel
    • , Athe M. Tsibris
    • , Margaret E. Ackerman
    • , R. Brad Jones
    • , Douglas F. Nixon
    •  & James B. Whitney
  • Brief Communications Arising |

    • Benjamin Descours
    • , Gael Petitjean
    •  & Monsef Benkirane
  • Reviews

  • Review Article |

    By analysing particle production in high-energy nuclear collisions, the phase boundary of strongly interacting matter is located and the phase structure of quantum chromodynamics is elucidated, implying quark–hadron duality.

    • Anton Andronic
    • , Peter Braun-Munzinger
    • , Krzysztof Redlich
    •  & Johanna Stachel
  • Articles

  • Article |

    Therapeutic T cells bearing ligands engineered to optimize adhesion and transmigration through the blood–brain barrier can be targeted to brain tumours.

    • Heba Samaha
    • , Antonella Pignata
    • , Kristen Fousek
    • , Jun Ren
    • , Fong W. Lam
    • , Fabio Stossi
    • , Julien Dubrulle
    • , Vita S. Salsman
    • , Shanmugarajan Krishnan
    • , Sung-Ha Hong
    • , Matthew L. Baker
    • , Ankita Shree
    • , Ahmed Z. Gad
    • , Thomas Shum
    • , Dai Fukumura
    • , Tiara T. Byrd
    • , Malini Mukherjee
    • , Sean P. Marrelli
    • , Jordan S. Orange
    • , Sujith K. Joseph
    • , Poul H. Sorensen
    • , Michael D. Taylor
    • , Meenakshi Hegde
    • , Maksim Mamonkin
    • , Rakesh K. Jain
    • , Shahenda El-Naggar
    •  & Nabil Ahmed
  • Article |

    Differential DNA methylation and the long-range effects of chromatin organization lead to pronounced differences in recombination landscape between males and females.

    • Kevin Brick
    • , Sarah Thibault-Sennett
    • , Fatima Smagulova
    • , Kwan-Wood G. Lam
    • , Yongmei Pu
    • , Florencia Pratto
    • , R. Daniel Camerini-Otero
    •  & Galina V. Petukhova
  • Article |

    The crystal structure of anion channelrhodopsin-1 (ACR1) from the algae Guillardia theta provides insights into the basis of anion conductance.

    • Yoon Seok Kim
    • , Hideaki E. Kato
    • , Keitaro Yamashita
    • , Shota Ito
    • , Keiichi Inoue
    • , Charu Ramakrishnan
    • , Lief E. Fenno
    • , Kathryn E. Evans
    • , Joseph M. Paggi
    • , Ron O. Dror
    • , Hideki Kandori
    • , Brian K. Kobilka
    •  & Karl Deisseroth
  • Article |

    Crystal structures and molecular simulations of the designed anion-conducting channelrhodopsin iC++ provide molecular insights that enable structure-based design of channelrhodopsins with desirable properties for use as optogenetic tools.

    • Hideaki E. Kato
    • , Yoon Seok Kim
    • , Joseph M. Paggi
    • , Kathryn E. Evans
    • , William E. Allen
    • , Claire Richardson
    • , Keiichi Inoue
    • , Shota Ito
    • , Charu Ramakrishnan
    • , Lief E. Fenno
    • , Keitaro Yamashita
    • , Daniel Hilger
    • , Soo Yeun Lee
    • , Andre Berndt
    • , Kang Shen
    • , Hideki Kandori
    • , Ron O. Dror
    • , Brian K. Kobilka
    •  & Karl Deisseroth
  • Letters

  • Letter |

    Emission from the radio counterpart of the gravitation-wave event GW170817 was powered by a wide-angle outflow at early times, but probably dominated by a narrowly collimated jet at later times.

    • K. P. Mooley
    • , A. T. Deller
    • , O. Gottlieb
    • , E. Nakar
    • , G. Hallinan
    • , S. Bourke
    • , D. A. Frail
    • , A. Horesh
    • , A. Corsi
    •  & K. Hotokezaka
  • Letter |

    An analysis of the motions of six million stars in the Milky Way disk reveals substructures such as snail shells and ridges, indicating that our Galaxy has been recently perturbed.

    • T. Antoja
    • , A. Helmi
    • , M. Romero-Gómez
    • , D. Katz
    • , C. Babusiaux
    • , R. Drimmel
    • , D. W. Evans
    • , F. Figueras
    • , E. Poggio
    • , C. Reylé
    • , A. C. Robin
    • , G. Seabroke
    •  & C. Soubiran
  • Letter | | open

    Electron acceleration to very high energies is achieved in a single step by injecting electrons into a ‘wake’ of charge created in a 10-metre-long plasma by speeding long proton bunches.

    • E. Adli
    • , A. Ahuja
    • , O. Apsimon
    • , R. Apsimon
    • , A.-M. Bachmann
    • , D. Barrientos
    • , F. Batsch
    • , J. Bauche
    • , V. K. Berglyd Olsen
    • , M. Bernardini
    • , T. Bohl
    • , C. Bracco
    • , F. Braunmüller
    • , G. Burt
    • , B. Buttenschön
    • , A. Caldwell
    • , M. Cascella
    • , J. Chappell
    • , E. Chevallay
    • , M. Chung
    • , D. Cooke
    • , H. Damerau
    • , L. Deacon
    • , L. H. Deubner
    • , A. Dexter
    • , S. Doebert
    • , J. Farmer
    • , V. N. Fedosseev
    • , R. Fiorito
    • , R. A. Fonseca
    • , F. Friebel
    • , L. Garolfi
    • , S. Gessner
    • , I. Gorgisyan
    • , A. A. Gorn
    • , E. Granados
    • , O. Grulke
    • , E. Gschwendtner
    • , J. Hansen
    • , A. Helm
    • , J. R. Henderson
    • , M. Hüther
    • , M. Ibison
    • , L. Jensen
    • , S. Jolly
    • , F. Keeble
    • , S.-Y. Kim
    • , F. Kraus
    • , Y. Li
    • , S. Liu
    • , N. Lopes
    • , K. V. Lotov
    • , L. Maricalva Brun
    • , M. Martyanov
    • , S. Mazzoni
    • , D. Medina Godoy
    • , V. A. Minakov
    • , J. Mitchell
    • , J. C. Molendijk
    • , J. T. Moody
    • , M. Moreira
    • , P. Muggli
    • , E. Öz
    • , C. Pasquino
    • , A. Pardons
    • , F. Peña Asmus
    • , K. Pepitone
    • , A. Perera
    • , A. Petrenko
    • , S. Pitman
    • , A. Pukhov
    • , S. Rey
    • , K. Rieger
    • , H. Ruhl
    • , J. S. Schmidt
    • , I. A. Shalimova
    • , P. Sherwood
    • , L. O. Silva
    • , L. Soby
    • , A. P. Sosedkin
    • , R. Speroni
    • , R. I. Spitsyn
    • , P. V. Tuev
    • , M. Turner
    • , F. Velotti
    • , L. Verra
    • , V. A. Verzilov
    • , J. Vieira
    • , C. P. Welsch
    • , B. Williamson
    • , M. Wing
    • , B. Woolley
    •  & G. Xia
  • Letter |

    A teleported controlled-NOT gate is realized experimentally between two logical qubits implemented as superconducting cavity quantum memories, thus demonstrating an important tool for universal computation in a quantum modular architecture.

    • Kevin S. Chou
    • , Jacob Z. Blumoff
    • , Christopher S. Wang
    • , Philip C. Reinhold
    • , Christopher J. Axline
    • , Yvonne Y. Gao
    • , L. Frunzio
    • , M. H. Devoret
    • , Liang Jiang
    •  & R. J. Schoelkopf
  • Letter |

    The absolute timing of the photoelectric effect has proved difficult to measure, but the delay between photon arrival at a tungsten surface and ejection of photoelectrons has now been determined.

    • M. Ossiander
    • , J. Riemensberger
    • , S. Neppl
    • , M. Mittermair
    • , M. Schäffer
    • , A. Duensing
    • , M. S. Wagner
    • , R. Heider
    • , M. Wurzer
    • , M. Gerl
    • , M. Schnitzenbaumer
    • , J. V. Barth
    • , F. Libisch
    • , C. Lemell
    • , J. Burgdörfer
    • , P. Feulner
    •  & R. Kienberger
  • Letter |

    Studies of an Antarctic marine sediment core suggest that the East Antarctic Ice Sheet retreated in the vicinity of the Wilkes Subglacial Basin during extended warm periods of the late Pleistocene, when temperatures were similar to those predicted to occur within this century.

    • David J. Wilson
    • , Rachel A. Bertram
    • , Emma F. Needham
    • , Tina van de Flierdt
    • , Kevin J. Welsh
    • , Robert M. McKay
    • , Anannya Mazumder
    • , Christina R. Riesselman
    • , Francisco J. Jimenez-Espejo
    •  & Carlota Escutia
  • Letter |

    Isotopic and sedimentary analyses of soils at Pastoral Neolithic archaeological sites in Kenya demonstrate the long-term influence of nutrient enrichment on savannah environments that has accompanied pastoralist settlement over the past three millennia.

    • Fiona Marshall
    • , Rachel E. B. Reid
    • , Steven Goldstein
    • , Michael Storozum
    • , Andrew Wreschnig
    • , Lorraine Hu
    • , Purity Kiura
    • , Ruth Shahack-Gross
    •  & Stanley H. Ambrose
  • Letter |

    Training of mice to associate a particular sound frequency with locomotion results in selective suppression of cortical responses to that frequency during movement, consistent with a motor-dependent form of auditory cortical plasticity.

    • David M. Schneider
    • , Janani Sundararajan
    •  & Richard Mooney
  • Letter |

    Stimulating the intrinsic growth capacity of neurons and providing growth-supportive substrate and chemoattraction can allow axon regrowth across anatomically complete spinal cord injuries in adult rodents.

    • Mark A. Anderson
    • , Timothy M. O’Shea
    • , Joshua E. Burda
    • , Yan Ao
    • , Sabry L. Barlatey
    • , Alexander M. Bernstein
    • , Jae H. Kim
    • , Nicholas D. James
    • , Alexandra Rogers
    • , Brian Kato
    • , Alexander L. Wollenberg
    • , Riki Kawaguchi
    • , Giovanni Coppola
    • , Chen Wang
    • , Timothy J. Deming
    • , Zhigang He
    • , Gregoire Courtine
    •  & Michael V. Sofroniew
  • Letter |

    Cell collectives in embryonic tissues undergo a fluid-to-solid jamming transition, similar to those that occur in soft materials such as foams, emulsions and colloidal suspensions, to physically sculpt the vertebrate body axis.

    • Alessandro Mongera
    • , Payam Rowghanian
    • , Hannah J. Gustafson
    • , Elijah Shelton
    • , David A. Kealhofer
    • , Emmet K. Carn
    • , Friedhelm Serwane
    • , Adam A. Lucio
    • , James Giammona
    •  & Otger Campàs
  • Letter |

    Similarity of antibody responses in HIV-1 transmission pairs reveals a significant impact of the virus genome on imprinting antibody responses.

    • Roger D. Kouyos
    • , Peter Rusert
    • , Claus Kadelka
    • , Michael Huber
    • , Alex Marzel
    • , Hanna Ebner
    • , Merle Schanz
    • , Thomas Liechti
    • , Nikolas Friedrich
    • , Dominique L. Braun
    • , Alexandra U. Scherrer
    • , Jacqueline Weber
    • , Therese Uhr
    • , Nicolas S. Baumann
    • , Christine Leemann
    • , Herbert Kuster
    • , Jean-Philippe Chave
    • , Matthias Cavassini
    • , Enos Bernasconi
    • , Matthias Hoffmann
    • , Alexandra Calmy
    • , Manuel Battegay
    • , Andri Rauch
    • , Sabine Yerly
    • , Vincent Aubert
    • , Thomas Klimkait
    • , Jürg Böni
    • , Karin J. Metzner
    • , Huldrych F. Günthard
    • , Alexandra Trkola
    • , Alexia Anagnostopoulos
    • , Manuel Battegay
    • , Enos Bernasconi
    • , Jürg Böni
    • , Dominique L. Braun
    • , Heiner C. Bucher
    • , Alexandra Calmy
    • , Matthias Cavassini
    • , Angela Ciuffi
    • , Günter Dollenmaier
    • , Matthias Egger
    • , Luigia Elzi
    • , Jan Fehr
    • , Jacques Fellay
    • , Hansjakob Furrer
    • , Christoph A. Fux
    • , Huldrych F. Günthard
    • , David Haerry
    • , Barbara Hasse
    • , Hans H. Hirsch
    • , Matthias Hoffmann
    • , Irene Hösli
    • , Michael Huber
    • , Christian Kahlert
    • , Laurent Kaiser
    • , Olivia Keiser
    • , Thomas Klimkait
    • , Roger D. Kouyos
    • , Helen Kovari
    • , Bruno Ledergerber
    • , Gladys Martinetti
    • , Begona Martinez de Tejada
    • , Catia Marzolini
    • , Karin J. Metzner
    • , Nicolas Müller
    • , Dunja Nicca
    • , Paolo Paioni
    • , Guiseppe Pantaleo
    • , Matthieu Perreau
    • , Andri Rauch
    • , Christoph Rudin
    • , Alexandra U. Scherrer
    • , Patrick Schmid
    • , Roberto Speck
    • , Marcel Stöckle
    • , Philip Tarr
    • , Alexandra Trkola
    • , Pietro Vernazza
    • , Gilles Wandeler
    • , Rainer Weber
    •  & Sabine Yerly
  • Letter |

    A strategy developed to define off-target effects of gene-editing nucleases in whole organisms is validated and leveraged to show that CRISPR–Cas9 nucleases can be used effectively in vivo without inducing detectable off-target mutations.

    • Pinar Akcakaya
    • , Maggie L. Bobbin
    • , Jimmy A. Guo
    • , Jose Malagon-Lopez
    • , Kendell Clement
    • , Sara P. Garcia
    • , Mick D. Fellows
    • , Michelle J. Porritt
    • , Mike A. Firth
    • , Alba Carreras
    • , Tania Baccega
    • , Frank Seeliger
    • , Mikael Bjursell
    • , Shengdar Q. Tsai
    • , Nhu T. Nguyen
    • , Roberto Nitsch
    • , Lorenz M. Mayr
    • , Luca Pinello
    • , Mohammad Bohlooly-Y
    • , Martin J. Aryee
    • , Marcello Maresca
    •  & J. Keith Joung

Amendments & Corrections

Nature Index

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    Nature Index 2018 Rising Stars

    Creative minds drive the scientific enterprise. In recognition of their leading role, Nature Index 2018 Rising Stars profiles up-and-coming researchers in the natural sciences.