Volume 647 Issue 8089, 13 November 2025

Research reveals that many more people lose their lives because of the effects of rainfall and flooding than are routinely accounted for.

In Belize, women are tackling climate change and biodiversity loss on the ground, but gender equity is needed in government, too — COP30 should address this.

This bold approach could galvanize countries attending the COP30 summit.

Blocking the mechanism that cancer cells exploit to avoid destruction by the immune system could spur new treatments for the disease.

Footage from a lone camera incidentally located metres from a fault provides data on slippage duration and motion.

The fringe-lipped bat ambushes its prey, helping to make it an exceptionally efficient hunter.

Dimming of the starlight from RZ Piscium reveals that 24 unseen bodies are whizzing around the star.

A company’s plan to edit the genomes of human embryos worries some researchers — but it might reflect the changing attitudes towards the controversial approach.

A non-invasive imaging technique can translate scenes in your head into sentences. It could help to reveal how the brain interprets the world.

In a world first, a bespoke gene-editing therapy benefited one child. Now researchers plan to launch a clinical trial of the approach.

Limited COVID-19 surveillance data are hampering vaccination and health strategies, researchers say.

A ‘superflare’ 10 trillion times brighter than the Sun is confirmed as the record-holder for luminosity.

Although China needs to strengthen its leadership in artificial intelligence, semiconductors and energy, say researchers.

According to the Indian government, the experiment helped to reduce air pollution — but researchers attribute that to the weather.

Fitness influencers promote super-high-protein diets, but studies show there’s only so much the body can use.

Move over silicon: scientists want to use neurons to make powerful computers with minuscule energy needs.

Even small acts can make a big difference in driving positive environmental impacts.

Nobel laureate who helped to sequence the first bacterial and human genomes.

If it gets things right, the first major regulator of medicines to launch for 30 years could empower Africa to tackle African challenges around health and disease.

Universities are in thrall to a rankings system that prioritizes narrow aspects of academic life. Three changes would give institutions the freedom to explore fresh ways of working.

Rector and AI researcher Nataliya Shakhovska tells Nature how her institution is supporting students and staff members amid the war and about her hopes for the future.

Is it fair for grant reviewers — who are often our colleagues — to judge the legitimacy of career breaks due to personal circumstances?

Tools that track specific molecules in neurons have enabled researchers to probe previously unexplored aspects of neurobiology — although important caveats remain.

Haritakis Papaioannou combines a mountaineer’s know-how with a scientific eye to track the slow recovery of chamois populations in western Greece.

Age-related mutations give sperm-forming stem cells a selective advantage during sperm production, shaping disease risk and genetic variation in offspring.

A polymer with a 2D molecular structure stacks into tightly packed layers — forming films of nanoscale thicknesses that are nearly impermeable to gases and moisture.

Scientists have used low-error genome-sequencing methods in normal tissues from large cohorts of individuals to scan for mutations that set the stage for cancer.

The ability to change your mind in response to better evidence is a hallmark of human cognition. Experiments now show that chimps are capable of rational thought too.

The evolution of the jaw helped mammals to thrive. Fossil discoveries shed light on the diverse evolutionary journeys taken by joints between the skull and lower jaw.

The GREGoR consortium provides foundational resources and substrates for the future of rare disease genomics.

A materials platform using tantalum as a base layer and silicon as the substrate to construct superconducting qubits enables device performance improvements such as millisecond lifetimes and coherence times, as well as high time-averaged quality factors.

Aligning foundation models with human judgments enables them to more accurately approximate human behaviour and uncertainty across various levels of visual abstraction, while additionally improving their generalization performance.

Embedding non-porous MXene film into metal thin films can achieve unprecedented shielding performance, which can be used to protect electronic components and equipment from electromagnetic noise.

A majority methylammonium and iodine edge termination is observed by electron ptychography in the perovskite methylammonium lead iodide, and the stability of its edges and internal defects depends on the concentration and type of vacancies present.

Silicon solar cells with hybrid interdigitated back contacts have a power conversion efficiency approaching 95% of the theoretical limit and a fill factor approaching 98% of the theoretical limit.

Vector-stimuli-responsive magnetorheological fibrous materials can be mass-produced, which can be assembled into yarns and woven into a variety of fabrics with actuation and stiffening abilities.

Two-dimensional polyaramid polymers are synthesized to form nanofilms that exhibit the lowest gas permeability of any polymer by orders of magnitude, despite lacking crystallinity, enabling molecular-scale nanomechanical resonators and barrier materials.

A multimodal robotic platform is used to discover and optimize an electrocatalyst composition for formate oxidation.

High-resolution satellites reveal major uncertainties in methane emissions from global waste sites, highlighting the need to reconcile observed and reported data, with actionable insights to improve estimates and guide targeted mitigation efforts.

High-resolution computed tomography is used to reconstruct and analyse fossils of the herbivorous tritylodontid Polistodon and a newly named morganucodontid species called Camurocondylus, providing key insights into the evolution of the mammalian jaw joint.

A new version of nanorate DNA sequencing, with an error rate lower than five errors per billion base pairs and compatible with whole-exome and targeted capture, enables epidemiological-scale studies of somatic mutation and selection and the generation of high-resolution selection maps across coding and non-coding sites for many genes.

A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.

A systematic statistical genetics approach discovers CES drivers as hotspots of human de novo mutation and shows that clonal expansions in germline may both modulate the prevalence of disorders and lead to false-positive disease associations.

Sex bias and association with smoking history identified in the landscape of driver mutations and clonal expansions in normal human bladder tissue may explain the higher bladder cancer risk in men and smokers.

A study in Drosophila has identified a neural circuit that selectively suppress movement-encoding proprioceptors during self-generated movements such as walking and grooming.

Reframing of arousal as a latent dynamical system can reconstruct multidimensional measurements of large-scale spatiotemporal brain dynamics on the timescale of seconds in mice.

Loss-of-function variants of ABCA7, associated with Alzheimer’s disease, result in disrupted lipid metabolism, mitochondrial function, DNA repair and synaptic signalling pathways in the human brain.

A method using subtree pruning and regrafting-based tree assessment (SPRTA), which considers evolutionary relationships between lineages, enhances interpretability of phylogenetic analyses such as those of SARS-CoV-2 variants.

Structural and biochemical studies of the β-barrel-assembly machinery from Flavobacterium johnsoniae reveal a subunit composition and assembly that are distinct from those of the canonical Escherichia coli complex.

mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.

PLD4 loss-of-function mutations in patients with systemic lupus erythematosus leads to excessive activation of TLR7 and TLR9.

Red light- or ultrasound-controlled proximity labelling is engineered to stimulate clustering-induced receptor activation and downstream signalling amplification to promote antitumour immune responses.

Mechanical confinement of cancer cells at the tumour–microenvironment interface induces phenotype switching through chromatin remodelling by HMGB2, leading to a more invasive and drug-resistant state in melanoma.

A fresh approach to protein design that incorporates excited intermediate states enables precise control over the lifetime of protein interactions, with potential applications in cell-signalling modulation and in biosensors and synthetic circuits.

Cryo-electron microscopy was used to study human mechanistic target of rapamycin complex 1 (mTORC1) activation on lysosomal membranes, showing progressive recruitment by RAG–Ragulator, RHEB and RAPTOR, culminating in mTOR–membrane engagement and full enzyme activation.