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Current Issue of Nature


Volume 561 Issue 7724, 27 September 2018

Volume 561 Issue 7724, 27 September 2018

Volume 561 Issue 7724

Stellar outburst

The cover image is a visualization of the turbulent envelope of a luminous blue variable star surrounding the central high-density core. As their name suggests, these massive, evolved stars display large variations in their luminosity and size. In this week’s issue, Yan-Fei Jiang and his collaborators report 3D models that suggest the mechanism behind this phenomenon. They find that helium opacity plays an important part in triggering the outbursts and in setting their effective temperature of around 9,000 kelvin. The team predicts that these stars should also show variability at the 10–30% level on a timescale of days.

Cover image: Joseph Insley/ALCF

This Week

News in Focus

Comment

Technology

Careers

    Features

  • Columns

  • Career Column |

    Confronting loss can give rise to difficult career choices, says Summer Praetorius.

    • Summer Praetorius

Futures

  • Futures |

    A missed appointment.

    • Graham Robert Scott

Research

    News & Views

  • News & Views |

    Current biological sensors require bulky external power sources. Ultrathin solar cells have now been fabricated that can power flexible, wearable sensors for the precise and continuous monitoring of biological signals.

    • Shiming Zhang
    •  & Fabio Cicoira
  • News & Views |

    Chromosomes can exist outside the nucleus in rupture-prone structures called micronuclei. It emerges that micronuclei are fragile because their outer layer lacks some nuclear-envelope components.

    • Matthias Samwer
    •  & Daniel W. Gerlich
  • News & Views |

    Drug treatments for HIV infection require the long-term use of daily medication that can have toxic side effects. A pair of HIV-targeting antibodies might offer an alternative therapeutic approach.

    • Nancy L. Haigwood
  • News & Views |

    Mechanical structures have been made that exhibit self-guided, multi-step sequences of shape changes in response to an applied force. Such structures could have applications in flexible electronics and soft robotics.

    • Larry L. Howell
  • News & Views |

    A computational method has been devised that allows a structural motif found in proteins, known as a β-barrel, to be designed to bind specifically to any small molecule, opening the door to biotechnological applications.

    • Roberto A. Chica
  • Brief Communications Arising

  • Brief Communications Arising |

    • Hortensia Torres-Torrelo
    • , Patricia Ortega-Sáenz
    • , David Macías
    • , Masayo Omura
    • , Ting Zhou
    • , Hiroaki Matsunami
    • , Randall S. Johnson
    • , Peter Mombaerts
    •  & José López-Barneo
  • Brief Communications Arising |

    • Andy J. Chang
    • , Noah S. Kim
    • , Homza Hireed
    • , Alex Diaz de Arce
    • , Fabian E. Ortega
    • , Johannes Riegler
    • , Daniel V. Madison
    •  & Mark A. Krasnow
  • Articles

  • Article |

    Analysis of blood from a healthy human show that haematopoietic stem cells increase rapidly in numbers through early life, reaching a stable plateau in adulthood, and contribute to myeloid and B lymphocyte populations throughout life.

    • Henry Lee-Six
    • , Nina Friesgaard Øbro
    • , Mairi S. Shepherd
    • , Sebastian Grossmann
    • , Kevin Dawson
    • , Miriam Belmonte
    • , Robert J. Osborne
    • , Brian J. P. Huntly
    • , Inigo Martincorena
    • , Elizabeth Anderson
    • , Laura O’Neill
    • , Michael R. Stratton
    • , Elisa Laurenti
    • , Anthony R. Green
    • , David G. Kent
    •  & Peter J. Campbell
  • Article |

    Combination therapy with the anti-HIV-1 monoclonal antibodies 3BNC117 and 10-1074 maintains long-term suppression in the absence of antiretroviral therapy in individuals with antibody-sensitive viral reservoirs.

    • Pilar Mendoza
    • , Henning Gruell
    • , Lilian Nogueira
    • , Joy A. Pai
    • , Allison L. Butler
    • , Katrina Millard
    • , Clara Lehmann
    • , Isabelle Suárez
    • , Thiago Y. Oliveira
    • , Julio C. C. Lorenzi
    • , Yehuda Z. Cohen
    • , Christoph Wyen
    • , Tim Kümmerle
    • , Theodora Karagounis
    • , Ching-Lan Lu
    • , Lisa Handl
    • , Cecilia Unson-O’Brien
    • , Roshni Patel
    • , Carola Ruping
    • , Maike Schlotz
    • , Maggi Witmer-Pack
    • , Irina Shimeliovich
    • , Gisela Kremer
    • , Eleonore Thomas
    • , Kelly E. Seaton
    • , Jill Horowitz
    • , Anthony P. West Jr
    • , Pamela J. Bjorkman
    • , Georgia D. Tomaras
    • , Roy M. Gulick
    • , Nico Pfeifer
    • , Gerd Fätkenheuer
    • , Michael S. Seaman
    • , Florian Klein
    • , Marina Caskey
    •  & Michel C. Nussenzweig
  • Article |

    The elucidation of general principles for designing β-barrels enables the de novo creation of fluorescent proteins.

    • Jiayi Dou
    • , Anastassia A. Vorobieva
    • , William Sheffler
    • , Lindsey A. Doyle
    • , Hahnbeom Park
    • , Matthew J. Bick
    • , Binchen Mao
    • , Glenna W. Foight
    • , Min Yen Lee
    • , Lauren A. Gagnon
    • , Lauren Carter
    • , Banumathi Sankaran
    • , Sergey Ovchinnikov
    • , Enrique Marcos
    • , Po-Ssu Huang
    • , Joshua C. Vaughan
    • , Barry L. Stoddard
    •  & David Baker
  • Article |

    The structure of a complex containing calcitonin gene-related peptide, the human calcitonin gene-related peptide receptor and the Gs heterotrimer, determined using Volta phase-plate cryo-electron microscopy, provides structural insight into the regulation of G-protein-coupled receptors by receptor activity modifying protein 1.

    • Yi-Lynn Liang
    • , Maryam Khoshouei
    • , Giuseppe Deganutti
    • , Alisa Glukhova
    • , Cassandra Koole
    • , Thomas S. Peat
    • , Mazdak Radjainia
    • , Jürgen M. Plitzko
    • , Wolfgang Baumeister
    • , Laurence J. Miller
    • , Deborah L. Hay
    • , Arthur Christopoulos
    • , Christopher A. Reynolds
    • , Denise Wootten
    •  & Patrick M. Sexton
  • Letters

  • Letter |

    Topologically protected edge states realized in a square array of ring resonators are used to demonstrate a robust source of heralded single photons produced by spontaneous four-wave mixing.

    • Sunil Mittal
    • , Elizabeth A. Goldschmidt
    •  & Mohammad Hafezi
  • Letter |

    Efficient terahertz harmonic generation—challenging but important for ultrahigh-speed optoelectronic technologies—is demonstrated in graphene through a nonlinear process that could potentially be generalized to other materials.

    • Hassan A. Hafez
    • , Sergey Kovalev
    • , Jan-Christoph Deinert
    • , Zoltán Mics
    • , Bertram Green
    • , Nilesh Awari
    • , Min Chen
    • , Semyon Germanskiy
    • , Ulf Lehnert
    • , Jochen Teichert
    • , Zhe Wang
    • , Klaas-Jan Tielrooij
    • , Zhaoyang Liu
    • , Zongping Chen
    • , Akimitsu Narita
    • , Klaus Müllen
    • , Mischa Bonn
    • , Michael Gensch
    •  & Dmitry Turchinovich
  • Letter |

    A scheme for implementing multi-step topological reorganization of a mechanical metamaterial is demonstrated, which proceeds autonomously, without the need for external control.

    • Corentin Coulais
    • , Alberico Sabbadini
    • , Fré Vink
    •  & Martin van Hecke
  • Letter |

    Biomechanical analyses of mammaliaform and cynodont fossils demonstrate that miniaturization drove the evolutionary transformation of the mammalian jaw, which preceded the optimization of bite force-to-joint load in the mandible

    • Stephan Lautenschlager
    • , Pamela G. Gill
    • , Zhe-Xi Luo
    • , Michael J. Fagan
    •  & Emily J. Rayfield
  • Letter |

    The diversity in the hydraulic traits of trees mediates ecosystem resilience to drought and will probably have an important role in future ecosystem–atmosphere feedback effects.

    • William R. L. Anderegg
    • , Alexandra G. Konings
    • , Anna T. Trugman
    • , Kailiang Yu
    • , David R. Bowling
    • , Robert Gabbitas
    • , Daniel S. Karp
    • , Stephen Pacala
    • , John S. Sperry
    • , Benjamin N. Sulman
    •  & Nicole Zenes
  • Letter |

    Somatosensory corticospinal neurons facilitate touch sensitivity and touch-evoked neuropathic pain in mice.

    • Yuanyuan Liu
    • , Alban Latremoliere
    • , Xinjian Li
    • , Zicong Zhang
    • , Mengying Chen
    • , Xuhua Wang
    • , Chao Fang
    • , Junjie Zhu
    • , Chloe Alexandre
    • , Zhongyang Gao
    • , Bo Chen
    • , Xin Ding
    • , Jin-Yong Zhou
    • , Yiming Zhang
    • , Chinfei Chen
    • , Kuan Hong Wang
    • , Clifford J. Woolf
    •  & Zhigang He
  • Letter |

    The mitotic spindle prevents normal nuclear envelope assembly on missegregated chromosomes, leading to spontaneous envelope disruption of micronuclei and subsequent genome instability.

    • Shiwei Liu
    • , Mijung Kwon
    • , Mark Mannino
    • , Nachen Yang
    • , Fioranna Renda
    • , Alexey Khodjakov
    •  & David Pellman
  • Letter |

    METTL3, the enzyme responsible for m6A modification, influences translation by interacting with eIF3h to mediate looping between the regions near the stop codon and 5′ cap of mRNA.

    • Junho Choe
    • , Shuibin Lin
    • , Wencai Zhang
    • , Qi Liu
    • , Longfei Wang
    • , Julia Ramirez-Moya
    • , Peng Du
    • , Wantae Kim
    • , Shaojun Tang
    • , Piotr Sliz
    • , Pilar Santisteban
    • , Rani E. George
    • , William G. Richards
    • , Kwok-Kin Wong
    • , Nicolas Locker
    • , Frank J. Slack
    •  & Richard I. Gregory
  • Letter |

    The retromer complex (the vacuolar protein sorting heterotrimer Vps26–Vps29–Vps35) has been resolved in association with membranes and the sorting nexin protein Vps5 using cryo-electron tomography.

    • Oleksiy Kovtun
    • , Natalya Leneva
    • , Yury S. Bykov
    • , Nicholas Ariotti
    • , Rohan D. Teasdale
    • , Miroslava Schaffer
    • , Benjamin D. Engel
    • , David. J. Owen
    • , John A. G. Briggs
    •  & Brett M. Collins

Amendments & Corrections

  • Author Correction |

    • Sietse van der Linde
    • , Laura M. Suz
    • , C. David L. Orme
    • , Filipa Cox
    • , Henning Andreae
    • , Endla Asi
    • , Bonnie Atkinson
    • , Sue Benham
    • , Christopher Carroll
    • , Nathalie Cools
    • , Bruno De Vos
    • , Hans-Peter Dietrich
    • , Johannes Eichhorn
    • , Joachim Gehrmann
    • , Tine Grebenc
    • , Hyun S. Gweon
    • , Karin Hansen
    • , Frank Jacob
    • , Ferdinand Kristofel
    • , Paweł Lech
    • , Miklos Manninger
    • , Jan Martin
    • , Henning Meesenburg
    • , Paivi Merila
    • , Manuel Nicolas
    • , Pavel Pavlenda
    • , Pasi Rautio
    • , Marcus Schaub
    • , Hans-Werner Schrock
    • , Walter Seidling
    • , Vit Šramek
    • , Anne Thimonier
    • , Iben Margrete Thomsen
    • , Hugues Titeux
    • , Elena Vanguelova
    • , Arne Verstraeten
    • , Lars Vesterdal
    • , Peter Waldner
    • , Sture Wijk
    • , Yuxin Zhang
    • , Daniel Žlindra
    •  & Martin I. Bidartondo
  • Publisher Correction |

    • Xuchu Que
    • , Ming-Yow Hung
    • , Calvin Yeang
    • , Ayelet Gonen
    • , Thomas A. Prohaska
    • , Xiaoli Sun
    • , Cody Diehl
    • , Antti Määttä
    • , Dalia E. Gaddis
    • , Karen Bowden
    • , Jennifer Pattison
    • , Jeffrey G. MacDonald
    • , Seppo Ylä-Herttuala
    • , Pamela L. Mellon
    • , Catherine C. Hedrick
    • , Klaus Ley
    • , Yury I. Miller
    • , Christopher K. Glass
    • , Kirk L. Peterson
    • , Christoph J. Binder
    • , Sotirios Tsimikas
    •  & Joseph L. Witztum

Nature Outlook

  • Nature Outlook |

    Brain cancer

    Brain cancer is one of the most aggressive and difficult-to-treat malignancies. Moreover, in the almost 50 years since the start of the war on cancer, the prospects for people who develop brain cancer have improved much more slowly than those of individuals with other types of cancer.