Subject: PLoS Computational Biology Volume 8(1) January 2012
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PLoS Computational Biology
Volume 8(1) January 2012

View Table of Contents on web site

Editorial

A Review of 2011 for PLoS Computational Biology
Rosemary Dickin, Chris James Hall, Laura K. Taylor, Andrew M. Collings, Ruth Nussinov, Philip E. Bourne

Perspective

Beyond Statistical Significance: Implications of Network Structure on Neuronal Activity
Ioannis Vlachos, Ad Aertsen, Arvind Kumar

Review

Computational and Statistical Analysis of Protein Mass Spectrometry Data
William Stafford Noble, Michael J. MacCoss

Research Articles

A Feedback Quenched Oscillator Produces Turing Patterning with One Diffuser
Justin Hsia, William J. Holtz, Daniel C. Huang, Murat Arcak, Michel M. Maharbiz

Balancing Feed-Forward Excitation and Inhibition via Hebbian Inhibitory Synaptic Plasticity
Yotam Luz, Maoz Shamir

Macro-level Modeling of the Response of C. elegans Reproduction to Chronic Heat Stress
Patrick D. McMullen, Erin Z. Aprison, Peter B. Winter, Luis A. N. Amaral, Richard I. Morimoto, Ilya Ruvinsky

Single Sample Expression-Anchored Mechanisms Predict Survival in Head and Neck Cancer
Xinan Yang, Kelly Regan, Yong Huang, Qingbei Zhang, Jianrong Li, Tanguy Y. Seiwert, Ezra E. W. Cohen, H. Rosie Xing, Yves A. Lussier

Senescent Cells in Growing Tumors: Population Dynamics and Cancer Stem Cells
Caterina A. M. La Porta, Stefano Zapperi, James P. Sethna

Learning and Generalization under Ambiguity: An fMRI Study
J. R. Chumbley, G. Flandin, D. R. Bach, J. Daunizeau, E. Fehr, R. J. Dolan, K. J. Friston

A Theory of Rate Coding Control by Intrinsic Plasticity Effects
J. Naudé, J. T. Paz, H. Berry, B. Delord

Dynamic Modelling under Uncertainty: The Case of Trypanosoma brucei Energy Metabolism
Fiona Achcar, Eduard J. Kerkhoven, Barbara M. Bakker, Michael P. Barrett, Rainer Breitling

Membrane Properties and the Balance between Excitation and Inhibition Control Gamma-Frequency Oscillations Arising from Feedback Inhibition
Michael N. Economo, John A. White

HIV-1 Polymerase Inhibition by Nucleoside Analogs: Cellular- and Kinetic Parameters of Efficacy, Susceptibility and Resistance Selection
Max von Kleist, Philipp Metzner, Roland Marquet, Christof Schütte

Prediction by Promoter Logic in Bacterial Quorum Sensing
Navneet Rai, Rajat Anand, Krishna Ramkumar, Varun Sreenivasan, Sugat Dabholkar, K. V. Venkatesh, Mukund Thattai

Parsimonious Higher-Order Hidden Markov Models for Improved Array-CGH Analysis with Applications to Arabidopsis thaliana
Michael Seifert, André Gohr, Marc Strickert, Ivo Grosse

Lipid Exchange Mechanism of the Cholesteryl Ester Transfer Protein Clarified by Atomistic and Coarse-grained Simulations
Artturi Koivuniemi, Timo Vuorela, Petri T. Kovanen, Ilpo Vattulainen, Marja T. Hyvönen

Global Analysis of Small Molecule Binding to Related Protein Targets
Felix A. Kruger, John P. Overington

Protein Design Using Continuous Rotamers
Pablo Gainza, Kyle E. Roberts, Bruce R. Donald

A Dynamic View of Domain-Motif Interactions
Eyal Akiva, Gilgi Friedlander, Zohar Itzhaki, Hanah Margalit

Adjusting Phenotypes by Noise Control
Kyung H. Kim, Herbert M. Sauro

Network Model of Immune Responses Reveals Key Effectors to Single and Co-infection Dynamics by a Respiratory Bacterium and a Gastrointestinal Helminth
Juilee Thakar, Ashutosh K. Pathak, Lisa Murphy, Réka Albert, Isabella M. Cattadori

Maximization of Learning Speed in the Motor Cortex Due to Neuronal Redundancy
Ken Takiyama, Masato Okada

Kinetic Rate Constant Prediction Supports the Conformational Selection Mechanism of Protein Binding
Iain H. Moal, Paul A. Bates

Residual Structures, Conformational Fluctuations, and Electrostatic Interactions in the Synergistic Folding of Two Intrinsically Disordered Proteins
Weihong Zhang, Debabani Ganguly, Jianhan Chen

Short Conduction Delays Cause Inhibition Rather than Excitation to Favor Synchrony in Hybrid Neuronal Networks of the Entorhinal Cortex
Shuoguo Wang, Lakshmi Chandrasekaran, Fernando R. Fernandez, John A. White, Carmen C. Canavier

Multi-scale Inference of Interaction Rules in Animal Groups Using Bayesian Model Selection
Richard P. Mann, Andrea Perna, Daniel Strömbom, Roman Garnett, James E. Herbert-Read, David J. T. Sumpter, Ashley J. W. Ward

Failure of Adaptive Self-Organized Criticality during Epileptic Seizure Attacks
Christian Meisel, Alexander Storch, Susanne Hallmeyer-Elgner, Ed Bullmore, Thilo Gross

Dopamine, Affordance and Active Inference
Karl J. Friston, Tamara Shiner, Thomas FitzGerald, Joseph M. Galea, Rick Adams, Harriet Brown, Raymond J. Dolan, Rosalyn Moran, Klaas Enno Stephan, Sven Bestmann

Landscape Epidemiology and Control of Pathogens with Cryptic and Long-Distance Dispersal: Sudden Oak Death in Northern Californian Forests
João A. N. Filipe, Richard C. Cobb, Ross K. Meentemeyer, Christopher A. Lee, Yana S. Valachovic, Alex R. Cook, David M. Rizzo, Christopher A. Gilligan

A Dynamical Model of Oocyte Maturation Unveils Precisely Orchestrated Meiotic Decisions
Benjamin Pfeuty, Jean-Francois Bodart, Ralf Blossey, Marc Lefranc

Joint Modelling of Confounding Factors and Prominent Genetic Regulators Provides Increased Accuracy in Genetical Genomics Studies
Nicoló Fusi, Oliver Stegle, Neil D. Lawrence

A Model of Ant Route Navigation Driven by Scene Familiarity
Bart Baddeley, Paul Graham, Philip Husbands, Andrew Philippides

A Mathematical Methodology for Determining the Temporal Order of Pathway Alterations Arising during Gliomagenesis
Yu-Kang Cheng, Rameen Beroukhim, Ross L. Levine, Ingo K. Mellinghoff, Eric C. Holland, Franziska Michor

A Viral Dynamic Model for Treatment Regimens with Direct-acting Antivirals for Chronic Hepatitis C Infection
Bambang S. Adiwijaya, Tara L. Kieffer, Joshua Henshaw, Karen Eisenhauer, Holly Kimko, John J. Alam, Robert S. Kauffman, Varun Garg


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