This page is brought to you by Brian Golding (Golding@McMaster.CA) and is copied locally here to speed your access. To go to the original page (should you find something interesting or should you wish to follow links) click on

Current Issue of PLoSBiology


Current Issue | PLOS Biology
Skip to main content
Advertisement
Table of Contents

July 2024

Despite the deep conservation of the DNA damage response (DDR) pathway, cells in different contexts vary widely in their susceptibility to DNA damage and their propensity to undergo apoptosis as a result of genomic lesions. One of the cell signaling pathways implicated in modulating the DDR is the highly conserved Wnt pathway, which is known to promote resistance to DNA damage caused by ionizing radiation in a variety of human cancers, but the mechanisms linking Wnt signal transduction to the DDR remain unclear. Ewen-Campen and Perrimon use a genetically encoded system in Drosophila to reliably induce consistent levels of DNA damage in vivo, and demonstrate that canonical Wnt signaling in the wing imaginal disc buffers cells against apoptosis in the face of DNA double-strand breaks. Wg, the primary Wnt ligand in Drosophila, activates epidermal growth factor receptor (EGFR) signaling via the ligand-processing protease Rhomboid, which, in turn, modulates the DDR in a Chk2-, p53-, and E2F1-dependent manner. The image shows two wing discs after Cas9-induced DNA damage. Apoptotic cells are highlighted by Dcp-1 expression (magenta), while cyan and white indicate Wg and Ci expression, respectively.

Image Credit: Ben Ewen-Campen

Essays

The new science of sleep: From cells to large-scale societies

Omer Sharon, Eti Ben Simon, Vyoma D. Shah, Tenzin Desel, Matthew P. Walker

Unsolved Mystery

Research Articles

Spontaneous single-nucleotide substitutions and microsatellite mutations have distinct distributions of fitness effects

Yevgeniy Plavskin, Maria Stella de Biase, Naomi Ziv, Libuše Janská, Yuan O. Zhu, David W. Hall, Roland F. Schwarz, Daniel Tranchina, Mark L. Siegal

Multicellular magnetotactic bacteria are genetically heterogeneous consortia with metabolically differentiated cells

George A. Schaible, Zackary J. Jay, John Cliff, Frederik Schulz, Colin Gauvin, Danielle Goudeau, Rex R. Malmstrom, S. Emil Ruff, Virginia Edgcomb, Roland Hatzenpichler

Related Articles

Dopamine and acetylcholine have distinct roles in delay- and effort-based decision-making in humans

Mani Erfanian Abdoust, Monja Isabel Froböse, Alfons Schnitzler, Elisabeth Schreivogel, Gerhard Jocham

Goal-directed attention transforms both working and long-term memory representations in the human parietal cortex

Huinan Hu, Anqi Li, Liang Zhang, Chuqi Liu, Liang Shi, Xiaojing Peng, Tong Li, Yu Zhou, Gui Xue

Retrieval of contextual memory can be predicted by CA3 remapping and is differentially influenced by NMDAR activity in rat hippocampus subregions

Magdalena Miranda, Azul Silva, Juan Facundo Morici, Marcos Antonio Coletti, Mariano Belluscio, Pedro Bekinschtein

Dominant activities of fear engram cells in the dorsal dentate gyrus underlie fear generalization in mice

Kun Cui, Xuetao Qi, Zilong Liu, Weiqi Sun, Peijie Jiao, Chang Liu, Jifu Tong, Xiaoyan Sun, Haojie Sun, Su Fu, Jiaxin Wang, Yawen Zheng, Tianyu Liu, Shuang Cui, Fengyu Liu, Jian Mao, Jie Zheng, You Wan, Ming Yi

Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer’s disease

Rikesh M. Rajani, Robert Ellingford, Mariam Hellmuth, Samuel S. Harris, Orjona S. Taso, David Graykowski, Francesca Kar Wey Lam, Charles Arber, Emre Fertan, John S. H. Danial, Matthew Swire, Marcus Lloyd, Tatiana A. Giovannucci, Mathieu Bourdenx, David Klenerman, Robert Vassar, Selina Wray, Carlo Sala Frigerio, Marc Aurel Busche

Aberrant activation of hippocampal astrocytes causes neuroinflammation and cognitive decline in mice

Jae-Hong Kim, Nakamura Michiko, In-Sun Choi, Yujung Kim, Ji-Young Jeong, Maan-Gee Lee, Il-Sung Jang, Kyoungho Suk

Related Articles

KCTD proteins regulate morphine dependence via heterologous sensitization of adenylyl cyclase 1 in mice

Zhong Ding, Chunsheng Zhang, Huicui Yang, Jiaojiao Chen, Zhiruo Sun, Xuechu Zhen

miR-203 secreted in extracellular vesicles mediates the communication between neural crest and placode cells required for trigeminal ganglia formation

Yanel E. Bernardi, Estefania Sanchez-Vasquez, Rocío Belén Márquez, Michael L. Piacentino, Hugo Urrutia, Izadora Rossi, Karina L. Alcântara Saraiva, Antonio Pereira-Neves, Marcel I. Ramirez, Marianne E. Bronner, Natalia de Miguel, Pablo H. Strobl-Mazzulla

Mapping mutational fitness effects across the coxsackievirus B3 proteome reveals distinct profiles of mutation tolerability

Beatriz Álvarez-Rodríguez, Sebastian Velandia-Álvarez, Christina Toft, Ron Geller

Canonical and noncanonical roles of Hop1 are crucial for meiotic prophase in the fungus Sordaria macrospora

Emeline Dubois, Stéphanie Boisnard, Henri-Marc Bourbon, Kenza Yefsah, Karine Budin, Robert Debuchy, Liangran Zhang, Nancy Kleckner, Denise Zickler, Eric Espagne

SAMD9L acts as an antiviral factor against HIV-1 and primate lentiviruses by restricting viral and cellular translation

Alexandre Legrand, Clara Dahoui, Clément De La Myre Mory, Kodie Noy, Laura Guiguettaz, Margaux Versapuech, Clara Loyer, Margaux Pillon, Mégane Wcislo, Laurent Guéguen, Clarisse Berlioz-Torrent, Andrea Cimarelli, Mathieu Mateo, Francesca Fiorini, Emiliano P. Ricci, Lucie Etienne

The cytidine deaminase APOBEC3A regulates nucleolar function to promote cell growth and ribosome biogenesis

Mason A. McCool, Carson J. Bryant, Laura Abriola, Yulia V. Surovtseva, Susan J. Baserga

Mutations in nucleotide metabolism genes bypass proteasome defects in png-1/NGLY1-deficient Caenorhabditis elegans

Katherine S. Yanagi, Briar Jochim, Sheikh Omar Kunjo, Peter Breen, Gary Ruvkun, Nicolas Lehrbach

Alternative TSS use is widespread in Cryptococcus fungi in response to environmental cues and regulated genome-wide by the transcription factor Tur1

Thi Tuong Vi Dang, Corinne Maufrais, Jessie Colin, Frédérique Moyrand, Isabelle Mouyna, Jean-Yves Coppée, Chinaemerem U. Onyishi, Joanna Lipecka, Ida Chiara Guerrera, Robin C. May, Guilhem Janbon

Short Reports

Signaling through the nicotinic acetylcholine receptor in the liver protects against the development of metabolic dysfunction-associated steatohepatitis

Heejin Jun, Shanshan Liu, Alexander J. Knights, Kezhou Zhu, Yingxu Ma, Jianke Gong, Ashley E. Lenhart, Xiaoling Peng, Yunying Huang, Jared P. Ginder, Christopher H. Downie, Erika Thalia Ramos, Klas Kullander, Robert T. Kennedy, X. Z. Shawn Xu, Jun Wu

Prophage induction can facilitate the in vitro dispersal of multicellular Streptomyces structures

Hoda Jaffal, Mounia Kortebi, Pauline Misson, Paulo Tavares, Malika Ouldali, Hervé Leh, Sylvie Lautru, Virginia S. Lioy, François Lecointe, Stéphanie G. Bury-Moné

Retrotransposon-mediated disruption of a chitin synthase gene confers insect resistance to Bacillus thuringiensis Vip3Aa toxin

Zhenxing Liu, Chongyu Liao, Luming Zou, Minghui Jin, Yinxue Shan, Yudong Quan, Hui Yao, Lei Zhang, Peng Wang, Zhuangzhuang Liu, Na Wang, Anjing Li, Kaiyu Liu, Bruce E. Tabashnik, David G. Heckel, Kongming Wu, Yutao Xiao

The evolution of antimicrobial peptide resistance in Pseudomonas aeruginosa is severely constrained by random peptide mixtures

Bernardo Antunes, Caroline Zanchi, Paul R. Johnston, Bar Maron, Christopher Witzany, Roland R. Regoes, Zvi Hayouka, Jens Rolff

Hyphae of the fungus Aspergillus nidulans demonstrate chemotropism to nutrients and pH

Riho Yamamoto, Hinata Miki, Ayaka Itani, Norio Takeshita

Methods and Resources

Individual canopy tree species maps for the National Ecological Observatory Network

Ben G. Weinstein, Sergio Marconi, Alina Zare, Stephanie A. Bohlman, Aditya Singh, Sarah J. Graves, Lukas Magee, Daniel J. Johnson, Sydne Record, Vanessa E. Rubio, Nathan G. Swenson, Philip Townsend, Thomas T. Veblen, Robert A. Andrus, Ethan P. White

A phylogeny-informed characterisation of global tetrapod traits addresses data gaps and biases

Mario R. Moura, Karoline Ceron, Jhonny J. M. Guedes, Rosana Chen-Zhao, Yanina V. Sica, Julie Hart, Wendy Dorman, Julia M. Portmann, Pamela González-del-Pliego, Ajay Ranipeta, Alessandro Catenazzi, Fernanda P. Werneck, Luís Felipe Toledo, Nathan S. Upham, João F. R. Tonini, Timothy J. Colston, Robert Guralnick, Rauri C. K. Bowie, R. Alexander Pyron, Walter Jetz

Single-fly genome assemblies fill major phylogenomic gaps across the Drosophilidae Tree of Life

Bernard Y. Kim, Hannah R. Gellert, Samuel H. Church, Anton Suvorov, Sean S. Anderson, Olga Barmina, Sofia G. Beskid, Aaron A. Comeault, K. Nicole Crown, Sarah E. Diamond, Steve Dorus, Takako Fujichika, James A. Hemker, Jan Hrcek, Maaria Kankare, Toru Katoh, Karl N. Magnacca, Ryan A. Martin, Teruyuki Matsunaga, Matthew J. Medeiros, Danny E. Miller, Scott Pitnick, Michele Schiffer, Sara Simoni, Tessa E. Steenwinkel, Zeeshan A. Syed, Aya Takahashi, Kevin H-C. Wei, Tsuya Yokoyama, Michael B. Eisen, Artyom Kopp, Daniel Matute, Darren J. Obbard, Patrick M. O’Grady, Donald K. Price, Masanori J. Toda, Thomas Werner, Dmitri A. Petrov

FURNA: A database for functional annotations of RNA structures

Chengxin Zhang, Lydia Freddolino

Meta-Research Article

“Best Paper” awards lack transparency, inclusivity, and support for Open Science

Malgorzata Lagisz, Joanna Rutkowska, Upama Aich, Robert M. Ross, Manuela S. Santana, Joshua Wang, Nina Trubanová, Matthew J. Page, Andrew Adrian Yu Pua, Yefeng Yang, Bawan Amin, April Robin Martinig, Adrian Barnett, Aswathi Surendran, Ju Zhang, David N. Borg, Jafsia Elisee, James G. Wrightson, Shinichi Nakagawa

Update Articles

Collective peroxide detoxification determines microbial mutation rate plasticity in E. coli

Rowan Green, Hejie Wang, Carol Botchey, Siu Nam Nancy Zhang, Charles Wadsworth, Francesca Tyrrell, James Letton, Andrew J. McBain, Pawel Paszek, Rok Krašovec, Christopher G. Knight

Related Articles

Behavioral adjustment of C. elegans to mechanosensory loss requires intact mechanosensory neurons

Michal Staum, Ayelet-Chen Abraham, Reema Arbid, Varun Sanjay Birari, Matanel Dominitz, Ithai Rabinowitch

Related Articles

Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling

Kaleeckal G. Harikumar, Peishen Zhao, Brian P. Cary, Xiaomeng Xu, Aditya J. Desai, Maoqing Dong, Jesse I. Mobbs, Chirine Toufaily, Sebastian G. B. Furness, Arthur Christopoulos, Matthew J. Belousoff, Denise Wootten, Patrick M. Sexton, Laurence J. Miller

Related Articles