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Volume 227, Issue 4
August 2024
EISSN 1943-2631

Volume 227, Issue 4, August 2024

The 2024 GSA Honors and Awards

Jef D Boeke and the Build-A-Genome Course
Genetics, Volume 227, Issue 4, August 2024, iyae083, https://doi.org/10.1093/genetics/iyae083

Review

Abraham Pedroza-Torres and others
Genetics, Volume 227, Issue 4, August 2024, iyae097, https://doi.org/10.1093/genetics/iyae097

WormBook

Cell and Organelle Biology

Juan Wang and others
Genetics, Volume 227, Issue 4, August 2024, iyae088, https://doi.org/10.1093/genetics/iyae088

Extracellular vesicles (EV) play increasingly diverse roles during development, physiology, and disease. In vivo studies in the nematode Caenorhabditis elegans have revealed insights into the mechanisms of EV formation and an array of EV functions for the EV-releasing cell or EV-receiving cells. This review summarizes the current state of the art and important directions for future research.

Meera V Sundaram and Nathalie Pujol
Genetics, Volume 227, Issue 4, August 2024, iyae072, https://doi.org/10.1093/genetics/iyae072

Brief Investigation

Cellular Genetics

Nicholas D Serra and others
Genetics, Volume 227, Issue 4, August 2024, iyae081, https://doi.org/10.1093/genetics/iyae081

Hedgehog is an important signaling protein in many organisms. Nematodes lack Hedgehog and most of its canonical signaling partners but instead have many divergent Hedgehog-related (Hh-r) secreted proteins and Patched-related transmembrane proteins related to the Hedgehog receptor. The authors show that C. elegans Hh-r proteins are stable components of the apical extracellular matrices that coat and protect external epithelia. These results can explain many phenotypes of Hh-r mutants and highlight ancient connections between Hedgehog proteins and the extracellular matrix.

Investigation

Cellular Genetics

Mitsutoshi Nakamura and Susan M Parkhurst
Genetics, Volume 227, Issue 4, August 2024, iyae101, https://doi.org/10.1093/genetics/iyae101

Cells have rapid and robust repair systems to survive daily damage. This study shows that calcium influx regulates the three distinct Drosophila Annexin recruitment patterns to the cell wound in order to organize an actomyosin ring for efficient wound closure.

Experimental Technologies and Resources

Kevin G Nyberg and others
Genetics, Volume 227, Issue 4, August 2024, iyae067, https://doi.org/10.1093/genetics/iyae067

Techniques for genetic manipulation in Drosophila melanogaster are powerful but not without limitations. Here, the authors detail a novel approach to achieve strong RNA knockdown in Drosophila using self-cleaving ribozymes. Ribozyme insertion via CRISPR/Cas9 into both nuclear and cytoplasmic noncoding RNAs and a male-specific splice variant of doublesex resulted in cleavage and efficient degradation of 3’ RNA fragments without observable off-target effects. This work demonstrates the potential of self-cleaving ribozymes for gene knockdown in Drosophila.

Gene Expression

Kalpana Makhijani and others
Genetics, Volume 227, Issue 4, August 2024, iyae087, https://doi.org/10.1093/genetics/iyae087

Genetics of Complex Traits

Haolong Wang and others
Genetics, Volume 227, Issue 4, August 2024, iyae090, https://doi.org/10.1093/genetics/iyae090
Shizhong Xu
Genetics, Volume 227, Issue 4, August 2024, iyae095, https://doi.org/10.1093/genetics/iyae095

Genome and Systems Biology

Carl E Hjelmen
Genetics, Volume 227, Issue 4, August 2024, iyae099, https://doi.org/10.1093/genetics/iyae099

This work highlights the importance of genome size and chromosome number in assembly assessment. While more than 41,000 eukaryotic genomes are available, only about 15,000 of them have corresponding genome size estimations. This work assesses the completeness of these genome assemblies in terms of deviation from estimated genome size and its relationship to a number of factors and assembly assessments. A new assembly assessment is proposed which is comparable across genomes with varying sizes and architecture.

Genome Integrity and Transmission

Bowen Man and others
Genetics, Volume 227, Issue 4, August 2024, iyae084, https://doi.org/10.1093/genetics/iyae084
Grant W Brown
Genetics, Volume 227, Issue 4, August 2024, iyae092, https://doi.org/10.1093/genetics/iyae092
Qianyan Li and others
Genetics, Volume 227, Issue 4, August 2024, iyae102, https://doi.org/10.1093/genetics/iyae102

Population and Evolutionary Genetics

Megan L Smith and Matthew W Hahn
Genetics, Volume 227, Issue 4, August 2024, iyae089, https://doi.org/10.1093/genetics/iyae089
Zachary B Hancock and others
Genetics, Volume 227, Issue 4, August 2024, iyae094, https://doi.org/10.1093/genetics/iyae094

Statistical Genetics and Genomics

Yifan Chen and others
Genetics, Volume 227, Issue 4, August 2024, iyae091, https://doi.org/10.1093/genetics/iyae091
Ivan Pocrnic and others
Genetics, Volume 227, Issue 4, August 2024, iyae103, https://doi.org/10.1093/genetics/iyae103
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