Subject: New issue: Nucleic Acids Research, Volume 54, Issue 8, 8 May 2026

Volume 54, Issue 8, 8 May 2026

View issue

NAR Breakthrough Article

Mechanism of single-strand annealing from native mass spectrometry and cryo-EM structures of RAD52 homolog Mgm101

Carter T Wheat and others

Haplotype-resolved genome assemblies of BJ and IMR-90 human fibroblast cell lines reveal extensive structural variation and enable reanalysis of historical sequencing data

T Rhyker Ranallo-Benavidez and others

Critical Reviews and Perspectives

On the molecular basis of enduring memory in neurons, and cell fate in fibroblasts

Peter R Cook

1950'2000: five decades of curiosity-driven discovery in alternative DNA structures

David Monchaud

Chemical Biology and Nucleic Acid Chemistry

In situ tracking of glycoRNAs on single-cell surface to reveal RNA heterogeneity and transport mechanism

Meilin Gong and others

Coupling DNA intercalation with redox catalysis: selective killing mechanism of glioblastoma by daidzin

Shreya Banerjee and others

Computational Biology

Discovering proteo-transcriptomic networks via biologically informed heterogeneous graph learning

Jingxian Duan and others

Gene Regulation, Chromatin and Epigenetics

PhoP-regulated VirK acts as an accessory factor to maintain virulence in polymyxin-resistant Klebsiella pneumoniae

Haibin Li and others

How interdiction of inositol pyrophosphate catabolism perturbs the fission yeast response to phosphate starvation

Jill Babor and others

H2A.Z facilitates Sox2-nucleosome interaction by promoting DNA and histone H3 tail mobility

Helen K Moos and others

Dual role of ZIC2 during neural induction: from priming transcription factor to enhancer activator

MarÃa Mariner-FaulÃ and others

HSF1 and YTHDC1 enhance DNA repair under heat stress by promoting repair-associated gene expression

Wenqing Ding and others

Genome Integrity, Repair and Replication

A new family of rolling-circle replication endonucleases widespread in archaeal viruses and plasmids

Yixuan Wang and others

K63-linked ubiquitylation of S2P'RNAPII regulates transcription in a DNAPK inter-dependent manner in response to double-strand breaks

Vasiliki Pantazi and others

Emergence and evolution of chimeric pseudogenes (Ï†genes) contribute to genetic and functional diversity of the human genome

Amruta R Jadhav and others

Replication protein A protects lagging strand gaps, restricting PARP inhibitor-induced synthetic lethality in BRCA1-deficient tumors

Pamela S VanderVere-Carozza and others

The DNA helicase HELQ promotes replication fork reversal in coordination with BRCA2- and FANCD2-mediated repair pathways

Yerkin Dunbayev and others

The interferon-stimulated gene product HERC5 inhibits human LINE-1 retrotransposition with an ISGylation-independent mechanism

Kei Nishimori and others

Genomics

The promise of AlphaFold for gene structure annotation

Helen R Davison and others

Impact of alternative splicing on Arabidopsis proteome

Andres V Reyes and others

Molecular and Structural Biology

Functional analyses identify the L1 ORF2p Cryptic domain as a hub for intramolecular interfaces required for retrotransposition

Afzaal M Shareef and others

FOXC2 represses NFAT1-dependent transcription through a DNA-facilitated protein'protein interaction

Xiaojuan Chen and others

Recognition of the wobble pair: quantum mechanical calculations of tRNA U34 or C34 modifications within the ribosomal decoding center

Yi Liu and others

Structure of the hibernating Francisella tularensis ribosome and mechanistic insights into its inhibition by antibiotics

Martin Klima and others

Ligands reshape the compactness, stability, and topology of telomeric G-quadruplex dimers

Luca Bertini and others

Flexible regulation of CRISPR/Cas12a activity by spatial confinement effect

Huan Yang and others

Zalpha and Zbeta domains of ADAR1 and ZBP1 bind G-quadruplexes with nanomolar affinities, establishing Zbeta as a G-quadruplex-specific domain

Charles W Kroft and others

Nucleic Acid Enzymes

Cell-type-specific ablation of siRNAs by Arabidopsis RTL1 reveals a role of phloem companion cells in systemic post-transcriptional gene silencing

Martin Lacroix and others

Systematic screening of archaeal MazF homologs reveals Tth-MazF1, a versatile, sequence-specific ribonuclease from Thermococcus thioreducens

Benjamin F Jepson and others

Mitochondrial DNA replication is regulated by endoplasmic reticulum-mitochondrial contact sites, the mitochondrial calcium uniporter, and manganese

Amaia Lopez de Arbina and others

Archaeal family B DNA polymerase facilitates lagging strand DNA replication in the Thermococcales

Geraldy Lie Stefanus Liman and others

A kinetic approach for mapping seed regions of CRISPR ribonucleoprotein and improving specificity

Wei Feng and others

AlphaFold3-guided tracrRNA redesign yields small monomeric Cas12f RNPs

Lulu Pan and others

A universal and orthogonal safety valve for CRISPR/Cas12a without chemical modification or external stimulation

Wang Luo and others

Nucleic Acid Therapeutics

Divalent siRNA for prion disease

Juliana E Gentile and others

Direct targeting of C9ORF72 repeat RNA with fluorinated antisense oligonucleotides

Halle M Barber and others

RNA and RNA-protein complexes

ADAR1 and ADAR2 associate with the RNA exosome and modulate RNA stability

Dragana VukiÄ‡ and others

Small regulatory RNAs modulate lactococcal susceptibility to cell wall-targeting antimicrobials

Milda MickutÄ- and others

Structure and sequence characteristics of 5²-stem-loop 1 modulate the escape from nsp1-mediated repression in SARS-CoV-2 variants

Julian B Schoth and others

Repurposed hnRNPC binds mature mRNAs and safeguards the mitotic transcriptome

Liat Lev-Ari and others

Cap-adjacent 2²-O-ribose methylation of RNA in C. elegans is required for postembryonic growth and germline development in the presence of the decapping exonuclease EOL-1

Eileen Clemens and others

Investigation of TRMT61B methyltransferase activity on mRNA and its effects on translation

Dorthy Fang and others

The tRNA dihydrouridine synthase DusA has a distinct mechanism in optimizing tRNAs for translation

Sarah K Schultz and others

Synthetic Biology and Bioengineering

Automated linear DNA assembly of A. thaliana's chloroplast and mitochondrial genome

Jianting Zhou and others

Exploring chromosomal position effects for predictable tuning of metabolic pathways in yeast

Haosen Hong and others

Operating CRISPR/Cas12a in a complex nucleic acid sequence background

Henning Hellmer and others

DUSP11 is an RNA triphosphatase that limits PspCas13b activity by destabilizing gRNA abundance in mammalian cells

Jacob Purcell and others

Multiplexed CRISPR base editing enables pulse-activated irreversible biocontainment of engineered bacteria

Sung Won Cho and others

Methods

HM-DyadCap ' capture and mapping of 5-hydroxymethylcytosine/5-methylcytosine CpG dyads in mammalian DNA

Lena Engelhard and others

CMDdemux: an efficient single cell demultiplexing method

Jianan Wang and others

Single-cell trajectory inference for detecting transient events in biological processes

Alexandre Hutton and others

OT-Curtains: an approach for studying protein interactions with DNA ends using optical tweezers and confocal fluorescence microscopy

Sara De BraganÃ§a and others

RNAdetector: fast and accurate predictor of RNA type-specific binding residues in protein sequences

Gang Hu and others

CSsingle: a unified tool for robust decomposition of bulk and spatial transcriptomic data across diverse single-cell references

Wenjun Shen and others

Systematic assessment of diverse RNA modifications using nanopore direct RNA sequencing

Xinqi Kang and others

Intrinsically disordered protein droplet-enhanced oligonucleotide assembly enables rapid oligonucleotide-to-protein expression

Taiji Ueno and others

Correction

Correction to ˜The 2026 Nucleic Acids Research database issue and the online molecular biology database collection'

Correction to "Nascent transcriptome of embryonic genome activation reveals a regulatory axis linking transcriptional priming to early lineage specification in mouse embryos"

Correction to ˜DNA damage signaling induced by the G-quadruplex ligand 12459 is modulated by PPM1D/WIP1 phosphatase'

Expression of Concern

Expression of Concern on ˜Differential induction of Leishmania donovani bi-subunit topoisomerase I'DNA cleavage complex by selected flavones and camptothecin: activity of flavones against camptothecin-resistant topoisomerase I'

This email is intended for bionet@evol.mcmaster.ca.