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Silicon microchips are the beating heart of modern computers. If they could also be used for chips in a quantum computer, that would be a potential path to scalable commercial quantum machines. But to date, the development of silicon-qubit-based systems has been difficult. A key challenge for all cryogenic quantum systems is that the electronic control circuitry sits at room temperature and the wiring needed to connect it to the qubits has to bridge a temperature difference of some 300 kelvin, limiting how large the system can grow. In this week’s issue, the HRL Quantum Team and Collaborators present a much larger and more integrated silicon-based quantum-computing platform than previously seen. Their quantum processor is connected by superconducting wires to a control chip that operates at only 4 kelvin. The system ran repeated rounds of error correction autonomously, suggesting the control architecture could be used in much larger systems. The set-up is captured on the cover: the motherboard with the 4 K cryo-controller is vertical and shown in orange, the cooler daughterboard holding the qubit chip, which runs at the millikelvin level, is blue and purple, with the superconducting cable between them in white. A second paper in this issue by Brennan Undseth and colleagues also tackles the issue of silicon-based qubits, this time enabling a mobile qubit to shuttle between four stationary qubits, allowing the team’s set-up to perform parity-check measurements that are at the core of quantum error correction.
Rebuilding the reciprocal care-oriented relationships between Amazonian Indigenous peoples and nature could address the predicted effects of climate change on biodiversity.
Some nucleotides have been shown to control metabolism by ‘gluing’ proteins together. Could other small molecules made naturally by cells have similar capabilities?
The development of two medical AI assistants highlights an unnerving challenge: as the technology races ahead, what is the best way to evaluate what works?
Spatially resolved transcriptomic technologies continue to enhance understanding of development and disease through a feedback loop involving academia and industry.
The saturation of geomagnetic activity with solar wind strength can be explained by a regression to the mean effect, suggesting that the impact of extreme geomagnetic storms can be twice as large as previously thought
Single-atom measurements show non-Gaussian order-parameter fluctuations and critical scaling across a continuous phase transition, highlighting the importance of full statistical distributions in understanding universality.
A silicon quantum processing unit executes high-fidelity multiqubit circuits, with all time-varying control signals generated by a digitally programmed cryogenic complementary metal–oxide–semiconductor controller and delivered to the low-noise, exchange-only qubit device through a high-density superconducting ribbon cable.
A silicon spin-qubit device comprising a shuttling bus for transporting qubits is used to achieve parity checks up to weight four, highlighting the feasibility and benefits of incorporating shuttling into semiconductor quantum processors.
Elastic instabilities in mechanical metamaterials can be harnessed to programme fracture behaviour, transforming instability from a failure mechanism into a design principle that increases fracture energy by up to tenfold.
A molten salt, high-pressure synthesis method enables solution-based production of diverse refractory metal nitride nanocrystals, expanding access to technologically important nitride materials for advanced applications.
Polydopamine-pillared composite graphene oxide membranes with tunable and stable interlayer spacing, featuring controllable interlayer spacing, are capable of sieving hydrated rubidium and potassium ions and delivering continuous freshwater production at high levels.
A catalytic stereoretentive decarbonylation step is used to form a chiral alkylnickel intermediate from easily available chiral amino acid and α-hydroxy-acid derivatives, providing a straightforward approach to stereocontrolled C(sp3)–C(sp3) bond formation.
A platform for synthesis of C-aryl glycosides using glycosyl sulfonyl hydrazides as redox-neutral radical precursors for cross-coupling produces versatile and readily diversifiable building blocks, expanding practical access to carbohydrate-derived therapeutics and chemical tools.
Experiments carried out at atmospheric conditions show that methanesulfonic acid is an important driver of particle formation and growth in cold marine environments, with simulations indicating enhanced cloud condensation nuclei concentrations, especially in polar regions.
Uniform sharing of public goods can boost cooperation in social networks, but often concentrates benefits among well-connected individuals, creating inequality despite greater collective success.
The Small Auxin Up RNA (SAUR) protein ZmSAUR72 in maize (Zea mays) promotes silk growth via regulation of H+-ATPase activity, and is a key determinant of the anthesis-silking interval and thus resilience to drought.
Combined single-cell transcriptomic and chromatin accessibility sequencing analysis of mouse primary visual cortex across postnatal development reveals that the glucocorticoid receptor drives astrocyte maturation to limit neuronal plasticity.
Researchers mapped how transcription factors define neuron lineages in fruit fly brains, revealing hierarchical genetic programs that shape and specialize circuits controlling motivated behaviours such as mating.
A massively parallel assay systematically charts the sequence-function landscape of the STING signalling protein, and the findings define molecular principles that tune STING activity and show its functional potential across immune contexts.
A large language model artificial intelligence agent operating in a sandboxed electronic health record system can autonomously take patient histories, order tests, interpret findings, diagnose conditions and propose treatments, outperforming experienced clinicians while adhering to safety standards and clinical guidelines.
Advances to the artificial intelligence system AMIE enable it to manage disease across multiple visits while reasoning over a corpus of clinical guidelines and patient history, outperforming primary care physicians on management reasoning tasks.
Purines can act as endogenous molecular glues in human cells by anchoring a rate-limiting enzyme in purine biosynthesis to its inhibitor, and modifying this mechanism could provide a way to improve the properties of thiopurine chemotherapeutic drugs.
Plants sense water deficiency through SAM8 protein condensation, which responds to reduced hydration and triggers stress adaptation by altering RNA export and gene translation.
Cryo-electron microscopy and biochemical reconstitution experiments in yeast provide insight into the assembly of the CMGE complex, a helicase that establishes bidirectional DNA replication in eukaryotic cells, and elucidate the role of the firing factor Sld2.
From programmable RNA architectures to next-generation materials for energy and health care, researchers are harnessing the unusual properties of the nanoscale to tackle some of society’s biggest challenges.