Spatial SL slope plotted against synchrony for seven subnetworks: default mode (DMN), frontoparietal (FPN), sensorimotor (SMN), visual (VN), limbic, subcortical and cerebellar. (A, B) Brain renderings of each subnetwork, including cortical and subcortical regions involved in neurodevelopment and aging. Subnetworks are defined using the AAL atlas. (C–E) Scatterplots of spatial SL slope against synchrony during rest (C), movie watching (D) and a sensorimotor task (E). Each point is one observation, colored by age. Marginal distributions appear on the axes, and fitted regression lines show a negative relationship in most subnetworks. Saha et al. 2026
Image Credit: Suman Saha
Education Articles
Ten simple rules for preparing and delivering effective funding pitches in competitive grant applications
PLOS Computational Biology: published October 7, 2026 | https://doi.org/10.1371/journal.pcbi.1014840
Ten simple rules to build genomics capacity for routine laboratory practice in the Global South
PLOS Computational Biology: published October 15, 2026 | https://doi.org/10.1371/journal.pcbi.1014863
Ten simple rules for developing a reporting appraisal tool
PLOS Computational Biology: published October 16, 2026 | https://doi.org/10.1371/journal.pcbi.1014841
Thirteen quick tips for bacteriophage genome annotation
PLOS Computational Biology: published October 26, 2026 | https://doi.org/10.1371/journal.pcbi.1014887
Eight quick tips for using the reactome knowledgebase
PLOS Computational Biology: published October 27, 2026 | https://doi.org/10.1371/journal.pcbi.1014891
Ten simple rules for designing your career pivot
PLOS Computational Biology: published October 27, 2026 | https://doi.org/10.1371/journal.pcbi.1014890
Ten simple rules for preparing a job application for an academic position
PLOS Computational Biology: published October 27, 2026 | https://doi.org/10.1371/journal.pcbi.1014889
Ten simple rules for teaching practical AI to health data teams
PLOS Computational Biology: published October 30, 2026 | https://doi.org/10.1371/journal.pcbi.1014915
Perspectives
From prompts to genomes: A constraint-first framework for AI-driven sequence design across life and viruses
PLOS Computational Biology: published October 15, 2026 | https://doi.org/10.1371/journal.pcbi.1014865
Ten simple rules for responsible use of AI and LLMs in computational biology
PLOS Computational Biology: published October 22, 2026 | https://doi.org/10.1371/journal.pcbi.1014882
Research Articles
Effects of spatial constraints of inhibitory connectivity on the dynamical development of criticality in spiking networks
PLOS Computational Biology: published October 1, 2026 | https://doi.org/10.1371/journal.pcbi.1014798
Demographic changes and behavioural responses shape vulnerability to infectious disease outbreaks
PLOS Computational Biology: published October 1, 2026 | https://doi.org/10.1371/journal.pcbi.1014319
Robust prediction of drug combination side effects in realistic settings
PLOS Computational Biology: published October 5, 2026 | https://doi.org/10.1371/journal.pcbi.1013619
DeCTCF: Decoding CTCF binding sequences by leveraging predicted epigenomic features
PLOS Computational Biology: published October 5, 2026 | https://doi.org/10.1371/journal.pcbi.1014848
Bioactivity-driven prediction of antibacterial synergy using machine learning models
PLOS Computational Biology: published October 5, 2026 | https://doi.org/10.1371/journal.pcbi.1014849
Machine learning and Voronoi-based decision boundaries for Bacterial vaginosis to determine population- specific microbial interactions
PLOS Computational Biology: published October 5, 2026 | https://doi.org/10.1371/journal.pcbi.1014767
A generalized scaling law reveals synchrony-driven reorganization of brain dynamics across human lifespan
PLOS Computational Biology: published October 5, 2026 | https://doi.org/10.1371/journal.pcbi.1014821
Quantifying antibiotic susceptibility and inoculum effects using transient dynamics of Pseudomonas aeruginosa
PLOS Computational Biology: published October 5, 2026 | https://doi.org/10.1371/journal.pcbi.1014827
Spatially resolved reaction–diffusion modeling reveals effects of intracellular spatial heterogeneity on yeast galactose network dynamics
PLOS Computational Biology: published October 5, 2026 | https://doi.org/10.1371/journal.pcbi.1014811
Repurposing ritonavir to induce proteasomal degradation of IE1 for inhibition of human cytomegalovirus replication
PLOS Computational Biology: published October 6, 2026 | https://doi.org/10.1371/journal.pcbi.1014867
Spatial Transcriptomics As Rasterized Image Tensors (STARIT) characterizes cell states with subcellular molecular heterogeneity
PLOS Computational Biology: published October 6, 2026 | https://doi.org/10.1371/journal.pcbi.1014845
Mobility hinders malaria elimination goals in the Brazilian Amazon
PLOS Computational Biology: published October 6, 2026 | https://doi.org/10.1371/journal.pcbi.1014843
CardamomOT: A mechanistic optimal transport-based framework for gene regulatory network inference, trajectory reconstruction and generative modeling
PLOS Computational Biology: published October 6, 2026 | https://doi.org/10.1371/journal.pcbi.1014838
HiFIseek: Gene-specific enrichment of high-impact mutations in associated genomic regions
PLOS Computational Biology: published October 6, 2026 | https://doi.org/10.1371/journal.pcbi.1014842
A physiologically constrained calibration framework for cardiovascular models applied to a paediatric synthetic sepsis population
PLOS Computational Biology: published October 7, 2026 | https://doi.org/10.1371/journal.pcbi.1014847
A joint mixture Tobit method with latent microbial abundance improves detection of microbiome–disease associations in zero-inflated data
PLOS Computational Biology: published October 7, 2026 | https://doi.org/10.1371/journal.pcbi.1014844
Awake alpha bursting emerges as the dynamic working state in a lateral geniculate thalamocortical cell model
PLOS Computational Biology: published October 8, 2026 | https://doi.org/10.1371/journal.pcbi.1014654
A statistical damage model for coupled mechano-electrophysiological axonal injury
PLOS Computational Biology: published October 9, 2026 | https://doi.org/10.1371/journal.pcbi.1014837
Hyper-mutational processes provide a head-start for weak cancer drivers: Explaining atypical KRAS variants
PLOS Computational Biology: published October 9, 2026 | https://doi.org/10.1371/journal.pcbi.1014858
How does explicit reliability guide choices? Effect of trustworthiness on choice and metacognition
PLOS Computational Biology: published October 9, 2026 | https://doi.org/10.1371/journal.pcbi.1014818
Dynamic workforce modulation and foraging efficiency in Eusocial insect colonies
PLOS Computational Biology: published October 9, 2026 | https://doi.org/10.1371/journal.pcbi.1014258
Latent encoding of movement in primary visual cortex
PLOS Computational Biology: published October 12, 2026 | https://doi.org/10.1371/journal.pcbi.1014826
Understanding cell fate decisions with temporal attention
PLOS Computational Biology: published October 12, 2026 | https://doi.org/10.1371/journal.pcbi.1014813
Identification of letters distorted by physiologically-inspired spatial scrambling
PLOS Computational Biology: published October 12, 2026 | https://doi.org/10.1371/journal.pcbi.1014856
Sparse neuronal C4 elevation induces network-wide transcriptomic and lipid-droplet remodeling in the cortical microenvironment
PLOS Computational Biology: published October 12, 2026 | https://doi.org/10.1371/journal.pcbi.1014871
Distinct extracellular architectures shape mechanical persistence in GPVI and CLEC-2 receptor assemblies
PLOS Computational Biology: published October 13, 2026 | https://doi.org/10.1371/journal.pcbi.1014884
Going around phase defects: Addressing a fundamental flaw of phase singularity detection
PLOS Computational Biology: published October 13, 2026 | https://doi.org/10.1371/journal.pcbi.1013963
The influence of cell morphology on the dynamics and stability of model bacterial communities
PLOS Computational Biology: published October 13, 2026 | https://doi.org/10.1371/journal.pcbi.1014874
Forecasting of infectious disease epidemics in sexual networks using attenuated renewal processes
PLOS Computational Biology: published October 13, 2026 | https://doi.org/10.1371/journal.pcbi.1013987
DipSkmer: Reference-free population genomics with diploid genome skims
PLOS Computational Biology: published October 13, 2026 | https://doi.org/10.1371/journal.pcbi.1014823
Interpretable neural networks prioritize cancer driver genes from genome-wide dependency landscapes
PLOS Computational Biology: published October 13, 2026 | https://doi.org/10.1371/journal.pcbi.1014869
Natural killer cell receptor signaling and activation depend on cell cycle stages
PLOS Computational Biology: published October 13, 2026 | https://doi.org/10.1371/journal.pcbi.1014825
MEGH-DDI: MolT5-driven edge-aware graph learning with Hop2Token representation for drug–drug interaction prediction
PLOS Computational Biology: published October 14, 2026 | https://doi.org/10.1371/journal.pcbi.1014393
How compartmentalization and proliferation shape the splenic T cell repertoire during an immune response to a complex antigen in mice
PLOS Computational Biology: published October 14, 2026 | https://doi.org/10.1371/journal.pcbi.1014859
Leveraging spatial structure to design spatially-targeted malaria interventions at the community-scale
PLOS Computational Biology: published October 15, 2026 | https://doi.org/10.1371/journal.pcbi.1014857
Weak dispersal and landscape size inevitably promote local biodiversity in heterogeneous metacommunities of competing species
PLOS Computational Biology: published October 16, 2026 | https://doi.org/10.1371/journal.pcbi.1014028
Computational deconvolution of drug sensitivity via single-cell–to–bulk transcriptome mapping
PLOS Computational Biology: published October 16, 2026 | https://doi.org/10.1371/journal.pcbi.1014862
The successor representation in high-risk drinking and alcohol-related contexts
PLOS Computational Biology: published October 21, 2026 | https://doi.org/10.1371/journal.pcbi.1014873
Proton transport drives allosteric conformational changes in the MmpL3 transporter
PLOS Computational Biology: published October 21, 2026 | https://doi.org/10.1371/journal.pcbi.1014880
Multiscale modeling reveals non-linear dynamics of AKT-mediated NO-ROS crosstalk in shear stress-induced endothelial phenotype
PLOS Computational Biology: published October 21, 2026 | https://doi.org/10.1371/journal.pcbi.1014860
SADRP: A structurally aware multi-modal framework for drug response prediction
PLOS Computational Biology: published October 21, 2026 | https://doi.org/10.1371/journal.pcbi.1014861
Spatio-temporal machine learning for multi-horizon prediction of bluetongue outbreaks
PLOS Computational Biology: published October 21, 2026 | https://doi.org/10.1371/journal.pcbi.1014870
Environmental volatility is associated with adaptive caution in visual search
PLOS Computational Biology: published October 21, 2026 | https://doi.org/10.1371/journal.pcbi.1014310
Cell-type dependence of effects from transcranial electric brain stimulation
PLOS Computational Biology: published October 22, 2026 | https://doi.org/10.1371/journal.pcbi.1014895
The evolutionary accessibility of cultural fitness landscapes
PLOS Computational Biology: published October 22, 2026 | https://doi.org/10.1371/journal.pcbi.1014830
A computational framework for modeling fluid and solid stresses in porous tissues with application to the trabeculated embryonic heart
PLOS Computational Biology: published October 23, 2026 | https://doi.org/10.1371/journal.pcbi.1014896
Visuomotor coordination on the road: Low-dimensional representations reveal adaptive, context-dependent reductions in the dimensionality of natural driving behavior
PLOS Computational Biology: published October 23, 2026 | https://doi.org/10.1371/journal.pcbi.1014056
An integrative computational approach for obstacle avoidance during action selection
PLOS Computational Biology: published October 26, 2026 | https://doi.org/10.1371/journal.pcbi.1013756
Calsequestrin localization at RyR2 clusters enables calcium wave propagation in ventricular myocytes
PLOS Computational Biology: published October 26, 2026 | https://doi.org/10.1371/journal.pcbi.1014449
An extensible deep learning framework for multi-type chromatin interaction prediction through hierarchical adaptation strategies
PLOS Computational Biology: published October 27, 2026 | https://doi.org/10.1371/journal.pcbi.1014911
Evolutionary and dynamic constraints converge on a conserved coupling sector in thermally adapted GH1 β-glucosidases
PLOS Computational Biology: published October 27, 2026 | https://doi.org/10.1371/journal.pcbi.1014879
KmerSignificance score: A discriminative and biologically informed framework for viral k-mer prioritization
PLOS Computational Biology: published October 27, 2026 | https://doi.org/10.1371/journal.pcbi.1014332
In silico prediction of metabolic trait robustness in microbial cells
PLOS Computational Biology: published October 27, 2026 | https://doi.org/10.1371/journal.pcbi.1014864
On real-time calibrated prediction for complex model-based decision support in pandemics: Part 1
PLOS Computational Biology: published October 28, 2026 | https://doi.org/10.1371/journal.pcbi.1014868
Individualised electrophysiological neural field models for the assessment of thalamocortical function in disorders of consciousness: A multicentre study
PLOS Computational Biology: published October 28, 2026 | https://doi.org/10.1371/journal.pcbi.1014905
Modeling reaction–diffusion processes in simplified to complex astroglial branchlet geometries using different simulation tools
PLOS Computational Biology: published October 28, 2026 | https://doi.org/10.1371/journal.pcbi.1014878
The evolutionary advantage of replacers in the Moran process
PLOS Computational Biology: published October 28, 2026 | https://doi.org/10.1371/journal.pcbi.1014892
Early vs late fusion of qMIDS with machine learning based classifiers for oral cancer diagnosis from gene expression data
PLOS Computational Biology: published October 28, 2026 | https://doi.org/10.1371/journal.pcbi.1014888
Cd47 deficiency in mouse brain under excitotoxic stress
PLOS Computational Biology: published October 29, 2026 | https://doi.org/10.1371/journal.pcbi.1014897
From 16S rDNA-seq count data to microbial interactions: A comprehensive benchmark of co-occurrence network inference methods
PLOS Computational Biology: published October 29, 2026 | https://doi.org/10.1371/journal.pcbi.1014898
Coupled beta and high-frequency oscillations emerge from synchronized bursting in a minimal model of the parkinsonian subthalamic nucleus
PLOS Computational Biology: published October 30, 2026 | https://doi.org/10.1371/journal.pcbi.1014921
ATP-independent entropy-driven dsRNA unwinding by DDX3X revealed by coarse-grained simulations and deep learning
PLOS Computational Biology: published October 30, 2026 | https://doi.org/10.1371/journal.pcbi.1014928
Degeneracy in neuronal bifurcation landscapes: Equivalent bifurcation sequences across distinct parameter sets
PLOS Computational Biology: published October 30, 2026 | https://doi.org/10.1371/journal.pcbi.1014893
Interpretable embeddings of speech explain and enhance the brain encoding performance of audio models
PLOS Computational Biology: published October 30, 2026 | https://doi.org/10.1371/journal.pcbi.1014906
Methods
A graph-attentive GAN for rare-cell-aware single-cell RNA-seq data generation
PLOS Computational Biology: published October 5, 2026 | https://doi.org/10.1371/journal.pcbi.1014601
Omics data discovery agents: Agent-supported retrieval, reanalysis, and synthesis of published omics data
PLOS Computational Biology: published October 6, 2026 | https://doi.org/10.1371/journal.pcbi.1014822
Computation-through-Dynamics Toolkit: Simulated datasets and quality metrics for dynamical models of neural activity
PLOS Computational Biology: published October 15, 2026 | https://doi.org/10.1371/journal.pcbi.1014755
Taxonova: Deep learning enables fast and confidence-aware microbiome species-level amplicon classification
PLOS Computational Biology: published October 29, 2026 | https://doi.org/10.1371/journal.pcbi.1014912
Software
DyME: An MD-based engine exploiting HTP mutagenesis for protein engineering and recognition mimicry
PLOS Computational Biology: published October 7, 2026 | https://doi.org/10.1371/journal.pcbi.1014221
Process bigraphs and the architecture of compositional systems biology
PLOS Computational Biology: published October 9, 2026 | https://doi.org/10.1371/journal.pcbi.1014819
Antimony 3: Extending human-readable model definitions for SBML Level 3 Core and Packages
PLOS Computational Biology: published October 12, 2026 | https://doi.org/10.1371/journal.pcbi.1014207