The 27th annual Bioinformatics Open Source Conference (BOSC 2026) arrives in Washington, DC, this July 14-15 as a COSI track of ISMB 2026. This year's program features visionary keynotes from Dr. Maryam Zaringhalam (Center for Open Science) and Dr. Eric Green (Illumina), alongside two panels on "Policies and Strategies for Resilient Open Science" and "Open Source in the Age of AI." From cutting-edge talks to the post-conference CollaborationFest (July 17-18), BOSC remains the essential gathering for those driving the future of open science and reproducible research. Help shape the global conversation by submitting your abstracts for talks and posters across topics such as data science, workflows, open AI/ML, translational bioinformatics, and outreach & training. The deadline for talk consideration is April 9, and no extensions will be granted. We are committed to an accessible community; if registration costs are a barrier, fee assistance is available (to those who qualify) to ensure all voices can participate. Don't miss your chance to contribute to the Open Source ecosystem. Scientists at all career levels are welcome! Submit your work and join us in DC this summer! Sincerely, The BOSC 2026 Organizing Committee - Nomi Harris, Karsten Hokamp, Jessica Maia, Hervé Ménager, Mónica Muñoz Torres, Van Truong, Deepak Unni, and Jason Williams. Learn more about BOSC 2026 at: https://www.open-bio.org/events/bosc-2026 Submit your abstract at https://www.open-bio.org/events/bosc-2026/submit With immense gratitude to our Gold Sponsors: The NIH Office of Data Science Strategy (ODSS) (https://datascience.nih.gov) and Seqera (https://seqera.io ). Join the Open Science conversation on social media: LinkedIn: https://www.linkedin.com/groups/14344023/ Bluesky: https://bsky.app/profile/bosc.bsky.social Slack: https://join.slack.com/t/obf-bosc/shared_invite/zt-n5ur1gsj-z2C~69_4lYTFPg5tbWA8Ew Monica Munoz Torres (to subscribe/unsubscribe the EvolDir send mail to golding@mcmaster.ca)