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Astrocytes are essential for the survival and activity of neurons. The image shows astrocytes harvested from adult mouse brains cultured for 1 week and stained by immunofluorescence for glial fibrillary acidic protein (green; cytoplasm) and 4′,6-diamidino-2-phenylindole (blue; nucleus). See McRae et al. Download October’s cover page
Image Credit: Melody P.Y. Leong
Research Articles
Yeast Nat4 regulates DNA damage checkpoint signaling through its N-terminal acetyltransferase activity on histone H4
PLOS Genetics: published October 2, 2024 | https://doi.org/10.1371/journal.pgen.1011433
C1-FDX is required for the assembly of mitochondrial complex I and subcomplexes of complex V in Arabidopsis
PLOS Genetics: published October 2, 2024 | https://doi.org/10.1371/journal.pgen.1011419
STAREG: Statistical replicability analysis of high throughput experiments with applications to spatial transcriptomic studies
PLOS Genetics: published October 3, 2024 | https://doi.org/10.1371/journal.pgen.1011423
The middle domain of Hsp104 can ensure substrates are functional after processing
PLOS Genetics: published October 3, 2024 | https://doi.org/10.1371/journal.pgen.1011424
Distinct cellular and junctional dynamics independently regulate the rotation and elongation of the embryonic gut in Drosophila
PLOS Genetics: published October 7, 2024 | https://doi.org/10.1371/journal.pgen.1011422
MAD1 upregulation sensitizes to inflammation-mediated tumor formation
PLOS Genetics: published October 7, 2024 | https://doi.org/10.1371/journal.pgen.1011437
Surface exclusion of IncC conjugative plasmids and their relatives
PLOS Genetics: published October 9, 2024 | https://doi.org/10.1371/journal.pgen.1011442
Tissue-specific knockout in the Drosophila neuromuscular system reveals ESCRT’s role in formation of synapse-derived extracellular vesicles
PLOS Genetics: published October 10, 2024 | https://doi.org/10.1371/journal.pgen.1011438
INO80 regulates chromatin accessibility to facilitate suppression of sex-linked gene expression during mouse spermatogenesis
PLOS Genetics: published October 15, 2024 | https://doi.org/10.1371/journal.pgen.1011431
Loss of PHF6 causes spontaneous seizures, enlarged brain ventricles and altered transcription in the cortex of a mouse model of the Börjeson–Forssman–Lehmann intellectual disability syndrome
PLOS Genetics: published October 15, 2024 | https://doi.org/10.1371/journal.pgen.1011428
Proximity labeling reveals new functional relationships between meiotic recombination proteins in S. cerevisiae
PLOS Genetics: published October 15, 2024 | https://doi.org/10.1371/journal.pgen.1011432
MBL-1/Muscleblind regulates neuronal differentiation and controls the splicing of a terminal selector in Caenorhabditis elegans
PLOS Genetics: published October 18, 2024 | https://doi.org/10.1371/journal.pgen.1011276
Behavioral screening reveals a conserved residue in Y-Box RNA-binding protein required for associative learning and memory in C. elegans
PLOS Genetics: published October 18, 2024 | https://doi.org/10.1371/journal.pgen.1011443
LD-transpeptidation is crucial for fitness and polar growth in Agrobacterium tumefaciens
PLOS Genetics: published October 21, 2024 | https://doi.org/10.1371/journal.pgen.1011449
HTL/KAI2 signaling substitutes for light to control plant germination
PLOS Genetics: published October 21, 2024 | https://doi.org/10.1371/journal.pgen.1011447
Celsr3 drives development and connectivity of the acoustic startle hindbrain circuit
PLOS Genetics: published October 21, 2024 | https://doi.org/10.1371/journal.pgen.1011415
Candida albicans pathways that protect against organic peroxides and lipid peroxidation
PLOS Genetics: published October 21, 2024 | https://doi.org/10.1371/journal.pgen.1011455
The Drosophila circadian clock gene cycle controls the development of clock neurons
PLOS Genetics: published October 21, 2024 | https://doi.org/10.1371/journal.pgen.1011441
Trajectory-centric framework TrajAtlas reveals multi-scale differentiation heterogeneity among cells, genes, and gene modules in osteogenesis
PLOS Genetics: published October 22, 2024 | https://doi.org/10.1371/journal.pgen.1011319
A comprehensive framework for trans-ancestry pathway analysis using GWAS summary data from diverse populations
PLOS Genetics: published October 23, 2024 | https://doi.org/10.1371/journal.pgen.1011322
Evolution of the pheV-tRNA integrated genomic island in Escherichia coli
PLOS Genetics: published October 24, 2024 | https://doi.org/10.1371/journal.pgen.1011459
Exposure to benzyl butyl phthalate (BBP) leads to increased double-strand break formation and germline dysfunction in Caenorhabditis elegans
PLOS Genetics: published October 24, 2024 | https://doi.org/10.1371/journal.pgen.1011434
Pangenome graph analysis reveals extensive effector copy-number variation in spinach downy mildew
PLOS Genetics: published October 25, 2024 | https://doi.org/10.1371/journal.pgen.1011452
The response to single-gene duplication implicates translation as a key vulnerability in aneuploid yeast
PLOS Genetics: published October 25, 2024 | https://doi.org/10.1371/journal.pgen.1011454
STIL overexpression shortens lifespan and reduces tumor formation in mice
PLOS Genetics: published October 28, 2024 | https://doi.org/10.1371/journal.pgen.1011460
Dual role for Headcase in hemocyte progenitor fate determination in Drosophila melanogaster
PLOS Genetics: published October 28, 2024 | https://doi.org/10.1371/journal.pgen.1011448