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Weilong Hao

Professional Preparation

Assistant Professor (2011-present), Wayne State University, Link (email: haow[at]wayne[dot]edu)

NSERC Postdoctoral Fellow (2010-2011), University of Toronto, with Dr. Donald E. Low

NSERC Postdoctoral Fellow (2009-2010), Indiana University, with Dr. Jeffrey D. Palmer

Postdoctoral Fellow in Biology (2007-2010), Indiana University, with Dr. Jeffrey D. Palmer

Ph.D in Computational Biology (2002-2007), McMaster University, with Dr. G. Brian Golding

M.Sc in Microiology, NanKai University, China

B.Sc in Microiology, NanKai University, China

Research Interests

My Ph.D research was to quantitatively investigate lateral gene transfer (LGT) in bacterial genome evolution. My postdoctoral projects at IU involved in mathematically and computationally detecting fine-scale gene transfers in eukaryotic mitochondrial genomes. My current postdoctoral project applies bioinformatics approaches on whole genome sequencing data using next-generation sequencing to provide deeper understanding of the evolution and epidemiology of a variety of microbial pathogen genomes. I have a broad interest in genome evolution. My goal is to address some fundemental questions in genome evolution using mathematical models, statistical frameworks, and bioinformatics approaches.

I am interested in:


2012 (22) Hao W. (2012) Fast rates of evolution in bacteria due to horizontal gene transfer, in Rapidly Evolving Genes and Genetic Systems, Oxford University Press, (Book Chapter) (in press).
(21) Alexander DC, Hao W, Gilmour M, Zittermann S, Sarabia A, Melano R, Peralta A, Lombos M, Warren K, Amatnieks Y, Virey E, Ma JH, Jamieson FB, Low DE and Allen VG. (2012) Escherichia coli O104:H4 infections associated with international travel. Emerging Infectious Diseases (in press). [Link]
2011 (20) Hao W and Palmer JD. (2011) HGT turbulence: Confounding phylogenetic influence of duplicative horizontal transfer and differential gene conversion. Mobile Genetic Elements 1:(in press). [Reprint]
(19) Hao W, Ma JH, Warren K, Tsang RS, Low DE, Jamieson FB and Alexander DC (2011) Extensive Genomic Variation within Clonal Complexes of Neisseria meningitidis. Genome Biol Evol 3:1406-1418. [Pubmed] [Reprint]
(18) Hao W (2011) Evidence of Intra-segmental Homologous Recombination in Influenza A virus. Gene 481:57-64. [Pubmed] [Reprint] [F1000 Evaluation]
2010 (17) Mower JP, Stefanovic S, Hao W, Gummow JS, Jain K, Ahmed D and Palmer JD (2010) Horizontal acquisition of multiple mitochondrial genes from a parasitic plant followed by gene conversion with host mitochondrial genes. BMC Biology 8: 150. [Pubmed] [Reprint] [Commentary by Archibald and Richards]
(16) Hao W# Richardson AO#, Zheng Y and Palmer JD (2010) Gorgeous mosaic of mitochondrial genes created by horizontal transfer and gene conversion. Proc Natl Acad Sci U S A 107: 21576-21581. [Pubmed] [Reprint] [Commentary by Archibald and Richards]
# these authors contributed equally to the published work.
(15) Hao W and Golding GB (2010) Inferring bacterial genome flux while considering truncated genes. Genetics 186: 411-426. [Pubmed] [Reprint]
(14) Hao W (2010) OrgConv: detection of gene conversion using consensus sequences and its application in plant mitochondrial and chloroplast homologs. BMC Bioinformatics 11: 114. highlyaccessed-large.gif [Pubmed] [Reprint]
(13) Hao W and Golding GB (2010) Pattern of Horizontal Gene Transfer in Bacteria, in Microbial Population Genetics, Horizon Scientific Press. (book chapter) [Publisher's website]
2009 (12) Hao W and Palmer JD (2009) Fine-scale mergers of chloroplast and mitochondrial genes create functional, transcompartmentally chimeric mitochondrial genes. Proc Natl Acad Sci U S A 106: 16728-16733. [Pubmed] [Reprint]
(11) Hao W and Golding GB (2009) Does Gene Translocation Accelerate the Evolution of Laterally Transferred Genes? Genetics 182:1365-1375. [Pubmed] [Reprint]
2008 (10) Hao W and Golding GB (2008) High Rates of Lateral Gene Transfer Are Not due to False Diagnosis of Gene Absence. Gene 421:27-31. [Pubmed] [Reprint]
(9) Hao W and Golding GB (2008) Uncovering Rate Variation of Lateral Gene Transfer during Bacterial Genome Evolution. BMC Genomics 9: 235. [Pubmed] [Reprint]
2007 (8) Higgs PG, Hao W and Golding GB (2007) Identification of Conflicting Selective Effects on Highly Expressed Genes. Evolutionary Bioinformatics 2: 1-13. [Pubmed] [Reprint]
(7) Marri PR#, Hao W# and Golding GB (2007) The Role of Laterally Transferred Genes in Adaptive Evolution. BMC Evolutionary Biology 7(Suppl 1):S8 (14 pages). [Pubmed] [Reprint]
# these authors contributed equally to the published work.
2006 (6) Hao W and Golding GB (2006) The Fate of Laterally Transferred Genes: Life in the Fast Lane to Adaptation or Death. Genome Research 16:636-643. [Pubmed] [Reprint] [Highlighted by I. King Jordan]
(5) Marri PR#, Hao W# and Golding GB (2006) Gene Gain and Gene Loss in Streptococcus: Is It Driven by Habitat? Molecular Biology and Evolution 23: 2379-2391. [Pubmed] [Reprint]
# these authors contributed equally to the published work.
(4) Hao W and Golding GB (2006) Asymmetrical Evolution of Cytochrome bd Subunits. Journal of Molecular Evolution 62: 132-142. [Pubmed] [Reprint]
2005 (3) Lee YK, Hao W, Ho PS, Nordling MM, Low CS, Kok TM and Rafter J (2005) Human Fecal Water Modifies Adhesion of Intestinal Bacteria to caco-2 Cells. Nutrition and Cancer 52: 35-42. [Pubmed]
2004 (2) Hao W and Golding GB (2004) Patterns of Bacterial Gene Movement. Molecular Biology and Evolution 21: 1294-1307. [Pubmed] [Reprint]
(1) Hao W and Lee YK (2004) Microflora of the Gastrointestinal Tract: A Review, in Public Health Microbiology: Methods and Protocols (Methods in Molecular Biology), pps. 491-502 Humana Press, Totowa, NJ. (book chapter) [Pubmed]

Last Updated: June 2nd 2011
© 2011, Weilong Hao