We invite applications for a postdoc position within the project "The influence of ecological factors on the quiescent state: from the characteristics of individual eukaryotic cells to population dynamics", funded by the Polish National Science Centre (NCN) OPUS grant. About the Project Background information: Quiescence (Q) is a fundamental survival state in eukaryotic cells, allowing organisms to persist under starvation conditions. The project aims to explore the cellular and molecular mechanisms underlying quiescent state variability and its impact on adaptation, antifungal resistance, and population dynamics. The project investigates how individual quiescent cells reorganize their internal structures and how these changes influence population-level survival, stress tolerance, and adaptation. Main questions are: What structural and metabolic changes occur in single quiescent cells over time, and how do they impact survival and regrowth? How do different quiescent phenotypes respond to antifungal treatments, and what are the mechanisms of resistance? How does population density affect quiescence-related survival strategies, and how the Allee Effect influence quiescent cell fitness? What evolutionary trade-offs exist between quiescence depth, regrowth potential, and stress resistance? About the Position The Postdoctoral researcher will focus on developing and applying advanced microscopy, microfluidics, and single-cell analysis techniques to investigate quiescence mainly at the individual cell level. The candidate will: * Characterize cytoskeletal, mitochondrial, and metabolic changes in quiescent cells. * Conduct live-cell imaging experiments to monitor quiescent cell aging and reactivation dynamics. * Investigate antifungal resistance mechanisms in quiescent yeast populations. * Collaborate with international partners to integrate advanced imaging and microfluidic technologies into the research workflow. * Contribute to mathematical modelling efforts linking single-cell characteristics to population-level dynamics. Host Institution & Location The PhD student will be based at the Institute of Environmental Sciences, Faculty of Biology of the Jagiellonian University in Kraków, Poland - one of the leading research institutes in Ecology and Evolution in Central Europe (www.eko.uj.edu.pl/en_GB). Kraków is a vibrant city with a rich cultural scene (European City of Culture 2000), hosting over 100 festivals and numerous cultural events annually. The city offers modern museums, theaters, cinemas, restaurants, and excellent access to outdoor activities such as hiking and biking. It is also well-connected to other European cities. Founding & Salary The position is for 4 years (after successful 1 year probation) and the salary is 140k PLN/year before tax. To estimate living costs in Kraków, applicants can use tools such as Numbeo (www.numbeo.com). Requirements * Hold a doctoral degree in an appropriate field (exact and natural sciences) obtained no earlier than seven years before 1st January 2026 (extensions possible, e.g., due to parental leave); and not obtained at the Jagiellonian University * Documented track record of scientific publications in peer- reviewed journals. * Proven experience in fluorescence microscopy, image analysis, and/or preferably microfluidic single-cell analysis techniques. * Motivation to initiate and grow a microfluidics research laboratory. * Strong analytical skills, combined with the ability to work independently while effectively coordinating and communicating within a multidisciplinary team. * Fluency in written and spoken English, as well as communication and organisational skills. * Readiness to collaborate with international research groups and to undertake short research stays abroad. * Willingness to mentor Ph.D. and Master's students within the laboratory. Deadline & Selection Process If interested, please send a cover letter explaining your background, skills, and interest in the project, CV, and contact information of two academics willing to provide references to dr hab. Dominika W³och-Salamon, Prof. UJ (dominika.wloch-salamon@uj.edu.pl). Review of applications is ongoing; apply by 22nd December, 2025 to ensure full consideration. The start date of the position is as soon as possible in 2026. We look forward to receiving your application! dr hab. Dominika W³och-Salamon prof. UJ Instytut Nauk o Œrodowisku/ Institute of Environmental Sciences Uniwersytet Jagielloñski/ Jagiellonian University + 48 12 664-51-35 ul. Gronostajowa 7; 30-387 Kraków ORCID: 0000-0002-0040-1838 "Science and everyday life cannot and should not be separated." Rosalind Franklin Dominika W³och-Salamon (to subscribe/unsubscribe the EvolDir send mail to golding@mcmaster.ca)