Adaptive Evolution: The role of Laterally Transferred Genes
Pradeep Reddy Marri, Weilong Hao and G. Brian Golding
Bacterial genomes develop new mechanisms to tide them over the imposing conditions that they encounter during the course of their evolution. Acquisition of new genes by lateral gene transfer may be one of the dominant ways of adaptation in bacterial genome evolution. Lateral gene transfer provides the bacterial genome with a new set of genes that help it to explore and adapt to new ecological niches. A maximum likelihood analysis was done on the five sequenced corynebacterial genomes to model the rates of gene insertions/deletions at various depths of the phylogeny. The study shows that the inferred rates of gene movement are more common on the external branches of the phylogeny and decrease as the phylogenetic depth increases. The newly acquired genes are under relaxed selection and evolve faster than their older counterparts. The five Corynebacterial genomes sequenced to date have evolved by acquiring between 8 - 14% of their genomes by LGT and an analysis of some of the functionally characterised LGTs has indicated that they may have a possible adaptive role. The entire list of specific genes for each of the sequenced corynebacterial species is listed below.

Species specific genes of Corynebacterium diphtheriae

clpB2 cobH cobIJ cobK cobN dcuB dirA glpF hypC hypD
hypE lldP metE nadB sdaC tnpA2 DIP0013 DIP0019 DIP0020 DIP0032
DIP0036 DIP0037 DIP0038 DIP0047 DIP0075 DIP0086 DIP0103 DIP0112 DIP0114 DIP0119
DIP0125 DIP0180 DIP0181 DIP0182 DIP0183 DIP0187 DIP0203 DIP0204 DIP0205 DIP0207
DIP0210 DIP0212 DIP0216 DIP0225 DIP0242 DIP0248 DIP0267 DIP0275 DIP0284 DIP0285
DIP0287 DIP0316 DIP0323 DIP0324 DIP0325 DIP0328 DIP0329 DIP0330 DIP0331 DIP0336
DIP0337 DIP0348 DIP0353 DIP0377 DIP0379 DIP0443 DIP0449 DIP0462 DIP0463 DIP0464
DIP0465 DIP0530 DIP0533 DIP0534 DIP0535 DIP0543 DIP0586 DIP0587 DIP0588 DIP0601
DIP0647 DIP0659 DIP0669 DIP0670 DIP0671 DIP0672 DIP0673 DIP0674 DIP0675 DIP0676
DIP0677 DIP0678 DIP0690 DIP0703 DIP0704 DIP0752 DIP0753 DIP0754 DIP0756 DIP0757
DIP0758 DIP0761 DIP0794 DIP0795 DIP0796 DIP0800 DIP0802 DIP0806 DIP0807 DIP0822
DIP0828 DIP0842 DIP0902 DIP0946 DIP1016 DIP1029 DIP1030 DIP1031 DIP1032 DIP1086
DIP1117 DIP1119 DIP1140 DIP1149 DIP1150 DIP1231 DIP1381 DIP1382 DIP1419 DIP1487
DIP1488 DIP1489 DIP1609 DIP1646 DIP1651 DIP1652 DIP1655 DIP1656 DIP1659 DIP1662
DIP1688 DIP1692 DIP1715 DIP1751 DIP1754 DIP1756 DIP1758 DIP1799 DIP1817 DIP1823
DIP1824 DIP1825 DIP1828 DIP1831 DIP1832 DIP1834 DIP1836 DIP1840 DIP1879 DIP1893
DIP1896 DIP1934 DIP1937 DIP1947 DIP1949 DIP1956 DIP1981 DIP1984 DIP1985 DIP1986
DIP2033 DIP2044 DIP2060 DIP2062 DIP2065 DIP2066 DIP2069 DIP2074 DIP2079 DIP2080
DIP2081 DIP2109 DIP2116 DIP2121 DIP2130 DIP2132 DIP2135 DIP2139 DIP2140 DIP2143
DIP2153 DIP2154 DIP2161 DIP2192 DIP2208 DIP2212 DIP2213 DIP2214 DIP2215 DIP2218
DIP2224 DIP2227 DIP2244 DIP2249 DIP2256 DIP2262 DIP2308 DIP2311 DIP2313 DIP2317
DIP2330 DIP2334 DIP2335 DIP2336 DIP2338

Laterally Transferred Genes

Gene Putative DonorFunction based on Annotation
DIP0036 Rhodospirillum rubrum Hypothetical protein
DIP0037 Nitrobacter winogradskyi Hypothetical protein
DIP0038 Nitroabcter winogradskyi Hypothetical protein
DIP0112 Lactobacillus casei Hypothetical protein
DIP0119 Chlorobium tepidum Hypothetical protein
DIP0125 Pseudomonas fluorescens Hypothetical protein
DIP0225 Bradyrhizobium sp. Putative secreted polysaccharide deacetylase
DIP0284 Pseudomonas syringae Putative ABC-transport system iron-binding secreted protein
DIP0287 Bacteroides/Chlorobium Two-component sensor protein
DIP0323 Erwinia carotovora Putative ABC transport system membrane protein
DIP0586 Thiobacillus denitrificans Putative siderophore biosynthesis related protein
DIP0647 Dechloromonas aromatica Hypothetical protein
DIP0669 Methylococcus capsulatus Putative hydrogenase maturation protein
DIP0672 Geobacter sulfurreducens Putative uptake hydrogenase small subunit
DIP0674 Campylobacter jejuni Putative Ni/Fe-hydrogenase B-type cytochrome subunit
DIP0753 Staphylococcus aureus Putative lantibiotic modifying enzyme
DIP0795 Campylobacter sp. Hypothetical protein
DIP0796 Gloeobacter violaceus Hypothetical protein
DIP0806 Nitrosococcus oceani Hypothetical protein
DIP0807 Magnetococcus magnetotacticum Hypothetical protein
DIP0902 Streptococcus suis Putative hydrolase
DIP1030 Desulfovibrio vulgaris Hypothetical protein
DIP1381 Pelobacter carbonolicus Putative biotin synthesis related protein
DIP1656 chlorobium/helicobacter Hypothetical protein
DIP1756 Lactobacillus sp. Putative DNA methyltransferase
DIP1834 Bacillus cereus Hypothetical protein
DIP1836 Eukaryote Repeats Collagen-like repeat protein
DIP1893 Streptococcus agalactiae Hypothetical protein
DIP1947 Pseudomonas aeruginosa Integrase
DIP1949 Proteobacteria Putative acetyltransferase
DIP1956 Actinobacillus pleuropneumoniae Hypothetical protein
DIP1984 Clostridium tetani Hypothetical protein
DIP2033 Xanthomonas sp. Putative transposase
DIP2060 Campylobacter lari Putative membrane protein
DIP2079 Proteobacteria Putative oxidoreductase
DIP2109 Desulfitobacterium hafniense Putative integral membrane protein
DIP2121 Dechloromonas aromatica Hypothetical protein
DIP2135 Neisseria meningitidis Putative zinc-binding alcohol dehydrogenase
DIP2244 Chlorobium chlorochromati Hypothetical protein
DIP2249 Anaeromyxobacter dehalogenes Putative nitric-oxide reductase
DIP2308 Xanthomonas campestris Conserved Hypothetical protein (possible plasmid origin)
DIP2311 Chlorobium sp. Hypothetical protein
DIP2313 Sinorhizobium meliloti Putative type I restriction/modification system DNA specificity protein
DIP2336 Exiguobacterium sp. Hypothetical protein
glpF Fusobacterium nucleatum Glycerol uptake facilitator protein
hypD Thiomicrospora denitrificans Hydrogenase isoenzymes formation protein
sdaC Firmicutes Serine transporter
tnpA2 Proteobacteria Transposase

Species specific genes of Corynebacterium efficiens

CE0058
CE0024 CE0025 CE0027 CE0043 CE0049 CE0059 CE0060 CE0063 CE0069
CE0071 CE0072 CE0083 CE0085 CE0098 CE0111 CE0114 CE0118 CE0122 CE0134
CE0155 CE0156 CE0157 CE0176 CE0181 CE0206 CE0217 CE0229 CE0230 CE0231
CE0237 CE0249 CE0252 CE0257 CE0258 CE0259 CE0260 CE0262 CE0266 CE0295
CE0303 CE0308 CE0314 CE0320 CE0321 CE0326 CE0329 CE0340 CE0349 CE0350
CE0351 CE0355 CE0361 CE0362 CE0367 CE0368 CE0369 CE0378 CE0379 CE0381
CE0403 CE0433 CE0444 CE0449 CE0451 CE0452 CE0488 CE0506 CE0510 CE0519
CE0526 CE0547 CE0604 CE0665 CE0668 CE0676 CE0710 CE0711 CE0713 CE0714
CE0715 CE0722 CE0724 CE0765 CE0816 CE0818 CE0820 CE0827 CE0829 CE0841
CE0850 CE0865 CE0866 CE0869 CE0870 CE0882 CE0914 CE0928 CE1010 CE1024
CE1027 CE1028 CE1032 CE1072 CE1073 CE1074 CE1086 CE1087 CE1088 CE1089
CE1094 CE1097 CE1098 CE1100 CE1103 CE1108 CE1110 CE1111 CE1119 CE1126
CE1130 CE1151 CE1187 CE1188 CE1192 CE1200 CE1201 CE1202 CE1203 CE1204
CE1205 CE1210 CE1216 CE1221 CE1222 CE1227 CE1229 CE1233 CE1237 CE1238
CE1243 CE1244 CE1245 CE1246 CE1247 CE1248 CE1256 CE1257 CE1271 CE1272
CE1280 CE1281 CE1282 CE1283 CE1286 CE1339 CE1340 CE1341 CE1354 CE1355
CE1371 CE1381 CE1394 CE1395 CE1398 CE1399 CE1402 CE1417 CE1450 CE1460
CE1462 CE1468 CE1473 CE1474 CE1475 CE1476 CE1478 CE1480 CE1493 CE1505
CE1508 CE1512 CE1513 CE1535 CE1568 CE1569 CE1577 CE1578 CE1579 CE1672
CE1673 CE1674 CE1676 CE1742 CE1756 CE1760 CE1762 CE1877 CE1928 CE1931
CE1935 CE1941 CE1943 CE1948 CE1949 CE1998 CE2034 CE2044 CE2105 CE2106
CE2111 CE2160 CE2166 CE2198 CE2214 CE2216 CE2219 CE2275 CE2279 CE2321
CE2326 CE2341 CE2356 CE2360 CE2362 CE2363 CE2367 CE2377 CE2379 CE2380
CE2381 CE2391 CE2393 CE2395 CE2396 CE2407 CE2450 CE2459 CE2463 CE2491
CE2505 CE2517 CE2551 CE2562 CE2563 CE2609 CE2618 CE2633 CE2634 CE2653
CE2669 CE2674 CE2679 CE2686 CE2694 CE2740 CE2743 CE2744 CE2747 CE2748
CE2760 CE2771 CE2777 CE2781 CE2800 CE2802 CE2852 CE2855 CE2876 CE2881
CE2882 CE2884 CE2885 CE2887 CE2888 CE2889 CE2890 CE2891 CE2893 CE2899
CE2907 CE2937 CE0008

Laterally Transferred Genes

Gene Putative DonorFunction based on Annotation
CE0008 Acinetobacter sp. Hypothetical protein
CE0024 Francisella talurensis Hypothetical protein
CE0063 Colwellia psychrerythreae Hypothetical protein
CE0069 Pseudomona syringae Putative ribosomal protein S6 modification protein
CE0098 Chromohalobacter salexigens Hypothetical protein
CE0111 Methanosarcina mazei Hypothetical protein
CE0217 Firmicutes Hypothetical protein
CE0229 Alkalilimnicola ehrlichei Hypothetical protein
CE0258 Rhodopirellula and Halobacterium Putative restriction enzyme subunit S
CE0266 Chlorobium/Nitrosomonas Hypothetical protein
CE0320 Rhodopseudomonas Hypothetical protein
CE0326 Fungi Putative 3-oxoacid CoA-transferase
CE0329 Bacillus sp. Putative beta-glucosidase
CE0350 Proteobacteria Hypothetical protein
CE0351 Pelodictyon sp. Hypothetical protein
CE0355 Yersinia pestis Hypothetical protein
CE0362 Proteobacteria Putative UDP-galactose 4-epimerase
CE0378 Streptococcus thermophilus Hypothetical protein
CE0379 Proteobacteria Hypothetical protein
CE0381 Desulfotalea psychrophila Putative lipopolysaccharide biosynthesis protein
CE0451 Pelobacter carbinolicus Hypothetical protein
CE0452 Nostoc sp. Hypothetical protein
CE0488 Azotobacter vinelandii Hypothetical protein
CE0722 Paracoccus denitrificans Putative 3-hydroxyacyl-CoA dehydrogenase
CE0724 Ralstonia/Xanthomonas sp. Hypothetical protein
CE0866 Bacillus licheniformis Hypothetical protein
CE0928 Rhodobacter sp. Hypothetical protein
CE1072 Burkholderia fungorum Putative transcription regulator
CE1073 Bordetella parapertussis Putative L-carnitine dehydratase
CE1086 Fusobacterium nucleatum Hypothetical protein
CE1088 Firmicutes Hypothetical protein
CE1108 Desulfitobacterium hafniense Hypothetical protein
CE1111 Magnetospirillum magnetotacticum Putative 3-alpha-hydroxysteroid dehydrogenase
CE1187 Firmicutes Hypothetical protein
CE1341 Solibacter ulistates Putative nisin resistance protein
CE1394 Alkalilimnicola ehrlichei Hypothetical protein
CE1398 Alkalilimnicola ehrlichei Hypothetical protein
CE1417 Dechloromonas aromatica Hypothetical protein
CE1450 Psychrobacter arcticus Hypothetical protein
CE1478 Magnetococcus sp. Hypothetical protein
CE1480 Archaea Hypothetical protein
CE1493 Enterobacter sp. Hypothetical protein
CE1578 Exiguobacterium sp. Hypothetical protein
CE1742 Aeropyrum pernix Hypothetical protein
CE1928 Sinorhizobium meliloti Hypothetical protein
CE1931 Rubrobacter sp. Putative periplasmic serine protease
CE1943 Rhodopirellula baltica Hypothetical protein
CE2367 Bdellovibrio bacteriovorus Hypothetical protein
CE2396 Firmicutes Hypothetical protein
CE2450 Erythrobacter sp. Hypothetical protein
CE2463 Azoarcus sp. Hypothetical protein
CE2674 Oceanobacillus iheyensis Hypothetical protein
CE2743 Nitrosococcus oceani Hypothetical protein
CE2744 Xylella fatidiosa Hypothetical protein
CE2747 Nitrosococcus oceani Hypothetical protein
CE2748 Xylella fatidiosa Hypothetical protein
CE2891 Desulfovibrio desulfuricans Hypothetical protein
CE2899 Desulfovibrio desulfuricans Hypothetical protein

Species specific genes of Corynebacterium glutamicum

bglY cg0031 cg0175 cg0231 cg0232 cg0255 cg0283 cg0308 cg0311 cg0372
cg0380 cg0440 cg0449 cg0606 cg0785 cg0801 cg0836 cg0851 cg0903 cg0904
cg0907 cg0909 cg1013 cg1025 cg1028 cg1057 cg1085 cg1087 cg1092 cg1095
cg1172 cg1180 cg1189 cg1241 cg1542 cg1549 cg1751 cg1770 cg1808 cg1860
cg1894 cg1900 cg1906 cg1914 cg1916 cg1918 cg1919 cg1924 cg1925 cg1972
cg1985 cg1986 cg2004 cg2025 cg2027 cg2049 cg2053 cg2073 cg2325 cg2351
cg2379 cg2439 cg2454 cg2462 cg2465 cg2480 cg2481 cg2548 cg2593 cg2665
cg2785 cg3108 cg3111 cg3120 cg3125 cg3228 cg3229 cg3230 cg3257 cg3268
cg3269 cg3270 cg3273 cg3309 cg3326 cg3377 cg3388 cg3401 cg3416 cg3433
cg4000 cg4005 cg4006 NCgl0002 NCgl0015 NCgl0017 NCgl0026 NCgl0039 NCgl0049 NCgl0050
NCgl0057 NCgl0058 NCgl0059 NCgl0060 NCgl0062 NCgl0082 NCgl0093 NCgl0094 NCgl0096 NCgl0097
NCgl0105 NCgl0107 NCgl0109 NCgl0110 NCgl0111 NCgl0115 NCgl0124 NCgl0129 NCgl0132 NCgl0134
NCgl0139 NCgl0150 NCgl0152 NCgl0157 NCgl0158 NCgl0159 NCgl0161 NCgl0163 NCgl0164 NCgl0165
NCgl0167 NCgl0168 NCgl0169 NCgl0171 NCgl0172 NCgl0173 NCgl0175 NCgl0176 NCgl0177 NCgl0178
NCgl0204 NCgl0220 NCgl0221 NCgl0223 NCgl0230 NCgl0234 NCgl0235 NCgl0237 NCgl0238 NCgl0239
NCgl0253 NCgl0256 NCgl0257 NCgl0259 NCgl0260 NCgl0266 NCgl0274 NCgl0280 NCgl0285 NCgl0287
NCgl0289 NCgl0292 NCgl0313 NCgl0314 NCgl0315 NCgl0321 NCgl0326 NCgl0329 NCgl0348 NCgl0349
NCgl0351 NCgl0353 NCgl0354 NCgl0355 NCgl0356 NCgl0357 NCgl0363 NCgl0364 NCgl0365 NCgl0374
NCgl0392 NCgl0393 NCgl0399 NCgl0412 NCgl0414 NCgl0416 NCgl0430 NCgl0443 NCgl0452 NCgl0453
NCgl0461 NCgl0462 NCgl0478 NCgl0481 NCgl0484 NCgl0498 NCgl0519 NCgl0526 NCgl0544 NCgl0545
NCgl0565 NCgl0572 NCgl0609 NCgl0615 NCgl0621 NCgl0634 NCgl0643 NCgl0655 NCgl0656 NCgl0660
NCgl0661 NCgl0683 NCgl0699 NCgl0717 NCgl0718 NCgl0728 NCgl0731 NCgl0734 NCgl0736 NCgl0749
NCgl0750 NCgl0758 NCgl0792 NCgl0793 NCgl0794 NCgl0796 NCgl0797 NCgl0798 NCgl0806 NCgl0837
NCgl0838 NCgl0840 NCgl0896 NCgl0898 NCgl0900 NCgl0901 NCgl0902 NCgl0903 NCgl0907 NCgl0940
NCgl0950 NCgl0956 NCgl0957 NCgl0958 NCgl0979 NCgl0980 NCgl0984 NCgl0992 NCgl0994 NCgl1007
NCgl1011 NCgl1013 NCgl1016 NCgl1018 NCgl1022 NCgl1034 NCgl1036 NCgl1038 NCgl1039 NCgl1041
NCgl1042 NCgl1043 NCgl1044 NCgl1045 NCgl1046 NCgl1049 NCgl1050 NCgl1052 NCgl1053 NCgl1054
NCgl1066 NCgl1073 NCgl1084 NCgl1091 NCgl1140 NCgl1142 NCgl1146 NCgl1152 NCgl1157 NCgl1158
NCgl1160 NCgl1168 NCgl1169 NCgl1173 NCgl1177 NCgl1192 NCgl1205 NCgl1223 NCgl1226 NCgl1234
NCgl1236 NCgl1254 NCgl1255 NCgl1260 NCgl1274 NCgl1276 NCgl1287 NCgl1297 NCgl1298 NCgl1300
NCgl1302 NCgl1303 NCgl1306 NCgl1307 NCgl1309 NCgl1312 NCgl1317 NCgl1335 NCgl1336 NCgl1337
NCgl1338 NCgl1339 NCgl1342 NCgl1351 NCgl1352 NCgl1357 NCgl1362 NCgl1368 NCgl1371 NCgl1372
NCgl1381 NCgl1382 NCgl1408 NCgl1429 NCgl1435 NCgl1451 NCgl1456 NCgl1457 NCgl1458 NCgl1461
NCgl1462 NCgl1475 NCgl1484 NCgl1485 NCgl1508 NCgl1519 NCgl1520 NCgl1526 NCgl1552 NCgl1553
NCgl1555 NCgl1556 NCgl1570 NCgl1571 NCgl1579 NCgl1617 NCgl1650 NCgl1651 NCgl1652 NCgl1655
NCgl1675 NCgl1676 NCgl1677 NCgl1679 NCgl1680 NCgl1681 NCgl1682 NCgl1683 NCgl1684 NCgl1685
NCgl1686 NCgl1687 NCgl1688 NCgl1689 NCgl1690 NCgl1691 NCgl1692 NCgl1693 NCgl1694 NCgl1696
NCgl1697 NCgl1698 NCgl1699 NCgl1700 NCgl1701 NCgl1702 NCgl1703 NCgl1704 NCgl1705 NCgl1706
NCgl1707 NCgl1708 NCgl1709 NCgl1710 NCgl1711 NCgl1712 NCgl1713 NCgl1714 NCgl1716 NCgl1717
NCgl1720 NCgl1721 NCgl1722 NCgl1723 NCgl1726 NCgl1727 NCgl1728 NCgl1729 NCgl1730 NCgl1732
NCgl1736 NCgl1737 NCgl1738 NCgl1739 NCgl1740 NCgl1741 NCgl1742 NCgl1743 NCgl1744 NCgl1745
NCgl1746 NCgl1747 NCgl1748 NCgl1749 NCgl1750 NCgl1751 NCgl1752 NCgl1753 NCgl1754 NCgl1755
NCgl1756 NCgl1757 NCgl1758 NCgl1759 NCgl1761 NCgl1762 NCgl1763 NCgl1764 NCgl1765 NCgl1766
NCgl1767 NCgl1768 NCgl1769 NCgl1770 NCgl1771 NCgl1772 NCgl1773 NCgl1774 NCgl1775 NCgl1777
NCgl1778 NCgl1779 NCgl1780 NCgl1781 NCgl1782 NCgl1783 NCgl1784 NCgl1785 NCgl1786 NCgl1787
NCgl1788 NCgl1789 NCgl1791 NCgl1792 NCgl1793 NCgl1794 NCgl1795 NCgl1796 NCgl1797 NCgl1798
NCgl1799 NCgl1800 NCgl1801 NCgl1802 NCgl1803 NCgl1804 NCgl1805 NCgl1806 NCgl1807 NCgl1808
NCgl1809 NCgl1810 NCgl1812 NCgl1813 NCgl1814 NCgl1815 NCgl1817 NCgl1818 NCgl1819 NCgl1820
NCgl1821 NCgl1822 NCgl1823 NCgl1824 NCgl1826 NCgl1827 NCgl1828 NCgl1829 NCgl1830 NCgl1831
NCgl1832 NCgl1833 NCgl1835 NCgl1837 NCgl1838 NCgl1841 NCgl1843 NCgl1844 NCgl1845 NCgl1848
NCgl1890 NCgl1891 NCgl1892 NCgl1893 NCgl1894 NCgl2000 NCgl2013 NCgl2036 NCgl2046 NCgl2063
NCgl2067 NCgl2068 NCgl2069 NCgl2070 NCgl2085 NCgl2109 NCgl2146 NCgl2147 NCgl2149 NCgl2182
NCgl2202 NCgl2216 NCgl2221 NCgl2223 NCgl2225 NCgl2235 NCgl2244 NCgl2247 NCgl2253 NCgl2260
NCgl2261 NCgl2262 NCgl2263 NCgl2299 NCgl2317 NCgl2318 NCgl2319 NCgl2330 NCgl2361 NCgl2373
NCgl2388 NCgl2403 NCgl2413 NCgl2417 NCgl2420 NCgl2421 NCgl2424 NCgl2427 NCgl2428 NCgl2452
NCgl2458 NCgl2461 NCgl2464 NCgl2466 NCgl2469 NCgl2476 NCgl2478 NCgl2483 NCgl2493 NCgl2494
NCgl2502 NCgl2503 NCgl2520 NCgl2524 NCgl2529 NCgl2546 NCgl2547 NCgl2548 NCgl2555 NCgl2556
NCgl2557 NCgl2561 NCgl2593 NCgl2602 NCgl2609 NCgl2614 NCgl2615 NCgl2620 NCgl2621 NCgl2633
NCgl2634 NCgl2635 NCgl2636 NCgl2639 NCgl2643 NCgl2649 NCgl2650 NCgl2657 NCgl2669 NCgl2681
NCgl2682 NCgl2701 NCgl2718 NCgl2720 NCgl2721 NCgl2722 NCgl2723 NCgl2724 NCgl2725 NCgl2745
NCgl2756 NCgl2758 NCgl2760 NCgl2765 NCgl2782 NCgl2783 NCgl2787 NCgl2788 NCgl2789 NCgl2811
NCgl2819 NCgl2820 NCgl2821 NCgl2823 NCgl2824 NCgl2825 NCgl2849 NCgl2850 NCgl2877 NCgl2886
NCgl2903 NCgl2904 NCgl2909 NCgl2919 NCgl2920 NCgl2922 NCgl2924 NCgl2951 NCgl2952 NCgl2953
NCgl2956 NCgl2957 NCgl2958 NCgl2960 NCgl2963 NCgl2972 NCgl2973 NCgl2975 NCgl2997 NCgl3014
NCgl3043 NCgl3047 NCgl3048 NCgl3049 NCgl3050 NCgl3054 NCgl3059 NCgl3060 NCgl3061 NCgl3067
NCgl3070 NCgl3071 NCgl3077 NCgl3077 NCgl3078 NCgl3099 tnp2f tnp6a int2

Laterally Transferred Genes

Gene Putative DonorFunction based on Annotation
cg1028 Nitrococcus/Shewanella sp. Putative restriction-modification system: methylase
cg1770 Proteobacteria DNA or RNA helicase of superfamily II
cg1985 Clostridium beijeirnikum Superfamily I DNA or RNA helicase
cg3120 Bacteroides thetaiotaomicron Hypothetical protein
NCgl0039 Acinetoabcter baumanii Hypothetical membrane protein
NCgl0059 Methanosarcina acetivorans Hypothetical protein
NCgl0060 Methanosarcina acetivorans Mg2+ and Co2+ transporter protein
NCgl0093 Leptospira interrogens Molecular chaperone, HSP90 family
NCgl0110 Pseudomonas syringae deoR family transcriptional regulator of sugar metabolism
NCgl0115 Proteobacteria 3-methyladenine DNA glycosylase
NCgl0176 Caulobacter crescentus Transcriptional regulator
NCgl0177 Acinetobacter sp. Hypothetical membrane protein
NCgl0220 Proteobacteria Monoamine oxidase
NCgl0221 Pelobacter carbanolicus Mg/Co/Ni transporter MgtE
NCgl0223 Methylococcus capsulatus Prephenate dehydrogenase
NCgl0234 Natronomonas pharaonis Hypothetical dioxygenase protein
NCgl0314 Vibrio vulnificus Zn-dependent hydrolase or glyoxylase
NCgl0349 Desulfuromonas acetoxidans Hypothetical membrane protein
NCgl0734 Lactobacillus casei Hypothetical protein
NCgl0896 Bacillus subtilis ABC-type transporter, ATPase component
NCgl0902 Shewanella oneidiensis Ribosomal protein L25
NCgl0940 Bdellovibrio bacteriovorus Hypothetical protein
NCgl0980 Desulfitobacter hafniense Exonuclease VII small subunit
NCgl1011 Mesorhizobium loti Hypothetical protein
NCgl1036 Ralstonia metallidurans Putative adenylate kinase
NCgl1038 Thiomicrospira crunogena Hypothetical protein
NCgl1046 Shewanella putrifaciens Hypothetical protein
NCgl1049 Bacteroides fragilis Arsenate reductase
NCgl1168 Streptococcus pyogenes Predicted nuclease of the RecB family
NCgl1260 Firmicutes guanosine polyphosphate pyrophosphohydrolases/synthetases
NCgl1274 Burkholderia pseudomallei N6-adenine-specific methylase
NCgl1287 Sinorhizobium meliloti Hypothetical protein
NCgl1298 Methanosarcina barkeri Hypothetical membrane protein
NCgl1342 Tropheryma whipplei N-acetylglutamate kinase
NCgl1371 Terrrabacter sp. 16S rRNA uridine-516 pseudouridylate synthase
NCgl1372 Terrrabacter sp. Cytidylate kinase
NCgl1381 Firmicutes Hypothetical protein
NCgl1461 Oceanobaillus iheyensis Dihydroorotate dehydrogenase
NCgl1508 Bdellovibrio bacteriovorus Cytochrome oxidase assembly protein
NCgl1687 Thermotoga maritima Hypothetical protein
NCgl1698 Staphylococcus epidermidis Hypothetical protein
NCgl1705 Proteobacteria Stress-sensitive restriction system protein 2
NCgl1711 Streptococcus sp. Hypothetical protein
NCgl1727 Geobacter sulfurreducens Hypothetical membrane protein
NCgl1739 Oceanobaillus iheyensis Hypothetical protein
NCgl1740 Lactobacillus delbrueckii Hypothetical protein
NCgl1743 Lactobacillus delbrueckii Hypothetical protein
NCgl1748 Cenarchaeum symbiosum Periplasmic serine protease
NCgl1754 Neurospora crassa Hypothetical protein
NCgl1765 Lactobacillus delbrueckii Hypothetical protein
NCgl1777 Bacillus cereus Hypothetical protein
NCgl1778 Bacillus cereus Hypothetical protein
NCgl1779 Rubrobacter sp. Micrococcal nuclease-like protein
NCgl1781 Rhodopirellula baltica Hypothetical protein
NCgl1784 Staphyloccus sp. Hypothetical protein
NCgl1786 Streptococcus agalactiae Hypothetical protein
NCgl1793 Fungi Hypothetical protein
NCgl1806 Proteobacteria Integrase
NCgl1817 Streptococcus agalactiae Di- and tricarboxylate transporter
NCgl1823 Cenarchaeum symbiosum Hypothetical protein
NCgl1841 Leuconostoc mesenteroides Hypothetical membrane protein
NCgl1844 Mycoplasma hypopneumoniae DNA-directed RNA polymerase sigma subunit SigB
NCgl2000 Desulfitobacter hafniense Glycerate kinase
NCgl2068 Xanthomonas sp. Isoleucyl-tRNA synthetase
NCgl2318 Bacillus clausii Putative chloromuconate cycloisomerase
NCgl2427 Rhodobacter spaeroides L-aminopeptidase/D-esterase
NCgl2476 Burkholderia sp. Succinyl-CoA synthetase alpha subunit
NCgl2520 Magnetospirillum magnetotacticum Hypothetical protein
NCgl2555 Staphylococcus saprophyticus Glucosamine-6-phosphate isomerase
NCgl2556 Magnetospirillum magnetotacticum N-acetylglucosamine-6-phosphate deacetylase
NCgl2643 Actinobacillus succinogenes N-formylmethionyl-tRNA deformylase
NCgl2650 Porphyromonas gingivalis ABC-type transporter, permease component
NCgl2725 Aspergillus nidulans Hypothetical membrane protein
NCgl2819 Bacteroides thetaiotaomicron Hypothetical protein

Species specific genes of Corynebacterium jeikeium

acpA acpM acx add ahpC ahpF alkM alr asa cbpA
choE cmk cysY deoD dhbB dhbE dhbF dnaQ echA4 entA
fabG2 fadB1 fadE3 fadH fes fxbA gcp gcvH gcvP gcvT
glpQ hisE hscA hsdM2 hsdS2 htpX ilvA jk0009 jk0012 jk0018
jk0029 jk0032 jk0043 jk0046 jk0048 jk0050 jk0052 jk0057 jk0060 jk0068
jk0070 jk0071 jk0082 jk0111 jk0140 jk0141 jk0142 jk0145 jk0176 jk0177
jk0178 jk0189 jk0196 jk0199 jk0200 jk0203 jk0206 jk0208 jk0217 jk0227
jk0228 jk0231 jk0232 jk0244 jk0257 jk0262 jk0311 jk0321 jk0323 jk0324
jk0335 jk0336 jk0344 jk0371 jk0385 jk0406 jk0410 jk0411 jk0413 jk0415
jk0428 jk0434 jk0435 jk0439 jk0442 jk0443 jk0447 jk0462 jk0485 jk0488
jk0489 jk0490 jk0502 jk0516 jk0517 jk0523 jk0524 jk0528 jk0547 jk0552
jk0553 jk0571 jk0574 jk0578 jk0580 jk0585 jk0607 jk0608 jk0620 jk0640
jk0641 jk0642 jk0643 jk0644 jk0645 jk0646 jk0647 jk0648 jk0649 jk0650
jk0653 jk0671 jk0672 jk0680 jk0683 jk0693 jk0694 jk0699 jk0700 jk0723
jk0726 jk0756 jk0759 jk0769 jk0770 jk0805 jk0810 jk0811 jk0816 jk0817
jk0821 jk0824 jk0826 jk0859 jk0893 jk0894 jk0895 jk0907 jk0916 jk0923
jk0928 jk0929 jk0930 jk0974 jk0975 jk1034 jk1069 jk1080 jk1099 jk1143
jk1154 jk1156 jk1176 jk1180 jk1203 jk1225 jk1234 jk1237 jk1247 jk1248
jk1249 jk1250 jk1274 jk1276 jk1284 jk1287 jk1305 jk1307 jk1310 jk1319
jk1327 jk1388 jk1410 jk1417 jk1419 jk1420 jk1435 jk1440 jk1441 jk1443
jk1455 jk1478 jk1489 jk1501 jk1515 jk1526 jk1539 jk1541 jk1542 jk1548
jk1552 jk1555 jk1567 jk1569 jk1571 jk1572 jk1573 jk1575 jk1580 jk1590
jk1600 jk1607 jk1608 jk1615 jk1639 jk1678 jk1704 jk1706 jk1707 jk1721
jk1725 jk1738 jk1742 jk1751 jk1783 jk1798 jk1815 jk1838 jk1850 jk1872
jk1874 jk1881 jk1889 jk1903 jk1904 jk1913 jk1924 jk1947 jk1950 jk1953
jk1957 jk1958 jk1961 jk1963 jk2000 jk2001 jk2009 jk2026 jk2038 jk2044
jk2045 jk2053 jk2057 jk2058 jk2059 jk2063 jk2070 jk2072 jk2080 jk2096
kdpA kdpB kdpC kdpD lipN matE mbtG mnhF mrr mxcB
nanA ocd ogt parB pbp1A pepA pknG pknJ pstX pvdA
resC rimJ rmlC rplM rpmD rpmH rshA rubA sapD sapE
sigM sigW ssb2 surA surB tcsS2 thiS thrC tnp3504a1 tnp3504e2
tnp3504j2 tnp3511a tnp3513a tnp3516d2 tnp3522a1 tnp3522a2 tnp3524a2 tnp3526 tnp3595 trpE
uvrA2 viuB cjk_0643

Laterally Transferred Genes

Gene Putative DonorFunction based on Annotation
acpA Franscisella talurensis Hypothetical protein
fes Yersinia fredrickseni Putative enterochelin esterase
jk0335 Bacillus sp. Hypothetical protein
jk0336 Streptococcus sp. Putative DNA recombinase
jk0410 Bordetella bronchiseptica Putative transcriptional regulator (LysR family)
jk0462 Microbulbifer degradans Putative helicase
jk0489 Carboxydothermus hydrogenoformans Hypothetical protein
jk0524 Thiomicrospira denitrificans Hypothetical protein
jk0640 Streptococcus sp. Hypothetical protein
jk0650 Actinobacillus pleuropneumoniae Putative nitroreductase family protein
jk0653 Actinobacillus pleuropneumoniae Putative nitroreductase family protein
jk0683 Rhodopseudomonas palustris Hypothetical protein
jk0894 Treponema denticola Hypothetical protein
jk0929 Lactobacillus sp. Putative permease of the major facilitator superfamily
jk0930 Treponema denticola Putative beta-glucosidase
jk1156 Sphingopyxis alaskensis Putative transcriptional regulator (GntR family)
jk1180 Thermotoga maritima Hypothetical protein
jk1248 Ralstonia sp. Hypothetical protein
jk1284 Geobacillus kaustophilus Putative oxidoreductase
jk1707 Xanthomonas sp. Hypothetical protein
jk1742 Lactobacillus casei Hypothetical protein
jk1838 Enterococcus faecium Putative transcriptional regulator (GntR family)
jk1947 Leuconostoc mesenteroides Putative 1-acylglycerol-3-phosphate O-acyltransferase
jk1950 Streptococcus sp. Putative transcriptional regulator (MarR family)
jk2038 Burkholderia sp. Hypothetical protein
jk2063 Proteobacteria Putative flavin-binding monooxygenase
lipN Photorhabdus luminescens Putative lipase/esterase LipN
pknJ Rhodoferax ferrireducens Serine/threonine protein kinase PknJ
sigM Mesorhizobium sp. ECF-family sigma factor M
surA Streptococcus sp. Hypothetical protein
surB Lactobacillus sp. Hypothetical protein

Department of Biology, McMaster University
1280 Main Street West, Hamilton, Ontario L8S 4K1
Canada