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Volume 654 Issue 8120, 25 June 2026
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Volume 654 Issue 8120, 25 June 2026

Sweetness and might

The cover shows black sugarcane (Saccharum officinarum), one of the two main species of Saccharum that have been crossed to form modern hybrid sugarcane cultivars. Sugarcane is the world’s leading sugar crop, renowned for its ability to hold high levels of sucrose in its stalks. But the genetic mechanisms underlying this remarkable storage capability have remained elusive, largely because of the extreme complexity of the hybrid sugarcane genome. As a result of its intricate breeding history, sugarcane has some 10–12 sets of chromosomes, which are challenging to unpick. In this week’s issue, Xingtan Zhang and colleagues present a genome assembly for a key sugarcane cultivar, formally called POJ2878, but informally known as the ‘king of sugarcane’. The researchers resolved 118 chromosomes and were able to clarify the genetic architecture that underlies sugarcane’s biomass productivity and sugar yield.

Cover image: Heather Angel/Nature Picture Library.

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    • This Review reflects on the joint power of genetic technologies, including untapped CRISPR–Cas techniques to combat hidden hunger and improve crop resilience, and argues in favour of their combined use to overcome these societal challenges.

      • Dominique Van Der Straeten
      • Mustafa Bulut
      • Alisdair R. Fernie
      Review Article
    • A Review of the immunological mechanisms of mRNA–lipid-nanoparticle vaccines for infectious diseases discusses how the components of this vaccine platform can be modified to fine-tune immune responses against challenging pathogens.

      • Michela Locci
      • Norbert Pardi
      Review Article
  • Articles

    • A technique combining atomically resolved scanning tunnelling microscopy with neural-quantum-state quantum Monte Carlo simulation of disordered 2D electron Wigner solids establishes a powerful framework to enable the clear identification of two distinct defect-induced disorder regimes.

      • Zhehao Ge
      • Conor Smith
      • Michael F. Crommie
      Article
    • A new AI system uses a large language model combined with tree and evolution search to quickly create expert-level empirical software and accelerate scientific progress, as demonstrated in a wide range of experimental tasks.

      • Eser Aygün
      • Anastasiya Belyaeva
      • Michael P. Brenner
      Article Open Access
    • By embedding core computer vision principles into a large-scale optical metasurface, an efficient vision processing system using far fewer parameters is demonstrated to outperform many digital models and enables deployment on edge devices.

      • Jiayong Peng
      • Mingcheng Luo
      • Chaoran Huang
      Article
    • Ring laser gyroscope lock-in has been eliminated using spontaneous symmetry breaking in a He–Ne laser, enabling accurate near-zero rotation sensing without external components, improving miniaturization and precision.

      • Yuan-Hao Mao
      • Ji-Peng Xu
      • Hui Jing
      Article Open Access
    • A lightweight and portable robot that administers isokinetic variable resistance training for juveniles with spinal muscular atrophy type II is shown to facilitate enduring neuromuscular recovery even after temporary exposure, helping patients perform sit-to-stand transitions.

      • Yuebing Li
      • Jiaxin Ren
      • Yanggang Feng
      Article
    • Near-infrared fluorescent carbon nanotubes exhibit light-induced quantum friction in water, in which exciton interactions slow nanoscale motion and enable optical control of diffusion and fluid dynamics.

      • Tanuja Kistwal
      • Krishan Kanhaiya
      • Sebastian Kruss
      Article Open Access
    • A supramolecular strategy, in which uniform, dynamic nanopores are constructed, overcomes the limitations of limited structural control, mechanical fragility or demanding synthesis in nanoporous anion-conducting membranes, providing a versatile tool for molecularly engineering transport pathways.

      • Ziang Xu
      • Dongcheng Lin
      • Kai Liu
      Article
    • Porous polyacrylonitrile membranes—typically used as non-selective support layers—can be used to achieve effective molecular refining of crude oil at steady state, enabling substantial reductions in energy consumption, cooling water, and CO2 emissions compared with distillation processes.

      • Jihoon Choi
      • Hyeokjun Seo
      • Dong-Yeun Koh
      Article
    • Accelerated Arctic glacier disintegration and a more dynamic sea ice cover are increasing iceberg-delivered dropstones in the deep ocean, reshaping seafloor habitats and extending cryospheric impacts far beyond glaciers.

      • Thomas Krumpen
      • Kirstin S. Meyer-Kaiser
      • Holger Schmithüsen
      Article Open Access
    • Researchers uncovered an enormous deep-sea accumulation of whale remains in the southeastern Indian Ocean, showing long-term, specialized ecosystems and an extensive fossil record that offers new insight into deep-ocean biodiversity and whale evolutionary history.

      • Xiaotong Peng
      • Peng Zhou
      • Hanyu Zhang
      Article Open Access
    • Analysis of 258 ancient genomes from southern Germany reveals a major demographic shift during the late fifth century, yet family structures persisted from Late Roman times, demonstrating cultural continuity despite profound demographic reorganization.

      • Jens Blöcher
      • Leonardo Vallini
      • Joachim Burger
      Article Open Access
    • Audit experiments on TikTok show asymmetric partisan exposure that is not explained by observable engagement metrics, with Republican-leaning accounts receiving more aligned content and Democratic-leaning accounts more cross-partisan recommendations.

      • Hazem Ibrahim
      • HyunSeok Daniel Jang
      • Yasir Zaki
      Article Open Access
    • The I3 pharyngeal enteric neuron in Caenorhabditis elegans detects high-salt conditions, and the GLR-9 ionotropic salt receptor expressed specifically in I3 regulates genes related to salt stress resistance in distal tissues.

      • Jihye Yeon
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    • HIV-1 capsid nuclear import at the nuclear pore complex is a bottleneck to resting T cell infection, but HIV-1 overcomes this by triggering receptor-mediated signalling during cell–cell spread to drive nuclear import and licence infection.

      • Dejan Mesner
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    • Humanized glucagon-like peptide 1 receptor (GLP1R) mouse models are used to investigate the neural circuitry through which small-molecule GLP1R agonists modulate feeding, with implications for how these orally delivered weight-loss drugs engage brain reward circuits.

      • Elizabeth N. Godschall
      • Taha Bugra Gungul
      • Ali D. Güler
      Article Open Access
    • Experiments in mice and humans show enhancement of T cell function following fasting and refeeding, caused by persistent immunometabolic reprogramming, with potential implications for nutritional interventions and adoptive cell therapy.

      • Alok Kumar
      • Dayana B. Rivadeneira
      • Greg M. Delgoffe
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    • Multimodal machine learning reveals that tumour microenvironments can be decomposed into spatially organized multicellular ecosystems, termed spatial ecotypes, that can be accessed non-invasively via liquid biopsy and used to profile individual cancers and target treatments.

      • Wubing Zhang
      • Erin L. Brown
      • Aaron M. Newman
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    • Treatment data for triple-negative breast cancer show the importance of macrophage subtypes and cancer-cell metaprograms for interferon signalling, HLA expression and cell cycle activity that are associated with a good response to neoadjuvant chemotherapy.

      • Yun Yan
      • Yiyun Lin
      • Nicholas Navin
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