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Current Issue of PLoSBiology

Current Issue | PLOS Genetics
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Table of Contents

April 2024

Cover

The gene drive transgenic Drosophila suzukii show red fluorescence.
Issue Image

In the quest to control disease-transmitting vectors and agricultural pests, the revolutionary CRISPR-based gene drive emerges as a powerful tool. The development of a novel CRISPR -based homing gene drive system targeting the Tdc2 gene with the previously untested vasa promoter in Drosophila suzukii paves the way for more effective and sustainable pest control strategies. See Ma et al.. Download April’s cover page.

Image Credit: Su-Han Ma

Research Articles

Genomic analyses of Symbiomonas scintillans show no evidence for endosymbiotic bacteria but does reveal the presence of giant viruses

Anna Cho, Gordon Lax, Samuel J. Livingston, Yumiko Masukagami, Mariia Naumova, Olivia Millar, Filip Husnik, Patrick J. Keeling

PLOS Genetics: published April 1, 2024 | https://doi.org/10.1371/journal.pgen.1011218

Belt and braces: Two escape ways to maintain the cassette reservoir of large chromosomal integrons

Egill Richard, Baptiste Darracq, Eloi Littner, Gael A. Millot, Valentin Conte, Thomas Cokelaer, Jan Engelstädter, Eduardo P. C. Rocha, Didier Mazel, Céline Loot

PLOS Genetics: published April 5, 2024 | https://doi.org/10.1371/journal.pgen.1011231

A small-molecule approach to restore female sterility phenotype targeted by a homing suppression gene drive in the fruit pest Drosophila suzukii

Suhan Ma, Xuyang Ni, Shimin Chen, Xiaomu Qiao, Xuejiao Xu, Weizhe Chen, Jackson Champer, Jia Huang

PLOS Genetics: published April 5, 2024 | https://doi.org/10.1371/journal.pgen.1011226

Genetic interaction mapping reveals functional relationships between peptidoglycan endopeptidases and carboxypeptidases

Manuela Alvarado Obando, Diego Rey-Varela, Felipe Cava, Tobias Dörr

PLOS Genetics: published April 10, 2024 | https://doi.org/10.1371/journal.pgen.1011234

Into the Wild: A novel wild-derived inbred strain resource expands the genomic and phenotypic diversity of laboratory mouse models

Beth L. Dumont, Daniel M. Gatti, Mallory A. Ballinger, Dana Lin, Megan Phifer-Rixey, Michael J. Sheehan, Taichi A. Suzuki, Lydia K. Wooldridge, Hilda Opoku Frempong, Raman Akinyanju Lawal, Gary A. Churchill, Cathleen Lutz, Nadia Rosenthal, Jacqueline K. White, Michael W. Nachman

PLOS Genetics: published April 10, 2024 | https://doi.org/10.1371/journal.pgen.1011228

The quantitative genetics of gene expression in Mimulus guttatus

Paris Veltsos, John K. Kelly

PLOS Genetics: published April 11, 2024 | https://doi.org/10.1371/journal.pgen.1011072

Bayesian approach to assessing population differences in genetic risk of disease with application to prostate cancer

Iain R. Timmins, The PRACTICAL Consortium, Frank Dudbridge

PLOS Genetics: published April 17, 2024 | https://doi.org/10.1371/journal.pgen.1011212

Tumor-associated macrophage subtypes on cancer immunity along with prognostic analysis and SPP1-mediated interactions between tumor cells and macrophages

Liu Xu, Yibing Chen, Lingling Liu, Xinyu Hu, Chengsi He, Yuan Zhou, Xinyi Ding, Minhua Luo, Jiajing Yan, Quentin Liu, Hongsheng Li, Dongming Lai, Zhengzhi Zou

PLOS Genetics: published April 22, 2024 | https://doi.org/10.1371/journal.pgen.1011235

Collider bias correction for multiple covariates in GWAS using robust multivariable Mendelian randomization

Peiyao Wang, Zhaotong Lin, Haoran Xue, Wei Pan

PLOS Genetics: published April 22, 2024 | https://doi.org/10.1371/journal.pgen.1011246

Better together against genetic heterogeneity: A sex-combined joint main and interaction analysis of 290 quantitative traits in the UK Biobank

Boxi Lin, Andrew D. Paterson, Lei Sun

PLOS Genetics: published April 24, 2024 | https://doi.org/10.1371/journal.pgen.1011221

The actin binding sites of talin have both distinct and complementary roles in cell-ECM adhesion

Darius Camp, Bhavya Venkatesh, Veronika Solianova, Lorena Varela, Benjamin T. Goult, Guy Tanentzapf

PLOS Genetics: published April 25, 2024 | https://doi.org/10.1371/journal.pgen.1011224

Unraveling the genetics of arsenic toxicity with cellular morphology QTL

Callan O’Connor, Gregory R. Keele, Whitney Martin, Timothy Stodola, Daniel Gatti, Brian R. Hoffman, Ron Korstanje, Gary A. Churchill, Laura G. Reinholdt

PLOS Genetics: published April 25, 2024 | https://doi.org/10.1371/journal.pgen.1011248

Dendrite intercalation between epidermal cells tunes nociceptor sensitivity to mechanical stimuli in Drosophila larvae

Kory P. Luedke, Jiro Yoshino, Chang Yin, Nan Jiang, Jessica M. Huang, Kevin Huynh, Jay Z. Parrish

PLOS Genetics: published April 25, 2024 | https://doi.org/10.1371/journal.pgen.1011237

Transcriptional control of visual neural circuit development by GS homeobox 1

Alexandra R. Schmidt, Haiden J. Placer, Ishmael M. Muhammad, Rebekah Shephard, Regina L. Patrick, Taylor Saurborn, Eric J. Horstick, Sadie A. Bergeron

PLOS Genetics: published April 26, 2024 | https://doi.org/10.1371/journal.pgen.1011139

Correlation-based tests for the formal comparison of polygenic scores in multiple populations

Sophia Gunn, Kathryn L. Lunetta

PLOS Genetics: published April 26, 2024 | https://doi.org/10.1371/journal.pgen.1011249

Hypoxia delays steroid-induced developmental maturation in Drosophila by suppressing EGF signaling

Michael J. Turingan, Tan Li, Jenna Wright, Abhishek Sharma, Kate Ding, Shahoon Khan, Byoungchun Lee, Savraj S. Grewal

PLOS Genetics: published April 26, 2024 | https://doi.org/10.1371/journal.pgen.1011232

The impact of developmental stage, tissue type, and sex on DNA double-strand break repair in Drosophila melanogaster

Elizabeth L. Graham, Joel Fernandez, Shagun Gandhi, Iqra Choudhry, Natalia Kellam, Jeannine R. LaRocque

PLOS Genetics: published April 29, 2024 | https://doi.org/10.1371/journal.pgen.1011250

Deep mutational scanning of Pneumocystis jirovecii dihydrofolate reductase reveals allosteric mechanism of resistance to an antifolate

Francois D. Rouleau, Alexandre K. Dubé, Isabelle Gagnon-Arsenault, Soham Dibyachintan, Alicia Pageau, Philippe C. Després, Patrick Lagüe, Christian R. Landry

PLOS Genetics: published April 29, 2024 | https://doi.org/10.1371/journal.pgen.1011252

Conserved and novel enhancers in the Aedes aegypti single-minded locus recapitulate embryonic ventral midline gene expression

Isabella Schember, William Reid, Geyenna Sterling-Lentsch, Marc S. Halfon

PLOS Genetics: published April 29, 2024 | https://doi.org/10.1371/journal.pgen.1010891

KmerAperture: Retaining k-mer synteny for alignment-free extraction of core and accessory differences between bacterial genomes

Matthew P. Moore, Mirjam Laager, Paolo Ribeca, Xavier Didelot

PLOS Genetics: published April 29, 2024 | https://doi.org/10.1371/journal.pgen.1011184