Subject: New issue: Nucleic Acids Research, Volume 54, Issue 7, 24 April 2026

Volume 54, Issue 7, 24 April 2026

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Chemical Biology and Nucleic Acid Chemistry

Acyclic serinol nucleic acid modification of siRNAs overcomes seed region mediated off-target effects while maintaining potency

Tyler Chickering and others

Computational Biology

Computational prediction-combined proteogenomics unveils widespread non-AUG translation initiation events in plants

Yuqian Zhang and others

Sequence patterns in RNA replication via the virtual circular genome mechanism

Paul G Higgs

Gene Regulation, Chromatin and Epigenetics

Developmental stage dominates cell-type identity and reveals a chromatin regulatory function for Rad50 in Drosophila

Thomas Boutet and others

SP1 antagonizes H3K27me3 to shape chromatin landscapes for RNA polymerase II recruitment during gastrulation

Xipeng Shen and others

RPA hyperphosphorylation hinders the resolution of R-loops and G-quadruplex-associated R-loops during RAS-driven senescence

Ylenia Cortolezzis and others

The 3D genomics of lampbrush chromosomes highlights the role of active transcription in chromatin organization

Timofey Lagunov and others

Heterochromatin reorganization associated with the transcriptional reprogramming under viral infection in Arabidopsis

Maria Luz Annacondia and others

MicroRNA-Mediated Obstruction of Stem'loop Alternative Splicing (MIMOSAS) regulates long-range alternative splicing in Drosophila

Kai Ruan and others

Multimodal profiling reveals cell type-specific pseudouridine modification and density-dependent translational regulation

Caroline A McCormick and others

Genome Integrity, Repair and Replication

Slx4 and Fun30/SMARCAD1 coordinate S-phase checkpoint regulation and replication fork protection in response to Top1'DNA crosslinks

Mathilde Courtes and others

Subtle-seq reveals frequent ageing-associated chromosome fragmentation on nucleosome core DNA

Ryuma Matsubara and others

Ubiquitylation of DNA polymerase beta via atypical K27 chains signals a DNA damage response

Qingming Fang and others

DNA-PKcs inhibitor AZD7648 reveals sgRNA cross-contaminants and enhanced sensitivity of genome engineering off-target activity in HSPCs

Nathan White and others

ACRC/GCNA is an essential protease that repairs DNA'protein crosslinks during vertebrate development

Cecile Otten and others

A developmental condensin I complex assists the Paramecium PiggyMac domesticated transposase during programmed DNA elimination

Thomas Balan and others

ATR and TopBP1 oppose to control dormant origin activity and global replication dynamics, providing a first defense against replication stress

StÃ©phane Koundrioukoff and others

ATM promotes PFKP nuclear translocation to balance glycolysis and homologous recombination repair

Haoyun Liu and others

Genomics

Frequent occurrence and predicted functions of tRNAs with 4-base-pair anticodon stems in bacteria: extended superwobble hypothesis

Fadel Fakih and others

Harnessing toxin-mediated ribosome stalling as a complementary tool to annotate bacterial ORFs

Eduardo A Troian and others

Molecular and Structural Biology

Nuclear speckle dynamics are controlled by polyphosphate inhibition of CLK proteins

Blanca LÃ¡zaro and others

Cryo-EM structures of anti Z-DNA antibodies in complex with antigen reveal distinct recognition modes of a left-handed geometry

Danielle Chin and others

rRNA expansion segments mediate ribosome dimerization as a conserved stress response

Wenhong Jiang and others

Nucleic Acid Enzymes

Precise, specific gene editing via a compact GoCas12m'FokI chimeric nuclease

Tin Marsic and others

Nucleic Acid Therapeutics

Phosphorothioate antisense oligonucleotide induced innate immune activation is attenuated by tryptophan oxidation products

Julia Pytte and others

Engineering polymeric RNA scaffolds as programmable combinatorial innate immune agonists

Yinying Yang and others

Development of a DUX4-targeting antibody oligonucleotide conjugate as a therapy for FSHD

Barbora Malecova and others

RNA and RNA-protein complexes

Epididymal extracellular vesicles harbor and convey mRNA to sperm for transfer to zygotes

Natalie A Trigg and others

Disrupting pegRNA intramolecular complementarity via PBS and spacer sequence alterations can enhance prime editing efficiency

Zsuzsanna BiczÃ³k and others

The Alteromonas macleodii ribosome enables consecutive incorporation of bulky D-amino acids into peptides

Takayuki Katoh and others

Synthetic Biology and Bioengineering

A versatile CRISPR-associated transposases-mediated toolkit for transcriptional regulation library

Yiwen Zhang and others

Methods

sc-rDSeq: a robust and cost-effective full-length total RNA sequencing method for single cells reveals multilayered heterogeneity in drug-resistant lung cancer cells

Xue Sun and others

Shape-constrained, changepoint additive models for time series omics data with cpam

Luke A Yates and others

DNAi: an open-source AI tool for unbiased DNA fiber analysis

Rapid photo-crosslinking in living cells reveals protein'nucleic acid dynamics on a timescale of minutes

Jakob Trendel and others

Corrections

Correction to ˜RNA binding protein Musashi1 interacts with the viral genomic RNA and restricts SARS-CoV-2 infection by repressing translation'

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