Postdoc position in microbiology with a focus on antibiotic heteroresistance At the Department of Medical Biochemistry and Microbiology, Uppsala University. Time-limited postdoc stipend 100% during 2 years beginning as soon as possible. Research group: Prof. Dan Andersson's research group is part of the Department of Medical Biochemistry and Microbiology and we work on bacterial genetics and evolution with a special focus on evolution of antibiotic resistance. The group presently consists of 15 people. More information can be found at: https://www.uu.se/en/department/medical-biochemistry-and-microbiology/research/andersson-dan-i Research project: The overall aim of this project is to understand the dynamics and fitness effects of gene copy number variation in bacteria. Of special interest is heteroresistance, a phenotype where in a main population of susceptible bacteria there exists a small resistant sub-population. We have previously shown that four different mechanisms can cause a transient increase in the copy number of antibiotic resistance genes and generate the resistant sub-population. These gene copy number (GCN) increases carry fitness costs that can be genetically ameliorated by compensatory stable resistance mutations that are less costly than the original copy number increase. These findings led to the novel hypothesis that heteroresistance mediated by GCN changes can facilitate and precede the evolution towards stable resistance. In this project, we want to understand the mechanisms underpinning the fitness costs of increased GCNs and whether the compensatory evolution also can be observed in antibiotic-treated patients. Qualifications: We are looking for a postdoc that has a PhD in microbiology, molecular biology, evolutionary biology or similar. The project will involve physiological and genetic analysis of bacteria (mainly E. coli), experimental evolution and WGS. We want a person with high creativity, ability to independently plan experiments as well as excellent analytical and practical skills. You should have high skills in written and spoken English and the ability to work in an interdisciplinary team. Instructions for application: Please send your application compiled in a single pdf file to Prof. Dan I. Andersson (Dan.Andersson@imbim.uu.se) before 31 Jan 2025 and include in your application. - A short letter that describes your research interests and a motivation for why you would be suitable for this position (maximum 2 pages) - Curriculum vitae including publication list - Copy of proof of passed PhD exam - Names, email addresses and telephone numbers to three references Dan I. Andersson, PhD Professor in Medical Bacteriology Director Uppsala Antibiotic Center (www.uac.uu.se) Uppsala University Dept. of Medical Biochemistry andMicrobiology Box 582, SE-751 23, Uppsala, Sweden phone: +46 (0)18 4714175 email:dan.andersson@imbim.uu.se Organisation number (UppsalaUniversity): 202100-2932 Web: www.uu.se Facebook:www.facebook.com/uppsala.universitet Twitter: @Uppsalauni Page Title När du har kontakt med oss på Uppsala universitet med e-post så innebär det att vi behandlar dina personuppgifter. För att läsa mer om hur vi gör det kan du läsa här: http://www.uu.se/om-uu/dataskydd-personuppgifter/ E-mailing Uppsala University means that we will process your personal data. For more information on how this is performed, please read here: http://www.uu.se/en/about-uu/data-protection-policy "Dan I. Andersson" (to subscribe/unsubscribe the EvolDir send mail to golding@mcmaster.ca)