Dear Colleagues, I have the pleasure to invite you to contribute to our symposium at the upcoming ESEB meeting in Barcelona www.eseb2025.com entitled "Genome Architecture and Their Role in Evolution" This Symposium is organised by Marcial Escudero, Petr Nguyen and myself Our symposium addresses one of the most transformative areas in evolutionary biology: how genomic structures shape evolution, in particular species formation and adaptation. This topic is timely and relevant, considering recent advances in genomics that reveal the significance of structural changes - such as genomic rearrangements, satellite DNA dynamics, and structure of centromeres - in driving speciation, adaptation, and sexual system evolution. This symposium will stimulate discussion on the cellular mechanisms by which genome architecture changes influence evolutionary processes, therefore bridge between the fields of cell biology, genomics and speciation. Our keynote speakers are: Dr. Kohta Yoshida whose experimental work on genomic rearrangements in nematodes offers a novel perspective on speciation and sexual system evolution, while Dr. Melissa Toups whose research on sex chromosomes provides essential insights into the drivers of sex chromosome turnover and recombination suppression. With kind regards Kay Prof. Dr. Kay Lucek Biodiversity Genomics Laboratory University of Neuchatel rue Emile-Argand 11 2000 Neuchatel Switzerland LUCEK Kay (to subscribe/unsubscribe the EvolDir send mail to golding@mcmaster.ca)