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Volume 655 Issue 8122, 9 July 2026
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Volume 655 Issue 8122, 9 July 2026

Discovery channels

Scientific discovery is essentially an iterative process, following the cycle of generating a hypothesis, designing an experiment to test that hypothesis and analysing the data collected. A key limiting factor in this process, especially in today’s increasingly multidisciplinary research landscape, is the depth and breadth of knowledge researchers can bring to bear on a given problem — people can only read so fast and assimilate so much. Two papers in this week’s issue present independent multi-agent AI systems aimed at helping researchers speed up the laboratory research cycle. Both systems can generate hypotheses, propose experiments to test their ideas, interpret the experimental results and then refine hypotheses on the basis of the data. Google DeepMind built its lab assistant, called Co-Scientist, with the large language model Gemini 2.0 and used it to seek out potential drug candidates to treat acute myeloid leukaemia. FutureHouse created its assistant, known as Robin, using OpenAI o4-mini and Anthropic Claude 3.7. It, too, was also designed to aid drug discovery, in this case potential treatments for dry age-related macular degeneration. Both teams emphasize that their systems are designed to collaborate with researchers, with human scientists remaining in control.

Cover image: Carl De Torres/Optics Lab.

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Research

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    • This Review examines the opportunities and challenges introduced by new datasets and computational techniques in urban crime research, and outlines future directions for leveraging these advances effectively.

      • Gian Maria Campedelli
      • Zubin Jelveh
      • Patrick Sharkey
      Review Article
  • Articles

    • Using the parameter-free Angular Distribution of Pairwise Distances for measuring directional correlations, evidence is found for coherent anisotropic structures extending over gigaparsec scales, challenging the assumption that the Universe becomes statistically isotropic on sufficiently large scales.

      • Francesco Sylos Labini
      • Marco Galoppo
      Article
    • Using LARES-2, LAGEOS and GRACE satellites, researchers measured Earth’s frame-dragging with unprecedented precision, strongly confirming general relativity, constraining alternative gravity theories, and improving measurements of Earth’s tides.

      • Ignazio Ciufolini
      • Antonio Paolozzi
      • Vahe Gurzadyan
      Article
    • By using a fibre-optical analogue of the physics of black holes, theoretical and experimental evidence is presented for the process underpinning the generation of Hawking radiation and its backreaction onto the optical pump.

      • Lorenzo M. Procopio
      • Raul Aguero-Santacruz
      • Ulf Leonhardt
      Article
    • Optical cooling in two-dimensional semiconductor heterostructures is demonstrated through phonon-assisted interfacial charge transfer, enabling cryogen-free thermal management without stringent quantum-efficiency requirements.

      • Jiamin Lin
      • Baixu Xiang
      • Weigao Xu
      Article
    • Cross-sectional scanning tunnelling microscopy shows a 2 nm carrier transfer length in bismuth-contacted monolayer MoS2 transistors, defining metal-contact scaling limits for sub-10 nm 2D electronic devices.

      • Zi-Liang Yang
      • Bo-Chao Huang
      • Ya-Ping Chiu
      Article Open Access
    • A volatile-assisted coordination strategy regulates surface defect chemistry and self-doping, thus stabilizing the stoichiometry of tin perovskite semiconductors, resulting in transistors that can maintain stable operation for a month at temperatures of 100 °C.

      • Geonwoong Park
      • Dong Hyeon Lee
      • Yong-Young Noh
      Article Open Access
    • Visualization of concentration-driven phase segregation within high-concentration interfacial layers in the context of high-energy lithium–sulfur batteries using liquid-cell electrochemical transmission electron microscopy reveals competitive interfacial reactions under lean electrolyte conditions at different phase boundaries.

      • Shiyuan Zhou
      • Fei Pei
      • Hong-Gang Liao
      Article
    • Viscoelastic phase separation is used to fabricate non-collapsible, air-rich networks in high-water-content hydrogels containing silica aerogel beads, allowing air to permeate through the material and enabling a tenfold increase in oxygen permeability over pristine hydrogels.

      • Xiao-Yun Yan
      • Shucong Li
      • Xuanhe Zhao
      Article Open Access
    • Chiral catalysts for hydrogen atom transfer are produced through a self-assembly mechanism that enables access to novel catalyst permutations, with applications including photochemical deracemization of 2-aryl pyrrolidines for use as pharmaceutical scaffolds.

      • Navadheer Yalamanchili
      • Jules Hugo Alexandre
      • Giuseppe Zuccarello
      Article Open Access
    • New high-precision neodymium isotope data measured on recently erupted lavas from the submarine Fani Maoré volcano in the Comoros archipelago allow the identification of heterogeneities dating back to Earth’s earliest history.

      • Claudine Israel
      • Catherine Chauvel
      • James Badro
      Article Open Access
    • Single-cell transcriptomics combined with morphological and ecological data show that the rapid evolutionary radiation of cichlid fishes in Lake Tanganyika was accompanied by dietary specialization across multiple layers of biological organization.

      • Antoine Fages
      • Maëva Luxey
      • Patrick Tschopp
      Article
    • Genetic sequencing of multiple late Neanderthals living less than 52,500 years ago provides an overview of genetic diversity and demonstrates that even low-coverage nuclear genome data can increase resolution of within-Neanderthal diversity.

      • Alba Bossoms Mesa
      • Elena Essel
      • Mateja Hajdinjak
      Article Open Access
    • Systems-level analyses of organ intrinsic nervous systems reveal that these networks are initially configured by lineage-dependent programmes, and their architecture and molecular identity are refined by intra-organ specific local cues.

      • I-Uen Yvonne Hsu
      • Jia Zhao
      • Rui B. Chang
      Article Open Access
    • High-throughput barcoded neuroanatomy of two closely related rodent species with divergent vocalizations reveals differences in long-range projection motifs in the brain that may support these differences in vocal complexity.

      • Emily C. Isko
      • Clifford E. Harpole
      • Arkarup Banerjee
      Article Open Access
    • Reparative microglia persist in the brain after stroke but become dysfunctional through ZFP384-mediated mechanisms; however, this process can be mitigated by targeting Zfp384 using therapeutic antisense oligonucleotides.

      • Jun Tsuyama
      • Seiichiro Sakai
      • Takashi Shichita
      Article
    • A fungal long non-coding RNA from Magnaporthe oryzae translocates into rice cells to sequester a host microRNA that normally represses PKR1, a negative immunity regulator, thereby facilitating infection and revealing a widespread RNA-based pathogen–host interaction mechanism.

      • Min He
      • Jia Su
      • Xuewei Chen
      Article Open Access
    • Co-Scientist is an AI system for structured scientific thinking and generates research hypotheses for experimental verification.

      • Juraj Gottweis
      • Wei-Hung Weng
      • Vivek Natarajan
      Article Open Access
    • Integration of ubiquitin clippases with sortase-based labelling and mass spectrometry reveals that a wide range of non-peptide molecules are ubiquitinated in vivo, and points to a potential role for ubiquitination in physiological glycogen breakdown.

      • Marco Jochem
      • Simon A. Cobbold
      • David Komander
      Article Open Access
    • High-resolution in situ cryo-electron tomography in Schizosaccharomyces pombe identifies SNOR protein, which binds to ribosomes during dormancy induced by glucose depletion, priming them for rapid reactivation of protein synthesis upon glucose repletion.

      • Maciej Gluc
      • Higor Rosa
      • Ahmad Jomaa
      Article Open Access
    • β-Arrestins, multifunctional adaptor proteins that regulate G-protein-coupled receptors (GPCRs), form phase-separated condensates, suggesting that β-arrestin liquid–liquid phase separation organizes and diversifies GPCR signalling functions.

      • Preston J. Anderson
      • Peng Xiao
      • Sudarshan Rajagopal
      Article Open Access
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