Table of Contents

Biological Sciences

• Agricultural Sciences

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    Crop intensification, land use, and on-farm energy-use efficiency during the worldwide spread of the green revolution

    • From the Cover

    Pedro Pellegrini and Roberto J. Fernández

    PNAS 2018 115 (10) 2335-2340; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1717072115

• Anthropology

  • Open Access

    Origins and genetic legacies of the Caribbean Taino

    Hannes Schroeder, Martin Sikora, Shyam Gopalakrishnan, Lara M. Cassidy, Pierpaolo Maisano Delser, Marcela Sandoval Velasco, Joshua G. Schraiber, Simon Rasmussen, Julian R. Homburger, María C. Ávila-Arcos, Morten E. Allentoft, J. Víctor Moreno-Mayar, Gabriel Renaud, Alberto Gómez-Carballa, Jason E. Laffoon, Rachel J. A. Hopkins, Thomas F. G. Higham, Robert S. Carr, William C. Schaffer, Jane S. Day, Menno Hoogland, Antonio Salas, Carlos D. Bustamante, Rasmus Nielsen, Daniel G. Bradley, Corinne L. Hofman and Eske Willerslev

    PNAS 2018 115 (10) 2341-2346; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1716839115

• Applied Biological Sciences

  • Open Access

    OligoMiner provides a rapid, flexible environment for the design of genome-scale oligonucleotide in situ hybridization probes

    Brian J. Beliveau, Jocelyn Y. Kishi, Guy Nir, Hiroshi M. Sasaki, Sinem K. Saka, Son C. Nguyen, Chao-ting Wu and Peng Yin

    PNAS 2018 115 (10) E2183-E2192; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1714530115
  • Open Access

    Synthetic addiction extends the productive life time of engineered Escherichia coli populations

    Peter Rugbjerg, Kira Sarup-Lytzen, Mariann Nagy and Morten Otto Alexander Sommer

    PNAS 2018 115 (10) 2347-2352; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1718622115
  • Open Access

    Revealing nascent proteomics in signaling pathways and cell differentiation

    Craig M. Forester, Qian Zhao, Nancy J. Phillips, Anatoly Urisman, Robert J. Chalkley, Juan A. Oses-Prieto, Li Zhang, Davide Ruggero and Alma L. Burlingame

    PNAS 2018 115 (10) 2353-2358; published ahead of print February 21, 2018, https://doi.org/10.1073/pnas.1707514115

• Biochemistry

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    Entropy drives selective fluorine recognition in the fluoroacetyl–CoA thioesterase from Streptomyces cattleya

    Amy M. Weeks, Ningkun Wang, Jeffrey G. Pelton and Michelle C. Y. Chang

    PNAS 2018 115 (10) E2193-E2201; published ahead of print February 16, 2018, https://doi.org/10.1073/pnas.1717077115
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    Translational control in the tumor microenvironment promotes lung metastasis: Phosphorylation of eIF4E in neutrophils

    Nathaniel Robichaud, Brian E. Hsu, Roman Istomine, Fernando Alvarez, Julianna Blagih, Eric H. Ma, Sebastian V. Morales, David L. Dai, Glenn Li, Margarita Souleimanova, Qianyu Guo, Sonia V. del Rincon, Wilson H. Miller, Santiago Ramón y Cajal, Morag Park, Russell G. Jones, Ciriaco A. Piccirillo, Peter M. Siegel and Nahum Sonenberg

    PNAS 2018 115 (10) E2202-E2209; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1717439115
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    Functional and physical interaction between yeast Hsp90 and Hsp70

    Andrea N. Kravats, Joel R. Hoskins, Michael Reidy, Jill L. Johnson, Shannon M. Doyle, Olivier Genest, Daniel C. Masison and Sue Wickner

    PNAS 2018 115 (10) E2210-E2219; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1719969115
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    Substrate binding to BamD triggers a conformational change in BamA to control membrane insertion

    James Lee, Holly A. Sutterlin, Joseph S. Wzorek, Michael D. Mandler, Christine L. Hagan, Marcin Grabowicz, David Tomasek, Mary D. May, Elizabeth M. Hart, Thomas J. Silhavy and Daniel Kahne

    PNAS 2018 115 (10) 2359-2364; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1711727115
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    Identification of the YEATS domain of GAS41 as a pH-dependent reader of histone succinylation

    Yi Wang, Jing Jin, Matthew Wai Heng Chung, Ling Feng, Hongyan Sun and Quan Hao

    PNAS 2018 115 (10) 2365-2370; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1717664115
  • Open Access

    Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies

    Kirby N. Swatek, Martina Aumayr, Jonathan N. Pruneda, Linda J. Visser, Stephen Berryman, Anja F. Kueck, Paul P. Geurink, Huib Ovaa, Frank J. M. van Kuppeveld, Tobias J. Tuthill, Tim Skern and David Komander

    PNAS 2018 115 (10) 2371-2376; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1710617115

• Biophysics and Computational Biology

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    Porin self-association enables cell-to-cell contact in Providencia stuartii floating communities

    Mariam El-Khatib, Chady Nasrallah, Julie Lopes, Que-Tien Tran, Guillaume Tetreau, Hind Basbous, Daphna Fenel, Benoit Gallet, Mathilde Lethier, Jean-Michel Bolla, Jean-Marie Pagès, Michel Vivaudou, Martin Weik, Mathias Winterhalter and Jacques-Philippe Colletier

    PNAS 2018 115 (10) E2220-E2228; published ahead of print February 23, 2018, https://doi.org/10.1073/pnas.1714582115
  • Open Access

    Tracking the route of molecular oxygen in O₂-tolerant membrane-bound [NiFe] hydrogenase

    Jacqueline Kalms, Andrea Schmidt, Stefan Frielingsdorf, Tillmann Utesch, Guillaume Gotthard, David von Stetten, Peter van der Linden, Antoine Royant, Maria Andrea Mroginski, Philippe Carpentier, Oliver Lenz and Patrick Scheerer

    PNAS 2018 115 (10) E2229-E2237; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1712267115
  • Open Access

    Structure of full-length human TRPM4

    Jingjing Duan, Zongli Li, Jian Li, Ana Santa-Cruz, Silvia Sanchez-Martinez, Jin Zhang and David E. Clapham

    PNAS 2018 115 (10) 2377-2382; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1722038115
  • Open Access

    G_i- and G_s-coupled GPCRs show different modes of G-protein binding

    Ned Van Eps, Christian Altenbach, Lydia N. Caro, Naomi R. Latorraca, Scott A. Hollingsworth, Ron O. Dror, Oliver P. Ernst and Wayne L. Hubbell

    PNAS 2018 115 (10) 2383-2388; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1721896115
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    Molecular basis for diversification of yeast prion strain conformation

    Yumiko Ohhashi, Yoshiki Yamaguchi, Hiroshi Kurahashi, Yuji O. Kamatari, Shinju Sugiyama, Boran Uluca, Timo Piechatzek, Yusuke Komi, Toshinobu Shida, Henrik Müller, Shinya Hanashima, Henrike Heise, Kazuo Kuwata and Motomasa Tanaka

    PNAS 2018 115 (10) 2389-2394; published ahead of print February 21, 2018, https://doi.org/10.1073/pnas.1715483115
  • Open Access

    Structural basis and energy landscape for the Ca²⁺ gating and calmodulation of the Kv7.2 K⁺ channel

    Ganeko Bernardo-Seisdedos, Eider Nuñez, Carolina Gomis, Covadonga Malo, Álvaro Villarroel and Oscar Millet

    PNAS 2018 115 (10) 2395-2400; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1800235115

• Cell Biology

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    Light-activated protein interaction with high spatial subcellular confinement

    Lorena Benedetti, Andrew E. S. Barentine, Mirko Messa, Heather Wheeler, Joerg Bewersdorf and Pietro De Camilli

    PNAS 2018 115 (10) E2238-E2245; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1713845115
  • Open Access

    STED nanoscopy of the centrosome linker reveals a CEP68-organized, periodic rootletin network anchored to a C-Nap1 ring at centrioles

    Rifka Vlijm, Xue Li, Marko Panic, Diana Rüthnick, Shoji Hata, Frank Herrmannsdörfer, Thomas Kuner, Mike Heilemann, Johann Engelhardt, Stefan W. Hell and Elmar Schiebel

    PNAS 2018 115 (10) E2246-E2253; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1716840115
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    Angiogenic patterning by STEEL, an endothelial-enriched long noncoding RNA

    H. S. Jeffrey Man, Aravin N. Sukumar, Gabrielle C. Lam, Paul J. Turgeon, Matthew S. Yan, Kyung Ha Ku, Michelle K. Dubinsky, J. J. David Ho, Jenny Jing Wang, Sunit Das, Nora Mitchell, Peter Oettgen, Michael V. Sefton and Philip A. Marsden

    PNAS 2018 115 (10) 2401-2406; published ahead of print February 21, 2018, https://doi.org/10.1073/pnas.1715182115

• Developmental Biology

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    Mitotic waves in the early embryogenesis of Drosophila: Bistability traded for speed

    Massimo Vergassola, Victoria E. Deneke and Stefano Di Talia

    PNAS 2018 115 (10) E2165-E2174; published ahead of print February 15, 2018, https://doi.org/10.1073/pnas.1714873115
  • Open Access

    Robo and Ror function in a common receptor complex to regulate Wnt-mediated neurite outgrowth in Caenorhabditis elegans

    Jiaming Wang and Mei Ding

    PNAS 2018 115 (10) E2254-E2263; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1717468115
  • Open Access

    Pulmonary alveolar type I cell population consists of two distinct subtypes that differ in cell fate

    Yanjie Wang, Zan Tang, Huanwei Huang, Jiao Li, Zheng Wang, Yuanyuan Yu, Chengwei Zhang, Juan Li, Huaping Dai, Fengchao Wang, Tao Cai and Nan Tang

    PNAS 2018 115 (10) 2407-2412; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1719474115

• Ecology

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    Global rise in emerging alien species results from increased accessibility of new source pools

    • From the Cover

    Hanno Seebens, Tim M. Blackburn, Ellie E. Dyer, Piero Genovesi, Philip E. Hulme, Jonathan M. Jeschke, Shyama Pagad, Petr Pyšek, Mark van Kleunen, Marten Winter, Michael Ansong, Margarita Arianoutsou, Sven Bacher, Bernd Blasius, Eckehard G. Brockerhoff, Giuseppe Brundu, César Capinha, Charlotte E. Causton, Laura Celesti-Grapow, Wayne Dawson, Stefan Dullinger, Evan P. Economo, Nicol Fuentes, Benoit Guénard, Heinke Jäger, John Kartesz, Marc Kenis, Ingolf Kühn, Bernd Lenzner, Andrew M. Liebhold, Alexander Mosena, Dietmar Moser, Wolfgang Nentwig, Misako Nishino, David Pearman, Jan Pergl, Wolfgang Rabitsch, Julissa Rojas-Sandoval, Alain Roques, Stephanie Rorke, Silvia Rossinelli, Helen E. Roy, Riccardo Scalera, Stefan Schindler, Kateřina Štajerová, Barbara Tokarska-Guzik, Kevin Walker, Darren F. Ward, Takehiko Yamanaka and Franz Essl

    PNAS 2018 115 (10) E2264-E2273; published ahead of print February 5, 2018, https://doi.org/10.1073/pnas.1719429115
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    Optically functional isoxanthopterin crystals in the mirrored eyes of decapod crustaceans

    Benjamin A. Palmer, Anna Hirsch, Vlad Brumfeld, Eliahu D. Aflalo, Iddo Pinkas, Amir Sagi, Shaked Rosenne, Dan Oron, Leslie Leiserowitz, Leeor Kronik, Steve Weiner and Lia Addadi

    PNAS 2018 115 (10) 2299-2304; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1722531115
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    Demographic compensation does not rescue populations at a trailing range edge

    Seema Nayan Sheth and Amy Lauren Angert

    PNAS 2018 115 (10) 2413-2418; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1715899115
  • Open Access

    Trophic redundancy reduces vulnerability to extinction cascades

    Dirk Sanders, Elisa Thébault, Rachel Kehoe and F. J. Frank van Veen

    PNAS 2018 115 (10) 2419-2424; published ahead of print February 21, 2018, https://doi.org/10.1073/pnas.1716825115

• Evolution

  • Open Access

    The timescale of early land plant evolution

    Jennifer L. Morris, Mark N. Puttick, James W. Clark, Dianne Edwards, Paul Kenrick, Silvia Pressel, Charles H. Wellman, Ziheng Yang, Harald Schneider and Philip C. J. Donoghue

    PNAS 2018 115 (10) E2274-E2283; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1719588115
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    Climate-mediated hybrid zone movement revealed with genomics, museum collection, and simulation modeling

    • From the Cover

    Sean F. Ryan, Jillian M. Deines, J. Mark Scriber, Michael E. Pfrender, Stuart E. Jones, Scott J. Emrich and Jessica J. Hellmann

    PNAS 2018 115 (10) E2284-E2291; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1714950115
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    Select and resequence reveals relative fitness of bacteria in symbiotic and free-living environments

    Liana T. Burghardt, Brendan Epstein, Joseph Guhlin, Matt S. Nelson, Margaret R. Taylor, Nevin D. Young, Michael J. Sadowsky and Peter Tiffin

    PNAS 2018 115 (10) 2425-2430; published ahead of print February 16, 2018, https://doi.org/10.1073/pnas.1714246115

• Genetics

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    NLR surveillance of essential SEC-9 SNARE proteins induces programmed cell death upon allorecognition in filamentous fungi

    Jens Heller, Corinne Clavé, Pierre Gladieux, Sven J. Saupe and N. Louise Glass

    PNAS 2018 115 (10) E2292-E2301; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1719705115
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    Unleashing meiotic crossovers in hybrid plants

    Joiselle Blanche Fernandes, Mathilde Séguéla-Arnaud, Cécile Larchevêque, Andrew H. Lloyd and Raphael Mercier

    PNAS 2018 115 (10) 2431-2436; published ahead of print November 28, 2017, https://doi.org/10.1073/pnas.1713078114
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    Massive crossover elevation via combination of HEI10 and recq4a recq4b during Arabidopsis meiosis

    Heïdi Serra, Christophe Lambing, Catherine H. Griffin, Stephanie D. Topp, Divyashree C. Nageswaran, Charles J. Underwood, Piotr A. Ziolkowski, Mathilde Séguéla-Arnaud, Joiselle B. Fernandes, Raphaël Mercier and Ian R. Henderson

    PNAS 2018 115 (10) 2437-2442; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1713071115

• Immunology and Inflammation

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    Carbon monoxide protects the kidney through the central circadian clock and CD39

    Matheus Correa-Costa, David Gallo, Eva Csizmadia, Edward Gomperts, Judith-Lisa Lieberum, Carl J. Hauser, Xingyue Ji, Binghe Wang, Niels Olsen Saraiva Câmara, Simon C. Robson and Leo E. Otterbein

    PNAS 2018 115 (10) E2302-E2310; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1716747115
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    Genetic rescue of lineage-balanced blood cell production reveals a crucial role for STAT3 antiinflammatory activity in hematopoiesis

    Huiyuan Zhang, Haiyan S. Li, Emily J. Hillmer, Yang Zhao, Taylor T. Chrisikos, Hongbo Hu, Xiao Wu, Erika J. Thompson, Karen Clise-Dwyer, Karen A. Millerchip, Yue Wei, Nahum Puebla-Osorio, Saakshi Kaushik, Margarida A. Santos, Bin Wang, Guillermo Garcia-Manero, Jing Wang, Shao-Cong Sun and Stephanie S. Watowich

    PNAS 2018 115 (10) E2311-E2319; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1713889115
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    Role of glutathione metabolism in host defense against Borrelia burgdorferi infection

    Mariska Kerstholt, Hedwig Vrijmoeth, Ekta Lachmandas, Marije Oosting, Mihaela Lupse, Mirela Flonta, Charles A. Dinarello, Mihai G. Netea and Leo A. B. Joosten

    PNAS 2018 115 (10) E2320-E2328; published ahead of print February 14, 2018, https://doi.org/10.1073/pnas.1720833115
  • Open Access

    MHC-mismatched mixed chimerism restores peripheral tolerance of noncross-reactive autoreactive T cells in NOD mice

    Mingfeng Zhang, Jeremy J. Racine, Qing Lin, Yuqing Liu, Shanshan Tang, Qi Qin, Tong Qi, Arthur D. Riggs and Defu Zeng

    PNAS 2018 115 (10) E2329-E2337; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1720169115
  • Open Access

    Signal peptide of HIV envelope protein impacts glycosylation and antigenicity of gp120

    Jason Yolitz, Catherine Schwing, Julia Chang, Donald Van Ryk, Fatima Nawaz, Danlan Wei, Claudia Cicala, James Arthos and Anthony S. Fauci

    PNAS 2018 115 (10) 2443-2448; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1722627115
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    Neutrophils recruited through high endothelial venules of the lymph nodes via PNAd intercept disseminating Staphylococcus aureus

    • From the Cover

    Ania Bogoslowski, Eugene C. Butcher and Paul Kubes

    PNAS 2018 115 (10) 2449-2454; published ahead of print January 29, 2018, https://doi.org/10.1073/pnas.1715756115
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    Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion

    Lyndsay Avery, Jessica Filderman, Andrea L. Szymczak-Workman and Lawrence P. Kane

    PNAS 2018 115 (10) 2455-2460; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1712107115

• Medical Sciences

  • Open Access

    Sarcomeric perturbations of myosin motors lead to dilated cardiomyopathy in genetically modified MYL2 mice

    Chen-Ching Yuan, Katarzyna Kazmierczak, Jingsheng Liang, Zhiqun Zhou, Sunil Yadav, Aldrin V. Gomes, Thomas C. Irving and Danuta Szczesna-Cordary

    PNAS 2018 115 (10) E2338-E2347; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1716925115
  • Open Access

    Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice

    Kan Xie, Devon P. Ryan, Brandon L. Pearson, Kristin S. Henzel, Frauke Neff, Ramon O. Vidal, Magali Hennion, Isabelle Lehmann, Melvin Schleif, Susanne Schröder, Thure Adler, Birgit Rathkolb, Jan Rozman, Anna-Lena Schütz, Cornelia Prehn, Michel E. Mickael, Marco Weiergräber, Jerzy Adamski, Dirk H. Busch, Gerhard Ehninger, Anna Matynia, Walker S. Jackson, Eckhard Wolf, Helmut Fuchs, Valerie Gailus-Durner, Stefan Bonn, Martin Hrabě de Angelis and Dan Ehninger

    PNAS 2018 115 (10) E2348-E2357; published ahead of print February 21, 2018, https://doi.org/10.1073/pnas.1707337115
  • Open Access

    Diagnostic utility of telomere length testing in a hospital-based setting

    Jonathan K. Alder, Vidya Sagar Hanumanthu, Margaret A. Strong, Amy E. DeZern, Susan E. Stanley, Clifford M. Takemoto, Ludmilla Danilova, Carolyn D. Applegate, Stephen G. Bolton, David W. Mohr, Robert A. Brodsky, James F. Casella, Carol W. Greider, J. Brooks Jackson and Mary Armanios

    PNAS 2018 115 (10) E2358-E2365; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1720427115
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    Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: A paradigm shift for host–microbe interactions

    Emrah Altindis, Weikang Cai, Masaji Sakaguchi, Fa Zhang, Wang GuoXiao, Fa Liu, Pierre De Meyts, Vasily Gelfanov, Hui Pan, Richard DiMarchi and C. Ronald Kahn

    PNAS 2018 115 (10) 2461-2466; published ahead of print February 21, 2018, https://doi.org/10.1073/pnas.1721117115
  • Open Access

    Molecular signatures of circulating melanoma cells for monitoring early response to immune checkpoint therapy

    Xin Hong, Ryan J. Sullivan, Mark Kalinich, Tanya Todorova Kwan, Anita Giobbie-Hurder, Shiwei Pan, Joseph A. LiCausi, John D. Milner, Linda T. Nieman, Ben S. Wittner, Uyen Ho, Tianqi Chen, Ravi Kapur, Donald P. Lawrence, Keith T. Flaherty, Lecia V. Sequist, Sridhar Ramaswamy, David T. Miyamoto, Michael Lawrence, Mehmet Toner, Kurt J. Isselbacher, Shyamala Maheswaran and Daniel A. Haber

    PNAS 2018 115 (10) 2467-2472; published ahead of print February 16, 2018, https://doi.org/10.1073/pnas.1719264115
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    Theory of signs and statistical approach to big data in assessing the relevance of clinical biomarkers of inflammation and oxidative stress

    Pietro Ghezzi, Kevin Davies, Aidan Delaney and Luciano Floridi

    PNAS 2018 115 (10) 2473-2477; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1719807115
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    Transcriptional factor ICER promotes glutaminolysis and the generation of Th17 cells

    Michihito Kono, Nobuya Yoshida, Kayaho Maeda and George C. Tsokos

    PNAS 2018 115 (10) 2478-2483; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1714717115

• Microbiology

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    Rocaglates as dual-targeting agents for experimental cerebral malaria

    David Langlais, Regina Cencic, Neda Moradin, James M. Kennedy, Kodjo Ayi, Lauren E. Brown, Ian Crandall, Michael J. Tarry, Martin Schmeing, Kevin C. Kain, John A. Porco, Jerry Pelletier and Philippe Gros

    PNAS 2018 115 (10) E2366-E2375; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1713000115
  • Open Access

    In vivo repressed genes of Vibrio cholerae reveal inverse requirements of an H⁺/Cl⁻ transporter along the gastrointestinal passage

    Fatih Cakar, Franz G. Zingl, Manuel Moisi, Joachim Reidl and Stefan Schild

    PNAS 2018 115 (10) E2376-E2385; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1716973115
  • Open Access

    Defining the sizes of airborne particles that mediate influenza transmission in ferrets

    Jie Zhou, Jianjian Wei, Ka-Tim Choy, Sin Fun Sia, Dewi K. Rowlands, Dan Yu, Chung-Yi Wu, William G. Lindsley, Benjamin J. Cowling, James McDevitt, Malik Peiris, Yuguo Li and Hui-Ling Yen

    PNAS 2018 115 (10) E2386-E2392; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1716771115
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    MotAB-like machinery drives the movement of MreB filaments during bacterial gliding motility

    Guo Fu, Jigar N. Bandaria, Anne Valérie Le Gall, Xue Fan, Ahmet Yildiz, Tâm Mignot, David R. Zusman and Beiyan Nan

    PNAS 2018 115 (10) 2484-2489; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1716441115
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    The secreted metabolome of Streptomyces chartreusis and implications for bacterial chemistry

    Christoph H. R. Senges, Arwa Al-Dilaimi, Douglas H. Marchbank, Daniel Wibberg, Anika Winkler, Brad Haltli, Minou Nowrousian, Jörn Kalinowski, Russell G. Kerr and Julia E. Bandow

    PNAS 2018 115 (10) 2490-2495; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1715713115
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    Structures of the prefusion form of measles virus fusion protein in complex with inhibitors

    Takao Hashiguchi, Yoshinari Fukuda, Rei Matsuoka, Daisuke Kuroda, Marie Kubota, Yuta Shirogane, Shumpei Watanabe, Kouhei Tsumoto, Daisuke Kohda, Richard Karl Plemper and Yusuke Yanagi

    PNAS 2018 115 (10) 2496-2501; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1718957115

• Neuroscience

  • Open Access

    Axogenic mechanism enhances retinal ganglion cell excitability during early progression in glaucoma

    Michael L. Risner, Silvia Pasini, Melissa L. Cooper, Wendi S. Lambert and David J. Calkins

    PNAS 2018 115 (10) E2393-E2402; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1714888115
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    Environmental enrichment and exercise are better than social enrichment to reduce memory deficits in amyloid beta neurotoxicity

    Mariza G. Prado Lima, Helen L. Schimidt, Alexandre Garcia, Letícia R. Daré, Felipe P. Carpes, Ivan Izquierdo and Pâmela B. Mello-Carpes

    PNAS 2018 115 (10) E2403-E2409; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1718435115
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    Long-term potentiation expands information content of hippocampal dentate gyrus synapses

    Cailey Bromer, Thomas M. Bartol, Jared B. Bowden, Dusten D. Hubbard, Dakota C. Hanka, Paola V. Gonzalez, Masaaki Kuwajima, John M. Mendenhall, Patrick H. Parker, Wickliffe C. Abraham, Terrence J. Sejnowski and Kristen M. Harris

    PNAS 2018 115 (10) E2410-E2418; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1716189115
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    Within- and across-trial dynamics of human EEG reveal cooperative interplay between reinforcement learning and working memory

    Anne G. E. Collins and Michael J. Frank

    PNAS 2018 115 (10) 2502-2507; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1720963115
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    Controlling of glutamate release by neuregulin3 via inhibiting the assembly of the SNARE complex

    Ya-Nan Wang, Dwight Figueiredo, Xiang-Dong Sun, Zhao-Qi Dong, Wen-Bing Chen, Wan-Peng Cui, Fang Liu, Hong-Sheng Wang, Hai-Wen Li, Heath Robinson, Er-Kang Fei, Bing-Xing Pan, Bao-Ming Li, Wen-Cheng Xiong and Lin Mei

    PNAS 2018 115 (10) 2508-2513; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1716322115
  • Open Access

    Adult-born neurons boost odor–reward association

    Anne Grelat, Laura Benoit, Sébastien Wagner, Carine Moigneu, Pierre-Marie Lledo and Mariana Alonso

    PNAS 2018 115 (10) 2514-2519; published ahead of print February 21, 2018, https://doi.org/10.1073/pnas.1716400115

• Pharmacology

  • Open Access

    Structure-based discovery of selective positive allosteric modulators of antagonists for the M₂ muscarinic acetylcholine receptor

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• Physiology

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    Placental physiology monitored by hyperpolarized dynamic ¹³C magnetic resonance

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    PNAS 2018 115 (10) E2429-E2436; published ahead of print February 14, 2018, https://doi.org/10.1073/pnas.1715175115
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• Plant Biology

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• Systems Biology

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    Metabolic division of labor in microbial systems

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    PNAS 2018 115 (10) 2526-2531; published ahead of print February 20, 2018, https://doi.org/10.1073/pnas.1716888115
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