Maintaining proper piRNA expression ensures the continued fertility of an organism, yet how these highly clustered genes are coordinately expressed in the C. elegans germ line remains unclear. Shown here is expression of the chromatin remodeler ISWI/ISW-1 (green) and an essential piRNA biogenesis factor PRDE-1 (magenta) which marks the piRNA locus. By acutely disrupting ISW-1 using a degron tag, we demonstrate that ISW-1 actively maintains a chromatin environment that permits PRDE-1 association. See Paniagua et al. Download July’s cover page.
Image Credit: Nancy Paniagua
Research Articles
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PLOS Genetics: published July 1, 2024 | https://doi.org/10.1371/journal.pgen.1011336
Unveiling the regulatory network controlling natural transformation in lactococci
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REV3 promotes cellular tolerance to 5-fluorodeoxyuridine by activating translesion DNA synthesis and intra-S checkpoint
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Improving population scale statistical phasing with whole-genome sequencing data
PLOS Genetics: published July 3, 2024 | https://doi.org/10.1371/journal.pgen.1011092
Regulators of rDNA array morphology in fission yeast
PLOS Genetics: published July 5, 2024 | https://doi.org/10.1371/journal.pgen.1011331
Across two continents: The genomic basis of environmental adaptation in house mice (Mus musculus domesticus) from the Americas
PLOS Genetics: published July 5, 2024 | https://doi.org/10.1371/journal.pgen.1011036
Exome sequencing identifies novel genetic variants associated with varicose veins
PLOS Genetics: published July 9, 2024 | https://doi.org/10.1371/journal.pgen.1011339
The Upstream Sequence Transcription Complex dictates nucleosome positioning and promoter accessibility at piRNA genes in the C. elegans germ line
PLOS Genetics: published July 10, 2024 | https://doi.org/10.1371/journal.pgen.1011345
Dynamic evolution of the heterochromatin sensing histone demethylase IBM1
PLOS Genetics: published July 11, 2024 | https://doi.org/10.1371/journal.pgen.1011358
Gene-vegetarianism interactions in calcium, estimated glomerular filtration rate, and testosterone identified in genome-wide analysis across 30 biomarkers
PLOS Genetics: published July 11, 2024 | https://doi.org/10.1371/journal.pgen.1011288
Meiotic double-strand break repair DNA synthesis tracts in Arabidopsis thaliana
PLOS Genetics: published July 16, 2024 | https://doi.org/10.1371/journal.pgen.1011197
Polygenic selection to a changing optimum under self–fertilisation
PLOS Genetics: published July 17, 2024 | https://doi.org/10.1371/journal.pgen.1011312
Genomic evidence reveals three W-autosome fusions in Heliconius butterflies
PLOS Genetics: published July 18, 2024 | https://doi.org/10.1371/journal.pgen.1011318
Genome-wide analysis of transcription-coupled repair reveals novel transcription events in Caenorhabditis elegans
PLOS Genetics: published July 19, 2024 | https://doi.org/10.1371/journal.pgen.1011365
APOER2 splicing repertoire in Alzheimer’s disease: Insights from long-read RNA sequencing
PLOS Genetics: published July 22, 2024 | https://doi.org/10.1371/journal.pgen.1011348
Transcriptional programs of Pitx2 and Tfap2a/Tfap2b controlling lineage specification of mandibular epithelium during tooth initiation
PLOS Genetics: published July 25, 2024 | https://doi.org/10.1371/journal.pgen.1011364
Maternal regulation of the vertebrate oocyte-to-embryo transition
PLOS Genetics: published July 25, 2024 | https://doi.org/10.1371/journal.pgen.1011343
A cytidine deaminase regulates axon regeneration by modulating the functions of the Caenorhabditis elegans HGF/plasminogen family protein SVH-1
PLOS Genetics: published July 26, 2024 | https://doi.org/10.1371/journal.pgen.1011367
Association of a rapidly selected 4.3kb transposon-containing structural variation with a P450-based resistance to pyrethroids in the African malaria vector Anopheles funestus
PLOS Genetics: published July 29, 2024 | https://doi.org/10.1371/journal.pgen.1011344
mRNA and circRNA mislocalization to synapses are key features of Alzheimer’s disease
PLOS Genetics: published July 29, 2024 | https://doi.org/10.1371/journal.pgen.1011359
REV1 coordinates a multi-faceted tolerance response to DNA alkylation damage and prevents chromosome shattering in Drosophila melanogaster
PLOS Genetics: published July 29, 2024 | https://doi.org/10.1371/journal.pgen.1011181
Spermatogenic cell-specific type 1 hexokinase (HK1S) is essential for capacitation-associated increase in tyrosine phosphorylation and male fertility in mice
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The LuxO-OpaR quorum-sensing cascade differentially controls Vibriophage VP882 lysis-lysogeny decision making in liquid and on surfaces
PLOS Genetics: published July 30, 2024 | https://doi.org/10.1371/journal.pgen.1011243
Floxuridine supports UPS independent of germline signaling and proteostasis regulators via involvement of detoxification in C. elegans
PLOS Genetics: published July 31, 2024 | https://doi.org/10.1371/journal.pgen.1011371
CED-5/CED-12 (DOCK/ELMO) can promote and inhibit F-actin formation via distinct motifs that may target different GTPases
PLOS Genetics: published July 31, 2024 | https://doi.org/10.1371/journal.pgen.1011330