Volume 642 Issue 8068, 19 June 2025

From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science.

A competition to develop computational approaches to detect ‘novelty’ in published papers will help metascientists to study how out-of-the-box research changes the scientific landscape.

Models estimating the levels of flight-directing staff need a rethink.

A toolkit outlines how academia can prevent various forms of misconduct.

Scientists observe the nematode’s behaviour in the wild for the first time.

Researchers fed moth larvae the chemical building blocks, and the insects’ enzymes did the rest.

In mice, engineered immune cells shrink pancreatic and other tumours bearing a mutant version of the KRAS protein.

The pull of a third galaxy could yank the Milky Way out of the path of Andromeda.

Massive telescope will map the Universe and provide an evolving record of the Solar System and distant stars.

Neuroscientists have found the regions that keep them apart.

Boom in infections in the West African nation is driven by the same viral strain that caused a global outbreak in 2022.

The model, called ether0, outperforms other advanced AIs at chemistry tasks and is a stepping stone towards automating the entire research pipeline.

Restrictions on immigration from 19 countries could disrupt infectious-disease research and international collaborations.

Pioneering organization aims to boost collaboration, track climate effects and improve disaster relief.

Hundreds of policies across the country have been designed to lure researchers and new graduates to settle there.

Research ships rarely brave the Greenland Sea in winter. Early this year, scientists ventured into the ice-covered waters to capture crucial data about the planet’s future.

Research is revealing the cellular mechanisms that link mental well-being and longevity.

The first US woman to fly in space said little about her personal life in public. A candid film discloses the pressures she endured.

The Abel prizewinner’s pragmatic approach to solving differential equations was influential across fields ranging from weather forecasting to starting nuclear chain reactions.

After decades of pioneering institutional change in Chinese research, neuroscientist Rao Yi explains why US hesitation might offer China an opportunity to catch up internationally.

Companies selling authorship slots thrive in a culture that equates success with a strong publication record. Customers, sleuths and the shadowy owner of a paper mill explain why.

Time-resolved cryo-electron microscopy can resolve protein motion on millisecond or even microsecond timescales, but the need for highly specialized tools and skills limits the method’s reach.

This interviewee rehabilitates illegally traded pangolins that fetch a high price on the black market.

The molecular feedback loops that program positional identity as salamander limbs develop and regrow could be harnessed for regenerative medicine.

The finding that the sea floor is a source of low-abundance elements in the ocean up-ends conventional views of marine biogeochemistry.

An ingenious technique reveals how stressed cells divide to produce progeny that have different traits — a phenomenon that can initiate cancer.

Most pixels in cameras detect only red, green or blue light. A sensor made from perovskite materials absorbs all three, improving image brightness and resolution.

International standards set for measuring location and time, and an unusual type of lake-water movement in this week’s pick from the Nature archive.

Genomic analyses of mother–father–fetus trios after early pregnancy loss uncover contributions from chromosomal abnormalities and subtle genetic variants.

A long-period radio transient with coincident radio and X-ray emission and observational properties unlike any known Galactic object has been observed by the Australian Square Kilometre Array Pathfinder.

An ultra-low-loss integrated photonic chip fabricated on a customized multilayer silicon nitride 300-mm wafer platform, coupled over fibre with high-efficiency photon number resolving detectors, is used to generate Gottesman–Kitaev–Preskill qubit states.

A colour sensor array based on multilayer monolithically stacked lead halide perovskite thin-film photodetectors achieves higher quantum efficiency and superior colour accuracy compared to conventional filter-based image sensors.

A facile light-triggered doping strategy involving a series of inactive photoactivable dopants is described that facilitates tunable regionally controlled n-doping of organic semiconductors, resulting in stable patterning of the doping profile at record high resolutions.

Acetic acid efficiently depolymerizes aliphatic and aromatic epoxy-amine thermosets used in carbon fibre-reinforced polymers (CFRPs) to yield recoverable monomers and pristine carbon fibres, which, based on process modelling, techno-economic analysis and life cycle assessment, could enable industrial recycling of CFRPs.

This study presents a nuclear magnetic resonance-based method to determine local structure and bonding of Pt single-atom catalysts.

Rare earth element and neodymium isotope data combined with models of particle cycling and sediment diagenesis suggest that the abyssal seafloor is a key driver of trace-metal biogeochemical cycles.

Increased atmospheric evaporative demand in recent years has increased drought severity by an average of 40% globally across both dry and wet regions, and the trend is likely to continue under future warming scenarios.

Atmospheric reanalyses combined with ocean observations and model simulations show that the extreme 2023 North Atlantic heatwave was primarily driven by anomalously weak winds leading to strongly shoaling mixed layers, with a smaller contribution from clearer skies.

Analysis of data on six stable crops, capturing two-thirds of global crop calories, allows estimation of agricultural impacts and the potential of global producer adaptations to reduce output losses owing to climate change.

Warming temperatures and interactions between plants are the main drivers of changes in Arctic plant communities in response to climate change, and there is no evidence of overall biotic homogenization.

A pangenome of wild and cultivated rice accessions captures the entire set of non-redundant genes and diversity in rice, and provides insights into the pathways involved in the evolution of rice.

Around 1 in 136 pregnancies is lost due to a pathogenic small sequence variant genotype in the fetus.

Individual dopaminergic neurons encode future rewards over distinct temporal horizons.

An algorithm called time–magnitude reinforcement learning (TMRL) extends distributional reinforcement learning to take account of reward time and magnitude, and behavioural and neurophysiological experiments in mice suggest that midbrain dopamine neurons use TMRL-like computations.

Illness signals from the gut reactivate and strengthen flavour representations in the amygdala to support learning from delayed postingestive feedback.

How NRXN1 variants affect multiple neuropsychiatric disorders is explored.

Single-cell RNA sequencing and spatial transcriptomic approaches reveal major expression changes in outer root cell types when grown in soil versus gel conditions, and also uncover how root tissues communicate and adapt to contrasting soil conditions at single-cell resolution.

A molecular analysis of axolotl limb regeneration has identified a positive genetic circuit that maintains posterior cell identity and can be used to reprogramme anterior cells into posterior cells.

A newly identified coronavirus isolated from farmed minks can use the receptor ACE2 to infect cells of different mammalian species, including human cells, which has implications for potential zoonotic spillover events.

Experiments in mouse models show that proper recovery of the intestinal microbiota following depletion, with or without faecal microbiota transplant therapy, is dependent on syntrophic interactions that occur only with specific dietary interventions.

A subset of antigen-presenting cells of myeloid origin that require PRDM16 and RORγt regulates T cell function to enable immune tolerance of food and commensal gut microorganisms.

Inhibition of a cardiac stroma-enriched mechanosensor, SRC—in concert with suppression of the TGFβ pathway—potentiates the reversal of fibroblast activation and alleviates contractile dysfunction in fibrotic hearts.

A study of human and mouse models of pancreatic cancer finds that inhibiting the lipid kinase PIKfyve interferes with the cancer’s lipid homeostasis, making it a potential target for drug development.

A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early events during cancer development.

A near-complete survey of transcription factor activities in Saccharomyces cerevisiae reveals that most transcription factors have both activator and repressor activities and limited overlap between their binding sites on DNA and regulation of nearby genes.

Using high-throughput functional profiling, how disordered regions control mRNA stability and translation is explored.

The structure and function of the MCR activation complex from Methanococcus maripaludis were revealed, demonstrating its ATP-dependent ability to activate MCR and form methane while uncovering a unique electron transfer pathway involving iron–sulfur clusters similar to the nitrogenase cofactor intermediates.