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Current Issue of PLoSBiology


Current Issue | PLOS Computational Biology
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Table of Contents

June 2026

The clonal architecture of a tumor results from the processes of cell division, cell death, and mutation. This mechanism gives rise to a mass of genetically distinct populations, leading to intra-tumor heterogeneity. We have designed a fully stochastic tumor evolution model that integrates genotypic inheritance with phenotype driven functional traits. Mutational events are associated with functional capabilities such as altered proliferation, increased mutation rates, limit evasion potential, or enhanced control over shared resources. The model is proven to reproduce observed behaviors, to improve our understanding of the system, and to help in testing predictions. Volpatto et al. 2026

Image Credit: Daniela Volpatto

Education Articles

Ten simple rules for teaching data science

Tiffany A. Timbers, Mine Çetinkaya-Rundel

Ten simple rules for executing an inherited research plan in computational biology

Sahar Javaheri Tehrani, Toni Ingolf Gossmann

Ten simple rules for writing a peer review

Farzana Rahman, Dan DeBlasio

Ten simple rules for turning your qualifying exam into an NIH-style fellowship proposal: A guide for graduate students

Courtney Peña-Lima, Cameron S. Bader, Brendan K. Ball, Troy C. Dildine, Mekhala V. Dissanayake, Iris van ‘t Erve, Albina Ibrayeva, Amy Nippert, M.K. Quinn, Chelse Spinner, Samuel Thompson, Antonio Tomasso, Crystal M. Botham

Ten simple rules for making the supplement increase your paper’s impact

Volker Grimm, Uta Berger, Stefano Mammola

Ten quick tips for classifying unknown bacteriophage

Fabian T. S. Bastiaanssen, Colin Hill, Andrey N. Shkoporov

Perspectives

Predictive modeling in biology and medicine: Digital twins and multi-scale modeling

Mark Alber, Amber Smith, Reinhard Laubenbacher, Roeland M. H. Merks

Review

On the conditions for shifts in metabolic strategies

Maarten J. Droste, Robert Planqué, Frank J. Bruggeman

Research Articles

A statistical framework for comparing epidemic forests

Cyril Geismar, Peter J. White, Anne Cori, Thibaut Jombart

Supervised deep learning with gene functional annotation for cell classification

Zhexiao Lin, Yuanyuan Gao, Wei Sun

On real-time calibrated prediction for complex model-based decision support in pandemics: Part 2

Trevelyan J. McKinley, Daniel B. Williamson, Xiaoyu Xiong, James M. Salter, Robert Challen, Leon Danon, Ben Youngman, Doug McNeall

Challenges and progress in RNA velocity: Comparative analysis across multiple biological contexts

Sarah Ancheta, Leah Dorman, Guillaume Le Treut, Abel Gurung, Greg Huber, Loïc A. Royer, Alejandro Granados, Merlin Lange

Data-driven model reveals increased stability of CAG-expanded huntingtin RNA due to MID1 binding

Yuhong Liu, Annika Reisbitzer, Domagoj Dorešić, Jan Hasenauer, Sybille Krauß, Tatjana Tchumatchenko

Assessing the importance of sex and disease-specific anatomy in electrophysiology and mechanical simulations with a newly developed public virtual cohort of four-chamber heart models

José Alonso Solís-Lemus, Rosie K. Barrows, Cristobal Rodero, Marina Strocchi, Natalie Montarello, Nishant Lahoti, Cesare Corrado, Abdul Qayyum, Shahrokh Rahmani, Caroline Roney, Gernot Plank, Christoph Augustin, Hao Xu, Alistair Young, Pras Pathmanathan, Ronak Rajani, Steven A. Niederer

Linking reduced prefrontal microcircuit inhibition in schizophrenia to EEG biomarkers in silico

Sana Rosanally, Frank Mazza, Heng Kang Yao, Faraz Moghbel, Hannah Seo, Etay Hay

PepAnno: A structure-aware deep learning framework for bioactive peptide prediction, structural visualization, and physicochemical profiling

Enyan Liu, Yueming Hu, Liya Liu, Yifan Chen, Shilong Zhang, Sida Li, Haoyu Chao, Luyao Xie, Yi Shen, Liangwei Wu, Julio Raúl Fernández Massó, Ming Chen

CIPHER: An end-to-end framework for designing optimized aggregated spatial transcriptomics experiments

Zachary Hemminger, Haley De Ocampo, Fangming Xie, Zhiqian Zhai, Jingyi Jessica Li, Roy Wollman

Cell differentiation can underpin the reproducibility of morphogenesis

Dominic K. Devlin, Austen R. D. Ganley, Nobuto Takeuchi

StPedf: Cell trajectory inference of spatial transcriptomics via spatial proximity embedding and spatial density-adaptive fusion

Yuan Zhang, Ziyan Sun, Zhixin Shi, Mengdi Nan, Yuhan Fu, Qing Ren, Jie Gao

Heuristic multi-site optimization for protein sequence design using Masked Protein Language Models

Lijuan Wang, Yuze Wang, Chen Qiu, Liwei Xiao, Xianliang Liu, Junjie Chen

Statistics of cortical representational drift can enable robust readout

Charles Micou, Timothy O’Leary

Evolution of phenocopying in a dynamical model of developmental trajectories

Yuuki Matsushita, Archishman Raju

Multi-stable oscillations in cortical networks with two classes of inhibition

Arnab Dey Sarkar, Bard Ermentrout

Interpreting higher-order dependence in multimorbidity using cohort data: A partial information decomposition approach

Cillian Hourican, Geeske Peeters, René J. F. Melis, Almar Kok, Natasja M. van Schoor, Sandra Wezeman, Mike Lees, Marcel G. M. Olde Rikkert, Rick Quax

Robust discovery of mutational signatures using power posteriors

Catherine Xue, Jeffrey W. Miller, Scott L. Carter, Jonathan H. Huggins

Catecholamine precursor modulation of human exploration: Evidence from a large gender-balanced sample

Angela Mariele Brands, Kilian Knauth, David Mathar, Tim Roedder, Kerstin Lisner, Jan Peters

A new method for augmenting short time series, with application to pain events in sickle cell disease

Kumar Utkarsh, Nirmish R. Shah, Tanvi Banerjee, Daniel M. Abrams

Stage-dependent role of NEK7 in the inactive-to-active conformational transition of NLRP3 monomer

Jin Peng, Wenjian Li, Hao Wang, Xiaohui Chen, Manjie Zhang, Bin Sun

WormSORT: A detection-based multiple object tracking model for individual silkworms in breeding environments

Hongkang Shi, Linbo Li, Shiping Zhu, Haibo He, Minghui Zhu, Jianfei Zhang

Fung-AI: An AI/ML-driven pipeline for antifungal peptide discovery

Daniel S. Berman, Libby M. Lewis, Tom D. Curtis, Olivia N. Tiburzi, Daniel F. Q. Smith, Arturo Casadevall, Laura J. Dunphy

A multilevel hierarchical framework for quantification of experimental heterogeneity in population snapshot data

David J. Warne, Xiangrun Zhu, Thomas P. Steele, Stuart T. Johnston, Scott A. Sisson, Matthew Faria, Ryan J. Murphy, Alexander P. Browning

Combining machine learning and iterative experiments to keep pace with emerging viral variants of concern

Thomas Sheffield, Ryan C. Bruneau, Stephen Won, Kenneth L. Sale, Brooke Harmon, Le Thanh Mai Pham

Mechanisms underlying spontaneous and evoked calcium responses in oligodendrocyte precursor cells: A modeling investigation

Martin Lardy, Leqi Wang, Claire Guerrier, Veronica T. Cheli, Pablo M. Paez, Anmar Khadra

A comparison of contact patterns derived from the population structure in agent-based models and empirical contact survey data

Janik Suer, Johannes Ponge, Michael Brüggemann, Jan Pablo Burgard, Vitaly Belik, Bernd Hellingrath, Alejandra Rincón Hidalgo, Andrzej K. Jarynowski, Richard Pastor, Huynh Thi Phuong, Steven Schulz, Ashish Thampi, Chao Xu, Marlli Zambrano, Rafael Mikolajczyk, André Karch, Veronika K. Jaeger, on behalf of the OptimAgent Consortium

A lactylation- and autophagy-associated prognostic signature reveals LSEC-derived CLEC3B as a novel mediator of hepatocellular carcinoma suppression

Youai Song, Yinkuan Ning, Meihui Li, Jianwei Lan, Liangchen Lei, Yufei Han, Zhuo Meng, Binjie Li, Pengpeng Liu, Quanyan Liu

Beyond the canonical: The role of post-transcriptional regulation in drug-target interaction prediction

Md Istiaq Ansari, Khandakar Tanvir Ahmed, Debby D. Wang, Kirill Medvedev, Wei Zhang

Integrative modelling of innate immune response dynamics during virus infection

Ramya Boddepalli, Harsh Chhajer, Rahul Roy

Towards modeling phage therapy

Rob J. de Boer, Robert Schooley, Alan S. Perelson

Cell-type resolved transcriptional network analysis of in vivo cellular senescence following injury

Alda Sabalic, Victoria Moiseeva, Andres Cisneros, Oleg Deryagin, Eusebio Perdiguero, Pura Muñoz-Cánoves, Jordi Garcia-Ojalvo

Adhesion and polarity-driven morphogenesis: Mechanisms and constraints in tissue formation

Yoshiyuki T. Nakamura, Chikara Furusawa, Kunihiko Kaneko

TCRBinder: Unified pre-trained language model with paired-chain synergy for predicting T-cell receptor binding specificity

Weihe Dong, Qiang Yang, Long Xu, Xiaokun Li, Kuanquan Wang, Suyu Dong, Gongning Luo, Xianyu Zhang, Tiansong Yang, Xin Gao, Guohua Wang

CARGO: A Cytometry Analysis framework via Regularized Graph Optimal-transport

Abida Sanjana Shemonti, Grzegorz B. Gmyrek, Katrien L. A. Quintelier, Sofie Van Gassen, Yvan Saeys, Marcella Willemsen, Joachim G. J. V. Aerts, Eva V. E. Madsen, J. Paul Robinson, Alex Pothen, Bartek Rajwa

A new cancer progression model: From synthetic tumors to real data and back

Daniela Volpatto, Sandro Gepiro Contaldo, Simone Pernice, Marco Beccuti, Francesca Cordero, Roberta Sirovich

The transcriptional gradient in negative-strand RNA viruses suggests a common RNA transcription mechanism

Connor R. King, Casey-Tyler Berezin, Brian Munsky, Jean Peccoud

Variable selection-combined causal mediation analysis for continuous treatments with application to large-dimensional biomedical data

Yajing Zhou, Kecheng Wei, Yahang Liu, Zhaoyang Li, Chen Huang, Guoyou Qin, Yongfu Yu

Evaluating vectors for the design of a spillover-disrupting Lassa virus transmissible vaccine

Scott L. Nuismer, Christopher H. Remien, Bruno Ghersi, Jenna Nichols, James Bangura, Emmanuel Amara, Marilyn C. Kanu, Osman T. Kanu, Edwin G. Lavalie, Mohamed Turay, Patrick L. K. Swaray, Mohamed A. Vandi, Joseph Hughes, Heinz Feldmann, Kyle Rosenke, Michael A. Jarvis, Andrew J. Davison

scRADAR: Dissecting intratumoral drug response heterogeneity at single-cell resolution via mechanism-guided prototype routing

Ren Qi, Wenjie Teng, Xin Yang, Peng Han, Alexey K. Shaytan, Bin Liu

Quantitative anatomy and biophysical modeling of ascending neuromodulatory systems in the developing rat neocortex

Cristina Colangelo, Alberto Muñoz, Alberto Antonietti, Vishal Sood, Alejandro Antón-Fernández, Joni Herttuainen, Armando Romani, Javier DeFelipe, Srikanth Ramaswamy

Predicting continuous outcomes: Some new tests of associative approaches to contingency learning

Julie Y. L. Chow, Hilary J. Don, Ben Colagiuri, Evan J. Livesey

Single-threshold–guided adaptive cancer therapy with partial-cycle treatment: A mechanistic and reinforcement learning analysis

Kexin Ma, Ningjing Wang, Zai Yang, Robert A. Cheke, Biao Tang

Delayed reward information is underweighted in reinforcement learning with dispersed feedback

Miruna Cotet, David Poensgen, Ian Krajbich

Systematic design of auxotrophic strains and media conditions to probe metabolic functions in E. coli

Roghaye Mohammadbeygi, Patrick F. Suthers, Fang-Yu Chung, Brian F. Pfleger, Costas D. Maranas

GHF-ACL: A novel contrastive learning framework with multi-order graph structures for herb-disease association prediction

Yunmeng Zhang, Xiuhong Wu, Qiutong Wang, Lin Shi, Meiling Liu, Guohua Wang

GATE: Adaptive learning with working memory by information gating in multi-lamellar hippocampal formation

Yuechen Liu, Zishun Wang, Chen Qiao, Zongben Xu

Linking retinal sampling in neural encoding models to temporal profiles of visual processing in humans

Niklas Müller, Hongye Chen, Sofie Wahlberg, H. Steven Scholte, Iris I. A. Groen

Detection, communication, and individual identification with deep audio embeddings: A case study with North Atlantic right whales

Irina Tolkova, Holger Klinck, Dana A. Cusano, Anke Kügler, Susan E. Parks

Correction

Correction: Viral escape-inspired framework for structure-guided dual bait protein biosensor design

Yee Chuen Teoh, Mohammed Sakib Noor, Sina Aghakhani, Jack Girton, Guiping Hu, Ratul Chowdhury

Related Articles

Methods

Histology-informed spatial domain identification through multi-view graph convolutional networks

Huihui Zhang, Jiaxing Chang, Zirong Li, Yue Sun, Pinli Hu, Haoxiu Wang, Hang Yang, Yonglin Ren, Xingtan Zhang, Zehua Chen, Kok Wai Wong, Haojing Shao

Exploring the structural lexicon of the Proteome via Metric Geometry

Elijah Gunther, Pablo G. Camara

Software

BeetleAtlas 2: An enhanced Tribolium castaneum web resource for tissue and developmental transcriptomics allowing refinement of gene predictions

David P. Leader, Muhammad T. Naseem, Janina L. Rinke, Kenneth Veland Halberg

pyhgf: A neural network library for predictive coding

Nicolas Legrand, Lilian Weber, Peter Thestrup Waade, Anna Hedvig Møller Daugaard, Mojtaba Khodadadi, Nace Mikuš, Christoph Mathys

GrassSV – hybrid method to detect structural variants in high throughput DNA-seq data

Dominik Witczak, Krzysztof Sychla, Julia Wysocka, Artur Laskowski, Wojciech Frohmberg, Marta Glowacka, Alicja Dzik, Piotr Lukasiak, Jacek Blazewicz, Aleksandra Swiercz

CoDaLoMic: An R package for modeling microbiome compositional and longitudinal data

Irene Creus-Martí, Andrés Moya, Francisco J. Santonja

HoloBio: A holographic microscopy tool for quantitative biological analysis

Waira Mona, Maria J. Gil-Herrera, Emanuel Mazo, Daniel Córdoba, Sofia Obando-Vasquez, Maria J. Lopera, Rene Restrepo, Carlos Trujillo, Ana Doblas, Raul Castaneda