The *Journal of Molecular Evolution* has established a series of periodic meetings rotating around the continents. The first meeting was in Washington, DC in March, 2023. We now are proud to organize the second meeting in Madrid, Spain, August 25-28, 2025, with support from Springer Nature and the National Museum of Natural Sciences-CSIC (Spain). Timed to coordinate in the days after the European Society of Evolution Biology meeting *ESEB 2025* in Barcelona, August 17-22, 2025, this meeting with free registration will feature invited talks from editorial board members, selected talks from submitted abstracts, and a poster session. https://www.mncn.csic.es/es/investigacion/JME2025 Cara Weisman (to subscribe/unsubscribe the EvolDir send mail to golding@mcmaster.ca)