This Research Matters article argues that a global commitment to basic science approaches in the areas of model organisms, "omics," gene editing, mathematical biology, ecology and systems biology could revolutionize our approach to the control of neglected diseases.
In 1961, the NIH began a little-known experiment in biological preprints which was killed off by pressure from publishers in 1967. This article reveals this hidden history and draws lessons.
This Perspective article highlights the promise and potential pitfalls of gene drive technologies in conservation, and the need for open, international, discussions concerning a technology that will have global ramifications.
This study of internal sugar industry documents explores what the industry knows about sugar, the microbiome, and cancer biomarkersĤ and when they knew it.
This course-based undergraduate research experience shows how the teaching laboratory can contribute to scientific advances while building student proficiency in biochemistry and preparedness for real-world challenge.
Natural history museums can uniquely engage students in hands-on learning. This Community Page article lays out the design of a museum-based program and its benefits to both undergraduate students and collections.
Kayaks rigged with underwater sensors allow paddlers to hear sonifications of real-time water temperature and underwater sounds, generating live music from the marine world while collecting valuable environmental research data.
Neurons in primary auditory cortex appear to encode stimulus identity rapidly at the onset of sounds, with dense, non-selective spiking that is distinct from the traditional selectivity inherent in receptive fields.
Sounds like speech or music seem continuous as we perceive them. Neurophysiological data show that, surprisingly, there are discretized time scales that are either preferred or avoided for processing temporally modulated sounds.
Examination of the crosstalk between glutamine metabolism and DNA repair pathways reveals novel insights into how glutamine deficiency promotes genomic instability and modulates the response to therapy in cancer.
This study combines forward genetics, cell lineage tracing and single-molecule imaging to explore how phenotypic variability emerges in the normally stereotypical development pattern of the nematode Caenorhabditis elegans.
Aging-induced thymic atrophy results in a decline in the establishment of central T cell tolerance. This study shows that this does not involve impairment of thymic regulatory T cells (tTregs); rather, more tTregs are made in an attempt to compensate for defects in thymocyte negative selection.
How does attention shape the way that we perceive value and make decisions? This study shows that neuronal encoding of offer value in dorsal anterior cingulate cortex partially depends on the upcoming decision; this dependence increases as offers are compared, reflecting the evolving economic decision.
Genome sequence analysis demonstrates that strains of a single fungal species, Aspergillus fumigatus, differ extensively in their secondary metabolism pathways, revealing how fungal chemodiversity is generated at the level of the genome.
Exoproducts secreted by the bacterium Pseudomonas aeruginosa alter the susceptibility of Staphylococcus aureus to multiple classes of antibiotics and impact the therapeutic outcome during the treatment of co-infections.
By modelling regional connectivity patterns, this study reveals that Australia's Great Barrier Reef has a network of around 100 coral reefs that are ideally suited to promoting the recovery of the ecosystem after major coral bleaching events.
Exposure to the stress hormone corticosterone during adolescence impairs decision-making behavior in adulthood, which is related to long-lasting changes in neurotrophin signaling. Decision making can be normalized by treatment with a drug that stimulates the neurotrophin trkB receptor.
A magnetoencephalography study in humans reveals a rapid reverse hierarchical activation along the dorsal visual pathway during the integration of local elements into a global object, supporting a global-to-local processing cascade that helps resolve ambiguities in noisy environments.
An epigenetic prion switch in yeast specializes the cells either into "pioneers" that readily disperse in water and disfavor inbreeding, or into "settlers" that have enhanced resilience and adhesion.
Methods and Resources
A simple nucleic acid extraction method that will help to streamline DNA amplification-based applications, making them more accessible and affordable to researchers and the broader community.
A systematic comparison of two widely used types of genetic perturbation, CRISPR-Cas9 and RNA interference (RNAi), reveals that while on-target efficacies are comparable, CRISPR has far fewer off-target effects than RNAi.