Subject: New issue: Nucleic Acids Research, Volume 53, Issue 6, 11 April 2025

Nucleic Acids Research

Volume 53, Issue 6, 11 April 2025

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20 Years of Open Access

In 2005 Nucleic Acids Research (NAR) transitioned from a subscription-based publishing model to an open access model. Now, 20 years later, NAR proudly stands as a leading journal in the field of biological sciences, providing barrier-free access to groundbreaking research.

To celebrate this milestone, we have created collection featuring the most cited paper (from standard article types) from each year since 2005. This collection showcases the research excellence that NAR fosters and demonstrates the impact of open access publishing.

Browse the papers

Editorial

Looking back at 20 years of Open Access publishing at Nucleic Acids Research

Rich Roberts

Chemical Biology and Nucleic Acid Chemistry

Reversible acetylation of ribosomal protein S1 serves as a smart switch for Salmonella to rapidly adapt to host stress

Yi-Lin Shen,Tian-Xian Liu and others

Computational Biology

In silico nanoscope to study the interplay of genome organization and transcription regulation

Soundhararajan Gopi,Giovanni B Brandani and others

Conservation assessment of human splice site annotation based on a 470-genome alignment

Ilia Minkin,Steven L Salzberg

Data Resources and Analyses

BioRels' data infrastructure: a scientific schema and exchange standard to transform and enhance biological data sciences

Jibo Wang,Amanda Turney and others

Gene Regulation, Chromatin and Epigenetics

Formation of multiple G-quadruplexes contributes toward BCR fragility associated with chronic myelogenous leukemia

Shivangi Sharma,Elizabeth Thomas and others

DGCR8 haploinsufficiency leads to primate-specific RNA dysregulation and pluripotency defects

Ana Colomer-Boronat,Lisanne I Knol and others

Fungal chromatin remodeler Isw1 modulates translation via regulating tRNA transcription

Jing Wang,Yueqi Zhang and others

Genomic regions occupied by both RARalpha and VDR are involved in the convergence and cooperation of retinoid and vitamin D signaling pathways

Hamidreza Mianesaz,LorÃ¡nd GÃ¶czi and others

Cooperation of a polymerizing SAM domain and an intrinsically disordered region enables full SAMD1 function on chromatin

Merle Geller,Yinghua Cao and others

Genome Integrity, Repair and Replication

Homeodomain protein PRRX1 anchors the Ku heterodimers at DNA double-strand breaks to promote nonhomologous end-joining

Yan Wang,Fuyuan Shen and others

Post-replicative lesion processing limits DNA damage-induced mutagenesis

Katarzyna H MasÅ‚owska,Ronald P Wong and others

Genomics

Long-read whole-genome sequencing-based concurrent haplotyping and aneuploidy profiling of single cells

Yan Zhao,Olga Tsuiko and others

Molecular and Structural Biology

Spatiotemporal dynamics of protamine'DNA condensation revealed by high-speed atomic force microscopy

Goro Nishide,Keesiang Lim and others

Direct RNA sequencing of the Escherichia coli epitranscriptome uncovers alterations under heat stress

SebastiÃ¡n Riquelme-Barrios,Leonardo VÃ¡squez-Camus and others

Light-dependent flavin redox and adduct states control the conformation and DNA-binding activity of the transcription factor EL222

Aditya S Chaudhari,Adrien Favier and others

Nucleic Acid Enzymes

Glycyl-tRNA sequestration is a unifying mechanism underlying GARS1-associated peripheral neuropathy

Natalia Mora,Erik F J Slot and others

A sequence-specific RNA acetylation catalyst

Supuni Thalalla Gamage,Shereen Howpay Manage and others

Nucleic Acid Therapeutics

AOC 1044 induces exon 44 skipping and restores dystrophin protein in preclinical models of Duchenne muscular dystrophy

Usue Etxaniz,Isaac Marks and others

RNA and RNA-protein complexes

Structural insights into lab-coevolved RNA'RBP pairs and applications of synthetic riboswitches in cell-free system

Keisuke Fukunaga,Takamasa Teramoto and others

Structural Biology

A dynamic structural unit of phase-separated heterochromatin protein 1alpha as revealed by integrative structural analyses

Ayako Furukawa,Kento Yonezawa and others

Synthetic Biology and Bioengineering

Light-induced expression of gRNA allows for optogenetic gene editing of T lymphocytes in vivo

Diego Velasquez Pulgarin,Nathalie Pelo and others

Targeted translation inhibition of chloroplast and mitochondrial mRNAs by designer pentatricopeptide repeat proteins

Nikolay Manavski,Serena Schwenkert and others

Methods

A mediator-free sonogenetic switch for therapeutic protein expression in mammalian cells

Jinbo Huang,Shuai Xue and others

Spuriously transcribed RNAs from CRISPR-sgRNA expression plasmids scaffold biomolecular condensate formation and hamper accurate genomic imaging

Shiqi Mao,Ruonan Wu and others

Single-cell genome and transcriptome sequencing without upfront whole-genome amplification reveals cell state plasticity of melanoma subclones

Koen Theunis,Sebastiaan Vanuytven and others

CASCADE-Cas3 enables highly efficient genome engineering in Streptomyces species

Christopher M Whitford,Peter Gockel and others

CellPie: a scalable spatial transcriptomics factor discovery method via joint non-negative matrix factorization

Sokratia Georgaka,William Geraint Morgans and others

True length of diverse capped RNA sequencing (TLDR-seq): 5²'3²-end sequencing of capped RNAs regardless of 3²-end status

Jamie Auxillos,Arnaud Stigliani and others

Corrections

Correction to ˜Fam170a deficiency causes male infertility by impairing histone-to-protamine exchange during mouse spermiogenesis'

20th Open Access Anniversary

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