The light-sensing mechanism in nematodes had previously only been characterized in Caenorhabditis elegans. Using forward genetic screening, Nakayama et al. identified genes involved in light avoidance behavior in the nematode Pristionchus pacificus, revealing both conserved and unique features between the two species. This image shows sensory neurons, some of which are involved in photoresponse, labeled with fluorescent proteins and filled with dye in P. pacificus. See Nakayama et al.
Image Credit: Kenichi Nakayama
Editorial
Onwards! Open science and the (PLOS) genetics community
PLOS Genetics: published November 28, 2024 | https://doi.org/10.1371/journal.pgen.1011466
Research Articles
A Foxf1-Wnt-Nr2f1 cascade promotes atrial cardiomyocyte differentiation in zebrafish
PLOS Genetics: published November 4, 2024 | https://doi.org/10.1371/journal.pgen.1011222
Evaluation of Bayesian Linear Regression models for gene set prioritization in complex diseases
PLOS Genetics: published November 4, 2024 | https://doi.org/10.1371/journal.pgen.1011463
Repeat mediated excision of gene drive elements for restoring wild-type populations
PLOS Genetics: published November 7, 2024 | https://doi.org/10.1371/journal.pgen.1011450
Contribution of p53-dependent and -independent mechanisms to upregulation of p21 in Fanconi anemia
PLOS Genetics: published November 7, 2024 | https://doi.org/10.1371/journal.pgen.1011474
Prediction of causal genes at GWAS loci with pleiotropic gene regulatory effects using sets of correlated instrumental variables
PLOS Genetics: published November 11, 2024 | https://doi.org/10.1371/journal.pgen.1011473
Glucocerebrosidase deficiency leads to neuropathology via cellular immune activation
PLOS Genetics: published November 11, 2024 | https://doi.org/10.1371/journal.pgen.1011105
A naturally occurring mitochondrial genome variant confers broad protection from infection in Drosophila
PLOS Genetics: published November 11, 2024 | https://doi.org/10.1371/journal.pgen.1011476
Inositol pyrophosphate catabolism by three families of phosphatases regulates plant growth and development
PLOS Genetics: published November 12, 2024 | https://doi.org/10.1371/journal.pgen.1011468
cGMP-dependent pathway and a GPCR kinase are required for photoresponse in the nematode Pristionchus pacificus
PLOS Genetics: published November 14, 2024 | https://doi.org/10.1371/journal.pgen.1011320
A non-canonical role of somatic Cyclin D/CYD-1 in oogenesis and in maintenance of reproductive fidelity, dependent on the FOXO/DAF-16 activation state
PLOS Genetics: published November 15, 2024 | https://doi.org/10.1371/journal.pgen.1011453
Neuronal fatty acid-binding protein enhances autophagy and suppresses amyloid-β pathology in a Drosophila model of Alzheimer’s disease
PLOS Genetics: published November 19, 2024 | https://doi.org/10.1371/journal.pgen.1011475
RAD52 and ERCC6L/PICH have a compensatory relationship for genome stability in mitosis
PLOS Genetics: published November 19, 2024 | https://doi.org/10.1371/journal.pgen.1011479
Cell non-autonomous signaling through the conserved C. elegans glycoprotein hormone receptor FSHR-1 regulates cholinergic neurotransmission
PLOS Genetics: published November 19, 2024 | https://doi.org/10.1371/journal.pgen.1011461
Protein phosphatase 1 catalytic subunit gamma is a causative gene for meat lightness and redness
PLOS Genetics: published November 20, 2024 | https://doi.org/10.1371/journal.pgen.1011467
A high-resolution haplotype collection uncovers somatic hybridization, recombination and intercontinental movement in oat crown rust
PLOS Genetics: published November 21, 2024 | https://doi.org/10.1371/journal.pgen.1011493
GWAS and 3D chromatin mapping identifies multicancer risk genes associated with hormone-dependent cancers
PLOS Genetics: published November 25, 2024 | https://doi.org/10.1371/journal.pgen.1011490
Sex and neo-sex chromosome evolution in beetles
PLOS Genetics: published November 25, 2024 | https://doi.org/10.1371/journal.pgen.1011477
Contact-dependent growth inhibition (CDI) systems deploy a large family of polymorphic ionophoric toxins for inter-bacterial competition
PLOS Genetics: published November 26, 2024 | https://doi.org/10.1371/journal.pgen.1011494
Methods
Cell type-specific weighting-factors to solve solid organs-specific limitations of single cell RNA-sequencing
PLOS Genetics: published November 18, 2024 | https://doi.org/10.1371/journal.pgen.1011436