Volume 647 Issue 8090, 20 November 2025

The host of the high-level meeting must not be swayed from its priorities, which are in line with the evidence from research.

People do not have to dismiss or exaggerate the climate threat to justify concerted action.

The purpose of the pre-Hispanic Monte Sierpe site in Peru has long baffled researchers.

Global cooling is not the only — or even the most consequential — effect of the biggest volcanic outbursts.

A bioproduction method that ties compound synthesis to bacterial survival could be used to mass-produce natural products.

Researchers have identified a specific genus in the mouse microbiome that aids weight loss, providing another potential route to anti-obesity treatments.

The co-discoverer of the structure of DNA helped to strengthen a US research institute and wrote a classic textbook, but also earned a reputation for racist and sexist comments.

Oceanographers hope to find otherworldly ecosystems at hydrothermal vents on the sea floor.

Researchers feel that pressures to publish are increasing, but the time and resources available to do research are decreasing, according to a survey by Elsevier.

The country is easing migration for young researchers to boost its competitiveness in artificial intelligence, robotics and new materials.

The milestone makes machine-learning trailblazer Yoshua Bengio the most cited researcher on Google Scholar.

A high-resolution digital map nearly doubles the known length of the ancient road network.

Trend flies in face of Trump-administration policies, but could yet see a rapid decrease, especially in science fields.

A vast study suggests that being multilingual can slow down cognitive ageing.

The company was created to use AI for world- changing science — and achieved that with AlphaFold. But the advent of large language models raises deep questions about the future of DeepMind.

Ethicists say AI-powered advances will threaten the privacy and autonomy of people who use neurotechnology.

A physician–scientist involved in the equitable-access initiative examines its achievements and discusses what can be done better when the world faces the next pandemic.

A thorough examination of artificial intelligence’s promise in politics rests on a thorny premise: democracy is an information system.

Andrew Robinson reviews five of the best science picks.

He helped to reveal the structure of life’s code, transformed science education and research, and remained a deeply controversial figure to the end.

Research in space is about more than discovery. It is a strategic asset and soft power that attracts partners and supports evidence-based decisions.

The world needs to move towards an approach to measure well-being rather than economic growth. Here’s how that can happen.

Mobility turns pragmatic as living costs and politics bite, Nature’s latest graduate survey shows.

Neema Mduma is a machine-intelligence researcher building a crop-science app.

Improved therapies to treat snakebite are needed. A new approach might lead to the development of more-effective treatments for use in the clinic.

Nanoparticles containing lanthanide ions are excellent light emitters. The addition of organic molecules means that they can be activated using electric currents.

A lecture to commemorate Nature’s first editor, and threats against a precious genetic resource that exists in indigenous livestock, in our weekly dip into Nature’s archive.

Rising temperatures and the introduction of non-native fishes have been linked to rapid changes in fish communities across the United States.

Little is known about the early history of lizards, snakes and their kin. New fossil discoveries reveal a complex evolutionary journey.

A comprehensive genome analysis suggests that women have more genetic risk variants for major depressive disorder than do men, with stronger links to metabolic traits.

An analogue to a type II burst from the early M dwarf StKM 1-1262 exhibits identical frequency, time and polarization properties to fundamental plasma emission from a solar type II burst.

Experiments reveal a speed limit for the spreading of spatial coherence during the formation of a weakly interacting Bose–Einstein condensate.

Angle-resolved photoemission spectroscopy shows that Weyl semimetal PtBi₂ harbours nodes in its superconducting gap, implying unconventional i-wave pairing symmetry.

Femtosecond photoexcitation drives a coherent twist–untwist motion of the moiré superlattice in 2° and 57° twisted WSe₂/MoSe₂ heterobilayers.

To turn on and obtain emission from lanthanide-doped insulating nanoparticles, an electrical excitation pathway coupling them to organic optical molecules to form nanohybrids is described, enabling tunable electroluminescence properties of LEDs fabricated from such materials.

The electroluminescence emitted from lanthanide fluoride nanocrystals functionalized with ligands is shown to be tunable, providing a method for exciton control in insulating nanocrystal systems and offering a pathway for spectrally precise electroluminescent materials.

A cross-attention-empowered SE(3)-equivariant graph neural network architecture named EZSpecificity was developed for predicting enzyme substrate specificity.

A new method for deracemization of atropisomers is described which leverages a P450 enzyme-mediated process involving bond rotation for enantioenrichment.

In the past three decades, fish abundance, richness and uniqueness have diverged across cold and warm streams, and the effects on native fish communities of stream warming and increases in introduced fishes have magnified each other.

A rhynchocephalian skeleton around 3–7 million years older than the oldest currently known lepidosaur fossil provides important insight into the origin of lizards and snakes.

Breugnathair elgolensis gen. et sp. nov., an early squamate identified from a newly discovered Middle Jurassic skeleton on the Isle of Skye, provides new evidence on the origins of snakes.

The evolutionary history of barley is analysed using ancient and modern DNA.

Activity in a set of parabranchial neurons in the mouse brain is increased during chronic pain, predicts coping behaviour, and can be modulated by circuits activated by survival threats.

Human host-associated cellular products may act as induction agents for bacteriophages.

Dietary cysteine enhances intestinal stem cell-mediated intestinal repair following injury by promoting CD8 T cell-regenerative immune responses.

A recombinant antivenom composed of eight nanobodies provides broad protection against venom-induced lethality and dermonecrosis in mice challenged with venoms from cobras, mambas and rinkhals snakes.

Imbalanced nucleotide metabolism leads to age- and mtDNA-dependent inflammatory responses and senescence-associated secretory phenotype in senescence.

STING-activation-induced necroptosis (STAIN) is a central pathogenic mechanism in both caspase-8-deficient inflammation and STING-associated vasculopathy with onset in infancy.

Myeloperoxidase, a highly expressed neutrophil protein, disassembles nucleosomes, facilitating neutrophil extracellular trap (NET) formation, and binds stably to NETs extracellularly.

A combined sequencing technique assesses 18 patients with high-grade serous ovarian cancer over a multi-year period from diagnosis to recurrence and shows drug resistance typically arises from selective expansion of one or a few clones present at diagnosis.

Holliday junctions maintain chromosome synapsis to enable crossover assurance in budding yeast.

Conditional ablation experiments show that key components of the synaptonemal complex protect double Holliday junction recombination intermediates to ensure their resolution into crossover products, which are required for accurate chromosome segregation during meiosis.

G2E3-catalysed H3K14 mono-ubiquitination is crucial for SUV39H compartmentalization and H3K9 trimethylation in pericentromeric heterochromatin, which is essential for proper euchromatin organization and transcriptional regulation in mammalian cells.

The authors discover a homeostatic process termed interstasis, in which an increased concentration of proteins within RNA–protein condensates induces the sequestration of their own mRNAs.