We are looking for a PhD student in evolutionary genetics interested
in contributing to a better understanding of the mechanisms that shape
mutation rates.

The project:
Germline mutations are the source of genetic variation and the
mechanism that fuels evolutionary change. They also influence a range
of evolutionary phenomena, including mutation load, extinction rates,
inbreeding depression and the maintenance of outcrossing. Additionally,
germline mutations are a major cause of disease. Understanding the factors
that shape the germline mutation rate has therefore been a long-standing
goal in evolutionary biology, but our appreciation of these factors
remains limited.  Mutations also occur in somatic cells. While these are
not inherited across generations, they are the main cause of cancer and
have been suggested to contribute to general ageing. The factors that
govern the somatic mutation rate are even less understood than those
that determine the germline mutation rate, and virtually nothing is
known about a putative connection between these mutation rates.

Using several Drosophila melanogaster model systems, in combination with
quantitative genetics, experimental evolution and direct manipulation of
resource allocation patterns, this project aims to explore somatic and
germline mutation rates from a life-history perspective, to determine
whether they are integrated components of organisms' general life-history
decisions. The work involves accumulation of mutations in different fly
lines, extracting DNA and building libraries for sequencing, as well as
bioinformatics analyses of sequence data.

Requirements:
Competitive candidates should have a strong interest in evolutionary
genetics, excellent analytical skills, and the ability to work both
independently and as part of a team. Excellent written and verbal
communication skills in English are essential. Candidates are further
expected to have experience in processing and analyzing high-throughput
genomic sequencing data and in statistical analysis. Previous experience
with Drosophila melanogaster or other insect systems, DNA extraction,
and library preparation is beneficial but not required.

We offer:
The position is fully funded for 4 years and may be extended for
up to 1 year, as students often teach 20% of their time. You can
read more about employment benefits at Link?ping University at
https://liu.se/en/work-at-liu/employee-benefits

Your workplace:
The PhD position is placed in the research group led by Professor
Urban Friberg at Link?ping University. Research in the group
focuses broadly on the evolutionary genetics of aging and sex
differences. You can read more about research in our group here
https://liu.se/en/research/friberg-lab. The PhD project is a collaboration
with Associate professor Martin Johnsson at SLU Uppsala and Professor
Matthew Webster at BMC Uppsala.

Link?ping University is a modern university, which attracts some 27
000 students from all over the world, offering an international and
stimulating research environment as well as providing a multitude of
opportunities for collaboration and social interactions. Link?ping is
situated in central Sweden, conveniently located only a couple of hours
by train/car from Stockholm and have beautiful and easily accessible
surroundings.

Application procedure:
All applications should be submitted through the Link?ping University
application system. Read more about the position and how to apply here
https://liu.se/en/work-at-liu/vacancies/26479

Please submit your application by May 5, 2025.

For informal enquiries about the position, please contact Professor
Urban Friberg: urban.friberg@liu.se

urban.friberg@liu.se

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