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Current Issue of PLoSBiology


Current Issue | PLOS Genetics
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Table of Contents

July 2024

Maintaining proper piRNA expression ensures the continued fertility of an organism, yet how these highly clustered genes are coordinately expressed in the C. elegans germ line remains unclear. Shown here is expression of the chromatin remodeler ISWI/ISW-1 (green) and an essential piRNA biogenesis factor PRDE-1 (magenta) which marks the piRNA locus. By acutely disrupting ISW-1 using a degron tag, we demonstrate that ISW-1 actively maintains a chromatin environment that permits PRDE-1 association. See Paniagua et al. Download July’s cover page.

Image Credit: Nancy Paniagua

Research Articles

A catalogue of recombination coldspots in interspecific tomato hybrids

Roven Rommel Fuentes, Ronald Nieuwenhuis, Jihed Chouaref, Thamara Hesselink, Willem van Dooijeweert, Hetty C. van den Broeck, Elio Schijlen, Henk J. Schouten, Yuling Bai, Paul Fransz, Maike Stam, Hans de Jong, Sara Diaz Trivino, Dick de Ridder, Aalt D. J. van Dijk, Sander A. Peters

Unveiling the regulatory network controlling natural transformation in lactococci

Frédéric Toussaint, Marie Henry de Frahan, Félix Poncelet, Jean-Marc Ladrière, Philippe Horvath, Christophe Fremaux, Pascal Hols

Improving population scale statistical phasing with whole-genome sequencing data

Rick Wertenbroek, Robin J. Hofmeister, Ioannis Xenarios, Yann Thoma, Olivier Delaneau

Regulators of rDNA array morphology in fission yeast

Alexandria J. Cockrell, Jeffrey J. Lange, Christopher Wood, Mark Mattingly, Scott M. McCroskey, William D. Bradford, Juliana Conkright-Fincham, Lauren Weems, Monica S. Guo, Jennifer L. Gerton

Exome sequencing identifies novel genetic variants associated with varicose veins

Dan-Dan Zhang, Xiao-Yu He, Liu Yang, Bang-Sheng Wu, Yan Fu, Wei-Shi Liu, Yu Guo, Chen-Jie Fei, Ju-Jiao Kang, Jian-Feng Feng, Wei Cheng, Lan Tan, Jin-Tai Yu

The Upstream Sequence Transcription Complex dictates nucleosome positioning and promoter accessibility at piRNA genes in the C. elegans germ line

Nancy Paniagua, C. Jackson Roberts, Lauren E. Gonzalez, David Monedero-Alonso, Valerie Reinke

Dynamic evolution of the heterochromatin sensing histone demethylase IBM1

Yinwen Zhang, Hosung Jang, Ziliang Luo, Yinxin Dong, Yangyang Xu, Yamini Kantamneni, Robert J. Schmitz

Meiotic double-strand break repair DNA synthesis tracts in Arabidopsis thaliana

Miguel Hernández Sánchez-Rebato, Veit Schubert, Charles I. White

Polygenic selection to a changing optimum under self–fertilisation

Matthew Hartfield, Sylvain Glémin

Genomic evidence reveals three W-autosome fusions in Heliconius butterflies

Nicol Rueda-M, Carolina Pardo-Diaz, Gabriela Montejo-Kovacevich, W. Owen McMillan, Krzysztof M. Kozak, Carlos F. Arias, Jonathan Ready, Shane McCarthy, Richard Durbin, Chris D. Jiggins, Joana I. Meier, Camilo Salazar

APOER2 splicing repertoire in Alzheimer’s disease: Insights from long-read RNA sequencing

Christina M. Gallo, Sabrina A. Kistler, Anna Natrakul, Adam T. Labadorf, Uwe Beffert, Angela Ho

Transcriptional programs of Pitx2 and Tfap2a/Tfap2b controlling lineage specification of mandibular epithelium during tooth initiation

Fan Shao, An-Vi Phan, Wenjie Yu, Yuwei Guo, Jamie Thompson, Carter Coppinger, Shankar R. Venugopalan, Brad A. Amendt, Eric Van Otterloo, Huojun Cao

Maternal regulation of the vertebrate oocyte-to-embryo transition

Ricardo Fuentes, Florence L. Marlow, Elliott W. Abrams, Hong Zhang, Manami Kobayashi, Tripti Gupta, Lee D. Kapp, Zachary DiNardo, Ronald Heller, Ruth Cisternas, Priscila García-Castro, Fabián Segovia-Miranda, Felipe Montecinos-Franjola, William Vought, Charles E. Vejnar, Antonio J. Giraldez, Mary C. Mullins

Association of a rapidly selected 4.3kb transposon-containing structural variation with a P450-based resistance to pyrethroids in the African malaria vector Anopheles funestus

Leon M. J. Mugenzi, Theofelix A. Tekoh, Stevia T. Ntadoun, Achille D. Chi, Mahamat Gadji, Benjamin D. Menze, Magellan Tchouakui, Helen Irving, Murielle J. Wondji, Gareth D. Weedall, Jack Hearn, Charles S. Wondji

mRNA and circRNA mislocalization to synapses are key features of Alzheimer’s disease

Samuel N. Smukowski, Cassidy Danyko, Jenna Somberg, Eli J. Kaufman, Meredith M. Course, Nadia Postupna, Melissa Barker-Haliski, C. Dirk Keene, Paul N. Valdmanis

REV1 coordinates a multi-faceted tolerance response to DNA alkylation damage and prevents chromosome shattering in Drosophila melanogaster

Varandt Khodaverdian, Tokio Sano, Lara Maggs, Gina Tomarchio, Ana Dias, Mai Tran, Connor Clairmont, Mitch McVey

Spermatogenic cell-specific type 1 hexokinase (HK1S) is essential for capacitation-associated increase in tyrosine phosphorylation and male fertility in mice

Yingchao Tian, Xiu Chen, Jie Pu, Yuxin Liang, Weixi Li, Xiaotong Xu, Xinshui Tan, Shuntai Yu, Tianyu Shao, Yan Ma, Bingwei Wang, Yongjie Chen, Yushan Li

Floxuridine supports UPS independent of germline signaling and proteostasis regulators via involvement of detoxification in C. elegans

Abhishek Anil Dubey, Anwesha Sarkar, Karolina Milcz, Natalia A. Szulc, Pankaj Thapa, Małgorzata Piechota, Remigiusz A. Serwa, Wojciech Pokrzywa

CED-5/CED-12 (DOCK/ELMO) can promote and inhibit F-actin formation via distinct motifs that may target different GTPases

Thejasvi Venkatachalam, Sushma Mannimala, Yeshaswi Pulijala, Martha C. Soto