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Current Issue of PLoSBiology


Current Issue | PLOS Computational Biology
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April 2026

This image illustrates cup formation on a phagocyte membrane during particle engulfment. Our modelling shows that membrane tension, a key but often overlooked physical factor, strongly influences phagocytic progression and can explain frustrated phagocytosis observed experimentally. We further show that biochemical signaling feeds back on membrane mechanics to reshape engulfment dynamics and enhance particle capture. These findings highlight the interplay between mechanics and signaling in phagocytosis, with implications for immunity, cell migration, and drug delivery. Shadmani et al. 2026

Image Credit: Peyman Shadmani and Behzad Mehrafrooz

Education Articles

Training biologists in Unix command-line skills: From curriculum to interactive online tutorials

Lucie Khamvongsa-Charbonnier, Robert Aboukhalil, Hélène Chiapello, Thomas Denecker, Pierre Poulain, Denis Puthier, Olivier Sand, Morgane Thomas-Chollier, Claire Toffano-Nioche

Ten simple rules for postdoctoral mums to stay competitive in academia

Belén Fadrique, Selene Báez

Ten simple rules for organising an effective student-led writing retreat

Nicholas W. Daudt, Claudia Hird, Eleanor R. M. Kelly, Elli E. Leinikki, Gretchen J. McCarthy, Ian S. Dixon-Anderson, Jackson E. Beagley, Jessica B. Moffitt, Joseph S. Curtis, Lindsay M. Wickman, Meghan L. Duffy, Preston L. Maluafiti, Saskia E. Foreman, William Carome, Leah M. Crowe

Ten common mistakes that could ruin your enrichment analysis

Anusuiya Bora, Matthew McKenzie, Mark Ziemann

Nine quick tips for software containerization

David Moreau, Kristina Wiebels

Perspective

Ten simple rules for mentoring and being mentored while neurodiverse

Adam B. Smith, Emily G. Adams, Ethan Abercrombie, Noor Bibi, Claire L. J. Bottini, Alissa J. Brown, Cybil N. Cavalieri, Alonwyn L. Clauser, Marlyse C. Duguid, Kasey D. Fowler-Finn, Jenna Hutchen, Victor Leite Jardim, Clarissa S. Rodriguez, Beck M. Swab, Steph Varghese

Research Articles

Explaining attractive and repulsive biases in the subjective visual vertical

Stefan Glasauer, W. Pieter Medendorp

Multidimensional scaling informed by F-statistic: Visualizing grouped microbiome data with inference

Hyungseok Kim, Soobin Kim, Jeffrey A. Kimbrel, Megan M. Morris, Xavier Mayali, Cullen R. Buie

Identifying the optimal rapid antigen test for screening and determining the end of isolation: A modeling study

Yong Dam Jeong, William S. Hart, Masahiro Ishikane, Kwang Su Kim, Jong Hyuk Byun, Il Hyo Jung, Montie T. Harrison, Kazuyuki Aihara, Norio Ohmagari, Christopher B. Brooke, Ruian Ke, Robin N. Thompson, Shingo Iwami

Emergence of multifrequency activity in a laminar neural mass model

Raul de Palma Aristides, Pau Clusella, Roser Sanchez-Todo, Giulio Ruffini, Jordi Garcia-Ojalvo

In silico assessment of arrhythmic risk following the implantation of engineered heart tissues in porcine hearts with varying infarct locations

Ricardo M. Rosales, Gonzalo R. Ríos-Muñoz, Ana María Sánchez de la Nava, María Eugenia Fernández-Santos, Javier Bermejo, Manuel Doblaré, Ana Mincholé, Esther Pueyo

Using cell-specific late-phase asthma mRNA biomarkers to repurpose drugs that concurrently reverse disease signatures across multiple immune cell-types

Mingming Zhang, Young Woong Kim, Chen Xi Yang, Gail M. Gauvreau, John Marcus FitzGerald, Louis-Philippe Boulet, Paul M. O’Byrne, Scott J. Tebbutt, Amrit Singh

A Bayesian modelling framework for estimating tick-borne pathogen transmission dynamics at the host-tick interface

Younjung Kim, Bruno Faivre, Thierry Boulinier, Célia Sineau, Clémence Galon, Sara Moutailler, Laure Bournez, Raphaëlle Métras

Exploring neural manifolds across a wide range of intrinsic dimensions

Jacopo Fadanni, Rosalba Pacelli, Alberto Zucchetta, Pietro Rotondo, Michele Allegra

Clustering single-cell multi-omics data via weighted distance penalty and adaptive consistent graph regularization

Wei Zhang, Yue Yu, Xiaoying Zheng, Juan Shen, Yuanyuan Li

Subunit-specific behavioral modulation of sensory tuning in the visual cortex

Julia M. Mayer, Wiktor F. Młynarski

Modeling spatial contrast sensitivity in responses of primate retinal ganglion cells to natural movies

Shashwat Sridhar, Michaela Vystrčilová, Mohammad H. Khani, Dimokratis Karamanlis, Helene M. Schreyer, Varsha Ramakrishna, Steffen Krüppel, Sören J. Zapp, Matthias Mietsch, Alexander S. Ecker, Tim Gollisch

A framework for constructing insect steering circuits

Robert Mitchell, Barbara Webb

A biophysical model of phagocytic cup dynamics: The effect of membrane tension

Peyman Shadmani, Behzad Mehrafrooz, Abbas Montazeri, David M. Richards

Rural-to-urban migrant worker mobility shaped measles epidemics in China

Peihua Wang, Xianwen Wang, Wenyi Zhang, Yong Wang, Sen Pei, Xiao-Ke Xu, Wan Yang

Efficiency, accuracy and robustness of probability generating function based parameter inference method for stochastic biochemical reactions

Shiyue Li, Yiling Wang, Zhanpeng Shu, Ramon Grima, Qingchao Jiang, Zhixing Cao

Nonlinear effects of noise on outbreaks of mosquito-borne diseases

Kyle J. -M. Dahlin, Karin Ebey, John E. Vinson, John M. Drake

How muscle ageing affects rapid goal-directed movement: mechanistic insights from a simple model

Delyle T. Polet, Christopher T. Richards

On the role of L-type Ca2+ and BK channels in a biophysical model of cartwheel interneurons

Matteo Martin, Jonathan E. Rubin, Morten Gram Pedersen

How the visual brain can learn to parse images using a multiscale, incremental grouping process

Sami Mollard, Sander M. Bohte, Pieter R. Roelfsema

Perceptual prediction error supports implicit process in motor learning

Xiaoyue Zhang, Wencheng Wu, Kunlin Wei

Unveiling gene perturbation effects through gene regulatory networks inference from single-cell transcriptomic data

Clelia Corridori, Merrit Romeike, Giorgio Nicoletti, Christa Buecker, Samir Suweis, Sandro Azaele, Graziano Martello

Developmental and aging changes in brain network switching dynamics revealed by EEG phase synchronization

Dionysios Perdikis, Rita Sleimen-Malkoun, Viktor Müller, Viktor Jirsa

Systematic prioritization of potential therapeutic targets for glomerulonephritis using multi-omics Mendelian randomization

Guoqiang Li, Fu Jianhan, Jiashu Gu, Yinhuai Wang, Jiachen Liu, Dong Yang, Dianjie Zeng, Pengcheng Zhao

Coherent cross-modal generation of synthetic biomedical data to advance multimodal precision medicine

Raffaele Marchesi, Nicolò Lazzaro, Walter Endrizzi, Gianluca Leonardi, Matteo Pozzi, Flavio Ragni, Stefano Bovo, Monica Moroni, Venet Osmani, Giuseppe Jurman

A phase-field model for vesicle membranes incorporating area-difference elasticity

Yihong Liang, Emine Celiker, Ping Lin

‘Backpropagation and the brain’ realized in cortical error neuron microcircuits

Kevin Max, Ismael Jaras, Arno Granier, Katharina A. Wilmes, Mihai A. Petrovici

Effects of sensorimotor delays and muscle force capacity limits on the performance of feedforward and feedback control in animals of different sizes

Sayed Naseel Mohamed Thangal, Heather L. More, C. David Remy, J. Maxwell Donelan

Spatio–temporal modelling of in vitro influenza A virus infection: The impact of defective interfering particles on the type I interferon response

Yimei Li, Bjarke Frost Nielsen, Simon A. Levin, Aartjan J.W. te Velthuis, Bryan T. Grenfell

Ensemble forecasts of COVID-19 activity to support Australia’s pandemic response: 2020–22

Robert Moss, Ruarai J. Tobin, Mitchell O’Hara-Wild, Adeshina I. Adekunle, Dennis Liu, Tobin South, Dylan J. Morris, Gerard E. Ryan, Tianxiao Hao, Aarathy Babu, Katharine L. Senior, James G. Wood, Nick Golding, Joshua V. Ross, Peter Dawson, Rob J. Hyndman, David J. Price, James M. McCaw, Freya M. Shearer

Sharing the spotlight: Uncovering common attentional dynamics across species

Mina Glukhova, Alejandro Tlaie, Robert Taylor, Pierre-Antoine Ferracci, Katharine Shapcott, Berkutay Mert, Olga Arne, Andrei Ciuparu, Raul C. Muresan, Martha N. Havenith, Marieke L. Schölvinck

Enhancing generalizability of model discovery across parameter space with multi-experiment equation learning for biological systems

Maria-Veronica Ciocanel, John T. Nardini, Kevin B. Flores, Erica M. Rutter, Suzanne S. Sindi, Alexandria Volkening

Monotherapy cancer drug-blind response prediction is limited to intraclass generalization

William G. Herbert, Nicholas Chia, Paul A. Jensen, Marina R. S. Walther-Antonio

Using experimental results of protein design to guide biomolecular energy-function development

Hugh K. Haddox, Gabriel J. Rocklin, Francis C. Motta, Devin Strickland, Samer F. Halabiya, Cameron Cordray, Hahnbeom Park, Eric Klavins, David Baker, Frank DiMaio

Phase-field modeling of border cell cluster migration in Drosophila

Naghmeh Akhavan, Alexander George, Michelle Starz-Gaiano, Bradford E. Peercy

Selective observation following betrayal shapes the social inference landscape

Sangkyu Son, Seng Bum Michael Yoo

Structural mechanisms underlying distinct binding and activities of 18:0 and 18:1 lysophosphatidic acids at LPA1 receptor

Ayobami Diyaolu, Peter Obi, Pravita Balijepalli, Kathryn E. Meier, Senthil Natesan

STARCall integrates image stitching, alignment, and read calling to enable scalable analysis of in situ sequencing data

Nicholas J. Bradley, Sriram Pendyala, Katie Partington, Douglas M. Fowler

How competition can drive allochronic divergence: A case study in the Marine Midge, Clunio marinus

Alexander G. G. Jacobsen, Tobias S. Kaiser, Chaitanya S. Gokhale

One model to rule them all: Unification of voltage-gated potassium channel models via deep non-linear mixed effects modelling

Domas Linkevicius, Angus Chadwick, Melanie I. Stefan, David C. Sterratt

Diversity in emergent cell locomotion from the coupling cytosolic and cortical Marangoni flows with reaction–diffusion dynamics

Blaž Ivšić, Dorijan Vulić, Igor Weber, Piotr Nowakowski, Ana-Sunčana Smith

Leveraging mathematical models to predict and control T-cell activation

Xabier Rey Barreiro, Jose Faro, Alejandro F. Villaverde

Systems biology analysis of vasodynamics in mouse cerebral arterioles during resting state and functional hyperemia

Hadi Esfandi, Mahshad Javidan, Eric R. McGregor, Rozalyn M. Anderson, Ramin Pashaie

A multi-omics framework for survival mediation analysis of high-dimensional proteogenomic data

Seungjun Ahn, Weijia Fu, Maaike van Gerwen, Lei Liu, Zhigang Li

Study of Protein-Protein Interactions in Septin Assembly: Multiple amphipathic helix domains cooperate in binding to the lipid membrane

S. Mahsa Mofidi, Abhilash Sahoo, Christopher J. Edelmaier, Stephen J. Klawa, Ronit Freeman, Amy Gladfelter, M. Gregory Forest, Ehssan Nazockdast, Sonya M. Hanson

Clustering of SARS-CoV-2 membrane proteins in lipid bilayer membranes

Joseph McTiernan, Yuanzhong Zhang, Siyu Li, Thomas E. Kuhlman, Umar Mohideen, Michael E. Colvin, Roya Zandi, Ajay Gopinathan

Refining biomarker-based clustering of cardiovascular inflammatory phenotypes in HIV using Recursive Feature Addition: A comparative evaluation approach

Rachel Mac Cann, Dana Alalwan, Gurvin Saini, Alejandro Abner Garcia Leon, Neeltje A. Kootstra, Padraig McGettrick, Aoife G Cotter, Alan Winston, Peter Reiss, Caroline Sabin, Patrick W. Mallon, on behalf of the UPBEAT-CAD, AIID and COBRA cohorts

Bifurcation of neural firing patterns driven by potassium dynamics and neuron–electrode geometry during high-frequency stimulation

Yue Yuan, Junyang Zhang, Chen Wang, Hao Yan, Ning Zhang, Kun Zhang, Zheshan Guo, Zhaoxiang Wang

MsgaBpred: A B-cell epitope predictor integrating AlphaFold3-predicted structures with multi-scale GCNs and pre-trained language model ESM-C

Shanyue Wang, Aoyun Geng, Zhenjie Luo, Yazi Li, Junlin Xu, Yajie Meng, Leyi Wei, Quan Zou, Zilong Zhang, Tao Wang, Feifei Cui

Stochastic intracellular calcium dynamics show preserved structures identified by deep learning classification

Jaesung Choi, Athokpam Langlen Chanu, Shakul Awasthi

Polyandry: A threat or an opportunity for the sterile insect technique?

Marine A. Courtois, Louise van Oudenhove, Suzanne Touzeau, Frédéric Grognard, Ludovic Mailleret

Individual and population level uncertainty interact to determine the performance of outbreak surveillance systems

Callum R. K. Arnold, Alex C. Kong, Amy K. Winter, William J. Moss, Bryan N. Patenaude, Matthew J. Ferrari

Evolutionary Kuramoto dynamics unravels origins of chimera states in neural populations

Thomas Zdyrski, Scott Pauls, Feng Fu

Population dynamics of generalist and specialist strategies under feast-famine cycles

Rintaro Niimi, Chikara Furusawa, Yusuke Himeoka

Complexity of resting cortical activity predicts neurophysiological responses to theta-burst stimulation but fails to generalize: A rigorous machine-learning approach

Matthew Herbert Ning, Haoqi Sun, Brice Passera, Duygu Bagci Das, Brandon Westover, Alvaro Pascual-Leone, Emiliano Santarnecchi, Mouhsin M. Shafi, Recep A. Ozdemir

Evaluating the utility of amino acid similarity-aware kmers to represent TCR repertoires for classification

Hannah Kockelbergh, Shelley C. Evans, Liam Brierley, Peter L. Green, Andrea L. Jorgensen, Elizabeth J. Soilleux, Anna Fowler

Learning the bistable cortical dynamics of the sleep-onset period

Zhenxing Hu, Manaoj Aravind, Xu Lei, J. Nathan Kutz, Jean-Julien Aucouturier

Methods

A standardized workflow for kinetic metabolic model curation and dissemination

Margaret Cook, Stella Anastasakis, Adel Heydarabadipour, Janis Shin, Diego Alba Burbano, James M. Carothers, Herbert M. Sauro

QoALa: A comprehensive workflow for viral quasispecies diversity comparison using long-read sequencing data

Nakarin Pamornchainavakul, Declan C. Schroeder, Kimberly VanderWaal

Semi-parametric empirical bayes method for multiplet detection in snATAC-seq with probabilistic multi-omic integration

Yuntian Wu, Haoran Hu, Wei Chen, Johann E. Gudjonsson, Lam C. Tsoi, Xiaoquan Wen

Cell type annotation for scATAC-seq via DNA large language model and graph domain adaptation

Yan Liu, Sheng Guan, He Yan, Long-Chen Shen, Ji-Peng Qiang, Guo Wei

Software

ntStat: k-mer characterization using occurrence statistics in raw sequencing data

Parham Kazemi, Lauren Coombe, René L. Warren, Inanc Birol