Contents
16 March 2018
Vol 359, Issue 6381
Vol 359, Issue 6381
Contents
This Week in Science
Editorial
Editors' Choice
Products & Materials
- New Products
A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.
In Brief
In Depth
- Complex behavior arose at dawn of humans
Advanced stone tools, pigment, and extensive networks emerged as environment changed.
- Nigeria hit by unprecedented Lassa fever outbreak
As efforts to contain it mount, researchers are racing to find out what is driving this year's surge in cases and deaths.
- Vibrations used to talk to quantum circuits
Sound waves could supplant microwaves in controlling quantum computers.
- Max Planck Society, at a crossroads, seeks new leaders
A wave of retirements offers a chance to recruit female institute directors and open up new research avenues.
- Concern as HIV prevention strategy languishes
Few countries promote prophylactic drug regimen, and many people shun it.
Feature
- Master planner
China's revered rocket scientist, Qian Xuesen, set in motion a system for engineers to control Chinese society.
Working Life
Letters
Books et al.
- Women's work
Stepping into scientific roles left vacant during World War I brought gains for women in and out of the laboratory
- Life in triplicate
A tale of triplets separated at birth raises red flags and questions about the role of nature and nurture
Policy Forum
- Societal inequalities amplify gender gaps in math
Egalitarian countries cultivate high-performing girls
Perspectives
- Rhythms: The dark side meets the light
Researchers examine the 24-hour biological clock in daytime-active baboons
- Circadian organization of the genome
The clock protein Rev-erbα regulates genome folding to establish circadian gene repression
- A landscape of disgust
Parasite avoidance behavior affects ecology and evolution in ways similar to predator avoidance
- Logic in babies
12-month-olds spontaneously reason using process of elimination
- Random copolymers that protect proteins
Synthetic polymers are designed to stabilize proteins in polar and nonpolar solvents
- Beyond PARP—POLθ as an anticancer target
Targeting cancers dependent on DNA polymerase θ has considerable clinical potential
Research Articles
- Diurnal transcriptome atlas of a primate across major neural and peripheral tissues
Daily rhythms of gene expression are analyzed in the baboon.
- Topological insulator laser: Theory
Lasing is observed in an edge mode of a designed optical topological insulator.
- Topological insulator laser: Experiments
Lasing is observed in an edge mode of a designed optical topological insulator.
- Phenotype risk scores identify patients with unrecognized Mendelian disease patterns
Electronic health records coupled with exome sequencing identify disease phenotypes linked to Mendelian inheritance.
Reports
- Random heteropolymers preserve protein function in foreign environments
Statistically random heteropolymers are designed using pattern analysis of protein sequence and surface chemistry.
- Real-time imaging of adatom-promoted graphene growth on nickel
Individual Ni atoms catalyzing the growth of a graphene flake along its edges were imaged on the millisecond time scale.
- Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis
An unusual radical enzyme forms an iron-carbon bond as the first step in the modification of a protein side chain.
- Oklahoma's induced seismicity strongly linked to wastewater injection depth
A Bayesian network approach implicates well depth as the most important operational factor for induced earthquakes.
- Protecting marine mammals, turtles, and birds by rebuilding global fisheries
Rebuilding fishery stocks will also promote recovery of threatened marine mammals, turtles, and birds.
- GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing
Plasmodium replication is interrupted for gamete production by eviction of a heterochromatin binding protein upstream of the relevant genes.
- Precursors of logical reasoning in preverbal human infants
The development of logical reasoning rekindles debate about the contributions of language to thinking.
- Factoring stream turbulence into global assessments of nitrogen pollution
Stream physics determines the maximum rate at which nitrate can be removed from the water.
- Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development
Astrocytes use microglia to prune redundant neuronal synapses.
- Rev-erbα dynamically modulates chromatin looping to control circadian gene transcription
The mechanism by which cellular clocks control chromatin dynamics is explored.
- Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging
Characterization of aging neuronal stem cells points to lysosomes as a key factor in maintaining stemness.
- Mutation dynamics and fitness effects followed in single cells
Mutation accumulation tracked in single bacterial cells reveals the dynamics of replication errors.
Technical Comments
From the AAAS Office of Publishing and Member Services
About The Cover
COVER Illustration of a nonmagnetic topological insulator laser: an array of microring resonators (circles) coupled by waveguides (ellipses) in a topological fashion. The red perimeter depicts the lasing topological edge mode, which exits through one of the two outputs (solid red triangle). Implementation of this design in an all-dielectric semiconductor enhances lasing performance and makes many diode lasers operate together as a single highly coherent laser. See pages 1230 and 1231.
Illustration: Valerie Altounian/Science