Subject: New issue: Nucleic Acids Research, Volume 54, Issue 6, 13 April 2026

Volume 54, Issue 6, 13 April 2026

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NAR Breakthrough Article

Dissecting the RNA-binding capacity of the multi-RRM protein Rrm4 essential for endosomal mRNA transport

Nina Kim Stoffel and others

Critical Reviews and Perspectives

MBNL proteins in health, disease, and therapeutic applications

Nikola MusiaÅ‚a-Kierklo and others

Chemical Biology and Nucleic Acid Chemistry

Site-specific ribozyme-mediated alkylation of DNA substrates

Yuanlin He and others

Dual regulation of HEPN RNase in fused MNT-HEPN toxin-antitoxin systems via protein OligoAMPylation and oligomerization

Jianyun Yao and others

Deep learning-guided dual-fitness evolution of T7 RNA polymerase for enhanced stability and activity

Fan Jiang and others

A general strategy to enhance aptamer affinity by suppressing dissociation through symmetric assembly

Zijie Zhang and others

5-Triazolyl uracil improves nucleobase stacking, pyrimidine recognition, biological activity, and specificity of RNA-binding triplex-forming peptide nucleic acids

Sara F Saei and others

Decoding nucleic acid contributions to phase separation and ordering in biomolecular condensates

Daniele Asnicar and others

S-SELeCT: a human-evolved serine integrase system for efficient large-cargo genome integration

Alfonso P Farruggio and others

Alexidine, identified as a Z-DNA inducer by the NanoZ screening platform, acts as a transcriptional regulator

Vinod Kumar Subramani and others

Computational Biology

A foundation model for nucleotide sequences

Xilin Shen and others

Poly(ADP-ribose) (PAR) exhibits ion-dependent structural properties distinct from RNA

Lipika Baidya and others

Boolean logic links chromatin accessibility states to gene expression variability across cell types

Seyed Amir Malekpour and others

Dissecting host stress responses for predictable heterologous gene expression in E. coli

Christoffer Rode and others

Data Resources and Analyses

An expanded reference catalog of translated open reading frames for biomedical research

Sonia Chothani and others

Gene Regulation, Chromatin and Epigenetics

Transient SUMOylation inhibition in human pre-adipocytes stably imprints a transcriptional beiging fate

Patrizia Maria Christiane Nothnagel and others

Regulation of YAP activity by nuclear G-actin binding

Hong Wang and others

Nucleoid-associated protein HU constrains transcription elongation to influence cellular functions, virulence, and drug tolerance in Mycobacterium tuberculosis

Meghna Santoshi and others

The birth, death, and evolutionary compensation of uORFs in Drosophila

Mengze Xu and others

B-type lamins maintain transcriptional homeostasis by spatially controlling chromatin'speckle proximity

Geun-Seup Shin and others

Endogenous promoter G-quadruplexes scaffold apurinic/apyrimidinic endonuclease (APE1) to drive gene expression

Yingling Chen and others

Trans-histone crosstalk establishes distinct H3K79 methylation zones with differential transcriptional functions

Na Hyun Park and others

A specific amount of RamA must be reached to trigger increased expression of AcrAB, enhance efflux, and confer multidrug resistance

Vito Ricci and Laura J V Piddock

Genome Integrity, Repair and Replication

Structure of an initiation complex of mycobacterial helicase-nuclease AdnAB at a blunt double-strand break reveals local melting that engages the 3² tracking strand at the ratchet pawl of the helicase motor

Garrett M Warren and others

A WYL transcriptional regulator activates the DNA damage response pathway in Acinetobacter species

Taylor J Ellison and others

Indel pattern-guided repair mapping reveals genome-wide DNA repair networks in CRISPR/Cas9 editing

Yanbin Wan and others

TRF2'RAP1 inhibits homology-directed repair of telomeres by promoting BLM-mediated removal of telomere R-loops

Fengshan Liang and Sandy Chang

A thumb-domain insertion balances processivity and fidelity in DNA polymerase epsilon

Noopur Singh and others

Transcription at an inducible common fragile site reveals replication origin strength hierarchy

Juliette Mandelbrojt and others

Structure of human lymphoid-specific helicase HELLS in its autoinhibited state

Gundeep Kaur and others

Genomics

State-dependent promoter switching mediates integrase gene transcription in the integrative and conjugative element ICEKp1 of Klebsiella pneumoniae

Guitian Liu and others

Molecular and Structural Biology

Unraveling the molecular mechanisms of vimentin interaction with G-quadruplex repeats

Marta Cozzaglio and others

Exploration of the proxiOME of large subunit ribosomal proteins reveals Acl1 and Bcl1 as cooperating dedicated chaperones of Rpl1

SÃ©bastien Favre and others

Toxin dimerization and a distinct DNA-binding architecture define chromosomal Phd-Doc regulation

Jin Young Park and others

The tRNA moieties of both aminoacyl-tRNA substrates of a cyclodipeptide synthase share a common binding site, as revealed by RNA microhelices mimicking tRNA acceptor arms

Zahra Marouf and others

LacI strikes a balance between stability and inducibility

Jinwen Yuan and others

Systematic discovery of bacterial anti-phage systems through a protein domain-centric strategy

Yanqiu Liu and others

Allosteric activation mechanism of the type VII CRISPR-Cas system

Shuqin Zhang and others

Nucleic Acid Enzymes

Single-turnover kinetic analysis of non-long terminal repeat retrotransposition defines the pathway and rate constants leading to second-strand synthesis

Tyler L Dangerfield and others

Elimination of cis-cleavage in CRISPR diagnostics for one-pot rapid nucleic acid detection

Wenhao Yin and others

Delineation of a novel assembly intermediate in Rous sarcoma virus integration pathway

Rahul Chadda and others

Regulated transformation system (RTS): sddi-mediated programmable shut-off and mode switching of base editors

Jiacheng Deng and others

Insights into spacer acquisition of the type V-A CRISPR'Cas system of Francisella novicida U112

Frank Hille and others

MDA5 generates compact ribonucleoprotein complexes via ATP-dependent double-stranded RNA unwinding

Salina Quack and others

Reversible RNA ADP-ribosylation on uracil bases

Yang Lu and others

Acinetobacter baumannii encodes multiple mutagenically and biochemically active DNA polymerase V variants

Debika Ojha and others

The trypanosome mRNA decapping enzyme ALPH1 prefers caps without m⁷G methylation and produces diphosphate RNA

Leticia Pereira and others

Nucleic Acid Therapeutics

Elucidating the kinetics of CRISPR'SaCas9 action to obtain effective HIV DNA excision with two gRNAs

Zhenghao Yu and others

RNA and RNA-protein complexes

Structure of a specialized 70S initiation complex

Dominic Arpin and others

Role of the anti-Shine'Dalgarno sequence of 16S rRNA in Flavobacterium johnsoniae

Fawwaz M Naeem and others

A nanopore-based HIV-1 reference epitranscriptome

Michael S Bosmeny and others

An RNA structural switch controlling bacterial toxin translation

Athina Eleftheraki and others

Inverted Alu repeats in loop-out exon skipping across hominoid evolution

Danielle Denisko and others

YqeK governs the acquisition and removal of nucleoside tetraphosphate caps in Firmicutes

Deblina Basu and others

m5C RNA methylation is dysregulated by oncogenic herpesviruses via c-Myc signaling to counteract host antiviral factors

Zhenyu Wu and others

The human branchpoint-interacting stem-loop sequence and structure regulates U2 snRNA expression, branchpoint recognition, and the transcriptome

Meredith B Stevers and others

Characterization of flexible RNA binding by tandem RNA recognition motifs through integrative ensemble modelling

Cristina K X Nguyen and others

RNA binding protein Musashi1 interacts with the viral genomic RNA and restricts SARS-CoV-2 infection by repressing translation

Sourav Ganguli and others

KREPA6 functions in RNA editing catalytic complex structural organization and gRNA utilization in Trypanosoma brucei

Brittney Davidge and others

Kozak sequences regulate gene expression in Trypanosoma brucei

Philip Stettler and others

Synthetic Biology and Bioengineering

High-throughput methods enabling random duplications, deletions, or nucleotide-constrained mutagenesis of entire DNA motifs

Marcus WÃ¤neskog and others

Enhancement of single-stranded template annealing activity by Rad52 during repair of CRISPR-induced dsDNA breaks

Haiyan Liu and others

PE-STAR: prime editing with SOS-triggered and RecJ-augmented repair enables high-efficiency editing in Escherichia coli

Xiaoyan Duan and others

Methods

Development and application of G4-Flame as a visual biosensor for G4-DNA

Ruyi Liu and others

Fast and accurate identification of emerging viral reassortment from genome sequences

Dehan Cai and others

Photocaged FLP recombinase for precise spatio-temporal control of gene expression

Jose Javier Vazquez Rodriguez and others

Breaking the stoichiometric limit of padlock probe ligation via catalytic hairpin assembly-and-cyclization

Fanming Meng and others

Accurate prediction of cohesin and RNA Polymerase II-associated chromatin interactions using convolutional neural networks

Ahmed Abbas and others

Programmable, target-induced fluorogenic CRISPR'tDeg platform for live-cell RNA visualization

Huimin Zhong and others

HAMMER: hairpin-based APOBEC3A-mediated mRNA editing reporter

Yanjun Chen and others

Efficient multi-kilobase knock-ins in mice and cell lines using CRISPR/Cas9 and rAAV donors with unbiased whole-genome characterization by LOCK-seq

Monica F Sentmanat and others

Live-cell decoding of labile post-translational modifications in APE1 with a rationally engineered nano-catcher

Ruilan Zhang and others

Corrections

Correction to ˜TDG orchestrates ATF4-dependent gene transcription during retinoic acid-induced cell fate acquisition'

Editor's Note

Editor's Note on ˜Snail1 transcriptional repressor binds to its own promoter and controls its expression'

Expression of Concern

Expression of Concern on ˜XRCC1 is phosphorylated by DNA-dependent protein kinase in response to DNA damage'

This email is intended for bionet@evol.mcmaster.ca.