Dear all,

We are pleased to announce the upcoming Physalia online course Practical
Somatic Variant Analysis in Cancer Genomics, taking place on 27-29
April .

Course website: ( https://www.physalia-courses.org/courses-workshops/cg26/
)

This 3-day hands-on workshop is designed to provide practical skills
in cancer genomics, with a strong focus on somatic variant detection,
annotation, and interpretation. Participants will follow the complete
analysis workflow, from raw sequencing data to the identification and
prioritization of potentially pathogenic mutations relevant to cancer
research and precision oncology.

The course combines theoretical lectures and hands-on sessions, using
whole-exome sequencing (WES) data from matched tumor-normal samples. All
reference resources (GRCh38, Panel of Normals, gnomAD, ClinVar, REVEL,
and other cancer-relevant databases) will be pre-staged for participants.

Key topics include:

Quality control and preprocessing of sequencing data

Read alignment and assessment of alignment quality

Biological and computational differences between germline and somatic
variants

Somatic variant calling using GATK4 Mutect2

Variant filtering strategies and use of population databases

Variant annotation with Ensembl VEP

Variant analysis, prioritization, and visualization in R Best regards,

Carlo

Carlo Pecoraro, Ph.D
Physalia-courses DIRECTOR
info@physalia-courses.org
mobile: +49 17645230846
( https://www.linkedin.com/in/physalia-courses-a64418127/ )

"info@physalia-courses.org" <info@physalia-courses.org>

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