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Current Issue of PLoSBiology


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December 2024

This artwork illustrates bacterial trails towards nutrient-releasing marine aggregates. The pseudo-colored aggregate consists of tiny crude oil droplets embedded in a matrix of microbes and biopolymers. The variation in color intensity around the aggregate abstractly represents a eutrophic microzone of high bacterial abundance. In this work, we develop a data-driven model to determine under what conditions such bacterial microzones may reshape the nutrient fields. The multiple versions of the core pattern are inspired by Andy Warhol's style and represent the rich diversity in particulate, chemical, and bacterial species of the oceans. Kapellos et al

Image Credit: George E Kapellos

Education Articles

Hands-on training about data clustering with orange data mining toolbox

Janez Demšar, Blaž Zupan

Using genomic data and machine learning to predict antibiotic resistance: A tutorial paper

Faye Orcales, Lucy Moctezuma Tan, Meris Johnson-Hagler, John Matthew Suntay, Jameel Ali, Kristiene Recto, Phelan Glenn, Pleuni Pennings

Research Articles

Stable developmental patterns of gene expression without morphogen gradients

Maciej Majka, Nils B. Becker, Pieter Rein ten Wolde, Marcin Zagorski, Thomas R. Sokolowski

Parallel development of object recognition in newborn chicks and deep neural networks

Lalit Pandey, Donsuk Lee, Samantha M. W. Wood, Justin N. Wood

Mapping genes for human face shape: Exploration of univariate phenotyping strategies

Meng Yuan, Seppe Goovaerts, Michiel Vanneste, Harold Matthews, Hanne Hoskens, Stephen Richmond, Ophir D. Klein, Richard A. Spritz, Benedikt Hallgrimsson, Susan Walsh, Mark D. Shriver, John R. Shaffer, Seth M. Weinberg, Hilde Peeters, Peter Claes

Theta oscillations optimize a speed-precision trade-off in phase coding neurons

Adrián F. Amil, Albert Albesa-González, Paul F. M. J. Verschure

Image-based force inference by biomechanical simulation

Michiel Vanslambrouck, Wim Thiels, Jef Vangheel, Casper van Bavel, Bart Smeets, Rob Jelier

Social conformity is a heuristic when individual risky decision-making is disrupted

Mark A. Orloff, Dongil Chung, Xiaosi Gu, Xingchao Wang, Zhixian Gao, Guiding Song, Chandana Tatineni, Shuai Xu, Brooks Casas, Pearl H. Chiu

Long distance calls: Negligible information loss of little auk social vocalisations due to high frequency propagation losses

Anna N. Osiecka, Przemysław Bryndza, Elodie F. Briefer, Katarzyna Wojczulanis-Jakubas

scMSI: Accurately inferring the sub-clonal Micro-Satellite status by an integrated deconvolution model on length spectrum

Yuqian Liu, Yan Chen, Huanwen Wu, Xuanping Zhang, Yuqi Wang, Xin Yi, Zhiyong Liang, Jiayin Wang

Expansion of epileptogenic networks via neuroplasticity in neural mass models

Elif Köksal-Ersöz, Pascal Benquet, Fabrice Wendling

Predicting proprioceptive cortical anatomy and neural coding with topographic autoencoders

Max Grogan, Kyle P. Blum, Yufei Wu, J. Alex Harston, Lee E. Miller, A. Aldo Faisal

Measuring genetic diversity across populations

Niloufar Abhari, Caroline Colijn, Arne Mooers, Paul Tupper

Public surface disinfection every 2 hours can reduce the infection risk of norovirus in airports up to 83%

Nan Zhang, Linan Zhuang, Marco-Felipe King, Hua Qian, Min Zhu

Whole brain functional connectivity: Insights from next generation neural mass modelling incorporating electrical synapses

Michael Forrester, Sammy Petros, Oliver Cattell, Yi Ming Lai, Reuben D. O’Dea, Stamatios Sotiropoulos, Stephen Coombes

Circuits and mechanisms for TMS-induced corticospinal waves: Connecting sensitivity analysis to the network graph

Gene J. Yu, Federico Ranieri, Vincenzo Di Lazzaro, Marc A. Sommer, Angel V. Peterchev, Warren M. Grill

Modelling the effectiveness of antiviral treatment strategies to prevent household transmission of acute respiratory viruses

Hind Zaaraoui, Clarisse Schumer, Xavier Duval, Bruno Hoen, Lulla Opatowski, Jérémie Guedj

OneNet—One network to rule them all: Consensus network inference from microbiome data

Camille Champion, Raphaëlle Momal, Emmanuelle Le Chatelier, Mathilde Sola, Mahendra Mariadassou, Magali Berland

Large scale paired antibody language models

Henry Kenlay, Frédéric A. Dreyer, Aleksandr Kovaltsuk, Dom Miketa, Douglas Pires, Charlotte M. Deane

Oscillatory dynamics of Rac1 activity in Dictyostelium discoideum amoebae

Marko Šoštar, Maja Marinović, Vedrana Filić, Nenad Pavin, Igor Weber

Federated privacy-protected meta- and mega-omics data analysis in multi-center studies with a fully open-source analytic platform

Xavier Escriba-Montagut, Yannick Marcon, Augusto Anguita-Ruiz, Demetris Avraam, Jose Urquiza, Andrei S. Morgan, Rebecca C. Wilson, Paul Burton, Juan R. Gonzalez

Preserving friendships in school contacts: An algorithm to construct synthetic temporal networks for epidemic modelling

Lucille Calmon, Elisabetta Colosi, Giulia Bassignana, Alain Barrat, Vittoria Colizza

Bacterial clustering amplifies the reshaping of eutrophic plumes around marine particles: A hybrid data-driven model

George E. Kapellos, Hermann J. Eberl, Nicolas Kalogerakis, Patrick S. Doyle, Christakis A. Paraskeva

Quantitative and Kinetic Proteomics Reveal ApoE Isoform-dependent Proteostasis Adaptations in Mouse Brain

Nathan R. Zuniga, Noah E. Earls, Ariel E. A. Denos, Jared M. Elison, Benjamin S. Jones, Ethan G. Smith, Noah G. Moran, Katie L. Broce, Gerome M. Romero, Chad D. Hyer, Kimberly B. Wagstaff, Haifa M. Almughamsi, Mark K. Transtrum, John C. Price

Uncovering population contributions to the extracellular potential in the mouse visual system using Laminar Population Analysis

Atle E. Rimehaug, Anders M. Dale, Anton Arkhipov, Gaute T. Einevoll

Hierarchical marker genes selection in scRNA-seq analysis

Yutong Sun, Peng Qiu

Mechanical network equivalence between the katydid and mammalian inner ears

Emine Celiker, Charlie Woodrow, Òscar Guadayol, Leonidas-Romanos Davranoglou, Christian M. Schlepütz, Beth Mortimer, Graham K. Taylor, Stuart Humphries, Fernando Montealegre-Z

Adapting to time: Why nature may have evolved a diverse set of neurons

Karim G. Habashy, Benjamin D. Evans, Dan F. M. Goodman, Jeffrey S. Bowers

Neural networks with optimized single-neuron adaptation uncover biologically plausible regularization

Victor Geadah, Stefan Horoi, Giancarlo Kerg, Guy Wolf, Guillaume Lajoie

Tree polynomials identify a link between co-transcriptional R-loops and nascent RNA folding

Pengyu Liu, Jacob Lusk, Nataša Jonoska, Mariel Vázquez

Advanced vision transformers and open-set learning for robust mosquito classification: A novel approach to entomological studies

Ahmed Akib Jawad Karim, Muhammad Zawad Mahmud, Riasat Khan

A multi-scale study of thalamic state-dependent responsiveness

Jorin Overwiening, Federico Tesler, Domenico Guarino, Alain Destexhe

Dopamine facilitates the response to glutamatergic inputs in astrocyte cell models

Thiago Ohno Bezerra, Antonio C. Roque

Novel travel time aware metapopulation models and multi-layer waning immunity for late-phase epidemic and endemic scenarios

Henrik Zunker, René Schmieding, David Kerkmann, Alain Schengen, Sophie Diexer, Rafael Mikolajczyk, Michael Meyer-Hermann, Martin J. Kühn

Neuro-cognitive multilevel causal modeling: A framework that bridges the explanatory gap between neuronal activity and cognition

Moritz Grosse-Wentrup, Akshey Kumar, Anja Meunier, Manuel Zimmer

Randomness as a driver of inactivity in social groups

Abel Bernadou, Raphaël Jeanson

scMoMtF: An interpretable multitask learning framework for single-cell multi-omics data analysis

Wei Lan, Tongsheng Ling, Qingfeng Chen, Ruiqing Zheng, Min Li, Yi Pan

A framework for modelling desert locust population dynamics and large-scale dispersal

Renata Retkute, William Thurston, Keith Cressman, Christopher A. Gilligan

Optimisation strategies for directed evolution without sequencing

Jessica James, Sebastian Towers, Jakob Foerster, Harrison Steel

Predicting lung aging using scRNA-Seq data

Qi Song, Alex Singh, John E. McDonough, Taylor S. Adams, Robin Vos, Ruben De Man, Greg Myers, Laurens J. Ceulemans, Bart M. Vanaudenaerde, Wim A. Wuyts, Xiting Yan, Jonas Schuppe, James S. Hagood, Naftali Kaminski, Ziv Bar-Joseph

Evolution of cooperation in multichannel games on multiplex networks

Amit Basak, Supratim Sengupta

A computational model for angular velocity integration in a locust heading circuit

Kathrin Pabst, Evripidis Gkanias, Barbara Webb, Uwe Homberg, Dominik Endres

A mathematical model of plasmin-mediated fibrinolysis of single fibrin fibers

Roukayatou R. Ouedraogo, Hannah K. Sowers, Spencer R. Lynch, Nathan E. Hudson, Brittany E. Bannish

Sensitivity analysis of closed-loop one-chamber and four-chamber models with baroreflex

Karolina Tlałka, Harry Saxton, Ian Halliday, Xu Xu, Andrew Narracott, Daniel Taylor, Maciej Malawski

Adolescent and adult mice use both incremental reinforcement learning and short term memory when learning concurrent stimulus-action associations

Juliana Chase, Liyu Xia, Lung-Hao Tai, Wan Chen Lin, Anne G. E. Collins, Linda Wilbrecht

Machine learning mathematical models for incidence estimation during pandemics

Oscar Fajardo-Fontiveros, Mattia Mattei, Giulio Burgio, Clara Granell, Sergio Gómez, Alex Arenas, Marta Sales-Pardo, Roger Guimerà

A multivalent binding model infers antibody Fc species from systems serology

Armaan A. Abraham, Zhixin Cyrillus Tan, Priyanka Shrestha, Emily R. Bozich, Aaron S. Meyer

Evaluation and comparison of methods for neuronal parameter optimization using the Neuroptimus software framework

Máté Mohácsi, Márk Patrik Török, Sára Sáray, Luca Tar, Gábor Farkas, Szabolcs Káli

Extracting interpretable signatures of whole-brain dynamics through systematic comparison

Annie G. Bryant, Kevin Aquino, Linden Parkes, Alex Fornito, Ben D. Fulcher

Estimating the distribution of parameters in differential equations with repeated cross-sectional data

Hyeontae Jo, Sung Woong Cho, Hyung Ju Hwang

Predicting the infecting dengue serotype from antibody titre data using machine learning

Bethan Cracknell Daniels, Darunee Buddhari, Taweewun Hunsawong, Sopon Iamsirithaworn, Aaron R. Farmer, Derek A. T. Cummings, Kathryn B. Anderson, Ilaria Dorigatti

Surveillance for TB drug resistance using routine rapid diagnostic testing data: Methodological development and application in Brazil

Sarah E. Baum, Daniele M. Pelissari, Fernanda Dockhorn Costa, Luiza O. Harada, Mauro Sanchez, Patricia Bartholomay, Ted Cohen, Marcia C. Castro, Nicolas A. Menzies

Multicellular model of neuroblastoma proposes unconventional therapy based on multiple roles of p53

Kenneth Y. Wertheim, Robert Chisholm, Paul Richmond, Dawn Walker

Estimating the time-varying effective reproduction number via Cycle Threshold-based Transformer

Xin-Yu Zhang, Lan-Lan Yu, Wei-Yi Wang, Gui-Quan Sun, Jian-Cheng Lv, Tao Zhou, Quan-Hui Liu

Properties of winning Iterated Prisoner’s Dilemma strategies

Nikoleta E. Glynatsi, Vincent Knight, Marc Harper

Deciphering regulatory architectures of bacterial promoters from synthetic expression patterns

Rosalind Wenshan Pan, Tom Röschinger, Kian Faizi, Hernan G. Garcia, Rob Phillips

Cancer molecular subtyping using limited multi-omics data with missingness

Yongqi Bu, Jiaxuan Liang, Zhen Li, Jianbo Wang, Jun Wang, Guoxian Yu

Therapeutic dose prediction of α5-GABA receptor modulation from simulated EEG of depression severity

Alexandre Guet-McCreight, Frank Mazza, Thomas D. Prevot, Etienne Sibille, Etay Hay

The Burr distribution as a model for the delay between key events in an individual’s infection history

Nyall Jamieson, Christiana Charalambous, David M. Schultz, Ian Hall

Systematic benchmarking of deep-learning methods for tertiary RNA structure prediction

Akash Bahai, Chee Keong Kwoh, Yuguang Mu, Yinghui Li

Formal Comments

Response to comment on: Toward an optimal contraception dosing strategy

Brenda Lyn A. Gavina, Aurelio A. de los Reyes V, Mette S. Olufsen, Suzanne Lenhart, Johnny T. Ottesen

Related Articles

Comment on: Toward an optimal contraception dosing strategy

Giuseppe Benagiano, Andrea R. Genazzani, Giovanni Grandi, Sun-Wei Guo, Marwan Habiba

Related Articles

Methods

Mathematical basis and toolchain for hierarchical optimization of biochemical networks

Nisha Ann Viswan, Alexandre Tribut, Manvel Gasparyan, Ovidiu Radulescu, Upinder S. Bhalla

Homeodynamic feedback inhibition control in whole-brain simulations

Jan Stasinski, Halgurd Taher, Jil Mona Meier, Michael Schirner, Dionysios Perdikis, Petra Ritter

Differential quantification of alternative splicing events on spliced pangenome graphs

Simone Ciccolella, Davide Cozzi, Gianluca Della Vedova, Stephen Njuguna Kuria, Paola Bonizzoni, Luca Denti

Orchard: Building large cancer phylogenies using stochastic combinatorial search

Ethan Kulman, Rui Kuang, Quaid Morris

Software

ClustAll: An R package for patient stratification in complex diseases

Asier Ortega-Legarreta, Sara Palomino-Echeverria, Estefania Huergo, Vincenzo Lagani, Narsis A. Kiani, Pierre-Emmanuel Rautou, Nuria Planell Picola, Jesper Tegner, David Gomez-Cabrero

BharatSim: An agent-based modelling framework for India

Philip Cherian, Jayanta Kshirsagar, Bhavesh Neekhra, Gaurav Deshkar, Harshal Hayatnagarkar, Kshitij Kapoor, Chandrakant Kaski, Ganesh Kathar, Swapnil Khandekar, Saurabh Mookherjee, Praveen Ninawe, Riz Fernando Noronha, Pranjal Ranka, Vaibhhav Sinha, Tina Vinod, Chhaya Yadav, Debayan Gupta, Gautam I. Menon